HNRNPA2B1 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 53 results for "HNRNPA2B1"
i
  1. shRNA profiling of human Colo16 cells knocked down for Downstreams of hnRNP A2 ArrayExpress

    ID: E-GEOD-11865

    Description: ited knowledge of the downstream targets of hnRNP A2/B1 has, however, precluded a clear understanding of their roles in cancer cell growth. To define the pathways in...

  2. ROA2_PONAB UniProt:Swiss-Prot

    ID: Q5RBU8

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1 RRM 1 RRM 2 Low complexity ...

  3. ROA2_BOVIN UniProt:Swiss-Prot

    ID: Q2HJ60

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1 RRM 1 RRM 2 Low complexity ...

  4. ROA2_SAGOE UniProt:Swiss-Prot

    ID: Q9TTV2

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1 RRM 1 RRM 2 Low complexity ...

  5. Analysis of the gene expression pattern of bovine blastocysts at three stages of development ArrayExpress

    ID: E-GEOD-25606

    Description: ion. Gene candidates (IFNt, PLAC8, SSLP1, AKR1B1, HNRNPA2B1, ARGFX, NANOS, CCNB1) were selected and confirmed using Q-RT-PCR to validate the microarray data. Results: Our analysis show that hatched blastocysts are enriched in genes transcripts implicated in implantation, cell adhesion and extracellular matrix digestion. Early blastocysts expressed genes mainly involved in cell cycle control, transcription and translation. Q-RT-PCR validated most microarray results (87.5%). Some of the differentially expressed genes are interesting as potential markers of competence. Conclusions: Overall, our study provides new insights into the molecular regulation of blastocyst formation. In addition, it could help assess blastocyst staging and select better embryos based on the expression of quality markers. In the present study the Laval/Sirard_bovine_embryo_3K_V3.0 array was used to conduct a series of 18 hybridizations (for three Blastocysts stages (early, expended, hatched) with three biological replicates and dye swaps) in a loop design experiment....

  6. Downstreams of hnRNP A2 in Colo16 cells BioProject

    ID: PRJNA105671

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. shRNA profiling of human Colo16 cells knocked down for Downstreams of hnRNP A2 OmicsDI

    ID: E-GEOD-11865

    Date Released: 05-01-2014

    Description: ited knowledge of the downstream targets of hnRNP A2/B1 has, however, precluded a clear understanding of their roles in cancer cell growth. To define the pathways in...

  8. Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue ArrayExpress

    ID: E-GEOD-54418

    Description: components such as TDP-43, FUS, ATXN2, SMN, MAPT, HNRNPA2B1 and HNRNPA1 are crucial for the motor neuron diseases ALS / SMA and for the frontotemporal dementia FTD, here we studied mouse nervous tissue to identify mRNAs with selective dependence on Tia1 deletion. Transcriptome profiling with oligonucleotide microarrays in comparison of spinal cord and cerebellum, together with independent validation in quantitative reverse transcriptase PCR and immunoblots demonstrated several strong and consistent dysregulations. In...

  9. Whole-genome decay rate measurements in MDA-MB-231 cells transfected with HNRPA2B1 siRNAs versus controls ArrayExpress

    ID: E-GEOD-35756

    Description: Transcriptional profiling of MDA-MB-231 samples taken at 0, 1, 2 and 4hr timepoints upon exposure to alpha-amanitine, comparing the siRNA-mediated HNR...

  10. Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns ArrayExpress

    ID: E-GEOD-79157

    Description: ection of known splicing regulators such as hnRNP A2/B1, thereby indirectly influencing splice site selection. We conclude that changes in the expression of the polyadenylation factor CstF64 influences alternative splicing through indirect effects. HeLa cell line was stably transfected with shRNA plasmids targeting CstF64. Total RNA was isolated from CstF64 KD cells and wild-type control cells using Trizol according to manufacturer’s protocols. Samples were deep sequenced in duplicate using the Illumina GAIIx system....

  11. An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR BioProject

    ID: PRJNA297688

    Keywords: Epigenomics

    Access Type: download

    dataset.description: t specific interaction was between HOTAIR and the heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, a member of a family of proteins involved in nascent mRNA processing and RNA matchmaking. Our data suggest that A2/B1 are key contributors to HOTAIR-mediated chromatin regulation in breast cancer cells: A2/B1 knockdown reduces HOTAIR-dependent breast cancer cell invasion and decreases PRC2 activity at the majority of HOTAIR-dependent loci. We found that the B1 isoform, which differs from A2 by 12 additional amino acids, binds with highest specificity to HOTAIR. B1 also binds chromatin and associates preferentially with R...
  12. Muscle Developmental Defects in Heterogeneous Nuclear Ribonucleoprotein A1 Knockout Mice BioProject

    ID: PRJNA314880

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. Analysis of the gene expression pattern of bovine blastocysts at three stages of development BioProject

    ID: PRJNA134253

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ion. Gene candidates (IFNt, PLAC8, SSLP1, AKR1B1, HNRNPA2B1, ARGFX, NANOS, CCNB1) were selected and confirmed using Q-RT-PCR to validate the microarray data. Results: Our analysis show that hatched blastocysts are enriched in genes transcripts implicated in implantation, cell adhesion and extracellular matrix digestion. Early blastocysts expressed genes mainly involved in cell cycle control, transcription and translation. Q-RT-PCR validated most microarray results (87.5%). Some of the differentially expressed genes are interesting as potential markers of competence. Conclusions: Overall, our study provides new insights into the molecular regulation of blastocyst formation. In addition, it could help assess blastocyst staging and select better embryos based on the expression of quality markers. Overall design: In the present study the Laval/Sirard_bovine_embryo_3K_V3.0 array was used to conduct a series of 18 hybridizations (for three Blastocysts stages (early, expended, hatched) with three biological replicates and dye swaps) in a loop design experiment....
  14. Whole-genome decay rate measurements in MDA-MB-231 cells transfected with HNRPA2B1 siRNAs versus controls BioProject

    ID: PRJNA155927

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. A long noncoding RNA mediates both activation and repression of immune response genes. BioProject

    ID: PRJNA175479

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response Overall design: Examination of Mus musculus (C57BL/6 background) gene expression changes following stimulation with Pam3Cys4 in presence or absence of shRNA specifically targetting lncRNA-COX2...
  16. Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue BioProject

    ID: PRJNA236474

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: components such as TDP-43, FUS, ATXN2, SMN, MAPT, HNRNPA2B1 and HNRNPA1 are crucial for the motor neuron diseases ALS / SMA and for the frontotemporal dementia FTD, here we studied mouse nervous tissue to identify mRNAs with selective dependence on Tia1 deletion. Transcriptome profiling with oligonucleotide microarrays in comparison of spinal cord and cerebellum, together with independent validation in quantitative reverse transcriptase PCR and immunoblots demonstrated several strong and consistent dysregulations. In...
  17. Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns BioProject

    ID: PRJNA315060

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ection of known splicing regulators such as hnRNP A2/B1, thereby indirectly influencing splice site selection. We conclude that changes in the expression of the polyadenylation factor CstF64 influences alternative splicing through indirect effects. Overall design: HeLa cell line was stably transfected with shRNA plasmids targeting CstF64. Total RNA was isolated from CstF64 KD cells and wild-type control cells using Trizol according to manufacturer’s protocols. Samples were deep sequenced in duplicate using the Illumina GAIIx system....
  18. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (splicing arrays) ArrayExpress

    ID: E-GEOD-34992

    Description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...

  19. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (RNA-Seq) ArrayExpress

    ID: E-GEOD-34995

    Description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...

  20. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (CLIP-Seq) ArrayExpress

    ID: E-GEOD-34993

    Description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...


Displaying 20 of 53 results for "HNRNPA2B1"