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Displaying 20 of 197 results for "ESAM"
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  1. Cell Image Library Dataset CIL:39073 CIL

    ID: 39073

    Description: and mesonephros were fluoresently stained with an endothelial and germ cell marker called PECAM (platelet endothelial cell adhesion molecule). The long projections extending from the right are the

    Data Types: image

  2. Inflammation-induced chemokine expression in uveal melanoma cell lines stimulates monocyte chemotaxis OmicsDI

    ID: E-GEOD-55983

    Date Released: 08-02-2014

    Description: We used an in vitro co-culture system in which UM cell lines and T cells were cultured together, but separated by a membrane. UM gene expression was quantified using a microarray. Protein expression in the supernatant was quantified with ELISA or cytometric bead array. For the monocyte migration assay, a trans-well plate was used. Results: Gene-expression analysis of UM cell lines showed that co-culture with activated T cells resulted in an upregulation of chemokines such as CXCL8, CXCL9, CXCL10, CXCL11, CCL2, CCL5, vascular endothelial growth factor (VEGF), intracellular adhesion

  3. Transcription profiling of rat nucleus accumbens of alcohol-preferring animals following chronic ethanol consumption ArrayExpress

    ID: E-GEOD-13524

    Description: Rap1ga1, Ece1, Dhrs3, Plod1, Kif1b, Nmnat1, Srpr, Esam) significantly different between the CA and W groups located within both mouse and rat ethanol QTLs, suggesting that these genes may contribute to ethanol drinking behavior. In conclusion, the robust differences in gene expression found between the CA and W groups, but not observed between the MSA and W groups, may be a result of the higher daily ethanol intakes of the CA group, and/or its initial ethanol withdrawal. Experiment Overall Design: 10 samples each of control, continuous ethanol and limited access ethanol...

  4. Using Oligo Array Analysis to Determine Genes of Importance in the Meninges and Associated Vasculature Function and their Sensitivity to Amphetamine T... ArrayExpress

    ID: E-GEOD-23093

    Description: decreased more with AMPH than EIH, and Cldn 9 and Esam were increase only by AMPH. It is not known how these changes affect BBB function and integrity. Gene expression patterns in MAV were compared to two regions of brain (striatum and parietal cortex) to identify genes important to MAV function and determine whether their expressions were sensitive to a neurotoxic exposure to amphetamine....

  5. Imprints of atherosclerosis are present in circulating T cells of patients with Familial Hypercholesterolemia BioProject

    ID: PRJNA97641

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: LDL, elevated amounts of scavenger receptors and adhesion molecules, and differences in the regulation of intracellular lipoprotein metabolism compared to monocytes from healthy individuals. Furthermore, the monocyte subpopulation of CD14+/CD16+ cells is less frequent in FH but exhibits significantly higher levels of CD11c and CD29 which increases the likelihood for their transmigration through the endothelial layer. The presence of increased amounts of CD69 in T lymphocytes from FH patients suggests that these cells are more activated than control cells. Our results indicate that some important steps of atherosclerosis formation already take place in circulating blood cells which extends current atherosclerosis models to the plasma compartment. Keywords: atherosclerosis, T cells, Familial Hypercholesterolemia Overall design: 23 T cells samples: 3 homozygous FH, 7 heterozygous FH, 13 control participants...
  6. Increased CD226 Expression on CD8+ T cells in Patients with Systemic Sclerosis OmicsDI

    ID: E-GEOD-63903

    Date Released: 01-02-2015

    Description: xpression of genes related to immune response and cell adhesion, including CD226 (also known as DNAX accessory molecule-1, DNAM-1), was significantly altered. Moreover, detailed analysis of CD226 revealed that CD226highCD8+ T cells were increased in SSc patients (mean, 50.7%) compared with healthy controls (32.9%) and were appreciably associated with the severity of skin sclerosis and interstitial lung disease. Further, CD226highCD8+ T cells from SSc patients produced abundant IL-13 and were positively correlated with the cytotoxic capacity of CD8+ T cells against HUVECs. Finally, the neutralization of CD226 impaired IL-13 production and cytolysis against HUVECs. These findings indicate that upregulated CD226 expressio...

  7. Pam3Cys-treated HUVEC before and after TLR2 knockdown BioProject

    ID: PRJNA144041

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n directly activate the endothelium by binding to endothelial cell (EC) Toll-like receptor 2 (TLR2). In this report, we perform the most comprehensive analysis to date of the immune-related genes regulated after activation of endothelial TLR2 by bacterial di- and triacylated lipopeptides. We found that TLR2 activation specifically induces the expression of IL6, IL8, CSF2, CSF3...
  8. Altered Hepatic Gene Expression Profiles Associated with Myocardial Ischemia BioProject

    ID: PRJNA112115

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in the liver. Genes related to tissue remodeling, adhesion molecules, and morphogenesis were significantly upregulated in the livers of mice with myocardial I/R or infarction, but not in those with liver I/R. Myocardial ischemia, but not changes in the hemodynamic state, was postulated to significantly alter hepatic gene expression. Moreover, detailed analysis of the signaling pathway suggested the presence of humoral factors that intervened between the heart and liver. To address these points, we utilized isolated primary hepatocytes and showed that osteopontin released from the heart actually altered the signaling pathways of primary hepatocytes to those observed in the livers of mice under myocardial ischemia. Moreover, osteopontin stimulated primary hepatocytes to secrete vascular endothelial growth factor-A, which is important for tissue remodeling. Conclusion...
  9. Efficient detection and purification of cell populations using synthetic microRNA switches ArrayExpress

    ID: E-GEOD-60633

    Description: Isolation of specific cell types, including pluripotent stem cell (PSC)-derived populations, is frequently accomplished using

  10. Expression data from thymic and lymph node mesenchymal stromal subsets ArrayExpress

    ID: E-GEOD-76974

    Description: tanding of primary and secondary lymphoid stromal cell heterogeneity and ontogeny remains limited. Here, using genome-wide expression profiling and phenotypic and localization studies, we identify a functionally distinct subse...

  11. Decorin and EphA2 mediate Carcinoembryonic Antigen Cell Adhesion Molecule 1-L inhibition of colorectal cancer metastasis OmicsDI

    ID: E-GEOD-73208

    Date Released: 09-26-2015

    Description: ersus CT cells. Decorin was detected at the peri-endothelial layers of large blood vessels and in liver stellate cells. In metastatic lesions, it was expressed in pericyte-like cells covering capillary endothelium. Phosphokinase differential screening revealed reduced Ephrin type-A receptor 2 (EphA2) expression and activity in CC1-L- versus CT-expressing cells. Treatment of CT cells with recombinant Dcn led to decreased migration and invasion and decreased EphA2-mediated Erk and Akt signaling. CRC patients exhibiting high CC1 and DCN expression, in combination with low EPHA2 expression, benefit from longer 10-year survival than those with high EPHA2 expression. Conclusion CC1-L expression in poorly differentiated CRC inhibits liver metastasis through increased Decorin expression and EphA2-mediated signaling. Quadriplicate samples of each mouse colon cancer cell lines (control cells versus those expressing either short or long isoform of CEACAM1) have been used for RNA extraction...

  12. An RNA-Seq transcriptome and splicing database of neurons, glia, and vascular cells of the cerebral cortex ArrayExpress

    ID: E-GEOD-52564

    Description: To better understand the function of the various cell types of the brain, we prospectively purified neurons, astrocytes, oligodendrocyte precursor cells, newly formed oligodendrocytes, mye...

  13. Genome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease) ArrayExpress

    ID: E-GEOD-49045

    Description: nsive shock and peripheral edema due to transient endothelial hyperpermeability. SCLS is often accompanied by a monoclonal gammopathy of unknown significance (MGUS). Using Affymetrix Single Nucleotide Polymorphism (SNP) microarrays, we performed the first genome-wide SNP analysis of SCLS in a cohort of 12 disease subjects and 18 controls. Exome capture sequencing was performed on genomic DNA f...

  14. PRJNA259162 BioProject

    Access Type: download

    dataset.description: Isolation of specific cell types, including pluripotent stem cell (PSC)-derived populations, is frequently accomplished using
  15. Transcription profiling of human bone marrow endothelial cells in patients with multiple myeloma OmicsDI

    ID: E-GEOD-14230

    Date Released: 05-04-2014

    Description: ne/molecular fingerprint of multiple myeloma (MM) endothelial cells (MMECs), also identifying some of the vascular mechanisms that govern the malignant progression from quiescent monoclonal gammopat...

  16. esenchymal Stem/Progenitors and Other Endometrial Cell Types from Women with Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential... ArrayExpress

    ID: E-GEOD-48301

    Description: ting the gene expression of different endometrial cell populations, including stem cells and their differentiated progeny. Design and setting: A prospective study conducted at an academic medical center. Patients and Main Outcome Measures: Proliferative phase endometrium was obtained from 6 overweight/obese PCOS (NIH criteria) and 6 overweight/obese controls. Microarray analysis was performed on fluorescence-activated cell sorting (FACS)-isolated endometrial epithelial cells (eEP),

  17. An RNA-Seq transcriptome and splicing database of neurons, glia, and vascular cells of the cerebral cortex BioProject

    ID: PRJNA229389

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: To better understand the function of the various cell types of the brain, we prospectively purified neurons, astrocytes, oligodendrocyte precursor cells, newly formed oligodendrocytes, mye...
  18. Cell Image Library Dataset CIL:11211 CIL

    ID: 11211

    Description: Upper: capillary endothelial cell junction in the rete mirabile of the gas bladder of the toadfish Opsanus tau shows dense intrac...

    Data Types: image

  19. Transcription profiling by array of human circulating monocytes from patients with familial hypercholesterolemia, homozygous or heterozygous mutant fo... ArrayExpress

    ID: E-GEOD-6054

    Description: LDL, elevated amounts of scavenger receptors and adhesion molecules, and differences in the regulation of intracellular lipoprotein metabolism compared to monocytes from healthy individuals. Furthermore, the monocyte subpopulation of CD14+/CD16+ cells is less frequent in FH but exhibits significantly higher levels of CD11c and CD29 which increases the likelihood for their transmigration through the endothelial layer. The presence of increased amounts of CD69 in T lymphocytes from FH patients suggests that these cells are more activated than control cells. Our results indicate that some important steps of atherosclerosis formation already take place in circulating blood cells which extends current atherosclerosis models to the plasma compartment. Experiment Overall Design: 25 monocytes samples: 5 homozygous FH, 7 heterozygous FH, 13 control participants...

  20. Transcription profiling by array of human CD3 positive T cells from patients with familial hypercholesterolemia ArrayExpress

    ID: E-GEOD-6088

    Description: LDL, elevated amounts of scavenger receptors and adhesion molecules, and differences in the regulation of intracellular lipoprotein metabolism compared to monocytes from healthy individuals. Furthermore, the monocyte subpopulation of CD14+/CD16+ cells is less frequent in FH but exhibits significantly higher levels of CD11c and CD29 which increases the likelihood for their transmigration through the endothelial layer. The presence of increased amounts of CD69 in T lymphocytes from FH patients suggests that these cells are more activated than control cells. Our results indicate that some important steps of atherosclerosis formation already take place in circulating blood cells which extends current atherosclerosis models to the plasma compartment. Experiment Overall Design: 23 T cells samples: 3 homozygous FH, 7 heterozygous FH, 13 control participants...


Displaying 20 of 197 results for "ESAM"