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Displaying 20 of 6,023 results for "FANCD2"
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  1. FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis ArrayExpress

    ID: E-GEOD-46902

    Description: Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility t...

  2. FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis BioProject

    ID: PRJNA202990

    Keywords: Epigenomics

    Access Type: download

  3. Structure of the FANCI-FANCD2 complex PDB

    ID: PDB:3S4W

    Description: Fanconi anemia group I protein homolog, Fanconi anemia ...

  4. Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1 ArrayExpress

    ID: E-GEOD-43330

    Description: Fanconi anemia (FA) is a genetic disorder characterized by congenital abnormalities, bone mar...

  5. Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1 BioProject

    ID: PRJNA185443

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Gene expression profiles of murine Runx1;Runx3 double deficient cKit+Sca1+Lin- hematopoietic stem/progenitor cells ArrayExpress

    ID: E-GEOD-51107

    Description: uman inherited bone marrow failure syndromes like Fanconi anemia (FA), caused by defective DNA repair. Indeed, Runx1;Runx3 DKO cells showed mitomycin C hypersensitivity, due to impairment of monoubiquitinated-FANCD2 recruitment to DNA damage foci, although FANCD2 monoubiquitination in the FA pathway was unaffected. RUNX1 and RUNX3 interact with FANCD2 independent of CBFβ, suggesting non-transcriptional role for RUNX in DNA repair. These findings suggest that RUNX dysfunction causes DNA repair defec...

  7. Tailoring heated intra-peritoneal Mitomycin C for peritoneal metastases originating from colorectal carcinoma – A translational approach to improve... BioProject

    ID: PRJNA217767

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eparate assays. Thirty-seven genes related to the FA-BRCA pathway, ATM-ATR pathway and enzymatic activation of MMC were correlated on expression array platform to MMC sensitivity. Low sensitivity correlated with a decrease in BLM (p=0.01) and BRCA2 (p=0.02) on mRNA expression level. Both genes are part of the Fanconi Anaemia-BRCA (FA-BRCA) pathway and therefore, functionality of the FA-BRCA pathway in cell lines was determined using chromosomal breakage assay and Western Blot for key protein FANCD2. However...
  8. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair ArrayExpress

    ID: E-GEOD-35698

    Description: exacerbates genomic instability in cells lacking FANCD2, a mediator of the Fanconi Anemia pathway for ICL repair. Brca1 therefore has two separate roles in ICL repair, whereas FANCD2 provides a key activity that can not be bypassed by ablation of 53BP1 or Ku. B cells were stimulated to undergo class switch recombination in vitro. Chromatin from B cells was harvested 72 hours post-stimulation and used for RPA ChIP to study the extent of resection of DNA DSBs....

  9. Oxymetholone therapy of Fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling ArrayExpress

    ID: E-GEOD-58724

    Description: We used Fancd2-/- mice to understand its mechanism of action. Transcriptome analysis of cKit+ Sca1+ Lin- (KSL) cells discovered that only f...

  10. Gene expression profiles of murine Runx1;Runx3 double deficient cKit+Sca1+Lin- hematopoietic stem/progenitor cells BioProject

    ID: PRJNA221199

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: uman inherited bone marrow failure syndromes like Fanconi anemia (FA), caused by defective DNA repair. Indeed, Runx1;Runx3 DKO cells showed mitomycin C hypersensitivity, due to impairment of monoubiquitinated-FANCD2 recruitment to DNA damage foci, although FANCD2 monoubiquitination in the FA pathway was unaffected. RUNX1 and RUNX3 interact with FANCD2 independent of CBFβ, suggesting non-transcriptional role for RUNX in DNA repair. These findings suggest that RUNX dysfunction causes DNA repair defec...
  11. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair BioProject

    ID: PRJNA152035

    Keywords: Epigenomics

    Access Type: download

    dataset.description: exacerbates genomic instability in cells lacking FANCD2, a mediator of the Fanconi Anemia pathway for ICL repair. Brca1 therefore has two separate roles in ICL repair, whereas FANCD2 provides a key activity that can not be bypassed by ablation of 53BP1 or Ku. Overall design: B cells were stimulated to undergo class switch recombination in vitro. Chromatin from B cells was harvested 72 hours post-stimulation and used for RPA ChIP to study the extent of resection of DNA DSBs....
  12. Molecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Pre... ArrayExpress

    ID: E-GEOD-74685

    Description: rsely related to proliferation, the expression of Fanconi Anemia complex genes was strongly associated with increased cell cycle progression. Inhibition of FANCA, FANCC, FANCD2 and BRCA2 expression reduced prostate cancer growth. The limited molecular diversity across metastases may result from bottlenecks imposed by the dissemination process, limited evolutionary time between metastatic seeding and tumor sampling, intermixing of tumor clones, and selection resulting from treatment pressures. Though exceptions exist, evaluating a single metastasis provides a reasonable assessment of the key molecular processes that occur throughout the spectrum of disseminated tumors within an individual, and may be used for selecting treatments ba...

  13. Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure ArrayExpress

    ID: E-GEOD-56363

    Description: g confirmed increased expression of BRCA1, BRIP1, FANCD2 and RAD51 in non-responsive compared with responsive advanced squamous cervical cancer, both in the initial set of 21 cervical cancer samples and the second set of 24 samples. Twenty-one patients with locally advanced squamous cell carcinoma (FIGO stage IIB-IIIB) were enrolled in the genomics study. A tissue fragment from a primary biopsy specimen was harvested from each patient prior to the therapy. Tissue samples were stored in liquid nitrogen until use for RNA extraction. One-color microarray experiment was performed to measure differences in gene expression between cervical cancer samples with 6-month complete response (12 patients ) and non-complete response (9 patients). Complet response group was considered as reference....

  14. Oxymetholone therapy of Fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling BioProject

    ID: PRJNA253277

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure BioProject

    ID: PRJNA243049

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis OmicsDI

    ID: E-GEOD-46902

    Date Released: 07-17-2013

    Description: Fanconi Anemia (FA) is a rare genetic disorder characterized by an increased susceptibility t...

  17. FACOS_HUMAN UniProt:Swiss-Prot

    ID: Q96PS1

    Description: FANCD2 opposite strand protein

  18. FACOS_BOVIN UniProt:Swiss-Prot

    ID: Q32KZ5

    Description: FANCD2 opposite strand protein

  19. Fatty acid composition of developing tree peony (Paeonia section Moutan DC.) seeds and transcriptome analysis during seed development ArrayExpress

    ID: E-MTAB-3377

    Description: Tree peony (Paeonia ostii section Moutan DC.) is known for its excellent ornamental and medicinal values. In 2011, seeds from P. ostii have been ident...

  20. Data from: Genome-wide association study in Arabidopsis thaliana of natural variation in seed oil melting point, a widespread adaptive trait in plants Dryad

    DateIssued: 03-14-2016

    Description: Seed oil melting point is an adaptive, quantitative trait determined by the relative proportions of the fatty acids that compose the oil. Micro- and m...


Displaying 20 of 6,023 results for "FANCD2"