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Displaying 20 of 284 results for "FOXP1"
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  1. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [ChIP-Seq] OmicsDI

    ID: E-GEOD-31006

    Date Released: 06-25-2012

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  2. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes ArrayExpress

    ID: E-GEOD-32563

    Description: expression were found for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....

  3. Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming II BioProject

    ID: PRJNA195386

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming I BioProject

    ID: PRJNA195385

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. FOXP1 is a transcriptional Coactivator of Wnt/β-catenin signaling in Diffuse Large B-cell Lymphoma OmicsDI

    ID: PXD001485

    Date Released: 07-05-2016

    Description: aining a β-catenin-driven GFP (green fluorescent protein) transcriptional reporter were transduced with CDBF lentivirus. When integrated near an expressed and spliced gene, the cytomegalovirus (CMV) promoter of the CDBF vector drives constitutive BFP (blue fluorescence protein) expression and by virtue of the splice donor (SD) seque...

  6. A genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell qu... BioProject

    ID: PRJNA271860

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanist...
  7. A_PiggyBac_transposon_screen_in_pancreatic_cancer BioProject

    ID: PRJEB14663

    Keywords: Other

    Access Type: download

    dataset.description: eatic insertional mutagenesis screen. We identify Foxp1 as an oncogenic transcription factor that drives pancreatic cancer invasion and spread in a mouse model and correlates with lymph node metastasis in human patients with pancreatic cancer. The propensity of piggyBac for open chromatin also enabled ge...
  8. FXP1B_DANRE UniProt:Swiss-Prot

    ID: Q2LE08

    Description: Forkhead box protein P1-B C2H2-type Fork

  9. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells ArrayExpress

    ID: E-GEOD-41795

    Description: espread use even for intensely studied cell types like spinal motor neurons, is hindered by the long duration and low yields of existing protocols for in vitro differentiation and by the molecular heterogeneity of the populations generated. We report a combination of small molecules that induce up to 50% motor neurons within 3 weeks from human pluripot...

  10. DNA methylation status of CpG islands in normal and atherosclerotic human arteries ArrayExpress

    ID: E-GEOD-15552

    Description: (42%). The latter include HOX members, NOTCH1 and FOXP1, which are known to regulate angiogenesis, dedifferentiation, cell migration and macrophage function. The methylation status of selected CGIs was validated in further 10 subjects for either group. Expression patterns of these factors were compatible with the observed differential methylation. Our data suggest that one of the molecular changes associated with aberrant DNA methylation in advanced atherosclerosis is the regulation of critical transcription factor genes for the induction of a proatherogenic cellular phenotype. Two-condition experiment, i.e. normal vs. atherosclerotic arteries. 16 and 45 normal and atherosclerotic samples, respectively, were pooled and used to interrogate CpG island arrays in triplicate, for a total of six arrays. Each array was co-hybridized with untreated DNA (reference) and hypermethylated DNA obtained by biochemical filtration....

  11. MicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate ArrayExpress

    ID: E-GEOD-21036

    Description: ries. Tumors with the androgen-driven TMPRSS2-ERG fusion were significantly associated with a small, previously unrecognized, prostate-specific 3p14 deletion that, through mRNA expression and resequencing analysis, implicates FOXP1, RYBP and SHQ1 as candidate cooperative tumor suppressors. Comparison of transcriptome and DNA copy number data from primary tumors for prognostic impact revealed that CNAs robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. In sum, this integrative genomic analysis of a substantial cohort of tumors clarifies the role of several known cancer pathways in prostate cancer, implicates several new ones, reveals a previously unappreciated role for CNAs in prognosis and provides a blueprint for clinical development of pathway inhibitors. Human prostate samples were profiled on Agilent microRNA V2 arrays per manufacturer's instructions....

  12. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [protein binding microarray] OmicsDI

    ID: E-GEOD-31007

    Date Released: 05-02-2014

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  13. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes BioProject

    ID: PRJNA147119

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: expression were found for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Overall design: Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (http://tinyurl.com/3j7dcp6). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....
  14. FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation OmicsDI

    ID: E-GEOD-55497

    Date Released: 06-23-2016

    Description: To understand the developing striatum, key genes during development were identified using microarray analsyis tha could be considered as marker of med...

  15. Transcription profiling of mouse wild type and Ctip2-/- (Bcl11b) mutant striatum at P0 ArrayExpress

    ID: E-GEOD-9330

    Description: ngton’s disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development. Within the striatum, it is expressed by all MSN, while it is excluded from essentially all striatal interneurons. In the absence of Ctip2, MSN do not fully differentiate...

  16. The role of AR-associated factors in androgen signaling OmicsDI

    ID: E-GEOD-58309

    Date Released: 11-28-2014

    Description: n. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines after siRNA treatment. We a...

  17. Whole-transcript and exon-level expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate BioProject

    ID: PRJNA129695

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ries. Tumors with the androgen-driven TMPRSS2-ERG fusion were significantly associated with a small, previously unrecognized, prostate-specific 3p14 deletion that, through mRNA expression and resequencing analysis, implicates FOXP1, RYBP and SHQ1 as candidate cooperative tumor suppressors. Comparison of transcriptome and DNA copy number data from primary tumors for prognostic impact revealed that CNAs robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. In sum, this integrative genomic analysis of a substantial cohort of tumors clarifies the role of several known cancer pathways in prostate cancer, implicates several new ones, reveals a previously unappreciated role for CNAs in prognosis and provides a blueprint for clinical development of pathway inhibitors. Overall design: Human prostate samples were profiled on Affymetrix Human Exon 1.0 ST arrays per manufacturer's instructions....
  18. MicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate BioProject

    ID: PRJNA129699

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ries. Tumors with the androgen-driven TMPRSS2-ERG fusion were significantly associated with a small, previously unrecognized, prostate-specific 3p14 deletion that, through mRNA expression and resequencing analysis, implicates FOXP1, RYBP and SHQ1 as candidate cooperative tumor suppressors. Comparison of transcriptome and DNA copy number data from primary tumors for prognostic impact revealed that CNAs robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. In sum, this integrative genomic analysis of a substantial cohort of tumors clarifies the role of several known cancer pathways in prostate cancer, implicates several new ones, reveals a previously unappreciated role for CNAs in prognosis and provides a blueprint for clinical development of pathway inhibitors. Overall design: Human prostate samples were profiled on Agilent microRNA V2 arrays per manufacturer's instructions....
  19. DNA methylation status of CpG islands in normal and atherosclerotic human arteries BioProject

    ID: PRJNA115995

    Keywords: Epigenomics

    Access Type: download

    dataset.description: (42%). The latter include HOX members, NOTCH1 and FOXP1, which are known to regulate angiogenesis, dedifferentiation, cell migration and macrophage function. The methylation status of selected CGIs was validated in further 10 subjects for either group. Expression patterns of these factors were compatible with the observed differential methylation. Our data suggest that one of the molecular changes associated with aberrant DNA methylation in advanced atherosclerosis is the regulation of critical transcription factor genes for the induction of a proatherogenic cellular phenotype. Overall design: Two-condition experiment, i.e. normal vs. atherosclerotic arteries. 16 and 45 normal and atherosclerotic samples, respectively, were pooled and used to interrogate CpG island arrays in triplicate, for a total of six arrays. Each array was co-hybridized with untreated DNA (reference) and hypermethylated DNA obtained by biochemical filtration....
  20. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray] OmicsDI

    ID: E-GEOD-31948

    Date Released: 05-02-2014

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...


Displaying 20 of 284 results for "FOXP1"