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  1. Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping PDB

    ID: PDB:2KIU

    Description: Forkhead box protein P1

  2. Molecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia ArrayExpress

    ID: E-GEOD-84987

    Description: PAX5 is a tumor suppressor in B-ALL, while the role of PAX5 fusion protein...

  3. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS BioProject

    ID: PRJNA145685

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Elucidation of FOXP1 target genes in DLBCL by RNA-Seq BioProject

    ID: PRJEB9852

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Molecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia BioProject

    ID: PRJNA335837

    Keywords: Other

    Access Type: download

  6. Gene expression in human umbilical cord endothelial cells following FoxP1 knockdown BioProject

    ID: PRJNA146529

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Elucidation of FOXP1 target genes in DLBCL by ChIP-Seq BioProject

    ID: PRJEB9851

    Keywords: Other

    Access Type: download

  8. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS ArrayExpress

    ID: E-GEOD-31560

    Description: Forkhead box protein P1 (Foxp1), a transcription

  9. FOXP1 orchestration of ASD-relevant signaling pathways ArrayExpress

    ID: E-GEOD-62718

    Description: Mutations in the gene encoding the transcription factor forkhead box P1 or FOXP1 occur in patients with ...

  10. FOXP1 orchestration of ASD-relevant signaling pathways. BioProject

    ID: PRJNA264860

    Keywords: Other

    Access Type: download

  11. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS OmicsDI

    ID: E-GEOD-31560

    Date Released: 11-14-2011

    Description: Forkhead box protein P1 (Foxp1), a transcription

  12. The role of Foxp1/2/4 in lung endoderm identity BioProject

    ID: PRJNA271852

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. The role of Foxp1/4 in lung development BioProject

    ID: PRJNA151001

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. The forkhead transcription factor FOXP1 profile in B-cells and B-cell lymphoma cell lines ArrayExpress

    ID: E-GEOD-69009

    Description: Expression of the forkhead transcription factor FOXP1 is essential for early B cell developm...

  15. Gene expression in human umbilical cord endothelial cells following FoxP1 knockdown ArrayExpress

    ID: E-GEOD-32968

    Description: o search for genes regulated by the transcription factor Forkhead box Protein P1 (FoxP1...

  16. Elucidation of FOXP1 target genes in diffuse large B-cell lymphoma cells by ChIP-Seq ArrayExpress

    ID: E-MTAB-3741

    Description: ChIP-Sequencing of 4 diffuse large B-cell lymphoma cell lines expressing different amounts of FOXP1 was performed in order to identify target genes...

  17. Recruitment of FOXP1 to target genes in diffuse large B-cell lymphoma (DLBCL) cells BioProject

    ID: PRJNA189234

    Keywords: Epigenomics

    Access Type: download

  18. FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma ArrayExpress

    ID: E-GEOD-62419

    Description: ights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines. Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleo...

  19. The forkhead transcription factor FOXP1 profile in B-cells and B-cell lymphoma cell lines BioProject

    ID: PRJNA284282

    Keywords: Epigenomics

    Access Type: download

  20. Gene expression profiling of FOXP1-silenced diffuse large B-cell lymphoma (DLBCL) cell lines BioProject

    ID: PRJNA291431

    Keywords: Transcriptome or Gene expression

    Access Type: download

  21. FOXP1 in ABC DLBCL BioProject

    ID: PRJNA271357

    Keywords: Transcriptome or Gene expression

    Access Type: download

  22. Recruitment of FOXP1 to target genes in diffuse large B-cell lymphoma (DLBCL) cells ArrayExpress

    ID: E-GEOD-44243

    Description: Identification of FOXP1 target genes in the OCI-Ly1 DLBCL cell line by ChIP-on-chip Three replicates of the FOXP1 ChIP-on-chip wer...

  23. Elucidation of FOXP1 target genes in diffuse large B-cell lymphoma cells by RNA-Seq ArrayExpress

    ID: E-MTAB-3740

    Description: Elucidation of FOXP1 target genes by RNA-Seq of DLBCL cell lines transfected with siRNAs targeting FOXP1 expression...

  24. FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma BioProject

    ID: PRJNA264062

    Keywords: Transcriptome or Gene expression

    Access Type: download

  25. Retroviral overexpression or siRNA mediated knockdown of FOXP1 in DLBCL cell lines and primary human B cells BioProject

    ID: PRJNA222854

    Keywords: Transcriptome or Gene expression

    Access Type: download

  26. The role of Foxp1/4 in lung development ArrayExpress

    ID: E-GEOD-34584

    Description: Foxp1/4 transcription factors are conserved transcriptional repressors expressed in overlapping patterns during lung development as...

  27. FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation BioProject

    ID: PRJNA239801

    Keywords: Transcriptome or Gene expression

    Access Type: download

  28. Subtype Specific Addiction of the Activated B Cell Subset of Diffuse Large B Cell Lymphoma to FOXP1 ArrayExpress

    ID: E-GEOD-63257

    Description: transcript and target gene profiling reveal that FOXP1 acts directly and indirectly by enforcing known ABC-DLBCL hallmarks, including Chronically Activated B cell receptor ...

  29. FOXP1 orchestration of ASD-relevant signaling pathways. OmicsDI

    ID: E-GEOD-62718

    Date Released: 12-08-2015

    Description: Mutations in the gene encoding the transcription factor forkhead box P1 or FOXP1 occur in patients with ...

  30. FOXP1_BOVIN UniProt:Swiss-Prot

    ID: A4IFD2

    Description: Forkhead box protein P1 C2H2-type Fork-head

  31. FOXP1_RAT UniProt:Swiss-Prot

    ID: Q498D1

    Description: Forkhead box protein P1 C2H2-type Fork-head

  32. Non-IG Aberrations of FOXP1 in B-Cell Malignancies Lead to an Aberrant Expression of N-Truncated Isoforms of FOXP1 BioProject

    ID: PRJNA217945

    Keywords: Transcriptome or Gene expression

    Access Type: download

  33. Retroviral overexpression or siRNA mediated knockdown of FOXP1 in DLBCL cell lines and primary human B cells ArrayExpress

    ID: E-GEOD-51382

    Description: the role of and target genes of the transcription factor FOXP1 in mature human B cells and in B cell non-Hodkgin lymhomas, we performed gene express...

  34. of knockdowns using custom siRNA pools targeting FOXP1 exons 18 or 18b in human embryonic stem cells... ArrayExpress

    ID: E-GEOD-30995

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  35. Non-IG Aberrations of FOXP1 in B-Cell Malignancies Lead to an Aberrant Expression of N-Truncated Isoforms of FOXP1 ArrayExpress

    ID: E-GEOD-50514

    Description: The transcription factor FOXP1 is implicated in the pathogenesis of B-cell lymphomas through immunoglobulin hea...

  36. Gene expression in human umbilical cord endothelial cells following FoxP1 knockdown OmicsDI

    ID: E-GEOD-32968

    Date Released: 06-02-2014

    Description: o search for genes regulated by the transcription factor Forkhead box Protein P1 (FoxP1...

  37. Gene expression profiling of FOXP1-silenced diffuse large B-cell lymphoma (DLBCL) cell lines ArrayExpress

    ID: E-GEOD-71526

    Description: ntify differentially expressed genes regulated by FOXP1 in DLBCL cells via gene expression profiling of GCB-DLBCL (DB, K422) and ABC-DLBCL (OCI-Ly3, HBL-1) cell lines t...

  38. Subtype Specific Addiction of the Activated B Cell Subset of Diffuse Large B Cell Lymphoma to FOXP1 BioProject

    ID: PRJNA267114

    Keywords: Epigenomics

    Access Type: download

  39. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization ArrayExpress

    ID: E-GEOD-19534

    Description: Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutat...

  40. FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation ArrayExpress

    ID: E-GEOD-55497

    Description: To understand the developing striatum, key genes during development were identified using microarray analsyis tha could be considered as marker of med...

  41. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [ChIP-Seq] ArrayExpress

    ID: E-GEOD-31006

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  42. MicroRNA-150 Contributes to the Proficiency of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes... ArrayExpress

    ID: E-GEOD-49896

    Description: vel miR-150 expressed relatively higher levels of forkhead box P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 3’ UTRs having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that may enhance B-cell receptor (BCR) signaling, a putative CLL-growth/survival signal. Also, high-level expression of miR-150 levels was a significant independent predictor of longer treatment-free-survival (TFS) or overall survival (OS), wherea...

  43. Foxp1 is a rate-limiting and essential negative regulator of Tfh cell differentiation ArrayExpress

    ID: E-GEOD-50725

    Description: largely unknown. Here we find that transcription factor Foxp1, previously shown to be essential in maintaining T cell quiescence, is a rate-limiting and essential negative regulator of Tfh cell differentiation. Naïve CD4+ T cells constitutively express Foxp1A, and stimulation through the T cell receptor (TCR) transiently induces the expression of a sho...

  44. FOXP1_CHICK UniProt:Swiss-Prot

    ID: Q58NQ4

    Description: Forkhead box protein P1 C2H2-type Fork-head

  45. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [RNA-Seq] BioProject

    ID: PRJNA154623

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...
  46. Foxp1 is a rate-limiting and essential negative regulator of Tfh cell differentiation BioProject

    ID: PRJNA218582

    Keywords: Transcriptome or Gene expression

    Access Type: download

  47. Non-IG Aberrations of FOXP1 in B-Cell Malignancies Lead to an Aberrant Expression of N-Truncated Isoforms of FOXP1 OmicsDI

    ID: E-GEOD-50514

    Date Released: 09-27-2013

    Description: The transcription factor FOXP1 is implicated in the pathogenesis of B-cell lymphomas through immunoglobulin hea...

  48. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [ChIP-Seq] BioProject

    ID: PRJNA154619

    Keywords: Epigenomics

    Access Type: download

    dataset.description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...
  49. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization BioProject

    ID: PRJNA122255

    Keywords: Transcriptome or Gene expression

    Access Type: download

  50. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [protein binding microarray] ArrayExpress

    ID: E-GEOD-31007

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  51. The role of AR-associated factors in androgen signaling ArrayExpress

    ID: E-GEOD-58309

    Description: n. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines after siRNA treatment. We a...

  52. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray] ArrayExpress

    ID: E-GEOD-31948

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  53. MicroRNA-150 Contributes to the Proficiency of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes... BioProject

    ID: PRJNA215277

    Keywords: Transcriptome or Gene expression

    Access Type: download

  54. MicroRNA-150 Contributes to the Proficiency of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia by Regulating Expression of GAB1 and FOXP1 Genes... OmicsDI

    ID: E-GEOD-49896

    Date Released: 08-08-2014

    Description: vel miR-150 expressed relatively higher levels of forkhead box P1 (FOXP1) and GRB2-associated binding protein 1 (GAB1), genes with 3’ UTRs having evolutionary-conserved binding sites for miR-150. High-level expression of miR-150 could repress expression of these genes, which encode proteins that may enhance B-cell receptor (BCR) signaling, a putative CLL-growth/survival signal. Also, high-level expression of miR-150 levels was a significant independent predictor of longer treatment-free-survival (TFS) or overall survival (OS), wherea...

  55. The forkhead transcription factor FOXP1 profile in B-cells and B-cell lymphoma cell lines OmicsDI

    ID: E-GEOD-69009

    Date Released: 08-19-2015

    Description: Expression of the forkhead transcription factor FOXP1 is essential for early B cell developm...

  56. Med23-dependent gene expression programs in T cells BioProject

    ID: PRJNA259533

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n genes (Med23, IFNg, IL2, Egr2, c-Fos, c-Jun and Foxp1) was validated in the same RNA samples by real-time PCR. Overall design: TCR induced Med23-dependent gene expression was measured after unstimulation or stimulation for 6 hr in wildtype and Med23 knockout CD4 T cells....
  57. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization GEMMA

    ID: 2618

    Keywords: functional genomics

    Description: Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutat...

  58. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization OmicsDI

    ID: E-GEOD-19534

    Date Released: 09-08-2015

    Description: Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutat...

  59. The role of Foxp1/4 in lung development OmicsDI

    ID: E-GEOD-34584

    Date Released: 05-04-2014

    Description: Foxp1/4 transcription factors are conserved transcriptional repressors expressed in overlapping patterns during lung development as...

  60. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [protein binding microarray] BioProject

    ID: PRJNA154621

    Keywords: Other

    Access Type: download

  61. Med23-dependent gene expression programs in T cells ArrayExpress

    ID: E-GEOD-60779

    Description: n genes (Med23, IFNg, IL2, Egr2, c-Fos, c-Jun and Foxp1) was validated in the same RNA samples by real-time PCR. TCR induced Med23-dependent gene expression was measured after unstimulation or stimulation for 6 hr in wildtype and Med23 knockout CD4 T cells....

  62. The role of AR-associated factors in androgen signaling BioProject

    ID: PRJNA251976

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines after siRNA treatment. We a...
  63. Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming II ArrayExpress

    ID: E-GEOD-45504

    Description: rly understood. Here, we identify the Muscleblind-like RNA binding proteins, MBNL1 and MBNL2, as conserved and direct negative regulators of a large program of AS events that are differentially regulated between ESCs and other cell types. Knockdown of MBNL proteins in differentiated cells causes switching to an ESC-like AS pattern for at least half of these AS events. Among the events is an ESC-specific AS switch in the forkhead family transcription factor FOXP1 th...

  64. Suppressio​n of MicroRNA-9 by Mutant EGFR Signaling Induces FOXP1 to Enhance Glioblasto​ma Tumorigeni​city BioProject

    ID: PRJNA232148

    Keywords: Transcriptome or Gene expression

    Access Type: download

  65. Suppressio​n of MicroRNA-9 by Mutant EGFR Signaling Induces FOXP1 to Enhance Glioblasto​ma Tumorigeni​city ArrayExpress

    ID: E-GEOD-53504

    Description: The EGF-receptor (EGFR) is amplified and mutated in glioblastoma (GBM) where its common mutation, (∆EGFR, also called EGFRvIII) has a variety of act...

  66. FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma OmicsDI

    ID: E-GEOD-62419

    Date Released: 10-25-2014

    Description: ights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines. Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleo...

  67. of knockdowns using custom siRNA pools targeting FOXP1 exons 18 or 18b in human embryonic stem cells... OmicsDI

    ID: E-GEOD-30995

    Date Released: 04-14-2016

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  68. FOXP1 is a transcriptional Coactivator of Wnt/β-catenin signaling in Diffuse Large B-cell Lymphoma ProteomeXchange

    ID: PXD001485

    Instrument: LTQ Orbitrap Velos

    Date Released: 07-05-2016

  69. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray] BioProject

    ID: PRJNA155297

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...
  70. Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming I ArrayExpress

    ID: E-GEOD-45503

    Description: rly understood. Here, we identify the Muscleblind-like RNA binding proteins, MBNL1 and MBNL2, as conserved and direct negative regulators of a large program of AS events that are differentially regulated between ESCs and other cell types. Knockdown of MBNL proteins in differentiated cells causes switching to an ESC-like AS pattern for at least half of these AS events. Among the events is an ESC-specific AS switch in the forkhead family transcription factor FOXP1 th...

  71. Retroviral overexpression or siRNA mediated knockdown of FOXP1 in DLBCL cell lines and primary human B cells OmicsDI

    ID: E-GEOD-51382

    Date Released: 11-01-2014

    Description: the role of and target genes of the transcription factor FOXP1 in mature human B cells and in B cell non-Hodkgin lymhomas, we performed gene express...

  72. Gene expression profiling of FOXP1-silenced diffuse large B-cell lymphoma (DLBCL) cell lines OmicsDI

    ID: E-GEOD-71526

    Date Released: 12-08-2015

    Description: ntify differentially expressed genes regulated by FOXP1 in DLBCL cells via gene expression profiling of GCB-DLBCL (DB, K422) and ABC-DLBCL (OCI-Ly3, HBL-1) cell lines t...

  73. Foxp1 is a rate-limiting and essential negative regulator of Tfh cell differentiation OmicsDI

    ID: E-GEOD-50725

    Date Released: 06-03-2014

    Description: largely unknown. Here we find that transcription factor Foxp1, previously shown to be essential in maintaining T cell quiescence, is a rate-limiting and essential negative regulator of Tfh cell differentiation. Naïve CD4+ T cells constitutively express Foxp1A, and stimulation through the T cell receptor (TCR) transiently induces the expression of a sho...

  74. Elucidation of FOXP1 target genes in diffuse large B-cell lymphoma cells by ChIP-Seq OmicsDI

    ID: E-MTAB-3741

    Date Released: 11-30-2015

    Description: ChIP-Sequencing of 4 diffuse large B-cell lymphoma cell lines expressing different amounts of FOXP1 was performed in order to identify target genes...

  75. Recruitment of FOXP1 to target genes in diffuse large B-cell lymphoma (DLBCL) cells OmicsDI

    ID: E-GEOD-44243

    Date Released: 05-04-2014

    Description: Identification of FOXP1 target genes in the OCI-Ly1 DLBCL cell line by ChIP-on-chip Three replicates of the FOXP1 ChIP-on-chip wer...

  76. Transcription profiling by high throughput sequencing of Id-proteins (Id2 and Id3) gene knockout cells ArrayExpress

    ID: E-GEOD-64779

    Description: It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanist...

  77. Subtype Specific Addiction of the Activated B Cell Subset of Diffuse Large B Cell Lymphoma to FOXP1 OmicsDI

    ID: E-GEOD-63257

    Date Released: 01-09-2016

    Description: transcript and target gene profiling reveal that FOXP1 acts directly and indirectly by enforcing known ABC-DLBCL hallmarks, including Chronically Activated B cell receptor ...

  78. An epithelial paracrine pathway that induces an asthmatic phenotype through a neuropeptide-Y induced mechanism BioProject

    ID: PRJNA271848

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e) and Scgb1a1-Cre:Foxp1flox/flox:Foxp4flox/flox (Foxp1/4DKO) mutants, and did larger proximal airway microarray analysis, respectively....
  79. Elucidation of FOXP1 target genes in diffuse large B-cell lymphoma cells by RNA-Seq OmicsDI

    ID: E-MTAB-3740

    Date Released: 11-30-2015

    Description: Elucidation of FOXP1 target genes by RNA-Seq of DLBCL cell lines transfected with siRNAs targeting FOXP1 expression...

  80. Posttransplant diffuse large B-cell lymphoma: new genetic findings BioProject

    ID: PRJNA285495

    Keywords: Variation

    Access Type: download

  81. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [ChIP-Seq] OmicsDI

    ID: E-GEOD-31006

    Date Released: 06-25-2012

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  82. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes ArrayExpress

    ID: E-GEOD-32563

    Description: expression were found for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....

  83. Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming II BioProject

    ID: PRJNA195386

    Keywords: Transcriptome or Gene expression

    Access Type: download

  84. Muscleblind-like proteins regulate embryonic stem cell-specific alternative splicing and reprogramming I BioProject

    ID: PRJNA195385

    Keywords: Transcriptome or Gene expression

    Access Type: download

  85. FOXP1 is a transcriptional Coactivator of Wnt/β-catenin signaling in Diffuse Large B-cell Lymphoma OmicsDI

    ID: PXD001485

    Date Released: 07-05-2016

    Description: aining a β-catenin-driven GFP (green fluorescent protein) transcriptional reporter were transduced with CDBF lentivirus. When integrated near an expressed and spliced gene, the cytomegalovirus (CMV) promoter of the CDBF vector drives constitutive BFP (blue fluorescence protein) expression and by virtue of the splice donor (SD) seque...

  86. A genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell qu... BioProject

    ID: PRJNA271860

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanist...
  87. A_PiggyBac_transposon_screen_in_pancreatic_cancer BioProject

    ID: PRJEB14663

    Keywords: Other

    Access Type: download

    dataset.description: eatic insertional mutagenesis screen. We identify Foxp1 as an oncogenic transcription factor that drives pancreatic cancer invasion and spread in a mouse model and correlates with lymph node metastasis in human patients with pancreatic cancer. The propensity of piggyBac for open chromatin also enabled ge...
  88. FXP1B_DANRE UniProt:Swiss-Prot

    ID: Q2LE08

    Description: Forkhead box protein P1-B C2H2-type Fork

  89. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells ArrayExpress

    ID: E-GEOD-41795

    Description: espread use even for intensely studied cell types like spinal motor neurons, is hindered by the long duration and low yields of existing protocols for in vitro differentiation and by the molecular heterogeneity of the populations generated. We report a combination of small molecules that induce up to 50% motor neurons within 3 weeks from human pluripot...

  90. DNA methylation status of CpG islands in normal and atherosclerotic human arteries ArrayExpress

    ID: E-GEOD-15552

    Description: (42%). The latter include HOX members, NOTCH1 and FOXP1, which are known to regulate angiogenesis, dedifferentiation, cell migration and macrophage function. The methylation status of selected CGIs was validated in further 10 subjects for either group. Expression patterns of these factors were compatible with the observed differential methylation. Our data suggest that one of the molecular changes associated with aberrant DNA methylation in advanced atherosclerosis is the regulation of critical transcription factor genes for the induction of a proatherogenic cellular phenotype. Two-condition experiment, i.e. normal vs. atherosclerotic arteries. 16 and 45 normal and atherosclerotic samples, respectively, were pooled and used to interrogate CpG island arrays in triplicate, for a total of six arrays. Each array was co-hybridized with untreated DNA (reference) and hypermethylated DNA obtained by biochemical filtration....

  91. MicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate ArrayExpress

    ID: E-GEOD-21036

    Description: ries. Tumors with the androgen-driven TMPRSS2-ERG fusion were significantly associated with a small, previously unrecognized, prostate-specific 3p14 deletion that, through mRNA expression and resequencing analysis, implicates FOXP1, RYBP and SHQ1 as candidate cooperative tumor suppressors. Comparison of transcriptome and DNA copy number data from primary tumors for prognostic impact revealed that CNAs robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. In sum, this integrative genomic analysis of a substantial cohort of tumors clarifies the role of several known cancer pathways in prostate cancer, implicates several new ones, reveals a previously unappreciated role for CNAs in prognosis and provides a blueprint for clinical development of pathway inhibitors. Human prostate samples were profiled on Agilent microRNA V2 arrays per manufacturer's instructions....

  92. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [protein binding microarray] OmicsDI

    ID: E-GEOD-31007

    Date Released: 05-02-2014

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...

  93. Differential Gene Expression in Angelman syndrome deletion vs. int dup(15) Human Lymphocytes BioProject

    ID: PRJNA147119

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: expression were found for genes at the 15q locus like UBE3A, ATP10A and HERC2. A larger set of genes involved in chromatin remodeling, DNA repair and neurogenesis were found, at FAIRE peaks in AS deletion samples but had increased transcription in int dup(15) samples. There was a significant enhancement for genes with FOXP1 binding sites in the int dup(15) gene set and elevated FOXP1 protein could be detected in the nucleus of int dup(15) as compared to AS deletion cell lines. This analysis provides the first insights into transcriptional changes which may unveil new sets of genes and pathways contributing to both AS and autism pathogenesis. Overall design: Gene expression was performed using 100ng of total RNA from each subject as starting material for amplification and cRNA synthesis in accordance Affymetrix protocols (http://tinyurl.com/3j7dcp6). Hybridizations were performed to the Affy HumanGene_st_v1 chip and the signal data normalized using internal chip controls. Normalized expression data was then exported to a text file for subsequent expression analysis using the EXPANDER software analysis suite....
  94. FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation OmicsDI

    ID: E-GEOD-55497

    Date Released: 06-23-2016

    Description: To understand the developing striatum, key genes during development were identified using microarray analsyis tha could be considered as marker of med...

  95. Transcription profiling of mouse wild type and Ctip2-/- (Bcl11b) mutant striatum at P0 ArrayExpress

    ID: E-GEOD-9330

    Description: ngton’s disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development. Within the striatum, it is expressed by all MSN, while it is excluded from essentially all striatal interneurons. In the absence of Ctip2, MSN do not fully differentiate...

  96. The role of AR-associated factors in androgen signaling OmicsDI

    ID: E-GEOD-58309

    Date Released: 11-28-2014

    Description: n. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines after siRNA treatment. We a...

  97. Whole-transcript and exon-level expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate BioProject

    ID: PRJNA129695

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ries. Tumors with the androgen-driven TMPRSS2-ERG fusion were significantly associated with a small, previously unrecognized, prostate-specific 3p14 deletion that, through mRNA expression and resequencing analysis, implicates FOXP1, RYBP and SHQ1 as candidate cooperative tumor suppressors. Comparison of transcriptome and DNA copy number data from primary tumors for prognostic impact revealed that CNAs robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. In sum, this integrative genomic analysis of a substantial cohort of tumors clarifies the role of several known cancer pathways in prostate cancer, implicates several new ones, reveals a previously unappreciated role for CNAs in prognosis and provides a blueprint for clinical development of pathway inhibitors. Overall design: Human prostate samples were profiled on Affymetrix Human Exon 1.0 ST arrays per manufacturer's instructions....
  98. MicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate BioProject

    ID: PRJNA129699

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ries. Tumors with the androgen-driven TMPRSS2-ERG fusion were significantly associated with a small, previously unrecognized, prostate-specific 3p14 deletion that, through mRNA expression and resequencing analysis, implicates FOXP1, RYBP and SHQ1 as candidate cooperative tumor suppressors. Comparison of transcriptome and DNA copy number data from primary tumors for prognostic impact revealed that CNAs robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. In sum, this integrative genomic analysis of a substantial cohort of tumors clarifies the role of several known cancer pathways in prostate cancer, implicates several new ones, reveals a previously unappreciated role for CNAs in prognosis and provides a blueprint for clinical development of pathway inhibitors. Overall design: Human prostate samples were profiled on Agilent microRNA V2 arrays per manufacturer's instructions....
  99. DNA methylation status of CpG islands in normal and atherosclerotic human arteries BioProject

    ID: PRJNA115995

    Keywords: Epigenomics

    Access Type: download

    dataset.description: (42%). The latter include HOX members, NOTCH1 and FOXP1, which are known to regulate angiogenesis, dedifferentiation, cell migration and macrophage function. The methylation status of selected CGIs was validated in further 10 subjects for either group. Expression patterns of these factors were compatible with the observed differential methylation. Our data suggest that one of the molecular changes associated with aberrant DNA methylation in advanced atherosclerosis is the regulation of critical transcription factor genes for the induction of a proatherogenic cellular phenotype. Overall design: Two-condition experiment, i.e. normal vs. atherosclerotic arteries. 16 and 45 normal and atherosclerotic samples, respectively, were pooled and used to interrogate CpG island arrays in triplicate, for a total of six arrays. Each array was co-hybridized with untreated DNA (reference) and hypermethylated DNA obtained by biochemical filtration....
  100. An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray] OmicsDI

    ID: E-GEOD-31948

    Date Released: 05-02-2014

    Description: nt that changes the DNA binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency including OCT4, NANOG, NR5A2 and GDF3, while concomitantly repressing genes required for ESC differentiation. Remarkably, this isoform also promotes the maintenance of ESC pluripotency and t...


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