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Displaying 20 of 284 results for "FOXP1"
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  1. Agilent 244K aCGH data for human primary and metastatic prostate cancer samples BioProject

    ID: PRJNA129697

    Keywords: Variation

    Access Type: download

    dataset.description: ries. Tumors with the androgen-driven TMPRSS2-ERG fusion were significantly associated with a small, previously unrecognized, prostate-specific 3p14 deletion that, through mRNA expression and resequencing analysis, implicates FOXP1, RYBP and SHQ1 as candidate cooperative tumor suppressors. Comparison of transcriptome and DNA copy number data from primary tumors for prognostic impact revealed that CNAs robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. In sum, this integrative genomic analysis of a substantial cohort of tumors clarifies the role of several known cancer pathways in prostate cancer, implicates several new ones, reveals a previously unappreciated role for CNAs in prognosis and provides a blueprint for clinical development of pathway inhibitors. Overall design: Human prostate samples were profiled on Agilent 244K aCGH arrays per manufacturer's instructions. Either matched normal DNA or a pooled reference normal DNA was used as the reference....
  2. Variable glutamine-rich repeats modulate the function of the transcriptional regulator SSN6 ArrayExpress

    ID: E-GEOD-70209

    Description: Excessive expansions of glutamine (Q)-rich repeats in various human proteins are known to result in severe neurodegenerative disorders s...

  3. Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of i... ArrayExpress

    ID: E-GEOD-83379

    Description: e patterns of DNA methylation in human macrophage-like U937 cells following infection with Burkholderia pseudomallei, an intracellular bacterial pathogen and the causative agent of human melioidosis. Our analyses revealed significant changes in host cell DNA methylation, at multiple CpG sites in the host cell genome, following infection. Infectio...

  4. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes OmicsDI

    ID: E-GEOD-32563

    Date Released: 10-10-2014

    Description: expression were found for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (http://tinyurl.com/3j7dcp6). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....

  5. Molecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia OmicsDI

    ID: E-GEOD-84987

    Date Released: 07-30-2016

    Description: PAX5 is a tumor suppressor in B-ALL, while the role of PAX5 fusion protein...

  6. Additional file 12: Table S7. of A novel approach identifies the first transcriptome networks in bats: a new genetic model for vocal communication Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3607160_D2

    Release Date: 12-14-2016

    Description: FOXP1-target relationships identified in the midnight blue network. (XLSX 23 kb)

  7. Suppressio​n of MicroRNA-9 by Mutant EGFR Signaling Induces FOXP1 to Enhance Glioblasto​ma Tumorigeni​city OmicsDI

    ID: E-GEOD-53504

    Date Released: 06-03-2014

    Description: The EGF-receptor (EGFR) is amplified and mutated in glioblastoma (GBM) where its common mutation, (∆EGFR, also called EGFRvIII) has a variety of act...

  8. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells BioProject

    ID: PRJNA178210

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: espread use even for intensely studied cell types like spinal motor neurons, is hindered by the long duration and low yields of existing protocols for in vitro differentiation and by the molecular heterogeneity of the populations generated. We report a combination of small molecules that induce up to 50% motor neurons within 3 weeks from human pluripot...
  9. Expression data from wild type and Ctip2-/- (Bcl11b) mutant mouse striatum at P0 BioProject

    ID: PRJNA103005

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ngton’s disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development. Within the striatum, it is expressed by all MSN, while it is excluded from essentially all striatal interneurons. In the absence of Ctip2, MSN do not fully differentiate...
  10. Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of i... BioProject

    ID: PRJNA325736

    Keywords: Epigenomics

    Access Type: download

    dataset.description: e patterns of DNA methylation in human macrophage-like U937 cells following infection with Burkholderia pseudomallei, an intracellular bacterial pathogen and the causative agent of human melioidosis. Our analyses revealed significant changes in host cell DNA methylation, at multiple CpG sites in the host cell genome, following infection. Infectio...
  11. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations #323 Ndar Papers

    ID: 323

    Description: identified 21 de novo mutations, 11 of which were protein altering. Protein-altering mutations were significantly enriched for changes at highly conserved residues. We identified potentially causative de novo events in 4 out of 20 probands, particularly among more severely affected individuals, in FOXP1, GRIN2B, SCN1A and LAMC3. In the FOXP1 mutation carrier, we also observed a rare inherited CNTNAP2 missense variant, and we provide functional support for a mult...

    Types: Observational Study

  12. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span ArrayExpress

    ID: E-GEOD-4402

    Description: a member of the Sir-2 family of NAD(+)-dependent protein deacetylases, has been shown to regulate nematode aging via the insulin/IGF pathway transcription factor daf-16. Treatment of C. elegans with the small molecule resveratrol, however, extends life span in a manner fully dependent upon sir-2.1, but independent of daf-16. Microarray analysis of worms treated with resveratrol demonstrat...

  13. Med23-dependent gene expression programs in T cells OmicsDI

    ID: E-GEOD-60779

    Date Released: 09-01-2014

    Description: n genes (Med23, IFNg, IL2, Egr2, c-Fos, c-Jun and Foxp1) was validated in the same RNA samples by real-time PCR. TCR induced Med23-dependent gene expression was measured after unstimulation or stimulation for 6 hr in wildtype and Med23 knockout CD4 T cells....

  14. STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR SPECTROSCOPY PDB

    ID: PDB:1CFH

    Description: COAGULATION FACTOR IX (THE GLA AND AROMATIC AMINO ACID STACK DOMAINS FROM RESIDUES 1 - 47) (NMR, 15 STRUCTURES)

  15. NMR STRUCTURE OF CALCIUM ION-BOUND GAMMA-CARBOXY-GLUTAMIC ACID-RICH DOMAIN OF FACTOR IX PDB

    ID: PDB:1CFI

    Description: COAGULATION FACTOR IX

  16. Transcription profiling by array of fibroblasts from TTP knock out mice ArrayExpress

    ID: E-GEOD-5324

    Description: ristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived...

  17. Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming I OmicsDI

    ID: E-GEOD-45503

    Date Released: 05-04-2014

    Description: rly understood. Here, we identify the Muscleblind-like RNA binding proteins, MBNL1 and MBNL2, as conserved and direct negative regulators of a large program of AS events that are differentially regulated between ESCs and other cell types. Knockdown of MBNL proteins in differentiated cells causes switching to an ESC-like AS pattern for at least half of these AS events. Among the events is an ESC-specific AS switch in the forkhead family transcription factor FOXP1 th...

  18. CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA PDB

    ID: PDB:1G2E

    Description: PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGEN HUD/RNA COMPLEX

  19. Solution structure of the surp1 domain in splicing factor, arginine/serine-rich 8 PDB

    ID: PDB:2E60

    Description: Splicing factor, arginine/serine-rich 8

  20. NMR structure of RNA recognition motif 2 (RRM2) of Homo sapiens splicing factor, arginine/serine-rich 1 PDB

    ID: PDB:2M7S

    Description: Serine/arginine-rich splicing factor 1


Displaying 20 of 284 results for "FOXP1"