FOXP1 | bioCADDIE Data Discovery Index
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Displaying 20 of 284 results for "FOXP1"
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  1. Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs) PDB

    ID: PDB:1WQJ

    Description: Insulin-like growth factor binding protein 4, Insulin-like growth

  2. Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients ArrayExpress

    ID: E-GEOD-65153

    Description: -3p regulates the expression of the transcription factor CNOT1, that in turn regulates the expression of AU-rich element (ARE)-containing target genes AKT3, BCL2, THSB2 and CYR61, all belonging to the focal adhesion pathway. Indeed, CNOT1 expression was found significantly higher, whereas that of the ARE-containing target genes was significantly lower in BM-infiltrating cells than in primary tumors. Our findings about a role of the focal adhesion pathway, regulated by miR-659-3p through CNOT1, in NB metastatic process are intriguing for the development of new therapeutic strategies aimed to interrupt the metastatic process. To evaluate the effect of miR-659-3p up- and down-regulation on gene expression, HTLA-230 and SH-SY5Y cells were transfected with specific miR-659-3p mirVana™ mimic and inhibitor, respectively (Ambion, Life Technologies, Carlsbad, CA, USA, catalog# MC and MH 11582). Samples transfected with mirVana™ miRNA Mimic Negative Control #1 and mirVana™ miRNA Inhibitor Negative Control #1 were used as reference conditions. Transfection was p...

  3. Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients BioProject

    ID: PRJNA273286

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -3p regulates the expression of the transcription factor CNOT1, that in turn regulates the expression of AU-rich element (ARE)-containing target genes AKT3, BCL2, THSB2 and CYR61, all belonging to the focal adhesion pathway. Indeed, CNOT1 expression was found significantly higher, whereas that of the ARE-containing target genes was significantly lower in BM-infiltrating cells than in primary tumors. Our findings about a role of the focal adhesion pathway, regulated by miR-659-3p through CNOT1, in NB metastatic process are intriguing for the development of new therapeutic strategies aimed to interrupt the metastatic process. Overall design: To evaluate the effect of miR-659-3p up- and down-regulation on gene expression, HTLA-230 and SH-SY5Y cells were transfected with specific miR-659-3p mirVana™ mimic and inhibitor, respectively (Ambion, Life Technologies, Carlsbad, CA, USA, catalog# MC and MH 11582). Samples transfected with mirVana™ miRNA Mimic Negative Control #1 and mirVana™ miRNA Inhibitor Negative Control #1 were used as reference conditions. Tr...
  4. Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. PDB

    ID: PDB:5FNQ

    Description: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

  5. Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz PDB

    ID: PDB:3LTF

    Description: Epidermal growth factor receptor (E.C.2.7.10.-)/ Protein spitz complex

  6. Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant PDB

    ID: PDB:3LTG

    Description: Epidermal growth factor receptor (E.C.2.7.10.-)/ Protein spitz complex

  7. Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. PDB

    ID: PDB:5FZN

    Description: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

  8. Novel Molecular Architecture of YopM-a Leucine-rich Effector Protein from Yersinia pestis PDB

    ID: PDB:1JL5

    Description: outer protein YopM

  9. Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. PDB

    ID: PDB:5FNU

    Description: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

  10. Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. PDB

    ID: PDB:5FNR

    Description: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

  11. Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. PDB

    ID: PDB:5FZJ

    Description: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

  12. Solution structure of the TRAF-type zinc finger domains (102-164) from human TNF receptor associated factor 4 PDB

    ID: PDB:2YUC

    Description: TNF receptor-associated factor 4

  13. Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. PDB

    ID: PDB:5FNT

    Description: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

  14. Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor. PDB

    ID: PDB:5FNS

    Description: KELCH-LIKE ECH-ASSOCIATED PROTEIN 1

  15. Crystal structure of the light and hvem complex PDB

    ID: PDB:4RSU

    Description: Tumor necrosis factor ligand superfamily member 14, soluble form, Tumor necrosis factor receptor superfamily member 14...

  16. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening PDB

    ID: PDB:5JAL

    Description: Platelet-activating factor acetylhydrolase (E.C.3.1.1.47)

  17. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening PDB

    ID: PDB:5JAN

    Description: Platelet-activating factor acetylhydrolase (E.C.3.1.1.47)

  18. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening PDB

    ID: PDB:5JAO

    Description: Platelet-activating factor acetylhydrolase (E.C.3.1.1.47)

  19. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening PDB

    ID: PDB:5JAP

    Description: Platelet-activating factor acetylhydrolase (E.C.3.1.1.47)

  20. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening PDB

    ID: PDB:5JAH

    Description: Platelet-activating factor acetylhydrolase (E.C.3.1.1.47)


Displaying 20 of 284 results for "FOXP1"