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  1. Solution structure of the RNA recognition motif of Ewing Sarcoma(EWS) protein PDB

    ID: PDB:2CPE

    Description: RNA-binding protein EWS

  2. An interaction with Ewing's sarcoma breakpoint protein EWS defines the subset of ETS factors rearranged in prostate cancer BioProject

    ID: PRJNA297431

    Keywords: Epigenomics

    Access Type: download

  3. Additional file 1: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3634613_D15

    Release Date: 12-15-2016

    Description: List of significant FUS binding peaks within or close (within 10 kb distance) to annotated genes. (XLSX 11 kb)

  4. RNA immunoprecipitation (RIP)-Chip analysis for EWS-bound mRNA BioProject

    ID: PRJNA138649

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Homo sapiens : EWSR1/FL1 and E2F3 regulatory targets in Ewings Sarcoma BioProject

    ID: PRJNA213583

    Keywords: genome sequencing

    Access Type: download

  6. Additional file 1: Table S1. of Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 fu... Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3602915_D1

    Release Date: 12-14-2016

    Description: Top 400 DEGs analysis result. A) GO term result of DAVID analysis. B) KEGG pathway result list. (XLSX 19 kb)

  7. Regulation of exon definition and apoptosis by the Ewing's Sarcoma Protein ArrayExpress

    ID: E-GEOD-47790

    Description: The Ewing's Sarcoma Protein EWS belongs to the TET family (FUS/TLS, EWS, TAF15) of RNA and DNA...

  8. RNA immunoprecipitation (RIP)-Chip analysis for EWS-bound mRNA ArrayExpress

    ID: E-GEOD-29313

    Description: Although EWS/FLI-1 fusion protein is responsible for most Ewing’s sarcoma family tumors (ESFT), the ...

  9. Correlation between gene expression responses to FUS, EWS, and TAF15 reduction and the stress granule sequestering capacity ArrayExpress

    ID: E-GEOD-35578

    Description: nock-down of the FET-family of proteins; the FUS, EWS, and TAF15 proteins. The FET-proteins are thought to function as transcription factors, and this hypothesis is tested in the present study. Results provide important information of the genes w...

  10. Targeting EWSR1-FLI1 oncogene induced protein kinase C beta abolishes Ewing sarcoma growth in vivo BioProject

    ID: PRJNA167796

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. Low-dose actinomycin D preferentially disrupts EWS-FLI1DNA binding ArrayExpress

    ID: E-GEOD-45414

    Description: Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of E...

  12. Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein ArrayExpress

    ID: E-GEOD-48065

    Description: The Ewing’s sarcoma protein EWS belongs to the TET family (FUS/TLS, EWS, TAF15) of RNA and DNA...

  13. Targeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma ArrayExpress

    ID: E-GEOD-72673

    Description: netically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic transcriptional program associated with altered epigenetic marks throughout the genome. By use of an inhibitor (JQ1) blocking BET bromodomain binding

  14. Oncogenic Fusion Protein EWS-FLI1 is a Network Hub that Regulates Alternative Splicing ArrayExpress

    ID: E-GEOD-65941

    Description: pon proteins that modulate splice site selection. EWS-FLI1 is an Ewing sarcoma (ES) oncogene with an interactome that we demonstrate to have multiple partners in spliceosomal complexes. We evaluate EWS-FLI1 upon post-transcriptional gene regulation using both exon array and RNA-seq. Genes that potentially regulate ...

  15. Gene expression profiling of human Ewing sarcoma cells after knockdown of EGR2 or EWSR1-FLI1 ArrayExpress

    ID: E-GEOD-62090

    Description: resulting transcriptional signature with that of EWSR1-FLI1-silenced Ewing sarcoma cells. In accordance with the strong EGR2-induction by EWSR1-FLI1, both genes highly significantly overlap in their transcriptional signatures. Gene-set enrichment analyses (GSEA) and DAVID (Database for Annotation, Visualisation and Integrated Di...

  16. RUNX3 Facilitates Growth of Ewing Sarcoma Cells ArrayExpress

    ID: E-GEOD-56900

    Description: . Approximately 85% of Ewing sarcomas harbor the EWS/FLI fusion protein, which arises from a chromosomal translocation, t(11:22)(q24:q12). EWS/FLI interacts with numerous lineage-essential transcription factors to maintain mesenchymal prog...

  17. EWS of Tipping Points Workshop Figshare

    ID: doi:10.6084/M9.FIGSHARE.658932.V1

    Release Date: 01-11-2016

    Description:

  18. EWS of Tipping Points Workshop Figshare

    ID: doi:10.6084/M9.FIGSHARE.658932

    Release Date: 07-04-2014

    Description:

  19. Targeting EWSR1-FLI1 oncogene induced protein kinase C beta abolishes Ewing sarcoma growth in vivo ArrayExpress

    ID: E-GEOD-38392

    Description: st Ewing sarcoma. We report the identification of Protein Kinase C Beta (PRKCB) as a protein specifically and highly expressed in Ewing sarcoma as compared to other pediatric cancers. Its transcriptional activation is directly regulated by the

  20. 5- AZA treatment of EWS cell lines BioProject

    ID: PRJNA156961

    Keywords: Transcriptome or Gene expression

    Access Type: download

  21. A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion ArrayExpress

    ID: E-GEOD-34800

    Description: nd provided new insight into oncogenesis. We used RNA-Seq to investigate samples diagnosed as small round cell tumors of bone, possibly Ewing sarcoma, but lacking the canonical EWSR1-ETS translocation. A new fusion was observed between the BCL6 co-repressor (...

  22. Expression profiling of Ewing sarcoma samples ArrayExpress

    ID: E-GEOD-34620

    Description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. A genome-wide association study of at least 401 French ES patients compared to either 684 French or 3668 US self-described Caucasian controls consistently revealed candidate loci at ch...

  23. Homo sapiens strain:A673 cell line : EWS function in Ewing sarcoma BioProject

    ID: PRJNA174537

    Keywords: transcriptome

    Access Type: download

  24. EWS and FUS Bind a Subset of Transcribed Genes Encoding Proteins Enriched in RNA Regulatory Functions BioProject

    ID: PRJNA297201

    Keywords: Epigenomics

    Access Type: download

  25. Expression profiles of Ewing family of tumors authenticate distinct molecular entities ArrayExpress

    ID: E-GEOD-60740

    Description: differences of FET-ETS, BCOR-CCNB3, CIC-DUX4 and EWSR1-NFATc2 tumors samples with a number of other sarcomas. Unsupervised clustering of gene expression profiles fully discriminates these four molecular entities. Specific gene signatures and pathways were further validated in model cell lines. While a clear inflammatory signature characterizes EWSR1-NFATc2 tumors, BCOR-CCNB3 ...

  26. EWS siRNA knock-down in HeLa cell line ArrayExpress

    ID: E-GEOD-22929

    Description: HeLa cell line was trasfected by a EWS siRNA oligo causing knock-down of EWS or a siRNA scrambled oligo Three biological replicates were labeled in...

  27. RNA immunoprecipitation (RIP)-Chip analysis for EWS-bound mRNA OmicsDI

    ID: E-GEOD-29313

    Date Released: 06-26-2012

    Description: Although EWS/FLI-1 fusion protein is responsible for most Ewing’s sarcoma family tumors (ESFT), the ...

  28. Cotranscriptional exon skipping in the genotoxic stress response ArrayExpress

    ID: E-GEOD-21840

    Description: lternative exon inclusion by affecting elongating RNA polymerase II. We report here that various genotoxic stress inducers, including camptothecin, inhibit the interaction between EWS, an RNA polymerase II-associated factor, and YB-

  29. EWS siRNA knock-down in HeLa cell line BioProject

    ID: PRJNA127931

    Keywords: Transcriptome or Gene expression

    Access Type: download

  30. Homo sapiens strain:TTC-466 cell line : EWS/ERG function in Ewing sarcoma BioProject

    ID: PRJNA213798

    Keywords: transcriptome

    Access Type: download

  31. Differences between NOR1 and EWS/NOR1 BioProject

    ID: PRJNA106887

    Keywords: Transcriptome or Gene expression

    Access Type: download

  32. Expression profiling of Ewing sarcoma samples BioProject

    ID: PRJNA151293

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. A genome-wide association study of at least 401 French ES patients compared to either 684 French or 3668 US self-described Caucasian controls consistently revealed candidate loci at chromosomes 1
  33. Transcription profiling of human NOR1- and EWS/NOR1-overexpressing 293 cells ArrayExpress

    ID: E-GEOD-11185

    Description: ferences between NOR1 and its fusion gene product EWS/NOR1, we compared the gene expression profiles of NOR1- and EWS/NOR1-overexpressing 293 cells. Experiment Overall Design: We e...

  34. Gene expression profiling of human Ewing sarcoma cells after knockdown of EGR2 or EWSR1-FLI1. BioProject

    ID: PRJNA263177

    Keywords: Transcriptome or Gene expression

    Access Type: download

  35. Homo sapiens strain:A673 cell line : EWS/FLI function in Ewing sarcoma BioProject

    ID: PRJNA176544

    Keywords: transcriptome

    Access Type: download

  36. An interaction with Ewing's sarcoma breakpoint protein EWS defines the specific oncogenic mechanism of ETS factors rearranged in prostate cancer BioProject

    ID: PRJNA321758

    Keywords: Transcriptome or Gene expression

    Access Type: download

  37. EWS-Fli and LNC regulated genes in comparison to GFP samples BioProject

    ID: PRJNA259885

    Keywords: Transcriptome or Gene expression

    Access Type: download

  38. Transcription profiling of human pediatric alveolar (aRMS) and embryonal (eRMS) rhabdomyosarcoma, plus primary pediatric Ewings sarcoma (EWS) ArrayExpress

    ID: E-GEOD-967

    Description: Affymetrx U95Av2 GeneChip hybridizations, RNA extracted from primary human pediatric alveolar (aRMS) and embryonal (eRMS) rhabdomyosarcoma, plus primary pediatric Ewing's sa...

  39. EWS TC-71 cell lines: IGF-1R resistant BioProject

    ID: PRJNA148069

    Keywords: Transcriptome or Gene expression

    Access Type: download

  40. The effects of chimeric EWS/ETS protein in human mesenchymal progenitor cells (MPCs). BioProject

    ID: PRJNA101871

    Keywords: Transcriptome or Gene expression

    Access Type: download

  41. Transcription profiling of human mesenchymal progenitor stem cells overexpressing EWS/ETS protein ArrayExpress

    ID: E-GEOD-8665

    Description: We have examined the biological effect of EWS/ETS in human MPCs using UET-13 cells that are obtained by prolonging the lifespan of human bone marrow stromal cells using the ...

  42. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells [Agilent]. BioProject

    ID: PRJNA176041

    Keywords: Transcriptome or Gene expression

    Access Type: download

  43. Homo sapiens : LSD1 inhibitor HCI-2509 and gene expression in Ewing sarcoma (A673) BioProject

    ID: PRJNA213645

    Keywords: transcriptome

    Access Type: download

    dataset.description: EWS/ERG function in Ewing sarcoma
  44. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency Figshare

    ID: doi:10.6084/M9.FIGSHARE.1486425

    Release Date: 03-11-2016

    Description:

  45. Differential gene expression in GBS6 cells after EWS-POU5F1 knockdown BioProject

    ID: PRJNA113551

    Keywords: Transcriptome or Gene expression

    Access Type: download

  46. Gene expression profiling of human Ewing sarcoma cells after knockdown of EGR2 or EWSR1-FLI1. OmicsDI

    ID: E-GEOD-62090

    Date Released: 08-19-2015

    Description: resulting transcriptional signature with that of EWSR1-FLI1-silenced Ewing sarcoma cells. In accordance with the strong EGR2-induction by EWSR1-FLI1, both genes highly significantly overlap in their transcriptional signatures. Gene-set enrichment analyses (GSEA) and DAVID (Database for Annotation, Visualisation and Integrated Di...

  47. Additional file 2: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3634613_D12

    Release Date: 12-15-2016

    Description: List of significant EWS binding peaks within or close (within 10 kb distance) to annotated genes. (XLSX 15 kb)...

  48. Additional file 7: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3634613_D4

    Release Date: 12-15-2016

    Description: d on microarray data of genes presented with FUS, EWS, FUS and EWS, and Ac-H3K9 ChIP-seq peaks. (XLS 70 kb)...

  49. A673 Stable-Knockdown BioProject

    ID: PRJNA104527

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Ai retroviral constructs targeting the endogenous EWS/FLI fusion transcript (either EF-2-RNAi or EF-4-RNAi). Keywords: Expression analysis of RNAi knockdown of endogenous EWS/FLI Overall design: Eight samples total. Four luc-RNAi, and four EWS
  50. SNP chip data of EWS BioProject

    ID: PRJNA116647

    Keywords: Variation

    Access Type: download

  51. MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE PDB

    ID: PDB:1I3Z

    Description: EWS/FLI1 activated transcript 2 (SH2 domain); signaling lymphocytic activation molecule

  52. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency Figshare

    ID: doi:10.6084/M9.FIGSHARE.1486425.V1

    Release Date: 03-11-2016

    Description:

  53. EWS-Fli and LNC regulated genes in comparison to GFP samples ArrayExpress

    ID: E-GEOD-60949

    Description: RNA from A673 cells with shRNA-mediated knockdown of GFP (4 libraries), EWS-FLI1 (4 libraries), or lnc277 (7 li...

  54. Ewing samples and EWS-FLI-1 inhibited Ewing cell lines BioProject

    ID: PRJNA99237

    Keywords: Transcriptome or Gene expression

    Access Type: download

  55. pMPC EF vs control 3seq ArrayExpress

    ID: E-GEOD-60889

    Description: ranslocation between members of the FET family of RNA binding proteins and one of several ETS transcription factors, with the most common translocation being EWS-FLI1. EWS-FLI1 leads to c...

  56. 5- AZA treatment of EWS cell lines ArrayExpress

    ID: E-GEOD-36858

    Description: The Ewing Sarcoma cell lines A673, SK-ES-1, and SK-N-MC were treated with without 5-AZA to identify upregulated genes A673, SK-ES-1, and SK-N-MC were tre...

  57. Expression data for analysis of genes regulated by EWS/FLI1 protein levels in Ewing sarcoma cell line A673 BioProject

    ID: PRJNA320295

    Keywords: Transcriptome or Gene expression

    Access Type: download

  58. Cotranscriptional exon skipping in the genotoxic stress response BioProject

    ID: PRJNA126927

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lternative exon inclusion by affecting elongating RNA polymerase II. We report here that various genotoxic stress inducers, including camptothecin, inhibit the interaction between EWS, an RNA polymerase II-associated factor, and YB-
  59. Differential gene expression in GBS6 cells after EWS-POU5F1 knockdown ArrayExpress

    ID: E-GEOD-12320

    Description: Our objective is to clarify the function of EWS-POU5F1 chimera. Specifially, GBS6 cells were established from an undifferentiated bone sarcoma carrying translocation t(6;22)(p...

  60. Additional file 8: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3634613_D5

    Release Date: 12-15-2016

    Description: also presented with FUS and Ac-H3K9 (n = 35), EWS and Ac-H3K9 (n = 135), or FUS and EWS and Ac-H3K9 (n = 58) ChIP-seq peaks. The probe sets were used in GO analysis. (XLSX 41 kb)...

  61. EWS/ATF1 activates Fos and induces soft tissue sarcomas [Affymetrix] ArrayExpress

    ID: E-GEOD-41121

    Description: location, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated

  62. EWS TC-71 cell lines: IGF-1R resistant ArrayExpress

    ID: E-GEOD-34027

    Description: hanisms and pathways modulated by the resistance. EWS TC-71 cell line was exposed to increasing concentration to three different anti-IGF-1R drugs (HAb AVE1642, TKI NVP-AEW541, HAb CP-751,871, cell lines named respectively as TC/AVE, TC/AEW or TC/CP) for at least six mon...

  63. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells ArrayExpress

    ID: E-GEOD-41123

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  64. Transcription profiling of human Ewing sarcoma samples and EWS-FLI-1 inhibited Ewing sarcoma cell lines ArrayExpress

    ID: E-GEOD-7007

    Description: tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced E...

  65. siRNA profiling of human GBS6 cells after EWS-POU5F1 knockdown II ArrayExpress

    ID: E-GEOD-18901

    Description: e translocation resulted in a gene fusion between EWS and POU5F1. Gene expression analysis of t(6;22) undifferentiated sarcoma cell line GBS6 transfected with POU5F1 specific siRNA to investigate the function of EWS-POU5F1. Experiment Overall Design: 6 samples are analy...

  66. A functional liaison between E2F and the aberrant ETS oncogene EWS/FLI1 in Ewing's sarcoma ArrayExpress

    ID: E-GEOD-27524

    Description: nvestigated the genomic network of the ETS fusion EWS/FLI1 in Ewing's sarcoma (ESFT) as a model of ETS-driven tumorigenesis. ChIP-Seq and transcriptional analysis identified E2F3 as a principle co-factor of EWSFLI1 defining functionally distinct gene sets. While

  67. Genome-wide chromatin analysis of Ewing sarcoma (ATAC-seq) ArrayExpress

    ID: E-GEOD-61951

    Description: We show that EWS-FLI1, an aberrant transcription factor responsible for the pathogenesis of Ewing sarcoma, reprograms gene regulatory circuits b...

  68. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells [Agilent] ArrayExpress

    ID: E-GEOD-41122

    Description: location, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated

  69. RNAi profiling of human Ewings sarcoma A673 Stable-Knockdown ArrayExpress

    ID: E-GEOD-4560

    Description: Ai retroviral constructs targeting the endogenous EWS/FLI fusion transcript (either EF-2-RNAi or EF-4-RNAi). Experiment Overall Design: Eight samples total. Four luc-RNAi, and four EWS/FLI knockdown constructs (two each of EF-2-RNAi or EF-4-RNAi)....

  70. Gene expression profiling of myxoid liposarcomas (training set INT-A) ArrayExpress

    ID: E-GEOD-55464

    Description: FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initial...

  71. Correlation between gene expression responses to FUS, EWS, and TAF15 reduction and the stress granule sequestering capacity BioProject

    ID: PRJNA152231

    Keywords: Transcriptome or Gene expression

    Access Type: download

  72. pediatric sarcoma: rhabdomyosarcoma & Ewing's sarcoma BioProject

    ID: PRJNA88001

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Affymetrx U95Av2 GeneChip hybridizations, RNA extracted from primary human pediatric alveolar (aRMS) and embryonal (eRMS) rhabdomyosarcoma, plus primary pediatric Ewing's sa...
  73. hnRNPK knock down in Ewing cell line ArrayExpress

    ID: E-GEOD-60890

    Description: ranslocation between members of the FET family of RNA binding proteins and one of several ETS transcription factors, with the most common translocation being EWS-FLI1. EWS-FLI1 leads to c...

  74. Expression data from Ewing's sarcoma tumor samples ArrayExpress

    ID: E-GEOD-37371

    Description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions. We performed expression profiling of both miRNA and mRNA from the same Ewing's sarcoma tumors. We propose a novel s...

  75. microRNA expression data from Ewing's sarcoma tumor samples ArrayExpress

    ID: E-GEOD-37370

    Description: g sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions. We performed expression profiling of both miRNA and mRNA from the same Ewing's sarcoma tumors. We propose a novel s...

  76. RNAi profiling by array of human Ewings carcinoma cells to down regulate EWS-FLI1 ArrayExpress

    ID: E-MEXP-2759

    Description: We report here the DNA-binding profiles for all human and mouse ETS factors, which we generated using two different methods: a high-throughput microwell-b...

  77. ERG deregulation induces PIM-1 over-expression and aneuploidy in prostate epitheilial cells ArrayExpress

    ID: E-GEOD-32481

    Description: e main ERG oncogenic fusions: TMPRSS2/ERG (tERG), EWS/ERG and FUS/ERG,. We found that all the three ERG fusions significantly up-regulate PIM-1 expression in the NIH-3T3 cell line. PIM-1 is a serine/threonine kinase frequently over-expressed in cancers of haematological and epithelial origin. We show here that tERG expression induces PIM-1 in the non-malignant prostate cell line RWPE-1, strengthening the relat...

  78. Ewing's sarcoma miRNA expression ArrayExpress

    ID: E-TABM-1100

    Description: MicroRNA profile of 34 EWS by microarray

  79. Gene expression in Ewing tumor cell lines after STEAP1 silencing ArrayExpress

    ID: E-GEOD-26422

    Description: Ewing tumors (ET) are characterized by oncogenic EWS/ETS translocations and early metastasis. STEAP1 is a membrane-bound channel protein of unkown function. While overexpressed in many cancers, STEAP1 expression is strongly restricted to m...

  80. SNP chip data of EWS ArrayExpress

    ID: E-GEOD-15696

    Description: Ewing sarcoma is one of the solid tumor that developed in children. We performed SNP-chip analysis against 27 specimens of Ewing sarcoma using Affymet...

  81. The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes developmental defects in zebrafish embryos BioProject

    ID: PRJNA154077

    Keywords: Transcriptome or Gene expression

    Access Type: download

  82. Ewing Sarcoma ArrayExpress

    ID: E-GEOD-36859

    Description: ysis: Ewing Sarcoma GSE36858: 5- AZA treatment of EWS cell lines Refer to individual Series...

  83. EWS/ATF1 activates Fos and induces soft tissue sarcomas [Affymetrix]. BioProject

    ID: PRJNA176040

    Keywords: Transcriptome or Gene expression

    Access Type: download

  84. A673 inducible-rescue experiment BioProject

    ID: PRJNA104529

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: A673 Ewing's sarcoma cells, with inducible EWS/FLI cDNA, harboring the EF-2-RNAi retrovirus, induced (or uninduced) for the indicated time period. Keywords: time course Overa...
  85. Targeting EWSR1-FLI1 oncogene induced protein kinase C beta abolishes Ewing sarcoma growth in vivo OmicsDI

    ID: E-GEOD-38392

    Date Released: 07-17-2012

    Description: st Ewing sarcoma. We report the identification of Protein Kinase C Beta (PRKCB) as a protein specifically and highly expressed in Ewing sarcoma as compared to other pediatric cancers. Its transcriptional activation is directly regulated by the

  86. Additional file 9: of EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3634613_D8

    Release Date: 12-15-2016

    Description: List of FUS and EWS ChIP-seq peaks assigned with a position downstream the poly(A)-signal of a target gene. (XLSX 14 kb)

  87. Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription ArrayExpress

    ID: E-GEOD-31838

    Description: Using EWS-FLI and its parental transcription factor, FLI1, we created a unique experimental system to address questions regarding the gen...

  88. Genome-wide chromatin analysis of Ewing sarcoma (RNA-seq) ArrayExpress

    ID: E-GEOD-61950

    Description: We show that EWS-FLI1, an aberrant transcription factor responsible for the pathogenesis of Ewing sarcoma, reprograms gene regulatory circuits b...

  89. EWS-WT1 Oncogene Activates a Neuronal Reprogramming Factor ASCL1 and Mediates Partial Neural Differentiation ArrayExpress

    ID: E-GEOD-53301

    Description: A chromosomal translocation fusion gene product EWS-WT1 is the defining genetic event in Desmoplastic Small Round Cell Tumor (DSRCT), a rare but aggressive tumor with a high rate ...

  90. Gene expression profiling of myxoid liposarcomas (validation set INT-B) ArrayExpress

    ID: E-GEOD-55465

    Description: FUS-CHOP and EWS-CHOP balanced translocations characterize myxoid liposarcoma which encompasses myxoid (ML) and round cell (RC) variants initial...

  91. The human Ewing's Sarcoma oncoprotein EWS-FLI1 causes developmental defects in zebrafish embryos ArrayExpress

    ID: E-GEOD-31185

    Description: The fusion oncoprotein EWS-FLI1 arises from a t(11;22)(q24;q12) chromosomal translocation and causes Ewing's Sarcoma, a malignant bone tumor. The mechani...

  92. Pharmacologic Inhibition of Epigenetic Modification Reveals Targets of Aberrant Promoter Methylation in Ewing Sarcoma ArrayExpress

    ID: E-GEOD-44934

    Description: by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of transcription factors. Although genetic changes in Ewing sarcoma have been extensively researched, our understanding of the role of epigenetic modifications in this neop...

  93. Biological indicators of prognosis in Ewing's sarcoma: An emerging role for LGALS3BP BioProject

    ID: PRJNA106323

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: We create an experimental model of EWS cells that are chemoresistant and unable to give metastasis in mice and identify a molecular signature of potential prognostic ...
  94. EWS/WT1 co-operates with the loss of p53 to exert its oncogenic effects and up-regulates canonical Wnt pathway signaling ArrayExpress

    ID: E-GEOD-42649

    Description: ur (DSRCT). The translocation fuses exon 7 of the EWS gene to exon 8 of the WT1 gene (EWS/WT1). Two splice variants of EWS/WT1 exist, arising from the presence (+KTS) or absence (-KTS) of three amino acids: lysine, threonine and serine between zinc fingers...

  95. The PRC1 protein RING1B contributes to Ewing sarcoma tumorigenesis by repressing the NaV1.6 sodium channel and modulating the NF-kB pathway,... ArrayExpress

    ID: E-GEOD-71007

    Description: lecularly defined by reciprocal translocations of EWSR1 to an ETS transcription factor. The functions of EZH2 and BMI1, two proteins of the Polycomb group (PcG) of epigenetic repressors, have been previously shown to mediate ...

  96. ERG deregulation induces PIM-1 over-expression and aneuploidy in prostate epitheilial cells BioProject

    ID: PRJNA147785

    Keywords: Transcriptome or Gene expression

    Access Type: download

  97. Genome-wide chromatin analysis of Ewing sarcoma (ChIP-seq) ArrayExpress

    ID: E-GEOD-61944

    Description: We show that EWS-FLI1, an aberrant transcription factor responsible for the pathogenesis of Ewing sarcoma, reprograms gene regulatory circuits b...

  98. Ewing samples and EWS-FLI-1 inhibited Ewing cell lines GEMMA

    ID: 2503

    Keywords: functional genomics

    Description: tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced E...

  99. Genome-wide chromatin analysis of Ewing sarcoma (RNA-seq) BioProject

    ID: PRJNA262778

    Keywords: Transcriptome or Gene expression

    Access Type: download

  100. Kids First Pediatric Research Program in Susceptibility to Ewing Sarcoma Based on Germline Risk and Familial History of Cancer BioProject

    ID: PRJNA348787

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: Ewing sarcoma (EWS) is a deadly bone cancer that occurs in children and adolescents. Mounting evidence suggests that a genetic predisposition exis...

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