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Displaying 20 of 320 results for "EWSR1"
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  1. A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion OmicsDI

    ID: E-GEOD-34800

    Date Released: 06-24-2012

    Description: nd provided new insight into oncogenesis. We used RNA-Seq to investigate samples diagnosed as small round cell tumors of bone, possibly Ewing sarcoma, but lacking the canonical EWSR1-ETS translocation. A new fusion was observed between the BCL6 co-repressor (...

  2. Hypoxia modulates EWS-FLI1 transcriptional signature and enhances malignant properties of Ewing’s tumor cells in vitro BioProject

    ID: PRJNA120859

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility BioProject

    ID: PRJNA261972

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ions of aberrant nucleosome depletion mediated by EWSR1-FLI1, the chimeric transcription factor critical for the bone and soft tissue tumor Ewing sarcoma. As a class, histone deacetylase inhibitors were greatly overrepresented among active compounds. These compounds resulted in diminished accessibility at targeted sites by disrupting transcription of EWSR1-FLI1. Capitalizing on precise differences in chromatin accessibility for drug discovery efforts offers significant advantages because it does not depend on the a priori selection of a single molecular target and may detect novel biologically relevant pathways. Overall design: HT-FAIRE was performed on Human Umbilical Vein Endothelial Cells (HUVEC) in duplicate. No reference/control experiment is necessary....
  4. Oncogene-Mediated Alterations in Chromatin Conformation ArrayExpress

    ID: E-GEOD-37752

    Description: -wide chromosome conformation capture (Hi-C), ERG binding and gene expression, we demonstrate that oncogenic transcription factor over-expression is associated with global, reproducible and functionally coherent changes in chromatin organization. The results presented here have broader implications, as genomic alterations in other cancer types frequently give rise to aberrant transcription factor expression e.g., EWS-FLI1, c-Myc, n-Myc, PML-RARα. We used stable isogenic, normal benign prostate epithelial cell lines (RWPE1) that differ with respect to ERG3 over-expression. To test whether ERG over-expression is associated with global changes in chromatin structure, we performed unbiased chromatin interaction mapping using the Hi-C technique from both RWPE1-ERG and RWPE1-GFP cells, with biological replicates. Successful fill-in and ligation were determined as previously reported by testing for a known interaction between two...

  5. Effect of LOX-PP on the gene expression profile of the A673 cell line (Ewing sarcoma) ArrayExpress

    ID: E-GEOD-46407

    Description: ls and primary tumors and is downregulated by the EWS/FLI1 oncoprotein characteristic of these tumors. Using a doxycycline inducible system to restore LOX expression in an Ewing sarcoma derived cell line, we show that LOX displays tumor suppressor activities. Interestingly, we show that the tumor suppressor activity resides in the propeptide domain of LOX (L...

  6. Genomic Sequencing of Ewing Sarcoma dbGaP

    ID: phs000804.v1.p1

    Description: e. It is characterized by chimeric fusions of the EWS gene and an ETS family transcription factor. In this study, we performed massively parallel sequencing of a larger collection of Ewing sarcoma tumors to define the genomic landscape of this disease. We found...

  7. EWS-FLI1-transfection of HEK293 BioProject

    ID: PRJNA90505

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Gene expression profiling of myxoid liposarcomas (training set INT-A) BioProject

    ID: PRJNA239694

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initial...
  9. The PRC1 protein RING1B contributes to Ewing sarcoma tumorigenesis by repressing the NaV1.6 sodium channel and modulating the NF-kB pathway,... OmicsDI

    ID: E-GEOD-71007

    Date Released: 06-30-2016

    Description: lecularly defined by reciprocal translocations of EWSR1 to an ETS transcription factor. The functions of EZH2 and BMI1, two proteins of the Polycomb group (PcG) of epigenetic repressors, have been previously shown to mediate ...

  10. The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes Ewing's-type tumors in zebrafish BioProject

    ID: PRJNA154079

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Re-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for Ewing´s sarcoma BioProject

    ID: PRJNA159783

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells [Agilent]. OmicsDI

    ID: E-GEOD-41122

    Date Released: 05-13-2014

    Description: location, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated

  13. Gene expression profiling of myxoid liposarcomas (validation set INT-B) BioProject

    ID: PRJNA239692

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initial...
  14. Oncogenic Fusion Protein EWS-FLI1 is a Network Hub that Regulates Alternative Splicing OmicsDI

    ID: E-GEOD-65941

    Date Released: 04-04-2015

    Description: pon proteins that modulate splice site selection. EWS-FLI1 is an Ewing sarcoma (ES) oncogene with an interactome that we demonstrate to have multiple partners in spliceosomal complexes. We evaluate EWS-FLI1 upon post-transcriptional gene regulation using both exon array and RNA-seq. Genes that potentially regulate ...

  15. Gene expression profiles of control and EWS-FLI1-transduced neural crest stem cells BioProject

    ID: PRJNA283989

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. EWS/ATF1 activates Fos and induces soft tissue sarcomas [Affymetrix]. OmicsDI

    ID: E-GEOD-41121

    Date Released: 04-22-2013

    Description: location, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated

  17. Low-dose actinomycin D preferentially disrupts EWS-FLI1DNA binding. OmicsDI

    ID: E-GEOD-45414

    Date Released: 09-02-2013

    Description: Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of E...

  18. Anaylsis of the effect of down-regulation of the EWS-FLI1 fusion protein in Ewing Sarcoma cells by RNA-seq. BioProject

    ID: PRJNA230789

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes developmental defects in zebrafish embryos OmicsDI

    ID: E-GEOD-31185

    Date Released: 03-02-2012

    Description: The fusion oncoprotein EWS-FLI1 arises from a t(11;22)(q24;q12) chromosomal translocation and causes Ewing's Sarcoma, a malignant bone tumor. The mechani...

  20. Transcription profiling of human mesenchymal progenitor stem cells overexpressing EWS/ETS protein OmicsDI

    ID: E-GEOD-8665

    Date Released: 05-02-2014

    Description: We have examined the biological effect of EWS/ETS in human MPCs using UET-13 cells that are obtained by prolonging the lifespan of human bone marrow stromal cells using the ...


Displaying 20 of 320 results for "EWSR1"