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Displaying 20 of 797 results for "ETV6"
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  1. Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia GEMMA

    ID: 1832

    Keywords: functional genomics

    Description: ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AML1-positive patients are thus an interesting subgroup to study, and such studies should e...

  2. nd 14 differentially expressed genes characterize TEL/AML1-positive leukemia... OmicsDI

    ID: E-GEOD-9170

    Date Released: 05-02-2014

    Description: ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AML1-positive patients are thus an interesting subgroup to study, and such studies should el...

  3. Untreated 32Dcl3 cell lines expressing oncogenic tyrosine kinases or cells treated with small molecule inhibitors BioProject

    ID: PRJNA105997

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Oncogenic tyrosine kinases, such as BCR-ABL, TEL-ABL, TEL-PDGF-beta-R and FLT3-ITD, play a major role in the development of hematopoietic malignancy. They a...
  4. The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression OmicsDI

    ID: E-GEOD-29639

    Date Released: 12-05-2011

    Description: Background: ETV6/RUNX1 (E/R) (also known as TEL/AML1) is the most frequent gene fusion in childhood acute lymphoblastic leuk...

  5. Affymetrix SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples OmicsDI

    ID: E-GEOD-25116

    Date Released: 05-03-2014

    Description: exome of two cases of pediatric ALL carrying the ETV6/RUNX1 (TEL/AML1) fusion gene (the most common genetic subtype) and corresponding normal samples. A total of 14 somatic mutations were identified, including four and seven protein-altering nucleotide substitutions in each ALL. Twelve mutations (86%) occurred in genes previously described to be mutated in other types of cancer, but none was found to be recurrent in an extended series of 29 ETV6/RUNX1-positive ALLs. The number of single nucleotide mutations was similar to the number of copy number alterations as detected by single nucleotide polymorphism arrays. Although the true pathogene...

  6. Illumina SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples OmicsDI

    ID: E-GEOD-25102

    Date Released: 07-17-2012

    Description: exome of two cases of pediatric ALL carrying the ETV6/RUNX1 (TEL/AML1) fusion gene (the most common genetic subtype) and corresponding normal samples. A total of 14 somatic mutations were identified, including four and seven protein-altering nucleotide substitutions in each ALL. Twelve mutations (86%) occurred in genes previously described to be mutated in other types of cancer, but none was found to be recurrent in an extended series of 29 ETV6/RUNX1-positive ALLs. The number of single nucleotide mutations was similar to the number of copy number alterations as detected by single nucleotide polymorphism arrays. Although the true pathogene...

  7. Genome-scale DNA methylation profiling of TEL/AML positive childhood acute lymphoblastic leukaemia BioProject

    ID: PRJNA139999

    Keywords: Epigenomics

    Access Type: download

  8. PRJNA94565 BioProject

    Access Type: download

    dataset.description: ther, we found that each chromosomal abnormality (TEL/AML1, BCR/ABL, or MLL abnormalities) was associated with a characteristic gene expression signature that was shared by both cell lines and clinical samples. However, BCR/ABL was associated with a much more heterogeneous pattern of expression than were TEL/AML1 and MLL abnormalities. This observation has important implications for the study of BCR/ABL ALL. In addition, we systematically identified genes whose expression was associated with TEL/AML1, BCR/ABL, or MLL abnormalities in both clinical samples and cell lines. Although som...
  9. Untreated 32Dcl3 cell lines expressing oncogenic tyrosine kinases or cells treated with small molecule inhibitors GEMMA

    ID: 1653

    Keywords: functional genomics

    Description: Oncogenic tyrosine kinases, such as BCR-ABL, TEL-ABL, TEL-PDGF-beta-R and FLT3-ITD, play a major role in the development of hematopoietic malignancy. They a...

  10. TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a OmicsDI

    ID: E-GEOD-23842

    Date Released: 05-01-2014

    Description: lignant hematopoiesis. We explored the impact of TEL-AML1 (ETV6-RUNX1), the most common fusion protein in childhood leukemia, on miRNA expression and the leukemic phenotype. Using RNA interference, miRNA expression arrays, and quantitative PCR, we identified miRNA-494 and miRNA-3...

  11. Transcription profiling of human skeletal muscle response to effect of acute physiologic hyperinsulinemia ArrayExpress

    ID: E-GEOD-9105

    Description: ach subject were homogenized in RNAStat solution (Tel-Test Inc., Friendswood, TX), using a Polytron homogenizer (Brinkmann Instruments Westbury, NY). Total RNA was purified with RNeasy and DNase I treatment (Qiagen, Chatsworth, CA). RNA was prepared for hybridization to Affymetrix (Santa Clara, CA) HG-U133A arrays according to the manufacturer’s instructions....

  12. Gene expression data of diagnostic childhood T-ALL samples and human thymocytes ArrayExpress

    ID: E-GEOD-66638

    Description: ntly in the TAL/LMO molecular subtype, and in the TEL-JAK2 mouse model of cortical/mature T-ALL. Surface LTα1β2 protein was detected in primary mouse T-ALL cells, but only upon phorbol ester stimulation or absence of microenvironmental LTβR interaction. Indeed, in contrast to leukemic cells collected from transplanted Ltbr–/– mice or from co-cultures with Ltbr–/– mouse embryonic fibroblasts (MEF), those collected from Ltbr+/+ mice or from Ltbr+/+ MEF co-cultures presented no surface LT expression. Supporting the notion that LT signaling plays a role in T-ALL, inactivation of the Ltbr gene in mice resulted in a statistically significant delay in

  13. Transcription profiling of mouse mammary tumours developed in Wap-Cre;Etv6-NTRK3 mice OmicsDI

    ID: E-GEOD-9355

    Date Released: 03-27-2012

    Description: mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Act...

  14. Microarray expression profiles of mammary tumors developed in Wap-Cre;Etv6-NTRK3 mice BioProject

    ID: PRJNA103049

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Transcription profiling of mouse wild type and Pias1 null cells in response to IFN treatments to study the effect of PIAS1 on interferon (IFN) signali... ArrayExpress

    ID: E-GEOD-1552

    Description: 2h or 4h. Total RNA was prepared with RNA-STAT60 (TEL-TEST) and purified with the RNeasy kit (Qiagen). Double stranded complementary DNA was synthesized from 20 ug of total RNA according to Affymetrix methodology, and purified with Phase Lock Gels (Eppendorf). Biotin-labeled RNA was synthesized with the BioArray High Yield RNA Transcript Labeling Kit (Enzo). Samples were cleaned, fragmentated and hybridized to murine genome (MGU74Av2) Genechips (Affymetrix) as instructed. GeneChips were stained with phycoerythrin-streptavidin (Molecular Probes) and scanned with a GeneChip scanner (Affymetrix)....

  16. n profiling of mouse model that recapitulates the ETV6-NTRK3 fusion oncoprotein the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma... OmicsDI

    ID: E-GEOD-9354

    Date Released: 03-27-2012

    Description: mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Act...

  17. A Unique Rearrangement of PDGFRα and ETV6 in a new t(4;12;6) in a Patient with Acute Myeloid Leukemia (M4) Progressed from Chronic Myelomonocytic Leukemia.... BioProject

    ID: PRJNA318521

    Keywords: Variation

    Access Type: download

  18. RNA-sequencing of B-ALL cell lines, REH treated with LNA GapmeRs against four lncRNAs BioProject

    ID: PRJNA317295

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lysis of the long non-coding RNA transcriptome in ETV6/RUNX1 positive BCP-ALL, one of the most frequent subtypes of pediatric leukemia. An ETV6/RUNX1 expression signature was established, consisting of 596 lncRNAs (434 up and 162 down) using expression analysis of a series of primary patient samples. Subsequently, RNA sequencing from BCP-ALL cell lines and shRNA-mediated silencing of ETV6/RUNX1, illustrated t...
  19. The effect of dominant negative c-Jun, TAM67, on tumorigenesis of ETV6-NTRK3 transduced Eph4 cells BioProject

    ID: PRJNA103045

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. Transcription profiling of mouse mammary tumours developed in Wap-Cre;Etv6-NTRK3 mice ArrayExpress

    ID: E-GEOD-9355

    Description: mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Act...


Displaying 20 of 797 results for "ETV6"