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Displaying 20 of 320 results for "EWSR1"
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  1. FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice (I) BioProject

    ID: PRJNA317612

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: FUS/TLS is an RNA/DNA-binding protein associated with neurodegenerative diseases including amyotrophic late...
  2. Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma BioProject

    ID: PRJNA361521

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Ewing Sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TKs) and associated pathways...
  3. Transcription profiling of human Ewing sarcoma (A673) cells treated with cytarabine, doxorubicin and puromycin oral tongue squamous cell carcinomas to... ArrayExpress

    ID: E-GEOD-6930

    Description: to the discovery of modulators of the activity of EWS/FLI, the Ewing sarcoma associated oncoprotein. Cytarabine (ARA-C) was identified as the top hit in a small molecule library screen. ARA-C modulates EWS/FLI by decreasing EWS/FLI protein level and has striking effects on cellular viability and transformation in in vitro and in vivo models of Ewing sarcoma. With poor outcomes for patients with relapsed Ewing sarcoma and the well established safety profile of ARA-C, clinical trials testing ARA-C in Ewing sarcoma are warranted. Expre...

  4. Activation of Wnt/beta-catenin in Ewing sarcoma cells antagonizes EWS/ETS function and promotes phenotypic transition to more metastatic cell states BioProject

    ID: PRJNA305534

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Oncogenic Fusion Protein EWS-FLI1 is a Network Hub that Regulates Alternative Splicing BioProject

    ID: PRJNA275445

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Hypoxia modulates EWS-FLI1 transcriptional signature and enhances malignant properties of Ewing’s tumor cells in vitro ArrayExpress

    ID: E-GEOD-19197

    Description: the tumor cell microenvironment and approximately 1-1.5% of the genome is transcriptionally responsive to hypoxia with hypoxia-inducible factor-1 (HIF-1) as a major mediator of tra...

  7. A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion BioProject

    ID: PRJNA151127

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nd provided new insight into oncogenesis. We used RNA-Seq to investigate samples diagnosed as small round cell tumors of bone, possibly Ewing sarcoma, but lacking the canonical EWSR1-ETS translocation. A new fusion was observed between the BCL6 co-repressor (...
  8. EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development [gene expression] BioProject

    ID: PRJNA294699

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. Pooh cells BioProject

    ID: PRJNA100983

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: meric POU5F1 gene with physiological co-activator EWS, which is driven by the potent EWS promoter by translocation. The cell line termed Pooh (POU5F1/Oct-4/3 overexpressing human) cells expressed embryonic stem cell genes such as Nanog and also non-translocated POU5F1, lost mesenchymal phenotypes, and exhibited embryonal stem cell-like alveolar structure when implanted into the subcutaneous tissue of immunodeficient mice. Hierarchical analysis by microchip ...
  10. microRNA expression data from Ewing's sarcoma tumor samples BioProject

    ID: PRJNA159803

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions. We performed expression profiling of both miRNA and mRNA from the same Ewing's sarcoma tumors. We propose a novel s...
  11. Pharmacologic Inhibition of Epigenetic Modification Reveals Targets of Aberrant Promoter Methylation in Ewing Sarcoma BioProject

    ID: PRJNA192549

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of transcription factors. Although genetic changes in Ewing sarcoma have been extensively researched, our understanding of the role of epigenetic modifications in this neop...
  12. Expression data of mouse Ewing's sarcoma BioProject

    ID: PRJNA147149

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: were purified by microdissection, introduced with EWS-FLI1 or EWS-ERG retroviruses and transplanted into nude mice. Ewing’s sarcoma-like small round cell sarcoma developed at 100% penetrance, whereas tumor induction was less effective when growth place (GP)-derived cells were used. The different response of gene expression to EWS-FLI1 between FZ and GP cells suggests importance of the specific cellular context for EWS-FLI1 to induce Ewing’s sarcoma. The Wnt/β-catenin pathway was involved in close...
  13. EZH2 is a mediator of EWS-FLI1 driven tumor growth blocking endothelial and neuro-ectodermal differentiation BioProject

    ID: PRJNA112701

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. CD99 triggering induces a novel processes of death in Ewing's sarcoma cells involving reactivation of p53 functions and RAS upregulation. BioProject

    ID: PRJNA151803

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: CD99 is a transmembrane protein, whose expression is constantly associated to Ewing’s Sarcoma (EWS), a class of pediatric bone tumors ...
  15. The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis BioProject

    ID: PRJNA371619

    Access Type: download

    dataset.description: t neoplasm of the bone and soft tissue. Driven by EWS/Ets, or rarely variant, oncogenic fusions, Ewing Sarcoma is a biologically and clinically aggressive disease with a high propensity for metastasis. Our laboratory has previously identified t...
  16. Clear cell sarcoma human HEEBO microarray data ArrayExpress

    ID: E-GEOD-43045

    Description: g melanoma, with a predilection for young adults. EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12, is considered the definitional feature of the tumor. Conditional expression of the EWS-ATF1 human cDNA in th...

  17. Gene expression in Ewing tumor cell lines after STEAP1 silencing BioProject

    ID: PRJNA136799

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Ewing tumors (ET) are characterized by oncogenic EWS/ETS translocations and early metastasis. STEAP1 is a membrane-bound channel protein of unkown function. While overexpressed in many cancers, STEAP1 expression is strongly restricted to m...
  18. Clear cell sarcoma human HEEBO microarray data BioProject

    ID: PRJNA184178

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g melanoma, with a predilection for young adults. EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12, is considered the definitional feature of the tumor. Conditional expression of the EWS-ATF1 human cDNA in th...
  19. Expression data from Ewing's sarcoma tumor samples BioProject

    ID: PRJNA159805

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions. We performed expression profiling of both miRNA and mRNA from the same Ewing's sarcoma tumors. We propose a novel s...
  20. Expression data from A673 cell line treated with compounds at several doses and time points BioProject

    ID: PRJNA98089

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: to the discovery of modulators of the activity of EWS/FLI, the Ewing sarcoma associated oncoprotein. Cytarabine (ARA-C) was identified as the top hit in a small molecule library screen. ARA-C modulates EWS/FLI by decreasing EWS/FLI protein level and has striking effects on cellular viability and transformation in in vitro and in vivo models of Ewing sarcoma. With poor outcomes for patients with relapsed Ewing sarcoma and the well established safety profile of ARA-C, clinical trials testing ARA-C in Ewing sarcoma are warranted. Expre...

Displaying 20 of 320 results for "EWSR1"