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Displaying 50 of 53 results for "HNRNPA2B1"
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  1. Nuclear HNRNPA2B1 HITS-CLIP and RNA-seq BioProject

    ID: PRJNA287552

    Keywords: Other

    Access Type: download

  2. Crystal structure of hnRNPA2B1 in complex with RNA PDB

    ID: PDB:5EN1

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1/RNA Complex

  3. Crystal structure of hnRNPA2B1 in omplex with 10-mer RNA PDB

    ID: PDB:5HO4

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1/RNA Complex

  4. Nuclear HNRNPA2B1 HITS-CLIP and RNA-seq ArrayExpress

    ID: E-GEOD-70061

    Description: To identify HNRNPA2B1 binding sites on endogenous nuclear RNAs, we performed HITS-CLIP for endogenous HNRNPA2B1

  5. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons BioProject

    ID: PRJNA341985

    Access Type: download

  6. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA341996

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA342000

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA341999

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA341997

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA341992

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA341998

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA341995

    Keywords: Other

    Access Type: download

  13. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons ... BioProject

    ID: PRJNA341993

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons [iCLIP-seq] BioProject

    ID: PRJNA341994

    Keywords: Other

    Access Type: download

  15. Whole-genome landscape PARP1 in HEK293T cells BioProject

    ID: PRJNA301999

    Keywords: Epigenomics

    Access Type: download

    dataset.description: njunction with BRCA. PARP1 enzyme works modifying nuclear proteins by poly ADP-ribosylation. It was found that PARP1 and HNRNPA2B1 bind at termini of forum domains and may play a role in coordinated regulation of genes in forum domains (Tchurikov et al., 2013). Forum domains are long DNA fragments of excised chromosomal DNA. Mostly forum domain...
  16. ROA1_SCHAM UniProt:Swiss-Prot

    ID: P21522

    Description: Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homol...

  17. Nuclear HNRNPA2B1 HITS-CLIP and RNA-seq OmicsDI

    ID: E-GEOD-70061

    Date Released: 08-20-2015

    Description: To identify HNRNPA2B1 binding sites on endogenous nuclear RNAs, we performed HITS-CLIP for endogenous HNRNPA2B1

  18. Transcriptome profiling of hnRNP A2/B1 and A1 depleted cells ArrayExpress

    ID: E-GEOD-76151

    Description: prepare RNA-seq libraries of total RNA from hnRNP A2/B1 and A1 depleted A549 cells. Pro-seq libraries were prepared from A549 cells using Illumina adapters hnRNP A2/B1 and A1 depleted A...

  19. Sumoylated hnrnpa2b1 controls the sorting of miRNAs into two exosomes through binding to specific motifs OmicsDI

    ID: PXD000350

    Date Released: 04-16-2014

    Description: rol their localization into exosomes. The protein hnRNPA2B1 specifically binds exosomal miRNAs through the recognition of these motifs and controls their loading into exosomes. Moreover, hnRNPA2B1 in exosomes is sumoylated, and sumoylation controls the binding of hnRNPA2B1 to miRNAs. The loading of miRNAs into exosomes can be modulated by mutagenesis of the identified motifs or changes in hnRNPA2B1 expression levels. These findings identify hnRNPA2B1 as a key player in miRNA sorting into exosomes and provide potential tools ...

  20. Transcriptome profiling of hnRNP A2/B1 and A1 depleted cells BioProject

    ID: PRJNA306484

    Keywords: Transcriptome or Gene expression

    Access Type: download

  21. shRNA profiling of human Colo16 cells knocked down for Downstreams of hnRNP A2 ArrayExpress

    ID: E-GEOD-11865

    Description: ited knowledge of the downstream targets of hnRNP A2/B1 has, however, precluded a clear understanding of their roles in cancer cell growth. To define the pathways in...

  22. ROA2_PONAB UniProt:Swiss-Prot

    ID: Q5RBU8

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1 RRM 1 RRM 2 Low complexity ...

  23. ROA2_BOVIN UniProt:Swiss-Prot

    ID: Q2HJ60

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1 RRM 1 RRM 2 Low complexity ...

  24. ROA2_SAGOE UniProt:Swiss-Prot

    ID: Q9TTV2

    Description: Heterogeneous nuclear ribonucleoproteins A2/B1 RRM 1 RRM 2 Low complexity ...

  25. Analysis of the gene expression pattern of bovine blastocysts at three stages of development ArrayExpress

    ID: E-GEOD-25606

    Description: ion. Gene candidates (IFNt, PLAC8, SSLP1, AKR1B1, HNRNPA2B1, ARGFX, NANOS, CCNB1) were selected and confirmed using Q-RT-PCR to validate the microarray data. Results: Our analysis show that hatched blastocysts are enriched in genes transcripts implicated in implantation, cell adhesion and extracellular matrix digestion. Early blastocysts expressed genes mainly involved in cell cycle control, transcription and translation. Q-RT-PCR validated most microarray results (87.5%). Some of the differentially expressed genes are interesting as potential markers of competence. Conclusions: Overall, our study provides new insights into the molecular regulation of blastocyst formation. In addition, it could help assess blastocyst staging and select better embryos based on the expression of quality markers. In the present study the Laval/Sirard_bovine_embryo_3K_V3.0 array was used to conduct a series of 18 hybridizations (for three Blastocysts stages (early, expended, hatched) with three biological replicates and dye swaps) in a loop design experiment....

  26. Downstreams of hnRNP A2 in Colo16 cells BioProject

    ID: PRJNA105671

    Keywords: Transcriptome or Gene expression

    Access Type: download

  27. shRNA profiling of human Colo16 cells knocked down for Downstreams of hnRNP A2 OmicsDI

    ID: E-GEOD-11865

    Date Released: 05-01-2014

    Description: ited knowledge of the downstream targets of hnRNP A2/B1 has, however, precluded a clear understanding of their roles in cancer cell growth. To define the pathways in...

  28. Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue ArrayExpress

    ID: E-GEOD-54418

    Description: components such as TDP-43, FUS, ATXN2, SMN, MAPT, HNRNPA2B1 and HNRNPA1 are crucial for the motor neuron diseases ALS / SMA and for the frontotemporal dementia FTD, here we studied mouse nervous tissue to identify mRNAs with selective dependence on Tia1 deletion. Transcriptome profiling with oligonucleotide microarrays in comparison of spinal cord and cerebellum, together with independent validation in quantitative reverse transcriptase PCR and immunoblots demonstrated several strong and consistent dysregulations. In...

  29. Whole-genome decay rate measurements in MDA-MB-231 cells transfected with HNRPA2B1 siRNAs versus controls ArrayExpress

    ID: E-GEOD-35756

    Description: Transcriptional profiling of MDA-MB-231 samples taken at 0, 1, 2 and 4hr timepoints upon exposure to alpha-amanitine, comparing the siRNA-mediated HNR...

  30. Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns ArrayExpress

    ID: E-GEOD-79157

    Description: ection of known splicing regulators such as hnRNP A2/B1, thereby indirectly influencing splice site selection. We conclude that changes in the expression of the polyadenylation factor CstF64 influences alternative splicing through indirect effects. HeLa cell line was stably transfected with shRNA plasmids targeting CstF64. Total RNA was isolated from CstF64 KD cells and wild-type control cells using Trizol according to manufacturer’s protocols. Samples were deep sequenced in duplicate using the Illumina GAIIx system....

  31. An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR BioProject

    ID: PRJNA297688

    Keywords: Epigenomics

    Access Type: download

    dataset.description: t specific interaction was between HOTAIR and the heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, a member of a family of proteins involved in nascent mRNA processing and RNA matchmaking. Our data suggest that A2/B1 are key contributors to HOTAIR-mediated chromatin regulation in breast cancer cells: A2/B1 knockdown reduces HOTAIR-dependent breast cancer cell invasion and decreases PRC2 activity at the majority of HOTAIR-dependent loci. We found that the B1 isoform, which differs from A2 by 12 additional amino acids, binds with highest specificity to HOTAIR. B1 also binds chromatin and associates preferentially with R...
  32. Muscle Developmental Defects in Heterogeneous Nuclear Ribonucleoprotein A1 Knockout Mice BioProject

    ID: PRJNA314880

    Keywords: Transcriptome or Gene expression

    Access Type: download

  33. Analysis of the gene expression pattern of bovine blastocysts at three stages of development BioProject

    ID: PRJNA134253

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ion. Gene candidates (IFNt, PLAC8, SSLP1, AKR1B1, HNRNPA2B1, ARGFX, NANOS, CCNB1) were selected and confirmed using Q-RT-PCR to validate the microarray data. Results: Our analysis show that hatched blastocysts are enriched in genes transcripts implicated in implantation, cell adhesion and extracellular matrix digestion. Early blastocysts expressed genes mainly involved in cell cycle control, transcription and translation. Q-RT-PCR validated most microarray results (87.5%). Some of the differentially expressed genes are interesting as potential markers of competence. Conclusions: Overall, our study provides new insights into the molecular regulation of blastocyst formation. In addition, it could help assess blastocyst staging and select better embryos based on the expression of quality markers. Overall design: In the present study the Laval/Sirard_bovine_embryo_3K_V3.0 array was used to conduct a series of 18 hybridizations (for three Blastocysts stages (early, expended, hatched) with three biological replicates and dye swaps) in a loop design experiment....
  34. Whole-genome decay rate measurements in MDA-MB-231 cells transfected with HNRPA2B1 siRNAs versus controls BioProject

    ID: PRJNA155927

    Keywords: Transcriptome or Gene expression

    Access Type: download

  35. A long noncoding RNA mediates both activation and repression of immune response genes. BioProject

    ID: PRJNA175479

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response Overall design: Examination of Mus musculus (C57BL/6 background) gene expression changes following stimulation with Pam3Cys4 in presence or absence of shRNA specifically targetting lncRNA-COX2...
  36. Dysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue BioProject

    ID: PRJNA236474

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: components such as TDP-43, FUS, ATXN2, SMN, MAPT, HNRNPA2B1 and HNRNPA1 are crucial for the motor neuron diseases ALS / SMA and for the frontotemporal dementia FTD, here we studied mouse nervous tissue to identify mRNAs with selective dependence on Tia1 deletion. Transcriptome profiling with oligonucleotide microarrays in comparison of spinal cord and cerebellum, together with independent validation in quantitative reverse transcriptase PCR and immunoblots demonstrated several strong and consistent dysregulations. In...
  37. Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns BioProject

    ID: PRJNA315060

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ection of known splicing regulators such as hnRNP A2/B1, thereby indirectly influencing splice site selection. We conclude that changes in the expression of the polyadenylation factor CstF64 influences alternative splicing through indirect effects. Overall design: HeLa cell line was stably transfected with shRNA plasmids targeting CstF64. Total RNA was isolated from CstF64 KD cells and wild-type control cells using Trizol according to manufacturer’s protocols. Samples were deep sequenced in duplicate using the Illumina GAIIx system....
  38. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (splicing arrays) ArrayExpress

    ID: E-GEOD-34992

    Description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...

  39. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (RNA-Seq) ArrayExpress

    ID: E-GEOD-34995

    Description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...

  40. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (CLIP-Seq) ArrayExpress

    ID: E-GEOD-34993

    Description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...

  41. Analysis of pre-mRNA splicing trans-regulation in human lymphoblastoid cell lines BioProject

    ID: PRJNA230267

    Keywords: Transcriptome or Gene expression

    Access Type: download

  42. Sumoylated hnrnpa2b1 controls the sorting of miRNAs into two exosomes through binding to specific motifs ProteomeXchange

    ID: PXD000350

    Instrument: LTQ Orbitrap

    Date Released: 04-16-2014

  43. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (RNA-Seq) BioProject

    ID: PRJNA156297

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...
  44. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (CLIP-Seq) BioProject

    ID: PRJNA156301

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...
  45. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins (splicing arrays) BioProject

    ID: PRJNA156299

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alternative pre-mRNA splicing (AS) in human cells. Using splicing-sensitive microarrays, cross-link...
  46. MK886 treatment of H720 non-small cell lung cancer cell line BioProject

    ID: PRJNA92869

    Keywords: Transcriptome or Gene expression

    Access Type: download

  47. Systematic Discovery of Structural Elements Governing Mammalian mRNA Stability ArrayExpress

    ID: E-GEOD-35800

    Description: Decoding post-transcriptional regulatory programs underlying gene expression is a crucial step toward a predictive dynamical understanding of cellular...

  48. MK886 treatment of H720 non-small cell lung cancer cell line GEMMA

    ID: 2231

    Keywords: functional genomics

    Description: In this experiments different treatments were applied to lung cancer cell lines 1)H720 cell line suspension was treated by 1 micromole of 5-lipoxygen...

  49. Arabidopsis Messenger RNA N6-methyladenosine Demethylation Regulates Plant Development OmicsDI

    ID: E-GEOD-79523

    Date Released: 03-25-2016

    Description: proteins, such as YTH domain family proteins and HNRNPA2B1; m6A can also act as a structure switch to affect RNA-protein interactions for biological regulation. In Arabidopsis thaliana, the methyltransferase subunit MTA (the plant orthologue of human METTL3, encoded by At4g10760) was well characterized and FIP37 (the plant orthologue of human WTAP) was first identified as the interacting partner of MTA. Here we report the discovery and characterization of reversible m6A methylation mediated by AtALKBH10B (encoded by At4g02940) in A. thaliana, and noticeable roles of this RNA demethylase in affecting plant development and floral transition. Our findings reveal potential broad functions o...

  50. Arabidopsis Messenger RNA N6-methyladenosine Demethylation Regulates Plant Development ArrayExpress

    ID: E-GEOD-79523

    Description: proteins, such as YTH domain family proteins and HNRNPA2B1; m6A can also act as a structure switch to affect RNA-protein interactions for biological regulation. In Arabidopsis thaliana, the methyltransferase subunit MTA (the plant orthologue of human METTL3, encoded by At4g10760) was well characterized and FIP37 (the plant orthologue of human WTAP) was first identified as the interacting partner of MTA. Here we report the discovery and characterization of reversible m6A methylation mediated by AtALKBH10B (encoded by At4g02940) in A. thaliana, and noticeable roles of this RNA demethylase in affecting plant development and floral transition. Our findings reveal potential broad functions o...


Displaying 50 of 53 results for "HNRNPA2B1"