INPP5D | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 50 of 195 results for "INPP5D"
i
  1. Role and function of Inpp5d in BCR-ABL1 driven pre-B cells BioProject

    ID: PRJNA150229

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. DOK3_CHICK UniProt:Swiss-Prot

    ID: A3R064

    Description: y-Glu Phosphotyrosine Abolishes interaction with INPP5D/SHIP Strongly reduced tyrosine phosphorylation. Abolishes interaction with GRB2 and INPP5D/SHIP...

  3. DOK3_MOUSE UniProt:Swiss-Prot

    ID: Q9QZK7

    Description: uced IL2 secretion. No effect on interaction with INPP5D SH2 domain. Abolishes interaction with CSK SH2 domain. No effect on BCR-triggered tyrosine phosphorylation. Abolishes reduction of BCR-induced IL2 secretion, the interaction with INPP5D SH2 domain and BCR-triggered tyrosine phosphorylation; when associated with F-343 Some reduction of BCR-induced IL2 secretion. Some interaction with INPP5D SH2 domain. Some decrease in BCR-trig...

  4. Role and function of Inpp5d in BCR-ABL1 driven pre-B cells ArrayExpress

    ID: E-GEOD-34830

    Description: In order to investigate the function of Inpp5d in ALL, we isolated bone marrow cells from Inpp5d fl/fl mice and transformed them with BCR-ABL1. In a sec...

  5. Role and function of Inpp5d in BCR-ABL1 driven pre-B cells OmicsDI

    ID: E-GEOD-34830

    Date Released: 06-17-2013

    Description: In order to investigate the function of Inpp5d in ALL, we isolated bone marrow cells from Inpp5d fl/fl mice and transformed them with BCR-ABL1. In a sec...

  6. Solution structure of the human SHIP SH2 domain PDB

    ID: PDB:2YSX

    Description: Signaling inositol polyphosphate phosphatase SHIP II

  7. miRNA expression patterns in immature and CpG stimulated murine BMDCs ArrayExpress

    ID: E-GEOD-72716

    Description: s showed that miR-155 influenced the level of the phosphatase SHIP1 in DCs, and that the lack of SHIP1 in DCs was sufficient to break T cell tolerance in vivo, again in the absence of TLR induced DC maturation. Our study demonstrates that the overexpression of miR-155 in DCs is a critical event that is alone sufficient to break self tolerance and promote a CD8-mediated autoimmune response in vivo. This process is independent of the induction of conventional DC maturation markers, indicating that miR-155 regulation of SHIP represents a unique axis that regulates DC function in vivo. Dendritic cell culture: Bone marrow was flushed from tibias and femurs of mice with HBSS. Bone marrow cells were cultured at 2x106 cells/ml in 10 ml non-tissue culture treated dishes in RPMI 1640 containing 10% LPS-free FBS, Penicillin:streptomycin glutamine 2-mercaptoethanol (cRPMI), with 40ng/ml murine GM-CSF (Peprotech). On day 3 of cultures 10ml of fresh media was added also containing 40ng/ml GM-CSF. On days 6 and 8, 10ml of media was removed and centrifuged to collect cells, which were resuspended in 10ml f...

  8. Concerted action of Helios and Ikaros balances the strength of B cell receptor signaling and controls the expression of inositol 5-phosphatase SHIP BioProject

    ID: PRJNA124429

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Concerted action of Helios and Ikaros balances the strength of B cell receptor signaling and controls the expression of inositol 5-phosphatase SHIP ArrayExpress

    ID: E-GEOD-20946

    Description: Inositol 5-phosphatase SHIP is differentially expressed in Ikaros and Heli...

  10. Data from: Is sex advantageous in adverse environments? A test of the abandon-ship hypothesis Dryad

    DateIssued: 05-31-2017

    Description: oth sexual and asexual reproduction). The abandon-ship hypothesis predicts higher allocation to sex under stress to allow low-fitness individuals to recombine their genotype, potentially increasing offspring fitness. However, effective tests of the abandon-ship hypothesis, particularly in multicellular organisms, are lacking. Here we test the abandon-ship hypothesis,...

  11. Control of the inflammatory macrophage transcriptional signature by miR-155 ArrayExpress

    ID: E-GEOD-77425

    Description: IL-12, as well as suppression of miR-155 targets Inpp5d, Tspan14, Ptprj and Mafb. Overall, these data indicate that miR-155 plays an essential role in driving the differentiation and effector potential of inflammatory M1 macrophages. Total RNA was prepared from bone marrow-derived macrophages of miR-155 knockout mice (n=2 independent mice) treated in M0, M1 or M2 conditions (n=2 replicates per condition originating from different mice)...

  12. Crystal structure of a sHIP (UniProt Id: Q99XU0) mutant from Streptococcus pyogenes PDB

    ID: PDB:4PZ1

    Description: sHIP

  13. Lung cell responses to ship diesel exhaust particles BioProject

    ID: PRJNA269614

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages [validation] BioProject

    ID: PRJNA316924

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ith Mycobacterium tuberculosis, H37Rv strain (MOI 5). The regulatory network was then validated with WT and miR-155-/- BMM samples collected at 0 and 8 hours post-infection (three replicates each). This dataset represents WT and miR-155-/- BMM samples collected at 0 and 8 hours post-infection (three replicates each)....
  15. Gene expression data from Mycobacterium tuberculosis-infected WT and miR-155-/- bone-marrow derived macrophages [timecourse] BioProject

    ID: PRJNA316925

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ith Mycobacterium tuberculosis, H37Rv strain (MOI 5). The regulatory network was then validated with WT and miR-155-/- BMM samples collected at 0 and 8 hours post-infection (three replicates each). This dataset represents three replicates of WT C57BL/6 BMMs were collected at 0, 4, 8, 24, and 48 hours post-infection with Mycobacterium tuberculosis, H37Rv strain (MOI 5)....
  16. Data from: Evidence for ship noise impacts on humpback whale foraging behaviour Dryad

    DateIssued: 08-16-2016

    Description: ine organisms. This study examines the impacts of ship noise on bottom foraging humpback whales (Megaptera novaeangliae) in the western North Atlantic. Data were collected from 10 foraging whales using non-invasive archival tags that simultaneously recorded underwater movements and the acoustic environment at the whale. Using mixed models, we assess the effects of

  17. Concerted action of Helios and Ikaros balances the strength of B cell receptor signaling and controls the expression of inositol 5-phosphatase SHIP OmicsDI

    ID: E-GEOD-20946

    Date Released: 03-27-2012

    Description: Inositol 5-phosphatase SHIP is differentially expressed in Ikaros and Heli...

  18. Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma ArrayExpress

    ID: E-GEOD-40160

    Description: ing silencing of the apoptosis-inducer BIK and of INPP5D, an inhibitor of the PI3K-driven oncogenic pathway. The present study complements the GSE12453 and GSE14879 records by adding the following 10 samples: 5 primary tumor samples and 5 cell line samples. The 5 primary tumor samples represent 1000-2000 neoplastic cells microdissected from frozen biopsies of 5 cases of primary mediastinal B-cell lymphoma (PMBL). The 5 cell line samples represent 500-1000 living neoplastic cells isolated by fluorescence-activated cell sorting from growing cultures of the classical Hodgkin lymphoma (cHL) cell lines L1236, L428, KMH2 and HDLM2 and the lymphocyte-predominant Hodgkin lymphoma (lpHL) cell line DEV....

  19. Individual array-based gene expression patterns generated using total RNA prepared from whole blood of 991 participants of the SHIP-TREND cohort BioProject

    ID: PRJNA153267

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. Ship-trip data Dryad

    DateIssued: 11-16-2015

    Description: Ship-trips between source and recipient regions, including corresponding ballast water volume

  21. Data from: Size-dependent physiological responses of shore crabs to single and repeated playback of ship noise Dryad

    DateIssued: 05-10-2013

    Description: affected by both single and repeated exposure to ship-noise playback. Crabs experiencing ship-noise playback consumed more oxygen, indicating a higher metabolic rate and potentially greater stress, than those exposed to ambient-noise playback. The response to single ship-noise playback was size-dependent, with heavier crabs showing a stronger response than lighter individuals. Repeated exposure to ambient-noise playback led to increased oxygen consumption (likely due to handling stress), whereas repeat...

  22. Metabolic and gene expression changes induced by the naturally occurring deltaNp53 isoform link mTOR pathway and mitochondrial alterations to the prog... ArrayExpress

    ID: E-GEOD-37271

    Description: ncluding insulin signaling pathway members (IRS1, INPP5D, PLK3, MAP3K1, FGF5) and regulators of glucose metabolism (SLC2A2, CRYAB, LRCH1). Expression of other key metabolic genes were also altered in cells expressing ΔNp53:WTp53 tetramers, suggesting that global me tabolic changes might contribute to ΔNp53:WTp53 pathology. In collaboration with Metabolon (Durham, NC), we identified approximately one hundred metabolites that were significantly up- or down-regulated in H1299 cells expressing ΔNp53:WTp53. The metabolome analysis was a powerful complement to the gene expression data, and further suggested that the mTOR pathway (e.g. across-the-board up-regulation of amino acid levels) and mitochondrial function (e.g. up-regulation of carnitine, important for a-oxidation of fatty acids) was altered in cells expressing ΔNp53:WTp53. These findings were subsequently validated using biochemical and cell-based approaches. Furthermore, whereas equal expression of ΔNp53 and WTp53 cause accelerated aging in mammals, due to alternative splicing and translation initiation ΔNp53 is a naturally-occurring isoform whose expression levels can change throughout the lifetime. Thus, the cellular and molecular mechanisms identified from this work will likely reflect changes common to normal, physiological aging. Comparison of global gene expression profiles in WTp53 or ΔNp53:WTp53 expressed H1299 RNA from FACS sorted GFP positive hybrid to Affymatrix Gene The exp 0, exp 4 and exp 5 are independent replicate/transfections/biological experiments. The exp d, exp e and exp f are control experiments....

  23. Crystal structure of the novel protein and virulence factor sHIP (Q99XU0) from Streptococcus pyogenes PDB

    ID: PDB:4MER

    Description: protein Spy2034

  24. Lung cell responses to ship diesel exhaust particles OmicsDI

    ID: E-GEOD-63962

    Date Released: 02-08-2015

    Description: interphase towards exhaust gas and particles of a ship engine. The goal was to compare the responses towards different fuel combustions. The engine run either on diesel fuel (DF) or on Heavy Fuel Oil (HFO). The lung cells were exposed 3 times to each combustion ...

  25. s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells BioProject

    ID: PRJNA297832

    Keywords: Transcriptome or Gene expression

    Access Type: download

  26. Individual array-based gene expression patterns generated using total RNA prepared from whole blood of 991 participants of the SHIP-TREND cohort OmicsDI

    ID: E-GEOD-36382

    Date Released: 06-02-2014

    Description: e gene expression data of 991 participants of the SHIP-TREND cohort generated using RNA prepared from whole blood. *** Due to privacy concerns, the SNP and phenotype data is not available with unrestricted access. Individuals wishing to ...

  27. s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells ArrayExpress

    ID: E-GEOD-73758

    Description: odel expressing GFP from the stem cell-specific s-SHIP promoter to mark putative stem cells during postnatal prostate development. We showed that cells identified by s-SHIP/GFP expression are present transiently during early prostate development and localize to the basal cell layer of the epithelium. These prostate s-

  28. Individual array-based gene expression patterns generated using total RNA prepared from whole blood of 991 participants of the SHIP-TREND cohort ArrayExpress

    ID: E-GEOD-36382

    Description: e gene expression data of 991 participants of the SHIP-TREND cohort generated using RNA prepared from whole blood. *** Due to privacy concerns, the SNP and phenotype data is not available with unrestricted access. Individuals wishing to ...

  29. Eukaryotes : Retrospective eDNA assessement of harmful algae in ship ballast tanks and marine port sediments BioProject

    ID: PRJNA379043

    Keywords: raw sequence reads

    Access Type: download

  30. miRNA expression patterns in immature and CpG stimulated murine BMDCs BioProject

    ID: PRJNA294737

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s showed that miR-155 influenced the level of the phosphatase SHIP1 in DCs, and that the lack of SHIP1 in DCs was sufficient to break T cell tolerance in vivo, again in the absence of TLR induced DC maturation. Our study demonstrates that the overexpression of miR-155 in DCs is a critical event that is alone sufficient to break self tolerance and promote a CD8-mediated autoimmune response in vivo. This process is independent of the induction of conventional DC maturation markers, indicating that miR-155 regulation of SHIP represents a unique axis that regulates DC function in vivo. Overall design: Dendritic cell culture: Bone marrow was flushed from tibias and femurs of mice with HBSS. Bone marrow cells were cultured at 2x106 cells/ml in 10 ml non-tissue culture treated dishes in RPMI 1640 containing 10% LPS-free FBS, Penicillin:streptomycin glutamine 2-mercaptoethanol (cRPMI), with 40ng/ml murine GM-CSF (Peprotech). On day 3 of cultures 10ml of fresh media was added also containing 40ng/ml GM-CSF. On days 6 and 8, 10ml of media was removed and centrifuged to collect cells, which were resus...
  31. Ship-grade timber according to the 1803 Forestry Department report Dataverse

    Description: es of oak, pine, and deciduous trees suitable for ship building. Includes data on # of trees suitable at present and in future, as well as the fleet (Baltic or Black) for which the timber is designated. Organized by province....

    Person: Vasil'ev, Aleksej Ivanovich

    Release Date: 08-11-2013

  32. s-SHIP expression identifies a subset of murine basal prostate cells as neonatal stem cells OmicsDI

    ID: E-GEOD-73758

    Date Released: 04-03-2016

    Description: odel expressing GFP from the stem cell-specific s-SHIP promoter to mark putative stem cells during postnatal prostate development. We showed that cells identified by s-SHIP/GFP expression are present transiently during early prostate development and localize to the basal cell layer of the epithelium. These prostate s-

  33. Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma BioProject

    ID: PRJNA172980

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ing silencing of the apoptosis-inducer BIK and of INPP5D, an inhibitor of the PI3K-driven oncogenic pathway. Overall design: The present study complements the GSE12453 and GSE14879 records by adding the following 10 samples: 5 primary tumor samples and 5 cell line samples. The 5 primary tumor samples represent 1000-2000 neoplastic cells microdissected from frozen biopsies of 5 cases of primary mediastinal B-cell lymphoma (PMBL). The 5 cell line samples represent 500-1000 living neoplastic cells isolated by fluorescence-activated cell sorting from growing cultures of the classical Hodgkin lymphoma (cHL) cell lines L1236, L428, KMH2 and HDLM2 and the lymphocyte-predominant Hodgkin lymphoma (lpHL) cell line DEV....
  34. Control of the inflammatory macrophage transcriptional signature by miR-155 BioProject

    ID: PRJNA310299

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: IL-12, as well as suppression of miR-155 targets Inpp5d, Tspan14, Ptprj and Mafb. Overall, these data indicate that miR-155 plays an essential role in driving the differentiation and effector potential of inflammatory M1 macrophages. Overall design: Total RNA was prepared from bone marrow-derived macrophages of miR-155 knockout mice (n=2 independent mice) treated in M0, M1 or M2 conditions (n=2 replicates per condition originating from different mice)...
  35. Lung cell responses to ship diesel exhaust particles ArrayExpress

    ID: E-GEOD-63962

    Description: interphase towards exhaust gas and particles of a ship engine. The goal was to compare the responses towards different fuel combustions. The engine run either on diesel fuel (DF) or on Heavy Fuel Oil (HFO). The lung cells were exposed 3 times to each combustion ...

  36. 5083 type Al-Mg and 6082 type Al-Mg-Si alloys for ship building Figshare

    ID: doi:10.6084/M9.FIGSHARE.1390494.V1

    Release Date: 01-19-2016

    Description:

  37. Balanus amphitrite : Balanus amphitrite is a small striped barnacle BioProject

    ID: PRJNA43199

    Access Type: download

    dataset.description: Balanus amphitrite is a small striped barnacle commonly found in harbors and on ship hulls around the world.
  38. aquatic metagenome : Naval ship ballast water Targeted Locus (Loci) BioProject

    ID: PRJNA189672

    Keywords: targeted loci

    Access Type: download

  39. Ship extraction and categorization from ASTER VNIR imagery. Figshare

    ID: doi:10.6084/M9.FIGSHARE.1004811.V1

    Release Date: 01-18-2016

    Description:

  40. aquatic metagenome : Naval ship ballast water Targeted Locus BioProject

    ID: PRJNA196757

    Keywords: targeted loci

    Access Type: download

  41. 5083 type Al-Mg and 6082 type Al-Mg-Si alloys for ship building Figshare

    ID: doi:10.6084/M9.FIGSHARE.1390494

    Release Date: 04-22-2015

    Description:

  42. Control of the inflammatory macrophage transcriptional signature by miR-155 OmicsDI

    ID: E-GEOD-77425

    Date Released: 07-24-2016

    Description: IL-12, as well as suppression of miR-155 targets Inpp5d, Tspan14, Ptprj and Mafb. Overall, these data indicate that miR-155 plays an essential role in driving the differentiation and effector potential of inflammatory M1 macrophages. Total RNA was prepared from bone marrow-derived macrophages of miR-155 knockout mice (n=2 independent mice) treated in M0, M1 or M2 conditions (n=2 replicates per condition originating from different mice)...

  43. Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma OmicsDI

    ID: E-GEOD-40160

    Date Released: 09-24-2012

    Description: ing silencing of the apoptosis-inducer BIK and of INPP5D, an inhibitor of the PI3K-driven oncogenic pathway. The present study complements the GSE12453 and GSE14879 records by adding the following 10 samples: 5 primary tumor samples and 5 cell line samples. The 5 primary tumor samples represent 1000-2000 neoplastic cells microdissected from frozen biopsies of 5 cases of primary mediastinal B-cell lymphoma (PMBL). The 5 cell line samples represent 500-1000 living neoplastic cells isolated by fluorescence-activated cell sorting from growing cultures of the classical Hodgkin lymphoma (cHL) cell lines L1236, L428, KMH2 and HDLM2 and the lymphocyte-predominant Hodgkin lymphoma (lpHL) cell line DEV....

  44. An assessment of the ship drag penalty arising from light calcareous tubeworm fouling Figshare

    ID: doi:10.6084/M9.FIGSHARE.3101347.V1

    Release Date: 03-11-2016

    Description:

  45. Ship extraction and categorization from ASTER VNIR imagery. Figshare

    ID: doi:10.6084/M9.FIGSHARE.1004811

    Release Date: 12-30-2014

    Description:

  46. Metabolic and gene expression changes induced by the naturally occurring ΔNp53 isoform link mTOR pathway and mitochondrial alterations to the progero... BioProject

    ID: PRJNA159167

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ncluding insulin signaling pathway members (IRS1, INPP5D, PLK3, MAP3K1, FGF5) and regulators of glucose metabolism (SLC2A2, CRYAB, LRCH1). Expression of other key metabolic genes were also altered in cells expressing ΔNp53:WTp53 tetramers, suggesting that global me tabolic changes might contribute to ΔNp53:WTp53 pathology. In collaboration with Metabolon (Durham, NC), we identified approximately one hundred metabolites that were significantly up- or down-regulated in H1299 cells expressing ΔNp53:WTp53. The metabolome analysis was a powerful complement to the gene expression data, and further suggested that the mTOR pathway (e.g. across-the-board up-regulation of amino acid levels) and mitochondrial function (e.g. up-regulation of carnitine, important for a-oxidation of fatty acids) was altered in cells expressing ΔNp53:WTp53. These findings were subsequently validated using biochemical and cell-based approaches. Furthermore, whereas equal expression of ΔNp53 and WTp53 cause accelerated aging in mammals, due to alternative splicing and translation initiation ΔNp53 is a naturally-occurring isoform whose expression levels can change throughout the lifetime. Thus, the cellular and molecular mechanisms identified from this work will likely reflect changes common to normal, physiological aging. Overall design: Comparison of global gene expression profiles in WTp53 or ΔNp53:WTp53 expressed H1299 RNA from FACS sorted GFP positive hybrid to Affymatrix Gene The exp 0, exp 4 and exp 5 are independent replicate/transfections/biological experiments. The exp d, exp e and exp f are control experiments....
  47. Ship Recycling and Its Environmental Impact: A Brief Overview of Bangladesh Figshare

    ID: doi:10.6084/M9.FIGSHARE.1221427

    Release Date: 10-29-2014

    Description:

  48. An assessment of the ship drag penalty arising from light calcareous tubeworm fouling Figshare

    ID: doi:10.6084/M9.FIGSHARE.3101347

    Release Date: 03-30-2016

    Description:

  49. Analytic Hierarchy Process Approach for Selection of Ship Propulsion System Case Study Figshare

    ID: doi:10.6084/M9.FIGSHARE.1192293

    Release Date: 10-03-2014

    Description:

  50. Data from: Shape up or ship out: migratory behaviour predicts morphology across spatial scale in a freshwater fish Dryad

    DateIssued: 08-19-2015

    Description: 1. Migration is a widespread phenomenon, with powerful ecological and evolutionary consequences. Morphological adaptations to reduce the energetic cos...


Displaying 50 of 195 results for "INPP5D"