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Displaying 20 of 559 results for "JAK3"
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  1. Comparison of the expression profiles of wild-type (WT), Tyk2-deficient (Tyk2-/-) and kinase-inactive Tyk2 mutant (Tyk2K923E) NK cells BioProject

    ID: PRJNA282389

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Interferon alpha induced gene expression in SOCS1 and SOCS3 overexpressing melanoma and hepatoma cell lines. BioProject

    ID: PRJNA127915

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: receptors by masking its recognition site for the Janus kinases (JAK), by blocking the kinase activity of the JAKs and coincidentally hindering STAT molecules from binding to the kinases. They are also thought to ubiquitinate the JAKs resulting in their proteosomal degradation. The function of SOCS proteins in suppressing the interferon-alpha pathway has not yet been characterized exhaustively. This study should unveil links to understand the resistance in interferon-alpha therapy. As results we got almost complete silencing of JAK-STAT signaling in SOCS1 over-expressing cells and tissue-dependent partially suppressed gene induction in SOCS3 over-expressing cell lines. Overall design: Two human cancer cell lines (ME-15, HuH-7) were stably transfected with pcDNA3.1-SOCS plasmids in presence of geneticin and daughter cell lines were generated after singularization of cells. Next, or...
  3. Gene expression profiling of Type II Enteropathy-associated T-cell lymphoma BioProject

    ID: PRJNA289281

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Here we performed gene expression profiling on four Type II EATL samples in order to better characterize this disease. As Type II EATL is suggested to arise from CD8+ IELs, we integrated our data with publicly available profile of CD8αα and CD8αβ T-cells from healthy donors (GSE33374). Gene expression profiling independently demonstrated strong en...
  4. Expression data from NKYS transfected with siRNAs or plasmids OmicsDI

    ID: E-GEOD-75680

    Date Released: 07-30-2016

    Description: The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3

  5. Crystal structures of JAK1 and JAK2 inhibitor complexes PDB

    ID: PDB:3EYG

    Description: Tyrosine-protein kinase (E.C.2.7.10.2)

  6. PRJNA328967 BioProject

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: ested grains constitute a major dietary source of protein for people in developing nations. Insect C1 cysteine protease inhibition and immune response is important in this plant(seed)-insect interaction. A reference transcriptome of 35,118 contigs was de novo assembled from a pooled cDNA library from all life stages sequenced by Roche 454 Titanium technology. Gene...
  7. Design and Synthesis of a pan-JAK kinase inhibitor clinical candidate (PF-06263276) suitable for the treatment of inflammatory diseases of the... PDB

    ID: PDB:5TQ3

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  8. Microarray analysis of TNFα indcued senescence in Human umbilical vein endothelial cells BioProject

    ID: PRJNA383932

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: feron signature, and persistent activation of the Janus kinase (JAK) /signal transducer and activator of transcription (STAT) pathway in TNFα-mediated senescence. TNFα initiates a STAT-dependent autocrine loop leading to sustained inflammation, DNA damage, and expression of interferon response genes to lock cells into senescence. Further, we show STAT1/3 activation is necessary for cytokine and ROS production during TNFα-induced senescence. However, inhibition of STAT1/3 did not rescue cells from TNFα-mediated senescence. Rather, blockade of STAT activation accelerated senescence, suppressed genes that control the cell cycle, and modulated TNFα-induced senescence. Our findings suggest a positive feedback mechanism via a STAT pathway that sustains cytokine production and reveal a reciprocal regulatory role of JAK/STAT in TNFα-mediated senescence. Overall design: Human umbilical vein endothelial cells (HUVECs) were untreated or treated TNFα (5ng/ml) co...
  9. miRNA Microarray analysis of TNFα induced senescence in Human umbilical vein endothelial cells BioProject

    ID: PRJNA358247

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: feron signature, and persistent activation of the Janus kinase (JAK) /signal transducer and activator of transcription (STAT) pathway in TNFα-mediated senescence. TNFα initiates a STAT-dependent autocrine loop leading to sustained inflammation, DNA damage, and expression of interferon response genes to lock cells into senescence. Further, we show STAT1/3 activation is necessary for cytokine and ROS production during TNFα-induced senescence. However, inhibition of STAT1/3 did not rescue cells from TNFα-mediated senescence. Rather, blockade of STAT activation accelerated senescence, suppressed genes that control the cell cycle, and modulated TNFα-induced senescence. Our findings suggest a positive feedback mechanism via a STAT pathway that sustains cytokine production and reveal a reciprocal regulatory role of JAK/STAT in TNFα-mediated senescence. Overall design: Human umbilical vein endothelial cells (HUVECs) were untreated or treated TNFα (5ng/ml) co...
  10. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing ArrayExpress

    ID: E-GEOD-28703

    Description: signalling (67% of cases; NRAS, KRAS, FLT3, IL7R, JAK3, JAK1, SH2B3 and BRAF); alterations disrupting haemopoietic development (58%; GATA3, ETV6, RUNX1, IKZF1, EP300); and inactivating mutations in histone modifying genes (48%; EZH2, EED, SUZ12, SETD2 and EP300). We also identified new targets of mutation including DNM2, ECT2L and RELN. Ten of 12 ETP ALL cases harboured chromosomal rearrangements, several of which complex and resulted in the expression of novel chimeric in-frame fusion genes disrupting haemopoietic regulators. Thus, similar to myeloid malignancies, mutations that drive proliferation, impair differentiation and disr...

  11. Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatmen... PDB

    ID: PDB:5TQ8

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  12. Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatmen... PDB

    ID: PDB:5TQ7

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  13. Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatmen... PDB

    ID: PDB:5TQ5

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  14. Activation of the JAK/STAT pathway in Behcet’s Disease BioProject

    ID: PRJNA261006

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Crystal structures of JAK1 and JAK2 inhibitor complexes PDB

    ID: PDB:3FUP

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  16. Gene expression of Kit225 cells upon NC1153 treatment OmicsDI

    ID: E-GEOD-17007

    Date Released: 06-10-2011

    Description: NC1153 was shown to inhibit JAK3 tyrosine kinase. Lymphocytes survival depends on the integrity of STAT5, the primary dow...

  17. Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatmen... PDB

    ID: PDB:5TQ6

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  18. Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatmen... PDB

    ID: PDB:5TQ4

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  19. Gene expression profiling in erythroid progenitors through ontogeny OmicsDI

    ID: E-GEOD-37869

    Date Released: 05-03-2014

    Description: t has been reported that the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway regulates erythropoietin (EPO)-induced survival, proliferation, and maturation of early...

  20. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukaemia by whole genome sequencing ArrayExpress

    ID: E-GEOD-33315

    Description: including IL7R, NRAS, KRAS, FLT3, BRAF, JAK1 and JAK3 in ETP ALL. Moreover, we identified multiple new targets of mutation in including GATA3, EP300, RUNX1, DNM2, ECT2L, HNRNPA1 and HNRNPR, as well as genes known to be mutated in T-ALL, including NOTCH1, PHF6, and WT1.. Five of 12 ETP ALL cases harboured novel chromosomal translocations, several of which accompanied complex multichromosomal rearrangements and resulted in the expression of chimeric in-frame fusion genes disrupting hematopoietic regulators, including ETV6-INO80D, NAP1L1-MLLT10 and RUNX1-EVX1. These results indicate that although ETP ALL is genetically heterogeneous, activation of Ras and cytokine receptor signalling distinguishes this disease from non-ETP ALL....


Displaying 20 of 559 results for "JAK3"