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Displaying 20 of 320 results for "EWSR1"
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  1. CD99 triggering induces a novel processes of death in Ewing's sarcoma cells involving reactivation of p53 functions and RAS upregulation ArrayExpress

    ID: E-GEOD-36097

    Description: CD99 is a transmembrane protein, whose expression is constantly associated to Ewing’s Sarcoma (EWS), a class of pediatric bone tumors ...

  2. Expression profiles of Ewing family of tumors authenticate distinct molecular entities BioProject

    ID: PRJNA259386

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: differences of FET-ETS, BCOR-CCNB3, CIC-DUX4 and EWSR1-NFATc2 tumors samples with a number of other sarcomas. Unsupervised clustering of gene expression profiles fully discriminates these four molecular entities. Specific gene signatures and pathways were further validated in model cell lines. While a clear inflammatory signature characterizes EWSR1-NFATc2 tumors, BCOR-CCNB3 ...
  3. Expression data of mouse eSZ and GP cells with or without EWS-FLI1 BioProject

    ID: PRJNA147153

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Genome-wide chromatin analysis of Ewing sarcoma (ChIP-seq) BioProject

    ID: PRJNA262730

    Keywords: Epigenomics

    Access Type: download

    dataset.description: We show that EWS-FLI1, an aberrant transcription factor responsible for the pathogenesis of Ewing sarcoma, reprograms gene regulatory circuits b...
  5. Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription BioProject

    ID: PRJNA145117

    Keywords: Other

    Access Type: download

    dataset.description: Using EWS-FLI and its parental transcription factor, FLI1, we created a unique experimental system to address questions regarding the gen...
  6. Mouse Model of Clear Cell Sarcoma ArrayExpress

    ID: E-GEOD-41293

    Description: develop in mice bearing conditional activation of EWS-ATF1, compared to control mouse tissues from the chest wall as well as tumor samples from mouse models of synovial sarcoma and osteosarcoma achieved by conditional disr...

  7. The PRC1 protein RING1B contributes to Ewing sarcoma tumorigenesis by repressing the NaV1.6 sodium channel and modulating the NF-kB pathway,... BioProject

    ID: PRJNA290095

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. pediatric sarcoma: rhabdomyosarcoma & Ewing's sarcoma GEMMA

    ID: 2081

    Keywords: functional genomics

    Description: Affymetrx U95Av2 GeneChip hybridizations, RNA extracted from primary human pediatric alveolar (aRMS) and embryonal (eRMS) rhabdomyosarcoma, plus primary pediatric Ewing's sa...

  9. Whole genome transcription profiling of the JN-DSCRT1 cell line treated with Trabectedin ArrayExpress

    ID: E-MTAB-4532

    Description: e the effects of Trabectedin in the expression of EWS-WT1 target genes in relation to the drug growth inhibitory effect, the JN-DSCRT-1 cell line was treated for 1 hour with 5 nM of Trabectedin. Samples were collected at 6, 12 and 24 hours after drug washout. Three biological replicates were us...

  10. A673 treated cells reveals EZh2 is a mediator of EWS-FLI1 driven tumor growth blocking endothelial and neuro-ectodermal differentiation... ArrayExpress

    ID: E-GEOD-12692

    Description: one or soft tissue and are molecularly defined by ews/ets translocations. We identified histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) to be increased in ET. EZH2’s suppressive activity maintains stemness in norm...

  11. Effect of EWS/FLI1 and DAX1 silencing on the gene expression profile of the A673 Ewing cell line BioProject

    ID: PRJNA151705

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development [gene expression] ArrayExpress

    ID: E-GEOD-72704

    Description: EWS-FLI1, a multi-functional fusion oncogene, is exclusively detectable in Ewing sarcomas. However, previous studies reported that ...

  13. EWS-FLI1 reactivates a neural crest stem cell program in human neural crest-derived mesenchymal stem cells BioProject

    ID: PRJNA125985

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Targeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma BioProject

    ID: PRJNA294622

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Expression profiling of Ewing sarcoma samples OmicsDI

    ID: E-GEOD-34620

    Date Released: 06-24-2012

    Description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. A genome-wide association study of at least 401 French ES patients compared to either 684 French or 3668 US self-described Caucasian controls consistently revealed candidate loci at chromosomes 1

  16. Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein BioProject

    ID: PRJNA208844

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. Mouse Model of Clear Cell Sarcoma BioProject

    ID: PRJNA176464

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: develop in mice bearing conditional activation of EWS-ATF1, compared to control mouse tissues from the chest wall as well as tumor samples from mouse models of synovial sarcoma and osteosarcoma achieved by conditional disr...
  18. Mus musculus : Synovial and Clear Cell Sarcoma Mouse Models BioProject

    ID: PRJNA247995

    Keywords: exome

    Access Type: download

    dataset.description: ouse models after the expression of SS18-SSX2 and EWS-ATF1 fusion genes, respectively. A very rapid onset of visible tumors in the mouse CCS model relative to synovial sarcoma suggest that fewer additional hits may be required to foster progression of the tumor in CCS model. This may represent a fundamental difference...
  19. EWS-FLI1 reactivates a neural crest stem cell program in human neural crest-derived mesenchymal stem cells ArrayExpress

    ID: E-GEOD-21511

    Description: ors of unknown cellular origin. Most ESFT express EWS-FLI1, a chimeric protein which functions as a growth-promoting oncogene in ESFT but is toxic to most normal cells. A major difficulty in understanding EWS-FLI1 functi...

  20. Transcription profiling of mouse Pooh cell line (POU5F1/Oct-4/3 overexpressing human) ArrayExpress

    ID: E-GEOD-8113

    Description: meric POU5F1 gene with physiological co-activator EWS, which is driven by the potent EWS promoter by translocation. The cell line termed Pooh (POU5F1/Oct-4/3 overexpressing human) cells expressed embryonic stem cell genes such as Nanog and also non-translocated POU5F1, lost mesenchymal phenotypes, and exhibited embryonal stem cell-like alveolar structure when implanted into the subcutaneous tissue of immunodeficient mice. Hierarchical analysis by microchip ...


Displaying 20 of 320 results for "EWSR1"