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Displaying 20 of 320 results for "EWSR1"
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  1. EWS/WT1 co-operates with the loss of p53 to exert its oncogenic effects and up-regulates canonical Wnt pathway signaling. OmicsDI

    ID: E-GEOD-42649

    Date Released: 11-08-2014

    Description: ur (DSRCT). The translocation fuses exon 7 of the EWS gene to exon 8 of the WT1 gene (EWS/WT1). Two splice variants of EWS/WT1 exist, arising from the presence (+KTS) or absence (-KTS) of three amino acids: lysine, threonine and serine between zinc fingers...

  2. EwingFGFR1 : Deep sequencing in conjunction with expression and functional analyses reveals activation of FGFR1 in Ewing sarcoma BioProject

    ID: PRJEB8907

    Keywords: Other

    Access Type: download

    dataset.description: g sarcoma (ES) is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). Other contributing somatic mutations involved in disease development have only been observed at low frequency. Experimental design: Tumor samples of 116 Ewing sarcoma (ES...
  3. EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development [gene expression] OmicsDI

    ID: E-GEOD-72704

    Date Released: 03-06-2016

    Description: EWS-FLI1, a multi-functional fusion oncogene, is exclusively detectable in Ewing sarcomas. However, previous studies reported that ...

  4. Expression data from the inducible expression of EWS-FLI1 (EF) in embryoid bodies BioProject

    ID: PRJNA271644

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. EWS-WT1 Oncogene Activates a Neuronal Reprogramming Factor ASCL1 and Mediates Partial Neural Differentiation OmicsDI

    ID: E-GEOD-53301

    Date Released: 07-30-2015

    Description: A chromosomal translocation fusion gene product EWS-WT1 is the defining genetic event in Desmoplastic Small Round Cell Tumor (DSRCT), a rare but aggressive tumor with a high rate ...

  6. The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes Ewing's-type tumors in zebrafish ArrayExpress

    ID: E-GEOD-31186

    Description: The fusion oncoprotein EWS-FLI1 arises from a t(11;22)(q24;q12) chromosomal translocation and causes Ewing's Sarcoma, a malignant bone tumor. The mechani...

  7. Transcription profiling of human Ewing sarcoma samples and EWS-FLI-1 inhibited Ewing sarcoma cell lines OmicsDI

    ID: E-GEOD-7007

    Date Released: 05-02-2014

    Description: tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced E...

  8. The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes Ewing's-type tumors in zebrafish OmicsDI

    ID: E-GEOD-31186

    Date Released: 03-02-2012

    Description: The fusion oncoprotein EWS-FLI1 arises from a t(11;22)(q24;q12) chromosomal translocation and causes Ewing's Sarcoma, a malignant bone tumor. The mechani...

  9. Effect of EWS/FLI1 and DAX1 silencing on the gene expression profile of the A673 Ewing cell line OmicsDI

    ID: E-GEOD-36007

    Date Released: 06-27-2012

    Description: rmation of chimerical transcription factors (i.e. EWS/FLI1) that play a pivotal role in the pathogenesis of Ewing tumors by deregulating gene expression. We have recently demonstrated that DAX1 (NR0B1), an orphan nuclear receptor which was not previously implicated in cancer, is induced by the

  10. EWS-FLI1 reactivates a neural crest stem cell program in human neural crest-derived mesenchymal stem cells OmicsDI

    ID: E-GEOD-21511

    Date Released: 06-10-2011

    Description: ors of unknown cellular origin. Most ESFT express EWS-FLI1, a chimeric protein which functions as a growth-promoting oncogene in ESFT but is toxic to most normal cells. A major difficulty in understanding EWS-FLI1 functi...

  11. Differential gene expression in GBS6 cells after EWS-POU5F1 knockdown OmicsDI

    ID: E-GEOD-12320

    Date Released: 05-03-2014

    Description: Our objective is to clarify the function of EWS-POU5F1 chimera. Specifially, GBS6 cells were established from an undifferentiated bone sarcoma carrying translocation t(6;22)(p...

  12. EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development [ChIP-seq] OmicsDI

    ID: E-GEOD-72897

    Date Released: 03-05-2016

    Description: EWS-FLI1, a multi-functional fusion oncogene, is exclusively detectable in Ewing sarcomas. However, previous studies reported that ...

  13. Genomic Sequencing of Ewing Sarcoma BioProject

    ID: PRJNA261990

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: e. It is characterized by chimeric fusions of the EWS gene and an ETS family transcription factor. In this study, we performed massively parallel sequencing of a larger collection of Ewing sarcoma tumors to define the genomic landscape of this disease. We found...
  14. Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein OmicsDI

    ID: E-GEOD-48065

    Date Released: 06-19-2014

    Description: The Ewing’s sarcoma protein EWS belongs to the TET family (FUS/TLS, EWS, TAF15) of RNA and DNA...

  15. Gene expression profiles of control and EWS-FLI1-transduced neural crest stem cells OmicsDI

    ID: E-GEOD-68898

    Date Released: 05-25-2015

    Description: following transduction with GFP control vector or EWS-FLI1 vector. Expression was analyzed in stem cell conditions 5 days after transduction (undifferentiated conditions) and after 6 weeks in differentiation media (differentiation conditions). Changes in gen...

  16. In vivo gene expression changes in EW5 Ewing sarcoma xenografts after IGF-1R or mTOR blockade ArrayExpress

    ID: E-GEOD-67529

    Description: c genomic translocation that places an N-terminal EWSR1 gene in approximation with one of several ETS genes (typically FLI1). This aberration, in turn, alters the transcriptional regulation of more than five hundred genes ...

  17. Homo sapiens : Genomic Sequencing of Ewing Sarcoma BioProject

    ID: PRJNA261989

    Access Type: download

    dataset.description: e. It is characterized by chimeric fusions of the EWS gene and an ETS family transcription factor. In this study, we performed massively parallel sequencing of a larger collection of Ewing sarcoma tumors to define the genomic landscape of this disease. We found...
  18. EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development BioProject

    ID: PRJNA295293

    Access Type: download

  19. Pharmacologic Inhibition of Epigenetic Modification Reveals Targets of Aberrant Promoter Methylation in Ewing Sarcoma OmicsDI

    ID: E-GEOD-44934

    Date Released: 07-08-2015

    Description: by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of transcription factors. Although genetic changes in Ewing sarcoma have been extensively researched, our understanding of the role of epigenetic modifications in this neop...

  20. microRNA expression data from Ewing's sarcoma tumor samples OmicsDI

    ID: E-GEOD-37370

    Date Released: 06-21-2012

    Description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions. We performed expression profiling of both miRNA and mRNA from the same Ewing's sarcoma tumors. We propose a novel s...


Displaying 20 of 320 results for "EWSR1"