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Displaying 20 of 559 results for "JAK3"
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  1. Expression data from NKYS transfected with siRNAs or plasmids BioProject

    ID: PRJNA305040

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3
  2. Polynucleobacter yangtzensis strain:MWH-JaK3 : Polynucleobacter MWH-JaK3 Genome sequencing BioProject

    ID: PRJNA277963

    Keywords: Genome sequencing and assembly

    Access Type: download

  3. Gene expression of Kit225 cells upon NC1153 treatment BioProject

    ID: PRJNA117747

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: NC1153 was shown to inhibit JAK3 tyrosine kinase. Lymphocytes survival depends on the integrity of STAT5, the primary dow...
  4. Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker BioProject

    ID: PRJNA274578

    Keywords: Variation

    Access Type: download

  5. Methylation data and effect of JAK3 inhibition on human MO-to-DC and MO-to-MAC differentiation ArrayExpress

    ID: E-GEOD-75937

    Description: ts on the methylation profiles of DCs and MACs of JAK3 inhibitor PF-956980 The methylation profiles of bisulfite-modified DNA of human CD14+ monocytes were compared with derived dendritic cells (DCs), macrophages (MACs) following GM-CSF/IL-4 and GM-CSF incubation, and DC and MAC samples incubated with JAK3 inhibitor PF-956980 using the Infinium HumanMethylation450 BeadChips (...

  6. Expression data from NKYS transfected with siRNAs or plasmids ArrayExpress

    ID: E-GEOD-75680

    Description: The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3

  7. Cytoscan HD arrays data for Nodal marginal zone lymphoma (NMZL) BioProject

    ID: PRJNA281882

    Keywords: Variation

    Access Type: download

    dataset.description: 14) translocations; and ii) recurrently harbored +3 (14%), +12 (14%) and preferential usage of the IGHV4-34 gene (17%). WES (HiSeq 2500, Illumina; mean coverage per sample: 38x-114x) and high resolution SNP array (Cytoscan HD, Affymetrix) of tumor/normal DNA pairs from 18 discovery NMZL identified 557 non-synonymous somatic mutations (average: 30.8/case) affecting 504 genes and 51 copy number abnormalities (CNA) (average: 3.2/case). To further characterize mutation recurrence, the 504 discovered genes were investigated in an independent validation panel of 17 NMZL by targeted sequencing of tumor/normal DNA pairs (MiSeq; target region: 1.6 Mb; mean coverage per sample: 171x-386x). The 17 validation NMZL were also assessed for CNA by high resolution SNP arrays. RNAseq of 11 discovery NMZL did not identify any recurrent gene fusion. By compiling the results of WES and high resolution SNP array, 39 genes were recurrently affected in >3
  8. Structure of Janus kinase 2 with a pyrrolotriazine inhibitor PDB

    ID: PDB:3Q32

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  9. Transcription profiling of human CD4+ cutaneous T-cell lymphoma (CTCL) Sez-4 cell line activated with IL-2, IL-15 or IL-21 ArrayExpress

    ID: E-GEOD-8685

    Description: -regulated <40 genes. All three cytokines induced tyrosine phosphorylation of Jak1 and Jak3. However, only IL-2 and IL-15 strongly activated STAT5, PI3K/Akt, and MEK/ERK signaling pathways. In contrast, IL-21 selectively activated STAT3. Whereas all three cytokines protected CTCL cells from apoptosis, only IL-2 and IL-15 promoted their proliferation. The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the vastly different impact of IL-2 and IL-15 vs. IL-21 on malignant CD4+ T cells. They also suggest two n...

  10. Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D... BioProject

    ID: PRJNA152007

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ernal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% acute myeloid leukemias (AML) and confers a poor pro...
  11. Gene expression of Kit225 cells upon NC1153 treatment ArrayExpress

    ID: E-GEOD-17007

    Description: NC1153 was shown to inhibit JAK3 tyrosine kinase. Lymphocytes survival depends on the integrity of STAT5, the primary dow...

  12. Gene expression profiling of Type II Enteropathy-associated T-cell lymphoma ArrayExpress

    ID: E-GEOD-70652

    Description: EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Here we performed gene expression profiling on four Type II EATL samples in order to better characterize this disease. As Type II EATL is suggested to arise from CD8+ IELs, we integrated our data with publicly available profile of CD8αα and CD8αβ T-cells from healthy donors (GSE33374). Gene expression profiling independently demonstrated strong en...

  13. Comparison of the expression profiles of wild-type (WT), Tyk2-deficient (Tyk2-/-) and kinase-inactive Tyk2 mutant (Tyk2K923E) NK cells ArrayExpress

    ID: E-GEOD-68294

    Description: k2 and Tyk2K923E on the transcriptome of NK cells Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in...

  14. Interferon alpha induced gene expression in SOCS1 and SOCS3 overexpressing melanoma and hepatoma cell lines ArrayExpress

    ID: E-GEOD-22801

    Description: receptors by masking its recognition site for the Janus kinases (JAK), by blocking the kinase activity of the JAKs and coincidentally hindering STAT molecules from binding to the kinases. They are also thought to ubiquitinate the JAKs resulting in their proteosomal degradation. The function of SOCS proteins in suppressing the interferon-alpha pathway has not yet been characterized exhaustively. This study should unveil links to understand the resistance in interferon-alpha therapy. As results we got almost complete silencing of JAK-STAT signaling in SOCS1 over-expressing cells and tissue-dependent partially suppressed gene induction in SOCS3 over-expressing cell lines. Two human cancer cell lines (ME-15, HuH-7) were stably transfected with pcDNA3.1-SOCS plasmids in presence of geneticin and daughter cell lines were generated after singularization of cells. Next, original cell line...

  15. Activation of Sez-4 cell line with IL-2, IL-15 or IL-21. BioProject

    ID: PRJNA101899

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -regulated <40 genes. All three cytokines induced tyrosine phosphorylation of Jak1 and Jak3. However, only IL-2 and IL-15 strongly activated STAT5, PI3K/Akt, and MEK/ERK signaling pathways. In contrast, IL-21 selectively activated STAT3. Whereas all three cytokines protected CTCL cells from apoptosis, only IL-2 and IL-15 promoted their proliferation. The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the vastly different impact of IL-2 and IL-15 vs. IL-21 on malignant CD4+ T cells. They also suggest two n...
  16. Methylation data and effect of JAK3 inhibition on human MO-to-DC and MO-to-MAC differentiation OmicsDI

    ID: E-GEOD-75937

    Date Released: 12-19-2015

    Description: ts on the methylation profiles of DCs and MACs of JAK3 inhibitor PF-956980 The methylation profiles of bisulfite-modified DNA of human CD14+ monocytes were compared with derived dendritic cells (DCs), macrophages (MACs) following GM-CSF/IL-4 and GM-CSF incubation, and DC and MAC samples incubated with JAK3 inhibitor PF-956980 using the Infinium HumanMethylation450 BeadChips (...

  17. Affymetrix Genome-Wide Human SNP Array 6.0 data for Type II Enteropathy-associated T-cell lymphoma ArrayExpress

    ID: E-GEOD-70653

    Description: EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Genome-wide DNA copy number profiling of Type II EATL tumors and matched normal samples was performed to determine copy-number changes in this disease. Affymetrix SNP6 arrays were performed according to the manufacturer's directions on gDNA extracted from 4 tumors and 4 matched whole blood samples....

  18. Effect of a JAK inhibitor on gene expression of HUT78 cell line OmicsDI

    ID: E-GEOD-68562

    Date Released: 12-03-2015

    Description: increasing evidence that activating mutations in JAK genes and deregulated JAK/STAT signaling are important mechanisms involved in multiple B and T cell malignancies, including CTCL. Therefore, in this study we focused on studying the mutational status of JAK1, JAK2 and JAK3 genes in a series of human CTCL...

  19. Affymetrix Genome-Wide Human SNP Array 6.0 data for Type II Enteropathy-associated T-cell lymphoma BioProject

    ID: PRJNA289280

    Keywords: Variation

    Access Type: download

    dataset.description: EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Genome-wide DNA copy number profiling of Type II EATL tumors and matched normal samples was performed to determine copy-number changes in this disease. Overall design: Affymetrix SNP6 arrays were performed according to the manufacturer's directions on gDNA extracted from 4 tumors and 4 matched whole blood samples....
  20. Effect of JAK1/3 blockade on IL2 response in NK cells OmicsDI

    ID: E-GEOD-84562

    Date Released: 07-23-2016

    Description: IL2 signals are transmitted through JAK1 and JAK3, but the transcriptomic consequences of each to the overall response is unclear. Here we analyzed the relative contribution of...


Displaying 20 of 559 results for "JAK3"