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Displaying 20 of 719 results for "HIST1H2AE"
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  1. Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells [RNA-Seq] BioProject

    ID: PRJNA168656

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Mapping origins of replication in Arabidopsis thaliana: Examination of BrdU labeled DNA and unlabeled DNA in one cell type BioProject

    ID: PRJNA129357

    Keywords: Other

    Access Type: download

    dataset.description: ave also analyzed novel epigenome maps of various histone modifications and found links between origins and epigenetic signatures, which differ from or have not been reported for other eukaryotic systems. Arabidopsis origins tend to be embedded in G+C-rich regions within the 5’ half of genes, enriched in histone H2A.Z, H3K4me2/3 and acetylated H3 and H4, and depleted of H3K4me1 and H3K9me2. Our data establish the basis for the understanding of the epigenetic specification of origins of replication in Arabidopsis and have implications for the mechanisms of origin specification in other eukaryotes. Overall design: Examination of BrdU labelled DNA and unlabelled DNA in one cell type...
  3. H2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [RNA-Seq] BioProject

    ID: PRJNA172651

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embry...
  4. PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos BioProject

    ID: PRJNA259711

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ality. We detected the PRMT5-catalysed repressive H2A/H4R3me2s modification on LINE1 and IAP in early wildtype PGCs, directly implicating this mark in the maintenance of transposon silencing during DNA hypomethylation. PRMT5 subsequently translocates back to the cytoplasm of PGCs to participate in the previously described PIWI-interacting RNA (piRNA) pathway that promotes transposon silencing via de novo DNA re-methylation. Thus, PRMT5 has a novel direct role in genome defense during preimplantation development and in PGCs at the time of global DNA demethylation Overall design: PGCs mRNA profiles of embryonic day 11.5 dpc control (Blimp1Cre;Prmt5flox/+) and Prmt5 germ cell knockout (Blimp1Cre;Prmt5 flox/flox) were generated ...
  5. Genome-wide evolutionary analysis of eukaryotic DNA methylation BioProject

    ID: PRJNA122153

    Keywords: Other

    Access Type: download

    dataset.description: show that antagonism between DNA methylation and histone H2A.Z is conserved between plants and animals. Our data demonstrate that extant DNA methylation systems are mosaics of conserved and derived features, and indicate that gene body methylation is an ancient property of eukaryotic genomes. Keywords: Epigenetics Overall design: Examination of DNA methylation and transcription in plant, animal, and fungal genomes, and examination of how H2A.Z deposition relates to both methylation and transcription in puffer fish. Descriptions of the Samples' raw and processed data (provided as supplementary files) can be found in GSE19824_README.txt at the foot of this record....
  6. Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells [mRNA] BioProject

    ID: PRJNA169141

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. The actin-related protein Arp6 contributes to chromatin anchoring independently of its nucleosome remodeling activity BioProject

    ID: PRJNA102801

    Keywords: Epigenomics

    Access Type: download

    dataset.description: h contains Arp6 and Swr1 as components, exchanges H2A in nucleosomes with its variant H2AZ. We have investigated the chromosome-wide dynamic distribution of Arp6 and Swr1 in budding yeast cells by chromatin immunoprecipitati...
  8. Mapping origins of replication in Arabidopsis thaliana BioProject

    ID: PRJNA127085

    Access Type: download

    dataset.description: ave also analyzed novel epigenome maps of various histone modifications and found links between origins and epigenetic signatures, which differ from or have not been reported for other eukaryotic systems. Arabidopsis origins tend to be embedded in G+C-rich regions within the 5’ half of genes, enriched in histone H2A.Z, H3K4me2/3 and acetylated H4, and depleted of H3K4me1 and H3K9me2. Our data establish the basis for the understanding of the epigenetic specification of origins of replication in Arabidopsis and have implications for the mechanisms of origin specification in other eukaryotes. This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series...
  9. RNA abundance in wild-type and rtt109 -/- Candida albicans, with and without peroxide stress BioProject

    ID: PRJNA121051

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ing reactive oxygen species (ROS). Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase Rtt109 is important for yeast model organisms to survive DNA damage and maintain genome integrity. To assess the importance of Rtt109 for C. albicans pathogenicity, we deleted the predicted homologue of Rtt109 in the clinical C. albicans isolate, SC5314. C. al...
  10. Zea mays : Zea mays Epigenomics BioProject

    ID: PRJNA184710

    Keywords: Epigenomics

    Access Type: download

    dataset.description: analysis of phosphorylation of H3T3, H3ser-10 and H2A levels on this new centromere shows a pattern typical of a functional centromere. Meiotic analysis revealed that this dicentric chromosome is table and transmit very well. To examine the new sequences associated with CENH3 in this centromere, chromatin immunoprecipitation (ChIP) was carried out with anti-CENH3 antibodies and material from young seedlings with or without dicentric chromosome. We mapped the ChIP-Seq reads to the reference genome and found a 723kb region from the short a...
  11. Cohesin association to replication sites depends on Rad50 and promotes fork restart BioProject

    ID: PRJNA170884

    Keywords: Other

    Access Type: download

    dataset.description: nrichment at replication forks does not depend on H2A(X) formation, which differs from its loading requirements at DNA double-strand breaks (DSBs). However, cohesin localization is largely reduced in rad50delta mutants and cells lacking both Mec1 and Tel1 checkpoint kinases. Interestingly, cohesin loading at replication sites depends on the structural features of Rad50 that are important for bridging sister chromatids, including the CXXC hook domain and the length of the coiled-coil extensions. Together, these data reveal a novel function for cohesin in the maintenance of gen...
  12. H2A.Z inheritance during the cell cycle [expression array] OmicsDI

    ID: E-GEOD-41370

    Date Released: 01-11-2013

    Description: omes flanking the TSS becoming heterotypic (H2A.Z/H2A). Surprisingly, these nucleosomes remain heterotypic at M phase. At the TSS, we identify an unstable heterotypic H2A.Z-containing nucleosome in G1 which, strikingly, is lost following DNA replication. These dynamic changes in H2A.Z at the TSS mirror a global expansion of the NDR at S and M which, unexpectedly, is unrelated to transcriptional activity. Coincident with the loss of H2A.Z at promoters, it is targeted to the centromere when mitosis begins. We surveyed whole genome expression using microarrays, in combination with H2A.Z ChIP-Seq (Illumina) data, to stud...

  13. The Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends BioProject

    ID: PRJNA168290

    Keywords: Other

    Access Type: download

    dataset.description: ithin the context of chromatin where histones and histone-bound proteins represent barriers for resection enzymes. Here, we have identified the yeast nucleosome remodeling enzyme Fun30 as novel factor promoting DSB end resection. Fun30 is the major nucleosome remodeler promoting extensive Exo1- and Sgs1-dependent resection of DSBs while the RSC and INO80 chromatin remodeling complexes play redundant roles with Fun30 in resection adjacent to DSB ends. ATPase and helicase domains of Fun30, which are needed for nucleosome remodeling, are also required for resection. Fun30 is robustly recruited to ...
  14. Histone variant H2A.L.2 guides transition protein - dependent protamine assembly in male germ cells BioProject

    ID: PRJNA360424

    Keywords: Epigenomics

    Access Type: download

  15. Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila BioProject

    ID: PRJNA297597

    Keywords: Epigenomics

    Access Type: download

  16. Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks BioProject

    ID: PRJNA113725

    Keywords: Epigenomics

    Access Type: download

  17. Top1 and Top2-mediated replication fork integrity BioProject

    ID: PRJNA101273

    Keywords: Epigenomics

    Access Type: download

    dataset.description: and processing, and phosphorylation of Rad53 and ?H2A in S phase. The exonuclease Exo1 influences fork processing and DNA damage checkpoint activation in top1 top2 mutants. Our data are consistent with a coordinated action of Top1 and Top2 in counteracting the accumulation of torsional stress and sister chromatid entanglement at replication forks, thus preventing the diffusion of topological changes along large chromosomal regions. A failure in resolving fork-related topological constrains during S phase may therefore result in abnormal chromosome transitions, DNA damage checkpoint activation and chromosome breakage during segregation. Keywords: ChIP-chip analysis Overall design: S. cerevisiae chromosomes III–V, and chromosome VI highdensity oligonucleotide microarrays were provided by Affymetrix Custom Express Service (SC3456a520015F, P/N 520015; rikDACF, P/N 510636, respectively). Sequence and position of oligonucleotides on the microarrays ar...
  18. Genome-wide Replication-independent H3 Exchange Occurs Predominantly at Promoters and Implicates H3K56ac and Asf1 BioProject

    ID: PRJNA101263

    Keywords: Epigenomics

    Access Type: download

    dataset.description: In yeast, histone H3/H4 exchange independent of replication is poorly understood. Here, we analyzed the deposition of histone
  19. VprBP depletion effect on prostate cancer cell line GEO

    ID: geo.datasets:GDS4829

    Description: inding protein (VPRBP). VPRBP knockdown decreases histone H2A threonine 120 (H2AT120) phosphorylation and impairs the viability of DU145 cells. Results provide insight into the role of VprBP in regulating gene transcript...

    Types: Expression profiling by array

    Instrument: GPL10558


Displaying 20 of 719 results for "HIST1H2AE"