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Displaying 50 of 559 results for "JAK3"
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  1. JAK3 with covalent inhibitor PF-06651600 PDB

    ID: PDB:5TOZ

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  2. Crystal structure of JAK3 kinase domain in complex with an indazole substituted pyrrolopyrazine PDB

    ID: PDB:3ZC6

    Description: TYROSINE-PROTEIN KINASE JAK3 (E.C.2.7.10.2, 2.7.1.112)

  3. JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide PDB

    ID: PDB:4HVI

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  4. JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-hydroxy-1,2-dimethyl-propyl)-amide PDB

    ID: PDB:4HVG

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  5. Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor PDB

    ID: PDB:4RIO

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  6. JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-2-hydroxy-1,2-dimethyl-propyl PDB

    ID: PDB:4HVH

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  7. JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide PDB

    ID: PDB:4HVD

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  8. Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family PDB

    ID: PDB:3PJC

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  9. Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Disease PDB

    ID: PDB:4YTI

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  10. Jak3 with covalent inhibitor 7 PDB

    ID: PDB:5TTU

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  11. Crystal structure of JAK3 in complex with Compound 4 (FM381) PDB

    ID: PDB:5LWM

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  12. Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases PDB

    ID: PDB:4YTH

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  13. Crystal structure of JAK3 in complex with Compound 5 (FM409) PDB

    ID: PDB:5LWN

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  14. JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclopropyl-ethyl)-amide PDB

    ID: PDB:4I6Q

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  15. Jak3 with covalent inhibitor 4 PDB

    ID: PDB:5TTS

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  16. Jak3 with covalent inhibitor 6 PDB

    ID: PDB:5TTV

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  17. Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 PDB

    ID: PDB:3LXK

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  18. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue PDB

    ID: PDB:1YVJ

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.1.112)

  19. Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 PDB

    ID: PDB:3LXL

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  20. CRYSTAL STRUCTURE OF JAK3 KINASE DOMAIN IN COMPLEX WITH A PYRROLOPYRIDAZINE INHIBITOR PDB

    ID: PDB:5VO6

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  21. Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 PDB

    ID: PDB:3LXN

    Description: Non-receptor tyrosine-protein kinase TYK2 (E.C.2.7.10.2)

  22. JAK3 kinase domain in complex with 1-[(3S)-1-isobutylsulfonyl-3-piperidyl]-3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)urea PDB

    ID: PDB:4QT1

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  23. JAK3_RAT UniProt:Swiss-Prot

    ID: Q63272

    Description: Tyrosine-protein kinase JAK3 FERM SH2; atypical Protein...

  24. Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor PDB

    ID: PDB:3ZEP

    Description: TYROSINE-PROTEIN KINASE JAK3 (E.C.2.7.10.2, 2.7.1.112)

  25. Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 PDB

    ID: PDB:3LXP

    Description: Non-receptor tyrosine-protein kinase TYK2 (E.C.2.7.10.2)

  26. Crystal Structure of the Jak3 Kinase Domain Covalently Bound to N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-... PDB

    ID: PDB:4Z16

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  27. JAK3 in complex with a covalent EGFR inhibitor PDB

    ID: PDB:4V0G

    Description: TYROSINE-PROTEIN KINASE JAK3 (E.C.2.7.10.2)

  28. Inhibition of activation of Sez-4 cell line with IL-2 by Jak kinase inhibitors. BioProject

    ID: PRJNA101903

    Keywords: Transcriptome or Gene expression

    Access Type: download

  29. Effect of a JAK inhibitor on gene expression of HUT78 cell line ArrayExpress

    ID: E-GEOD-68562

    Description: increasing evidence that activating mutations in JAK genes and deregulated JAK/STAT signaling are important mechanisms involved in multiple B and T cell malignancies, including CTCL. Therefore, in this study we focused on studying the mutational status of JAK1, JAK2 and JAK3 genes in a series of human CTCL...

  30. Effect of JAK1/3 blockade on IL2 response in NK cells BioProject

    ID: PRJNA329657

    Keywords: Transcriptome or Gene expression

    Access Type: download

  31. Effect of JAK1/3 blockade on IL2 response in NK cells ArrayExpress

    ID: E-GEOD-84562

    Description: IL2 signals are transmitted through JAK1 and JAK3, but the transcriptomic consequences of each to the overall response is unclear. Here we analyzed the relative contribution of...

  32. Effect of a JAK inhibitor on gene expression of HUT78 cell line BioProject

    ID: PRJNA283116

    Keywords: Transcriptome or Gene expression

    Access Type: download

  33. Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide PDB

    ID: PDB:4QPS

    Description: Tyrosine-protein kinase JAK3 (E.C.2.7.10.2)

  34. Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D... ArrayExpress

    ID: E-GEOD-35907

    Description: ernal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% acute myeloid leukemias (AML) and confers a poor pro...

  35. Homo sapiens : Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9 Enhanced Gene Replaceme BioProject

    ID: PRJNA278158

    Keywords: genome sequencing

    Access Type: download

    dataset.description: Mutations of the Janus family kinase JAK3 gene cause severe combined immunodeficiency (SCID). JAK3
  36. Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases PDB

    ID: PDB:4YTF

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  37. Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Disease PDB

    ID: PDB:4YTC

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  38. Transcription profiling of human Sez-4 cell line starved of IL2 for 16h, followed by addition of IL-2 activation and or JAK inhibition ArrayExpress

    ID: E-GEOD-8687

    Description: -regulated <40 genes. All three cytokines induced tyrosine phosphorylation of Jak1 and Jak3. However, only IL-2 and IL-15 strongly activated STAT5, PI3K/Akt, and MEK/ERK signaling pathways. In contrast, IL-21 selectively activated STAT3. Whereas all three cytokines protected CTCL cells from apoptosis, only IL-2 and IL-15 promoted their proliferation. The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the vastly different impact of IL-2 and IL-15 vs. IL-21 on malignant CD4+ T cells. They also suggest two n...

  39. Methylation data and effect of JAK3 inhibition on human MO-to-DC and MO-to-MAC differentiation BioProject

    ID: PRJNA305748

    Keywords: Epigenomics

    Access Type: download

  40. Homo sapiens : Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9 Enhanced Gene Replaceme BioProject

    ID: PRJNA278160

    Keywords: genome sequencing

    Access Type: download

    dataset.description: Mutations of the Janus family kinase JAK3 gene cause severe combined immunodeficiency (SCID). JAK3
  41. Expression data from NKYS transfected with siRNAs or plasmids BioProject

    ID: PRJNA305040

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3
  42. Polynucleobacter yangtzensis strain:MWH-JaK3 : Polynucleobacter MWH-JaK3 Genome sequencing BioProject

    ID: PRJNA277963

    Keywords: Genome sequencing and assembly

    Access Type: download

  43. Gene expression of Kit225 cells upon NC1153 treatment BioProject

    ID: PRJNA117747

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: NC1153 was shown to inhibit JAK3 tyrosine kinase. Lymphocytes survival depends on the integrity of STAT5, the primary dow...
  44. Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker BioProject

    ID: PRJNA274578

    Keywords: Variation

    Access Type: download

  45. Methylation data and effect of JAK3 inhibition on human MO-to-DC and MO-to-MAC differentiation ArrayExpress

    ID: E-GEOD-75937

    Description: ts on the methylation profiles of DCs and MACs of JAK3 inhibitor PF-956980 The methylation profiles of bisulfite-modified DNA of human CD14+ monocytes were compared with derived dendritic cells (DCs), macrophages (MACs) following GM-CSF/IL-4 and GM-CSF incubation, and DC and MAC samples incubated with JAK3 inhibitor PF-956980 using the Infinium HumanMethylation450 BeadChips (...

  46. Expression data from NKYS transfected with siRNAs or plasmids ArrayExpress

    ID: E-GEOD-75680

    Description: The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3

  47. Cytoscan HD arrays data for Nodal marginal zone lymphoma (NMZL) BioProject

    ID: PRJNA281882

    Keywords: Variation

    Access Type: download

    dataset.description: 14) translocations; and ii) recurrently harbored +3 (14%), +12 (14%) and preferential usage of the IGHV4-34 gene (17%). WES (HiSeq 2500, Illumina; mean coverage per sample: 38x-114x) and high resolution SNP array (Cytoscan HD, Affymetrix) of tumor/normal DNA pairs from 18 discovery NMZL identified 557 non-synonymous somatic mutations (average: 30.8/case) affecting 504 genes and 51 copy number abnormalities (CNA) (average: 3.2/case). To further characterize mutation recurrence, the 504 discovered genes were investigated in an independent validation panel of 17 NMZL by targeted sequencing of tumor/normal DNA pairs (MiSeq; target region: 1.6 Mb; mean coverage per sample: 171x-386x). The 17 validation NMZL were also assessed for CNA by high resolution SNP arrays. RNAseq of 11 discovery NMZL did not identify any recurrent gene fusion. By compiling the results of WES and high resolution SNP array, 39 genes were recurrently affected in >3
  48. Structure of Janus kinase 2 with a pyrrolotriazine inhibitor PDB

    ID: PDB:3Q32

    Description: Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)

  49. Transcription profiling of human CD4+ cutaneous T-cell lymphoma (CTCL) Sez-4 cell line activated with IL-2, IL-15 or IL-21 ArrayExpress

    ID: E-GEOD-8685

    Description: -regulated <40 genes. All three cytokines induced tyrosine phosphorylation of Jak1 and Jak3. However, only IL-2 and IL-15 strongly activated STAT5, PI3K/Akt, and MEK/ERK signaling pathways. In contrast, IL-21 selectively activated STAT3. Whereas all three cytokines protected CTCL cells from apoptosis, only IL-2 and IL-15 promoted their proliferation. The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the vastly different impact of IL-2 and IL-15 vs. IL-21 on malignant CD4+ T cells. They also suggest two n...

  50. Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent non-responsiveness associated with a D... BioProject

    ID: PRJNA152007

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ernal tandem duplication (ITD) of the fms-related tyrosine kinase-3 (FLT3) gene occurs in 30% acute myeloid leukemias (AML) and confers a poor pro...

Displaying 50 of 559 results for "JAK3"