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Displaying 20 of 797 results for "ETV6"
  1. D275P mutant of alcohol dehydrogenase from protozoa Entamoeba histolytica PDB

    ID: PDB:2OUI

    Description: NADP-dependent alcohol dehydrogenase (E.C.

    dataset.creators: Tel-Or, S.
  2. A single amino acid substitution in the Clostridium beijerinckii alcohol dehydrogenase is critical for thermostabilization PDB

    ID: PDB:2B83

    Description: NADP-dependent alcohol dehydrogenase (E.C.

    dataset.creators: Tel-Or, S.
  3. Expression profiling of Ewing sarcoma samples ArrayExpress

    ID: E-GEOD-34620

    Description: oma a rare pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. A genome-wide association study of at least 401 French ES patients compared to either 684 French or 3668 US self-described Caucasian controls consistently revealed candidate loci at chromosomes 1 ...

  4. Expression data from ALL patients included in the set used to construct a classification signature (COALL cohort) BioProject

    ID: PRJNA110079

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: pes with a favorable prognosis characterized by a TEL-AML1-fusion, hyperdiploidy (>50 chromosomes) or E2A-PBX1 fusion and a smaller group with unfavorable outcome characterized by either a BCR-ABL-fusion, MLL-rearrangement or T-ALL. About 25% of precursor B-ALL are ...
  5. Methylation profiling of human pediatric acute lymphoblastic leukemia OmicsDI

    ID: E-MTAB-144

    Date Released: 05-03-2014

    Description: sing ten with high hyperdiploidy and ten with the ETV6/RUNX1 fusion, were included in the study. Four µg of methylated and input fraction DNA were analyzed with a classic MeDIP assay and subsequent microarray hybridization using the Nimbl...

  6. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing OmicsDI

    ID: E-GEOD-28703

    Date Released: 06-26-2012

    Description: disrupting haemopoietic development (58%; GATA3, ETV6, RUNX1, IKZF1, EP300); and inactivating mutations in histone modifying genes (48%; EZH2, EED, SUZ12, SETD2 and EP300). We also identified new targets of mutation including DNM2, ECT2L and RELN. Ten of 12 ETP ALL cases harboured chromosomal rearrangements, several of which complex and resulted in the expression of novel chimeric in-frame fusion genes disrupting haemopoietic regulators. Thus, similar to myeloid malignancies, mutations that drive proliferation, impair differentiation and disrupt histone modification are hallmarks of ETP ALL. Moreover, the global transcriptional profile of ETP ALL was similar to that of normal and myeloid leukaemia haemopoietic stem cel...

  7. Novel kinase fusion oncogenes in post-Chernobyl radiation-induced pediatric thyroid cancers ArrayExpress

    ID: E-GEOD-48850

    Description: g, including the two novel somatic rearrangements ETV6-NTRK3 and AGK-BRAF. Two other tumors harbored distinct fusions leading to overexpression of the nuclear receptor PPARγ. A lower prevalence of fusion oncogenes was found in a cohort of pediatric thyroid cancers from children from the same geographical regions that were not exposed to radiation. Radiation-induced thyroid cancers are a paradigm of tumorigenesis driven by fusion oncogenes that activate MAPK signaling or, less frequently, a PPARγ-driven transcriptional program. Examination of transcriptome profiles and genetic somatic changes in thyroid cancer....

  8. ETV5 Mediated Downstream Gene Activation in Spermatogonial Stem Cells ArrayExpress

    ID: E-GEOD-30683

    Description: ic factor (GDNF) regulated transcription factors, Ets variant gene 5 (Etv5), B-cell CLL/lymphoma 6, member B (Bcl6b) and POU domain, class-3 transcription factor-1 (Pou3f1). We reasoned that these three factors may function as a core-set of transcription factors, regulating genes responsible for maintaining the SSC population. Using transient short-interfering RNA oligonucleotides (siRNA) to individually target Etv5, Bcl6b and Pou3f1 within mouse SSC cultures, we ex...

  9. Expression data from ALL samples for patients included in the Dutch Childhood Oncology Group BioProject

    ID: PRJNA109831

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: pes with a favorable prognosis characterized by a TEL-AML1-fusion, hyperdiploidy (>50 chromosomes) or E2A-PBX1 fusion and a smaller group with unfavorable outcome characterized by either a BCR-ABL-fusion, MLL-rearrangement or T-ALL. About 25% of precursor B-ALL are ...
  10. Integrated Genetic and Epigenetic Analysis of Childhood ALL Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Ph... BioProject

    ID: PRJNA167629

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ising B-progenitor ALL with hyperdiploidy (N=26), ETV6-RUNX1 (N=27), TCF3-PBX1 (N=9), BCR-ABL1 (N=19), rearrangement of MLL (MLLr) (N=20), rearrangement of CRLF2 (N=11, CRLF2r), deletion of ERG (N=11), miscellaneous or normal karyotype (N=14), and T-lineage ALL (N=30), including 4 MLLr cases and 7 cases with early T-cell precursor immunophenotype. Genome-wide profiling of structural DNA alterations was performed for all cases using Affymetrix 500K and SNP 6.0 arrays. Affymetrix U133A gene expression profiling data was available for 154 cases [GEO Series GSE26281]. Genome-wide methylation profiling was performed using the HELP microarray assay, which measures methylation at approximately 50,000 CpGs distributed among 22,722 Refseq promoters. Methylation data was compared to that o...
  11. Gene expression profiling and genome-wide mapping of TEL-AML1 targets in acute leukemia OmicsDI

    ID: E-GEOD-79268

    Date Released: 03-19-2016

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  12. Unsupervised hierarchical clustering of iNPCs induced by 6 or 5 TFs BioProject

    ID: PRJNA153865

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. CDKN1B encoding the cyclin-dependent kinase inhibitor 1B (p27) is located in the minimally deleted region of 12p abnormalities in myeloid malignancies... BioProject

    ID: PRJNA137897

    Keywords: Variation

    Access Type: download

    dataset.description: ) occur in various hematological malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest. Design and Methods: We selected 7 patients with myeloid malignancies and small 12p...
  14. Zea mays subsp. mays : Zea mays subsp. mays Transcriptome or Gene expression BioProject

    ID: PRJNA285341

    Keywords: transcriptome

    Access Type: download

    dataset.description: mRNA-seq of maize chromosome 10 variants: N10, Ab10I, Ab10II, Ab10II-Tel, Ab10I-Pue, and K10L2
  15. Transcription profiling of mouse model or ERM deficiency - analysis of germ stem cell loss ArrayExpress

    ID: E-GEOD-2205

    Description: ew genes were increased in the TM4-ERM line. #5, #6 and #7. Primary Sertoli cells were purified from 4 week old wild; type or ERM knockout or from 10 week old ERM knockout mice and compared....

  16. Identification of RNAs associated with telomeres by enChIP-RNA-Seq OmicsDI

    ID: E-GEOD-60425

    Date Released: 04-17-2015

    Description: o isolate telomeres, a TAL protein, Telomere-TAL (Tel-TAL), recognizing a 19-bp sequence containing an array of TTAGGG (telomere repeats) was fused with 3xFLAG tag and NLS (3xFN-Tel-TAL) and LexA protein (3xFNLDD)11 were expressed in a mouse hematopoietic cell line, Ba/F3, respectively. The cells were crosslinked with formaldehyde, and crosslinked chromatin was fragmented by sonication. Subsequently, chromatin complexes containing 3xFN-Tel-TAL or 3xFNLDD were immunoprepicitated with anti-FLAG M2 Ab. Supplementary URL:

  17. Transcriptomic Classification of Genetically Engineered Mouse Models of Breast Carcinoma Identifies Human Subtype Counterparts OmicsDI

    ID: E-GEOD-42640

    Date Released: 05-03-2014

    Description: ap-Myc, and Trp53-/-. Interestingly, the TgWAPCre-Etv6 model mimicked the HER2-enriched subtype, a group of human tumors without a murine counterpart in previous comparative studies. Gene signature analysis identified hundreds of commonly expressed pathways between linked mouse and human subtypes, highlighting potentially common genetic drivers of tumorigenesis and candidate pathways for therapeutic intervention. Conclusion: This study consolidates murine models of breast carcinoma into the largest comprehensive transcriptomic dataset to date to identify human-mouse disease subtype counterparts. This approach illustrates the value of comparisons between species to identify murine models that faithfully mimic the human condition and indicates that multiple GEMMs are needed to represent the diversity of human breast cancers. These trans-species associations should guide model selection during preclinical study design to ensure appropriate representatives of the human disease subtypes are used. Keywords: breast cancer, comparative genomics, genetically engineered mouse models, and molecular pathway signatures refere...

  18. SNP data of MPD/MPN samples OmicsDI

    ID: E-GEOD-19647

    Date Released: 05-02-2014

    Description: isease progression including established targets (ETV6, TP53 and RUNX1), as well as new candidate genes on 7q, 16q, 19p and 21q. Moreover, trisomy 8 or amplification of 8q24 (MYC) was almost exclusively detected in JAK2V617F(-) cases with MPN-blast phase. Remarkably, copy-number neutral-loss of heterozygosity (CNN-LOH) on either 7q or 9p including homozygous JAK2V617F was related to decreased survival after leukemic transformation (p=0.01 and p=0.016, respectively). Our high density SNP-array analysis of MPN genomes in the chronic compared to leukemic stage identified novel target genes and provided prognostic insights associated with the evolution to leukemia. Keywords: SNP-chip To identify oncogenic lesions in MPD, we performed a genome-wide analysis of primary MPD samples using high-density SNP arrays (Affymetrix GeneChip)....

  19. Transcription profiling of human AML FAB-M0 samples OmicsDI

    ID: E-GEOD-17061

    Date Released: 06-10-2011

    Description: ription regulators such as CEBPA, CEBPD, PU.1 and ETV6 and the differentiation associated gene MPO appeared strongly down-regulated, in line with the very primitive state of this type of leukemia. Moreover, AML M0 cases appeared to have a strong positive correlation with a previously defined immature AML subgroup with adverse prognosis. AML-M0 leukemias frequently carry loss-of-function RUNX-1 mutation and unsupervised analyses revealed a striking distinction between cases with and without mutations. RUNX1 mutant AML-M0 samples showed a distinct up-regulation of B-cell-related genes, e.g. members of the B-cell receptor complex, transcriptions regulators RUNX3, ETS2, IRF8 or PRDM1 and major histocompatibility complex class II genes. Importantly, expression ...

  20. Genetic variegation of clonal architecture and stem cells in leukaemia OmicsDI

    ID: E-GEOD-24412

    Date Released: 12-16-2010

    Description: tion. We have examined this issue in ALL in which ETV6-RUNX1 gene fuson is an early or initiating genetic lesion followed by a modest number of driver copy number alterations. By multiplexing FISH probes for these mutations, up to eight genetic abnormalities can be detected in single cells, a genetic signature of sub-clones identified and a composite...

Displaying 20 of 797 results for "ETV6"