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Displaying 20 of 284 results for "FOXP1"
  1. Transcription profiling of mouse wild type and Ctip2-/- (Bcl11b) mutant striatum at P0 OmicsDI

    ID: E-GEOD-9330

    Date Released: 03-27-2012

    Description: ngton’s disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development. Within the striatum, it is expressed by all MSN, while it is excluded from essentially all striatal interneurons. In the absence of Ctip2, MSN do not fully differentiate...

  2. Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of i... OmicsDI

    ID: E-GEOD-83379

    Date Released: 06-17-2016

    Description: e patterns of DNA methylation in human macrophage-like U937 cells following infection with Burkholderia pseudomallei, an intracellular bacterial pathogen and the causative agent of human melioidosis. Our analyses revealed significant changes in host cell DNA methylation, at multiple CpG sites in the host cell genome, following infection. Infectio...

  3. Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1/D2/F/E/G from Human PDB

    ID: PDB:3S6N

    Description: Survival of motor neuron protein-interacting protein 1, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucle...

  4. Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism. NIMH

    ID: doi:10.15154/1271285

    Release Date: 03-07-2017

    attributes.description: orting two other known genes with recurrent DNVs (FOXP1 and KDM5B). Genes harboring functional DNVs significantly overlap with functional/disease gene sets known to be involved in ASD etiology, including FMRP targets and synaptic formation and transcriptional regulation genes. We dichotomized the probands into High-5HT and Normal-5HT groups based on normalized serotonin levels and identified novel genes related to the TGF- pathway in the High-5HT group using Network-based Gene Enrichment Analysis (NGSEA). Through analysis of rare recessively acting variants (RAVs), we found that rare compound heterozygotes (CHs) in the High-5HT group were enriched for loci in an ASD-associated gene set. Finally, we carried out rare variant group-wise transmission disequilibrium tests and observed significant association of rare variants in genes encoding the serotonin pathway with ASD. Conclusions: Our study identified novel genes harboring DNVs implicated in ASD. Leveraging 5-HT as an endophenotype, we identified genes pointing to the TGF- pathway as potentially contributing to hyperserotonemia in ASD. Our study demonstrates the value of 5-HT as an effective endophenotype for gene discovery in ASD, evincing the need for greater co...

Displaying 20 of 284 results for "FOXP1"