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Displaying 77 of 77 results for "FA2H"
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  1. Hydroxylase domain of scs7p PDB

    ID: PDB:4ZR1

    Description: Ceramide very long chain fatty acid hydroxylase SCS7 (E.C.1.-.-.-)

  2. Full length scs7p (only hydroxylase domain visible) PDB

    ID: PDB:4ZR0

    Description: Ceramide very long chain fatty acid hydroxylase SCS7 (E.C.1.-.-.-)

  3. FAD6E_ARATH UniProt:Swiss-Prot

    ID: P46313

    Description: Delta(12)-fatty-acid desaturase Helical Helical Helical Helical Helical Histidine box-1 Histidine box-2...

  4. Cytochrome P450SP alpha (CYP152B1) mutant F288G PDB

    ID: PDB:3AWP

    Description: Fatty acid alpha-hydroxylase (E.C.1.14.-.-)

  5. FA2H_RAT UniProt:Swiss-Prot

    ID: Q2LAM0

    Description: Fatty acid 2-hydroxylase Helical Helical Helical Helical Cytochrome b5 hem...

  6. FA2H_MACFA UniProt:Swiss-Prot

    ID: Q4R4P4

    Description: Fatty acid 2-hydroxylase Helical Helical Helical Helical Cytochrome b5 hem...

  7. Cytochrome P450SP alpha (CYP152B1) wild-type with palmitic acid PDB

    ID: PDB:3AWM

    Description: Fatty acid alpha-hydroxylase (E.C.1.14.-.-)

  8. FAH1_ARATH UniProt:Swiss-Prot

    ID: O48916

    Description: Dihydroceramide fatty acyl 2-hydroxylase FAH1 Helical Helical Helical Helical His-rich

  9. FAH2_ARATH UniProt:Swiss-Prot

    ID: Q9SUC5

    Description: Dihydroceramide fatty acyl 2-hydroxylase FAH2 Helical Helical Helical Helical

  10. Cytochrome P450SP alpha (CYP152B1) in complex with (R)-ibuprophen PDB

    ID: PDB:3VM4

    Description: Fatty acid alpha-hydroxylase (E.C.1.11.2.4)

  11. Cytochrome P450SP alpha (CYP152B1) mutant R241E PDB

    ID: PDB:3VNO

    Description: Fatty acid alpha-hydroxylase

  12. RNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids ArrayExpress

    ID: E-GEOD-53952

    Description: Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of to...

  13. RNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids BioProject

    ID: PRJNA234030

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Crystal Structure of FAAH in complex with inhibitor PDB

    ID: PDB:4HBP

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  15. 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with Carbamate inhibitor URB597 PDB

    ID: PDB:3LJ7

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.n2)

  16. Fatty Acid Amide Hydrolase regulates peripheral B cell receptor revision, polyreactivity and B1 cells in lupus ArrayExpress

    ID: E-GEOD-73112

    Description: FAAH expresson is induced in Sle2 splenic B cells. Increased peripheral B cell receptor revision, or selective peripheral expansion...

  17. 3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845 PDB

    ID: PDB:2WAP

    Description: FATTY-ACID AMIDE HYDROLASE 1 (E.C.3.5.1.4)

  18. Cytochrome P450SP alpha (CYP152B1) mutant L78F PDB

    ID: PDB:3AWQ

    Description: Fatty acid alpha-hydroxylase (E.C.1.14.-.-)

  19. 3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845 at 2.42A RESOLUTION PDB

    ID: PDB:3LJ6

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.n2)

  20. Cytochrome P450SP alpha (CYP152B1) mutant A245H PDB

    ID: PDB:3VTJ

    Description: Fatty acid alpha-hydroxylase (E.C.1.11.2.4.)

  21. Structure of FAAH with a non-steroidal anti-inflammatory drug PDB

    ID: PDB:4DO3

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  22. Cytochrome P450SP alpha (CYP152B1) mutant A245E PDB

    ID: PDB:3VOO

    Description: Fatty acid alpha-hydroxylase (E.C.1.11.2.4)

  23. 3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH 7-PHENYL-1-(5-(PYRIDIN-2... PDB

    ID: PDB:2WJ2

    Description: FATTY ACID AMIDE HYDROLASE 1 (E.C.3.5.1.4)

  24. Fatty Acid Amide Hydrolase regulates peripheral B cell receptor revision, polyreactivity and B1 cells in lupus BioProject

    ID: PRJNA296025

    Keywords: Transcriptome or Gene expression

    Access Type: download

  25. 3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH 7-PHENYL-1-(4-(PYRIDIN-2... PDB

    ID: PDB:2WJ1

    Description: FATTY-ACID AMIDE HYDROLASE 1 (E.C.3.5.1.4)

  26. RNASeq of Developing Arabidopsis Seeds Producing Hydroxy-Fatty Acids OmicsDI

    ID: E-GEOD-53952

    Date Released: 04-30-2015

    Description: Arabidopsis seeds expressing the castor fatty acid hydroxylase accumulate hydroxylated fatty acids up to 17% of to...

  27. Escherichia coli FAH1 : Escherichia coli FAH1 Genome sequencing and assembly BioProject

    ID: PRJNA224240

    Keywords: Genome sequencing and assembly

    Access Type: download

  28. SCS7_SCHPO UniProt:Swiss-Prot

    ID: O13846

    Description: Ceramide very long chain fatty acid hydroxylase-like protein C19G12.08 Cytoplasmic Helical Lumenal Helical Cytoplasmic...

  29. DNA Methylation Profiling of Glioblastoma: Impact on Gene Expression and Clinical Outcome (Agilent Expression Study) ArrayExpress

    ID: E-GEOD-22866

    Description: , BST2, OAS1, SLC13A5, GSTM5, ME1, UBXD3, TSPYL5, FAAH, C7orf13, and C3orf14. The expression of these genes may be tightly regulated by epigenetic mechanisms. The survival analysis identified six CpG sites associated with overall survival. The SOX10 promoter methylation status (two CpG sites) stratifies the patients in a way similar to MGMT with improved performance based on Area Under the Curve criteria (0.78 vs. 0.71, p-value < 5.10-4). The methylation status of FNDC3B, TBX3, DGKI, and FSD1 promoters identify patients with MGMT methylated tumors non-responding to STUPP treatment (p-value < 1.10-4). These markers have a potential impact on therapeutic decision. 40 glioblastoma samples and 6 control brain samples were analysed. 2 distinct series of hybridizations were carried out, each containing GBMs and control brains....

  30. DNA Methylation Profiling of Glioblastoma: Impact on Gene Expression and Clinical Outcome (Illumina) ArrayExpress

    ID: E-GEOD-22867

    Description: , BST2, OAS1, SLC13A5, GSTM5, ME1, UBXD3, TSPYL5, FAAH, C7orf13, and C3orf14. The expression of these genes may be tightly regulated by epigenetic mechanisms. The survival analysis identified six CpG sites associated with overall survival. The SOX10 promoter methylation status (two CpG sites) stratifies the patients in a way similar to MGMT with improved performance based on Area Under the Curve criteria (0.78 vs. 0.71, p-value < 5.10-4). The methylation status of FNDC3B, TBX3, DGKI, and FSD1 promoters identify patients with MGMT methylated tumors non-responding to STUPP treatment (p-value < 1.10-4). These markers have a potential impact on therapeutic decision. 55 glioblastoma samples and 3 control brain samples were analysed....

  31. X-RAY STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP124 IN COMPLEX WITH PHYTANIC ACID PDB

    ID: PDB:2WM4

    Description: PUTATIVE CYTOCHROME P450 124 (E.C.1.14.-.-)

  32. Structure of cytochrome P450 4B1 (CYP4B1) complexed with octane: An n-Alkane and fatty acid omega-hydroxylase with a covalently bound heme PDB

    ID: PDB:5T6Q

    Description: Cytochrome P450 4B1 (E.C.1.14.14.1)

  33. Crystal structure of fatty acid amide hydrolase with small molecule inhibitor PDB

    ID: PDB:3QK5

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  34. Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain PDB

    ID: PDB:1XKT

    Description: fatty acid synthase

  35. CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S PDB

    ID: PDB:2HPD

    Description: CYTOCHROME P450 (BM-3) (E.C.1.14.14.1) (HEMOPROTEIN DOMAIN) (FATTY ACID MONOOXYGENASE)

  36. Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration OmicsDI

    ID: E-GEOD-36399

    Date Released: 05-03-2014

    Description: nducted using RNAs collected from WT, Cnr1-/- and Faah-/- mouse blastocysts on day 4 of pregnancy. The results show that about 100 genes showed unidirectional changes under either elevated or silenced endocannabinoid signaling. Analysis of functional grouping of these genes revealed that multiple biological functions and pathways are affected under aberrant endocannabinoid signaling, including cell migration. Several genes from the microarray data were confirmed by quantitative RT-PCR. Cell motility assays validated the predicted compromised cell migration i...

  37. DNA Methylation Profiling of Glioblastoma: Impact on Gene Expression and Clinical Outcome (Agilent Expression Study) BioProject

    ID: PRJNA129141

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: , BST2, OAS1, SLC13A5, GSTM5, ME1, UBXD3, TSPYL5, FAAH, C7orf13, and C3orf14. The expression of these genes may be tightly regulated by epigenetic mechanisms. The survival analysis identified six CpG sites associated with overall survival. The SOX10 promoter methylation status (two CpG sites) stratifies the patients in a way similar to MGMT with improved performance based on Area Under the Curve criteria (0.78 vs. 0.71, p-value < 5.10-4). The methylation status of FNDC3B, TBX3, DGKI, and FSD1 promoters identify patients with MGMT methylated tumors non-responding to STUPP treatment (p-value < 1.10-4). These markers have a potential impact on therapeutic decision. Overall design: 40 glioblastoma samples and 6 control brain samples were analysed. 2 distinct series of hybridizations were carried out, each containing GBMs and control brains....
  38. Crystal structure of fatty acid amide hydrolase with small molecule inhibitor PDB

    ID: PDB:3QJ9

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  39. Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain PDB

    ID: PDB:3OJ8

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  40. Crystal structure of fatty acid amide hydrolase with small molecule compound PDB

    ID: PDB:3QKV

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  41. DNA Methylation Profiling of Glioblastoma: Impact on Gene Expression and Clinical Outcome (Illumina) BioProject

    ID: PRJNA129143

    Keywords: Epigenomics

    Access Type: download

    dataset.description: , BST2, OAS1, SLC13A5, GSTM5, ME1, UBXD3, TSPYL5, FAAH, C7orf13, and C3orf14. The expression of these genes may be tightly regulated by epigenetic mechanisms. The survival analysis identified six CpG sites associated with overall survival. The SOX10 promoter methylation status (two CpG sites) stratifies the patients in a way similar to MGMT with improved performance based on Area Under the Curve criteria (0.78 vs. 0.71, p-value < 5.10-4). The methylation status of FNDC3B, TBX3, DGKI, and FSD1 promoters identify patients with MGMT methylated tumors non-responding to STUPP treatment (p-value < 1.10-4). These markers have a potential impact on therapeutic decision. Overall design: 55 glioblastoma samples and 3 control brain samples were analysed....
  42. yl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase... PDB

    ID: PDB:3PR0

    Description: Fatty Acid Amide Hydrolase 1 (E.C.3.5.1.4)

  43. Crystal structure of fatty acid amide hydrolase PDB

    ID: PDB:3QJ8

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  44. rocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase... PDB

    ID: PDB:3K83

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.-)

  45. yl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase... PDB

    ID: PDB:3PPM

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  46. rocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase'... PDB

    ID: PDB:3K7F

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.-)

  47. Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase PDB

    ID: PDB:3K84

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.-)

  48. g-decalactone in strawberry fruit : Deciphering g-decalactone biosynthesis in strawberry fruit using a combination of genetic mapping and next-generat... BioProject

    ID: PRJEB5430

    Keywords: Other

    Access Type: download

    dataset.description: flavor. Lactones constitute an essential group of fatty acid-derived VOCs conferring peach-like aroma to a number of fruits including peach, plum, pineapple and strawberry. Although early studies on lactone biosynthesis suggest that several enzymatic pathways could be responsible for the diversi...
  49. CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE CONJUGATED WITH THE DRUG-LIKE INHIBITOR PF-750 PDB

    ID: PDB:2VYA

    Description: FATTY-ACID AMIDE HYDROLASE 1 (E.C.3.5.1.4)

  50. Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration ArrayExpress

    ID: E-GEOD-36399

    Description: nducted using RNAs collected from WT, Cnr1-/- and Faah-/- mouse blastocysts on day 4 of pregnancy. The results show that about 100 genes showed unidirectional changes under either elevated or silenced endocannabinoid signaling. Analysis of functional grouping of these genes revealed that multiple biological functions and pathways are affected under aberrant endocannabinoid signaling, including cell migration. Several genes from the microarray data were confirmed by quantitative RT-PCR. Cell motility assays validated the predicted compromised cell migration i...

  51. Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration BioProject

    ID: PRJNA153291

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nducted using RNAs collected from WT, Cnr1-/- and Faah-/- mouse blastocysts on day 4 of pregnancy. The results show that about 100 genes showed unidirectional changes under either elevated or silenced endocannabinoid signaling. Analysis of functional grouping of these genes revealed that multiple biological functions and pathways are affected under aberrant endocannabinoid signaling, including cell migration. Several genes from the microarray data were confirmed by quantitative RT-PCR. Cell motility assays validated the predicted compromised cell migration i...
  52. Fatty Acid Amide Hydrolase regulates peripheral B cell receptor revision, polyreactivity and B1 cells in lupus OmicsDI

    ID: E-GEOD-73112

    Date Released: 09-19-2015

    Description: FAAH expresson is induced in Sle2 splenic B cells. Increased peripheral B cell receptor revision, or selective peripheral expansion...

  53. CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE PDB

    ID: PDB:1MT5

    Description: Fatty-acid amide hydrolase (E.C.3.1.-.-)

  54. yl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase... PDB

    ID: PDB:4J5P

    Description: Fatty-acid amide hydrolase 1 (E.C.3.5.1.99)

  55. Human cytochrome P450 2E1 in complex with omega-imidazolyl-decanoic acid PDB

    ID: PDB:3GPH

    Description: Cytochrome P450 2E1 (E.C.1.14.14.1)

  56. Defining Behavioral and Molecular Differences Between Summer and Migratory Monarch Butterflies ArrayExpress

    ID: E-GEOD-14041

    Description: vrille and the locomotion-relevant tyramine beta hydroxylase gene. In addition, several differentially regulated genes (37.5% of total) are not annotated, suggesting unique functions associated with oriented flight behavior. We also identified 23 juvenile hormone-dependent genes in brain, which separate reproductive from non-reproductive monarchs; genes involved in longevity, fatty acid metabolism, and innate immunity are upregulated in non-reproductive (juvenile-hormone deficient) migrants. The results link key behavioral traits with gene expression profiles in brain that differentiate migratory from summer butterflies and thus show that seasonal changes in genomic function help define the migratory state. A total of 40 monarch butterflies were used for the microarray analysis. Of the 40, 10 (5 male/5 female) were summer butterflies (Designated as S) and 30 were fall butterflies. The fall butterflies were further divided into three groups: 10 (5 male/5 female) were untreated (F); 10 (5 male/5 female) were treated with methoprene (M), which is a juvenile hormone analog and induces the development of reproductive organs in migrant butterflies; and 10 (5 male/5 female) were treated with vehicle only (V). We collected total brain RNA from each of the 40 butterflies. The brain RNAs were amplified and then used to probe a custom Nimblegen array that was designed to analyze the 9,417 unique cDNA sequences established in our published EST library (). Our main interest is to find genes involved in migration. This includes genes regulating oriented fli...

  57. Defining Behavioral and Molecular Differences Between Summer and Migratory Monarch Butterflies BioProject

    ID: PRJNA112399

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: vrille and the locomotion-relevant tyramine beta hydroxylase gene. In addition, several differentially regulated genes (37.5% of total) are not annotated, suggesting unique functions associated with oriented flight behavior. We also identified 23 juvenile hormone-dependent genes in brain, which separate reproductive from non-reproductive monarchs; genes involved in longevity, fatty acid metabolism, and innate immunity are upregulated in non-reproductive (juvenile-hormone deficient) migrants. The results link key behavioral traits with gene expression profiles in brain that differentiate migratory from summer butterflies and thus show that seasonal changes in genomic function help define the migratory state. Overall design: A total of 40 monarch butterflies were used for the microarray analysis. Of the 40, 10 (5 male/5 female) were summer butterflies (Designated as S) and 30 were fall butterflies. The fall butterflies were further divided into three groups: 10 (5 male/5 female) were untreated (F); 10 (5 male/5 female) were treated with methoprene (M), which is a juvenile hormone analog and induces the development of reproductive organs in migrant butterflies; and 10 (5 male/5 female) were treated with vehicle only (V). We collected total brain RNA from each of the 40 butterflies. The brain RNAs were amplified and then used to probe a custom Nimblegen array that was designed to analyze the 9,417 unique cDNA sequences established in our published EST library (http://titan.biotec.uiuc.edu/cgi-bin/ESTWebsite/estima_start?seqSet=butterfly). Our main in...
  58. Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows (Pimephales promelas) ArrayExpress

    ID: E-GEOD-26958

    Description: onsistent with inhibition of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) and aromatase (CYP19), known molecular targets of prochloraz, plasma 17β-estradiol (E2) was reduced within 6 hours. Ex vivo E2 production was significantly reduced at all time-points, while ex vivo testosterone (T) production remained unchanged. Consistent with the decrease in E2 levels, plasma concentrations of the estrogen-responsive protein vitellogenin were significantly reduced at 24 h. Genes coding for CYP19, CYP17, and steroidogenic acute regu...

  59. X-RAY STRUCTURE OF THE SUBSTRATE-FREE MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP124 PDB

    ID: PDB:2WM5

    Description: PUTATIVE CYTOCHROME P450 124 (E.C.1.14.-.-)

    dataset.keywords: FATTY ACID
  60. T268A mutant heme domain of flavocytochrome P450 BM3 PDB

    ID: PDB:1YQO

    Description: Bifunctional P-450:NADPH-P450 reductase (E.C.1.14.14.1, 1.6.2.4)

    dataset.keywords: fatty acid hydroxylase
  61. T268N mutant cytochrome domain of flavocytochrome P450 BM3 PDB

    ID: PDB:1YQP

    Description: Bifunctional P-450:NADPH-P450 reductase (E.C.1.14.14.1, 1.6.2.4)

    dataset.keywords: fatty acid hydroxylase
  62. Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8 PDB

    ID: PDB:1PQ2

    Description: Cytochrome P450 2C8 (E.C.1.1414.1)

    dataset.keywords: TAXOL 6-HYDROXYLASE
  63. F393W mutant heme domain of flavocytochrome P450 BM3 PDB

    ID: PDB:1P0W

    Description: Heme domain of Bifunctional P-450:NADPH-P450 reductase (E.C.1.14.14.1)

    dataset.keywords: fatty acid hydroxylase
  64. Crystal Structure of Phe393His Cytochrome P450 BM3 PDB

    ID: PDB:1JME

    Description: BIFUNCTIONAL P-450:NADPH-P450 REDUCTASE (E.C.1.14.14.1)

    dataset.keywords: FATTY ACID HYDROXYLASE
  65. F393Y mutant heme domain of flavocytochrome P450 BM3 PDB

    ID: PDB:1P0X

    Description: Heme domain of Bifunctional P-450:NADPH-P450 reductase (E.C.1.14.14.1)

    dataset.keywords: fatty acid hydroxylase
  66. F393A mutant heme domain of flavocytochrome P450 BM3 PDB

    ID: PDB:1P0V

    Description: Heme domain of Bifunctional P-450:NADPH-P450 reductase (E.C.1.14.14.1)

    dataset.keywords: fatty acid hydroxylase
  67. CYTOCHROME P450 BM3 MUTANT IN COMPLEX WITH PALMITIC ACID PDB

    ID: PDB:2UWH

    Description: BIFUNCTIONAL P-450\: NADPH-P450 REDUCTASE (E.C.1.14.14.1)

  68. The Q403K mutnat heme domain of flavocytochrome P450 BM3 PDB

    ID: PDB:2NNB

    Description: Bifunctional P-450:NADPH-P450 reductase (E.C.1.14.14.1)

    dataset.keywords: fatty-acid hydroxylase
  69. Defining Behavioral and Molecular Differences Between Summer and Migratory Monarch Butterflies OmicsDI

    ID: E-GEOD-14041

    Date Released: 05-04-2014

    Description: vrille and the locomotion-relevant tyramine beta hydroxylase gene. In addition, several differentially regulated genes (37.5% of total) are not annotated, suggesting unique functions associated with oriented flight behavior. We also identified 23 juvenile hormone-dependent genes in brain, which separate reproductive from non-reproductive monarchs; genes involved in longevity, fatty acid metabolism, and innate immunity are upregulated in non-reproductive (juvenile-hormone deficient) migrants. The results link key behavioral traits with gene expression profiles in brain that differentiate migratory from summer butterflies and thus show that seasonal changes in genomic function help define the migratory state. A total of 40 monarch butterflies were used for the microarray analysis. Of the 40, 10 (5 male/5 female) were summer butterflies (Designated as S) and 30 were fall butterflies. The fall butterflies were further divided into three groups: 10 (5 male/5 female) were untreated (F); 10 (5 male/5 female) were treated with methoprene (M), which is a juvenile hormone analog and induces the development of reproductive organs in migrant butterflies; and 10 (5 male/5 female) were treated with vehicle only (V). We collected total brain RNA from each of the 40 butterflies. The brain RNAs were amplified and then used to probe a custom Nimblegen array that was designed to analyze the 9,417 unique cDNA sequences established in our published EST library (http://titan.biotec.uiuc.edu/cgi-bin/ESTWebsite/estima_start?seqSet=butterfly). Our main interest is to f...

  70. Cavard Agilent ArrayExpress

    ID: E-MEXP-2821

    Description: Through the combined use of glutamine synthase / GLUL immunostaining, and CTNNB1 genotyping, we previously analyzed nearly 200 hepatocellular carcino...

  71. Transcription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensiti... ArrayExpress

    ID: E-GEOD-7694

    Description: y exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid receptor antagonists exacerbated whereas receptor agonists attenuated allergic inflammation. These results demonstrate a protective role of the endocannabinoid system in contact allergy in the skin, and suggest a novel target for therapeutic intervention. Experiment Overall Design: Three wildtype mice (Wt) and three Cnr1-/-/Cnr2-/- (Ko) mice were used. Contact hypersensitivity was determined always at the right ears, which therefore were treated with DNFB (Tr). Left ears o...

  72. Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows (Pimephales promelas) BioProject

    ID: PRJNA136967

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: onsistent with inhibition of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) and aromatase (CYP19), known molecular targets of prochloraz, plasma 17β-estradiol (E2) was reduced within 6 hours. Ex vivo E2 production was significantly reduced at all time-points, while ex vivo testosterone (T) production remained unchanged. Consistent with the decrease in E2 levels, plasma concentrations of the estrogen-responsive protein vitellogenin were significantly reduced at 24 h. Genes coding for CYP19, CYP17, and steroidogenic acute regu...
  73. DNA Methylation Profiling of Glioblastoma: Impact on Gene Expression and Clinical Outcome (Agilent Expression Study) OmicsDI

    ID: E-GEOD-22866

    Date Released: 08-07-2015

    Description: , BST2, OAS1, SLC13A5, GSTM5, ME1, UBXD3, TSPYL5, FAAH, C7orf13, and C3orf14. The expression of these genes may be tightly regulated by epigenetic mechanisms. The survival analysis identified six CpG sites associated with overall survival. The SOX10 promoter methylation status (two CpG sites) stratifies the patients in a way similar to MGMT with improved performance based on Area Under the Curve criteria (0.78 vs. 0.71, p-value < 5.10-4). The methylation status of FNDC3B, TBX3, DGKI, and FSD1 promoters identify patients with MGMT methylated tumors non-responding to STUPP treatment (p-value < 1.10-4). These markers have a potential impact on therapeutic decision. 40 glioblastoma samples and 6 control brain samples were analysed. 2 distinct series of hybridizations were carried out, each containing GBMs and control brains....

  74. DNA Methylation Profiling of Glioblastoma: Impact on Gene Expression and Clinical Outcome (Illumina) OmicsDI

    ID: E-GEOD-22867

    Date Released: 03-27-2012

    Description: , BST2, OAS1, SLC13A5, GSTM5, ME1, UBXD3, TSPYL5, FAAH, C7orf13, and C3orf14. The expression of these genes may be tightly regulated by epigenetic mechanisms. The survival analysis identified six CpG sites associated with overall survival. The SOX10 promoter methylation status (two CpG sites) stratifies the patients in a way similar to MGMT with improved performance based on Area Under the Curve criteria (0.78 vs. 0.71, p-value < 5.10-4). The methylation status of FNDC3B, TBX3, DGKI, and FSD1 promoters identify patients with MGMT methylated tumors non-responding to STUPP treatment (p-value < 1.10-4). These markers have a potential impact on therapeutic decision. 55 glioblastoma samples and 3 control brain samples were analysed....

  75. Effects of a short-term exposure to the fungicide prochloraz on endocrine function and gene expression in female fathead minnows (Pimephales promelas) OmicsDI

    ID: E-GEOD-26958

    Date Released: 06-26-2012

    Description: onsistent with inhibition of cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17) and aromatase (CYP19), known molecular targets of prochloraz, plasma 17β-estradiol (E2) was reduced within 6 hours. Ex vivo E2 production was significantly reduced at all time-points, while ex vivo testosterone (T) production remained unchanged. Consistent with the decrease in E2 levels, plasma concentrations of the estrogen-responsive protein vitellogenin were significantly reduced at 24 h. Genes coding for CYP19, CYP17, and steroidogenic acute regu...

  76. Cannabinoid receptor double knockout mice (Cnr1 -/- /Cnr2 -/-) in CHS model BioProject

    ID: PRJNA99455

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: y exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid receptor antagonists exacerbated whereas receptor agonists attenuated allergic inflammation. These results demonstrate a protective role of the endocannabinoid system in contact allergy in the skin, and suggest a novel target for therapeutic intervention. Keywords: Strain (Wt versus Ko) and disease state (DNFB treated versus control). Overall design: Three wildtype mice (Wt) and three Cnr1-/-/Cnr2-/- (Ko) mice were used. Contact hypersensitivity was determined always at th...
  77. Cannabinoid receptor double knockout mice (Cnr1 -/- /Cnr2 -/-) in CHS model GEMMA

    ID: 552

    Keywords: functional genomics

    Description: y exacerbated allergic inflammation. In contrast, fatty acid amide hydrolase deficient mice, which have increased levels of the endocannabinoid anandamide, displayed reduced allergic responses in the skin. Cannabinoid receptor antagonists exacerbated whereas receptor agonists attenuated allergic inflammation. These results demonstrate a protective role of the endocannabinoid system in contact allergy in the skin, and suggest a novel target for therapeutic intervention. Last Updated (by provider): Jun 11 2007 Contributers: Andreas Zimmer Evelyn Gaffal Thomas Tüting Lihua Wang-Eckhardt Meliha Karsak...


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