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Displaying 10 of 48 results for "FCGR1A"
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  1. Murine Microglial Gene Expression after Abdominal Sepsis ArrayExpress

    ID: E-MTAB-4180

    Description: rescent activated cell sorting for CD11b+/CD45mid/CD64+ cells. For each sample, the brains of 3 mice were pooled. RNA was then isolated for transcriptome analysis....

  2. Expression data from a variant monocyte population following dendritc cell depletion ArrayExpress

    ID: E-GEOD-58263

    Description: of a variant population of splenic MHC Class II+ CD64+ Ly6C+ monocytes that are distinct from both circulating blood Ly6C+ monocytes and their tissue counterparts, but resemble Ly6C+ cells mobilized by exogenous G-CSF and Flt3L. The CD64+ Ly6C+ monocyte population is characterized by up-regulation of TLR signalling apparatus and an increased capacity to produce TNF-a following stimulation. Therefore, perturbation within the mononuclear phagocytic system in the absence of inflammation induces an alternative differentiation pathway that drives expansion of monocytes poised for innate immune activation. M...

  3. Expression data from a variant monocyte population following dendritc cell depletion BioProject

    ID: PRJNA251796

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of a variant population of splenic MHC Class II+ CD64+ Ly6C+ monocytes that are distinct from both circulating blood Ly6C+ monocytes and their tissue counterparts, but resemble Ly6C+ cells mobilized by exogenous G-CSF and Flt3L. The CD64+ Ly6C+ monocyte population is characterized by up-regulation of TLR signalling apparatus and an increased capacity to produce TNF-a following stimulation. Therefore, perturbation within the mononuclear phagocytic system in the absence of inflammation induces an alternative differentiation pathway that drives expansion of monocytes poised for innate immune activation. O...
  4. Transcription profiling by array of monocytes and neutrophils from eight healthy volunteers to compare the expression pattern and validate sample puri... ArrayExpress

    ID: E-MTAB-1573

    Description: tes and neutrophils, we isolated monocytes (CD45+ CD64+ CD14+ CD16-) and neutrophils (CD66b+ CD16+) from eight healthy volunteers....

  5. Transcription profiling by array of monocytes and neutrophils from eight healthy volunteers to compare the expression pattern and validate sample puri... OmicsDI

    ID: E-MTAB-1573

    Date Released: 06-03-2014

    Description: tes and neutrophils, we isolated monocytes (CD45+ CD64+ CD14+ CD16-) and neutrophils (CD66b+ CD16+) from eight healthy volunteers....

  6. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity BioProject

    ID: PRJNA115851

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: intervals, sequencing, microarray analysis and a high-throughput real-time RT-PCR approach using bone marrow-derived macrophages. Results: Within the originally identified Cdcs1-interval, three independent regions were detected that likely contain susceptibility-determining genetic factors (Cdcs1.1, Cdcs1.2, and Cdcs1.3). Combining results of candidate gene approaches revealed Fcgr1, Cnn3, Larp7, and Alpk1 as highly attractive candidate genes with polymorphisms in coding or regulatory regions and expression differences between susceptible and resistant mouse strains. Conclusions: Subcongenic analysis of the major susceptibility locus Cdcs1 on mouse chromosome 3 revealed a complex genetic structure. Candidate gene approaches revealed attractive genes within the identified regions with homologs that are located in human susceptibility regions for IBD. Overall design: Bone marrow derived macrophages (BMDM) of colitis susceptible C3Bir-Il10-/- and colitis resistant B6-Il10-/- as well as the Il10-/- reciprocal congenic strains CB-R1 (C3Bir genetic background carrying a long congenic chromosome 3 element containing Cdcs1 from B6, rendering this formerly susceptible background resistant) and BC-R3 (B6 genetic background that carries the Cdcs1-region of C3Bir) were cultured and stimulated with flagellin or left unstimulated. BMDM were obtained from 3 male mice per genotype and cultured in polystyrene 6-well culture plates. Before RNA-isolation, 3 wells per plate were stimulated with Cbir1 flagellin (and subsequently pooled for RNA isolation), the other 3 wells left unstimulated (and also pooled). In to...
  7. Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity GEMMA

    ID: 2429

    Keywords: functional genomics

    Description: intervals, sequencing, microarray analysis and a high-throughput real-time RT-PCR approach using bone marrow-derived macrophages. Results: Within the originally identified Cdcs1-interval, three independent regions were detected that likely contain susceptibility-determining genetic factors (Cdcs1.1, Cdcs1.2, and Cdcs1.3). Combining results of candidate gene approaches revealed Fcgr1, Cnn3, Larp7, and Alpk1 as highly attractive candidate genes with polymorphisms in coding or regulatory regions and expression differences between susceptible and resistant mouse strains. Conclusions: Subcongenic analysis of the major susceptibility locus Cdcs1 on mouse chromosome 3 revealed a complex genetic structure. Candidate gene approaches revealed attractive genes within the identified regions with homologs that are located in human susceptibility regions for IBD. Last Updated (by provider): Dec 16 2010 Contributers: Gwen Büchler John P Sundberg Hans J Hedrich Jason Beckwith Edward H Leiter Andre Bleich Lydia M Petell Daniel J Shaffer Benjamin L King Derry C Roopenian Jason P Affourtit...

  8. Primary human umbilical vein and arterial endothelial cells OmicsDI

    ID: E-GEOD-1539

    Date Released: 06-10-2011

    Description: as a negative selection step using CD14, CD45 and CD64 to remove residual contaminating leukocytes, followed by positive selection using a mouse anti-endothelial cell monoclonal antibody (anti-CD146/clone P1H12 purchased from Chemicon, Temecula, CA). Total processing time was limited to 20 to 24 hours. The homogeneous, viable, primary ECs were used immediately to construct the library. The construction of SAGE libraries was performed with the I-SAGE kit (Invitrogen, Carlsbad, CA) per manufacturer’s instructions Keywords: other...

  9. Expression data from Aortic Macrophages OmicsDI

    ID: E-GEOD-68968

    Date Released: 12-20-2015

    Description: Aortic macrophages (CD11bhighF4/80highCD45+MerTK+CD64+) were isolated from C57/B6 wild-type male mice aged 6-8 weeks before and 7 days after induction of sepsis by cecal puncture. 18-20 aortas were pooled per sample. Each condition contained three biological replicates....

  10. Transcriptomic profiling of lung monocytes and macrophages in mice ArrayExpress

    ID: E-MTAB-5012

    Description: CD11c+ alveolar macrophages, non-autofluorescent CD64+Ly-6C- interstitial macrophages and Ly-6Chi monocytes residing in the lung of WT mice. A fraction of these Ly-6Chi monocytes corresponded to classical blood monocytes associated with the lung vasculature, but another fraction did not depend on CCR2, the chemokine receptor required for monocyt...


Displaying 10 of 48 results for "FCGR1A"