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Displaying 20 of 2,991 results for "IRF1"
  1. Crystal structure of IRF-7 DBD apo form PDB

    ID: PDB:3QU3

    Description: Interferon regulatory factor 7

  2. STAT1 and IRF8 orchestrate IFNγ and LPS-mediated signal integration in the vasculature that leads to amplified pro-atherogenic responses BioProject

    ID: PRJNA214100

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The transcription factor Signal Transducer and Activator of Transcription (STAT) 1 is activated by Interferon g...
  3. Transcription profiling of mouse NIH3T3 cells were compared with myc/ras transformed NIH3T3 cells and with IRF1 expressing myc/ras transformed cells ArrayExpress

    ID: E-GEOD-6505

    Description: e been ascribed to mediate antitumor effects. IRF-1 is a major target gene of interferons. It inhibits cell proliferation and oncogenic transformation. Here we show that 60% of all mRNAs deregulat...

  4. The macrophage IRF8-IRF1 regulome is required for protection against infections, and is associated with chronic inflammation BioProject

    ID: PRJNA311948

    Access Type: download

  5. Microarray analysis of B16 cells in pigmentation oscillator OmicsDI

    ID: E-GEOD-54359

    Date Released: 06-03-2014

    Description: ntation cascade are recognized, negative feedback regulatory loops that can dampen the activated melanogenesis process are not completely understood. By designing a pigmentation oscillator, in this study we delineate the role of interferon gamma (IFN-γ) signaling in skin pigmentation homeostasis. IFN-γ signaling reversibly controls maturation of the key organelle melanosome by concerted regulation of several pigm...

  6. proj008_chipseq_experiment2 ArrayExpress

    ID: E-MTAB-2661

    Description: Interferon regulatory factor (IRF) 5 has a major role in defining inflammatory macrophage pol...

  7. HeLa cells: control vs IFN-gamma-treated BioProject

    ID: PRJNA316194

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: hesized that some products of endosome-localized, interferon-stimulated genes (ISGs) exhibit anti-viral activity by inhibiting thiol/disulfide interchange in viral Envs. Among the hundreds of ISGs, gamma-interferon (IFN)-inducible lysosomal thiolreductase (GILT) is the only molecule that resides in the endosomes/lysosomes and digests the S-S bonds of proteins under acidic conditions. We now report that GILT significantly inhibits the replication of retroviruses, including HIV-1 and MLV, by restricting both the early and late phases of their life cycles. Using the VSV-G pseudotyped HIV-1 model, we found that ...
  8. Transcription profiling of rats after treatment with tienilic acid ArrayExpress

    ID: E-GEOD-8252

    Description: lase), inflammation and cytotoxicity (e.g. IL-1b, interferon regulatory factor 1, macrophage stimulating protein 1, caspase-12), as well as those promoting liver regeneration (e.g. p27Kip1, DUSP6, serine dehydratase, spectrin bII, inhibin bA). These data support the hypothesis that danger signals in the form of cell-stress proteins and the generation of oxidative stress may be involved in initiating the immune response observed in TA-induced toxicity. Other recent data also indicate that the reactive metabolite of TA binds to other proteins in addition to CYP 2C Experiment Overall Design: Rats were orally dosed with TA or control sodium bicarbonate. Eight animals were divided into two groups: Group 1 consisted of two animals that received a single dose of TA, and the two control animals received only sodium bicarbonate. Group 1 was sacrificed 6 h after drug/vehicle administration. Group 2 also comprised of two animals, and they were given two doses of TA (given at t=0 and t=16 h) and sacrificed at 24 h. Control rats in group 2 received two oral doses of sodium bicarbonate. For microarray analysis, six Affymetrix chips were used: Group 1 samples (3 chips) was comprised of pooled RNA from control rats C1 and C2, and an individual chip for each treated animal T1 and T2; Group 2 (3 chips) poo...

  9. Interferon regulatory factor 5 expression levels regulate murine lupus in a type-I interferon-independent manner ArrayExpress

    ID: E-GEOD-17926

    Description: Polymorphisms in the transcription factor interferon regulatory factor 5 (IRF5) are strongly associated in hu...

  10. Interferon Regulatory Factor-8, an Integral Determinant of Myeloid-Derived Suppressor Cell Subset Development OmicsDI

    ID: E-GEOD-39228

    Date Released: 06-02-2014

    Description: a consequence of tumor-induced downregulation of interferon regulatory factor-8 (IRF-8), a key myeloid developmental transcription factor. We showed that: 1) IRF8-deficiency in mice generated myeloid populations highly homologous to tumor-induced MDSC; 2) IRF-8 overexpression in mice reduced MDSC accumulation and retarded tumor ...

  11. Identification of IFNg-regulated, IRF1-dependent genes in Shigella flexneri-infected mouse embryonic fibroblasts (MEFs) OmicsDI

    ID: E-MTAB-713

    Date Released: 01-25-2012

    Description: periment was designed to identify IFNg-regulated, IRF1-dependent genes during infection with the intracellular pathogen Shigella flexneri. WT and Irf1-/- MEFs were stim...

  12. proj008_submission ArrayExpress

    ID: E-MTAB-2032

    Description: Interferon regulatory factor (IRF) 5 has a major role in defining inflammatory macrophage pol...

  13. TGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors (CDPs) and Directs Subset Specification Towards Conventional... BioProject

    ID: PRJNA128559

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: re amplified in vitro with Flt3 ligand, stem cell factor, hyper-IL-6 and insulin- like growth factor-1. The four-factor cocktail readily induces self-renewal of MPPs and their progression into CDPs and has no self-renewal activity on CDPs. The amplified CDPs respond to all known DC poietins and generate all lymphoid tissue DCs in vivo and in vitro. Additionally, in vitro CDPs recapitulate the cell surface marker and gene expression profile of in vivo CDPs and possess a DC-primed transcription profile. Transforming gro...
  14. Genome-wide identification of BATF2 binding sites in HeLa-BATF2 cells BioProject

    ID: PRJNA279358

    Keywords: Epigenomics

    Access Type: download

    dataset.description: iption factors (BATFs) play profound roles in the regulatory networks of gene expression in tumor cells. BATF2, also known as SARI (suppressor of AP-1, regulated by interferon
  15. L-Myc expression by dendritic cells is required for optimal T-cell priming BioProject

    ID: PRJNA231672

    Keywords: Epigenomics

    Access Type: download

    dataset.description: The transcription factor IRF8 is a critical regulator of plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development in both mou...
  16. PolII transcription factor in Human HeLa S3 ArrayExpress

    ID: E-GEOD-12781

    Description: latform from Illumina for the human transcription factor PolII in HeLa S3 cells. The PolII ChIP was performed according to the same protocol as used for the STAT1 samples except that the cells were not stimulated using gamma-interferon prior to formaldehyde fixation. For data usage term...

  17. Upregulation of HLA expression in primary Uveal Melanoma by infiltrating leukocytes BioProject

    ID: PRJNA335794

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ing gene TAP1, and HLA transcriptional regulators IRF1, IRF8, CIITA, and NLRC5, revealing a higher transcriptional activity in prognostically-bad tumors. Implantation of fresh human tumor samples into SCID mice led to a loss of infiltrating leukocytes, and to a decreased expression of HLA class I and II genes , and their regulators. Our data provides evidence for a proper functioning HLA regulatory system in UM, offering a target for T-cell based therapies. NB: Here we show the PCR microarray (Illumina array). Overall design: Total RNA was isolated from (malignant) uveal melanoma cells is from stored tissue of surgically removed specimen....
  18. proj008_chipseq ArrayExpress

    ID: E-MTAB-2033

    Description: Interferon regulatory factor (IRF) 5 has a major role in defining inflammatory macrophage pol...

  19. IRF7_MOUSE UniProt:Swiss-Prot

    ID: P70434

    Description: Interferon regulatory factor 7 IRF tryptophan pentad repeat N6-acetyllysine; by KAT2A and KAT...

  20. Effects of trenbolone, flutamide and a mix of both in fathead minnow ovaries OmicsDI

    ID: E-GEOD-14100

    Date Released: 06-02-2014

    Description: ytomatosis viral oncogene homolog (Myc), Yin Yang 1 (YY1) and interferon regulator factor 1 (IRF1) were among the important transcription factors reciprocally regulated by trenbolone and flutamide, suggesting they may be specifically regulated by the AR. These regulatory molecules, in conjunction with other reciprocally regulated transcription factors, may function as early molecular switches to control phenotypic changes in gonad tissue architecture and function. Fathead minnows exposed for 48h to 0.5 ug trenbolone, 500 ug flutamide, or a mixture of both....

Displaying 20 of 2,991 results for "IRF1"