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Displaying 20 of 197 results for "ESAM"
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  1. Gene expression profiling reveals novel protective effects of Aminaphtone on ECV304 endothelial cells ArrayExpress

    ID: E-GEOD-83297

    Description: several vasoactive factors, like endothelin-1 and adhesion molecules. We analysed in vitro the effects of Aminaphtone on whole-genome gene expression. ECV304 endothelial cells were stimulated with IL-1β 100 U/ml in the presence or absence of Aminaphtone 6 μg/ml. Gene expression profiles...

  2. Acute venous hypertension induces local release of inflammatory cytokines and endothelial activation in humans OmicsDI

    ID: E-GEOD-38783

    Date Released: 06-02-2014

    Description: ions in homeostasis by promoting inflammation and endothelial cell (EC) activation. We used an experimental model of acute, local venous hypertension to study the changes in circulating inflammatory mediators and EC phenotype that occur in response to biomechanical stress. Methods and Results: Twenty-four healthy subjects (14 men, age 35±2 y...

  3. Transcription profiling of human bone marrow endothelial cells in patients with multiple myeloma ArrayExpress

    ID: E-GEOD-14230

    Description: ne/molecular fingerprint of multiple myeloma (MM) endothelial cells (MMECs), also identifying some of the vascular mechanisms that govern the malignant progression from quiescent monoclonal gammopat...

  4. Gene expression profiles of normal human mammary cell subpopulations FACS sorted based on expression of CD49f and EpCAM OmicsDI

    ID: E-GEOD-16997

    Date Released: 05-02-2014

    Description: ations in human mammary tissue, hematopoietic and endothelial cells were depleted from freshly isolated cell suspensions derived from reduction mammoplasties by fluorescence-activated <

  5. Astroglial Connexin 43 sets the blood brain barrier immune quiescence BioProject

    ID: PRJNA236552

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tes with the central nervous system (CNS), immune cell migration across the blood brain barrier (BBB) is kept at a very low level and the unique CNS microenvironment strictly restricts immune reactions. Here, we identified the astroglial gap junction protein Connexin 43 has a new actor of this homeostasis. We showed tha...
  6. Inhibition of VCAM-1 expression by CORM-3: the role of the ubiquitin proteasome system, p38 and mitochondrial respiration ArrayExpress

    ID: E-GEOD-22175

    Description: ates TNF-alpha mediated inflammatory responses in endothelial cells, yet, the underlying mechanism hereof is still elusive. We sought to explore potential mechanisms by which CO down-regulates VCAM-1 express...

  7. Mechanical shear effects on flexor tendon cells BioProject

    ID: PRJNA95253

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Adhesion formation after flexor tendon repair remains a clinical problem. Early postoperative motion after tendon repair has been d...
  8. Interaction between endothelium and chronic lymphocytic leukemia B-cells rescues from apoptosis and modulates gene expression profile of leukemic cell... BioProject

    ID: PRJNA138693

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ells (CLL) reside in close contact with activated endothelial cells (EC) in infiltrated tissues. Here, we investigated the interactions between EC and CLL cells, highlighting molecular networks involved in this ce...
  9. Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma BioProject

    ID: PRJNA111151

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. CLL: CD38+CD49d+ vs. CD38-CD49d- GEMMA

    ID: 2171

    Keywords: functional genomics

    Description: ed media from CCL3-stimulated macrophages induced endothelial cells to express VCAM-1, the CD49d ligand, likely through TNF? over-production. These effects were apparent in BMB from CD38+CD49d+CLL, where lymphoid infiltrates were characterized by a prominent meshwork of VCAM-1+ stromal/endothelial cells. Lastly, CD49d engagement by VCAM-1-transfectants increased viability of CD38+CD49d+ CLL cells. Altogether, CD38 and CD49d can be thought of as a part of a consecutive chain of events ultimately leading to improved survival of CLL cells. Last Updated (by provider): Jan 27 2009 Contributers: Antonella Zucchetto Gianluca Gaidano Dania Benedetti Riccardo Bomben Valter Gattei Francesca M Rossi Daniela Marconi Vito Franco Pietro Bulian Claudio Tripolo Michele Dal Bo Davide Rossi Giovanni Del Poeta Francesco Tedesco Massimo Deagan Fabio Malavasi Debora Lorenzon...

  11. Gene expression profile of murine bone marrow endosteal populations (1) OmicsDI

    ID: E-GEOD-17569

    Date Released: 06-10-2011

    Description: ions as a key component of the hematopoietic stem cell niche. But it is still unclear that the precise cellular and molecular contribution of endosteal cell populations on the HSC supportive ...

  12. Synthetic mRNA switches for detection and purification of cardiomyocytes and endothelial cells derived from human pluripotent stem cells [mRNA] BioProject

    ID: PRJNA259165

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. Expression data from thymic and lymph node mesenchymal stromal subsets. OmicsDI

    ID: E-GEOD-76974

    Date Released: 03-05-2016

    Description: tanding of primary and secondary lymphoid stromal cell heterogeneity and ontogeny remains limited. Here, using genome-wide expression profiling and phenotypic and localization studies, we identify a functionally distinct subse...

  14. Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils BioProject

    ID: PRJNA185178

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tomics approach was used in mice to compare these cell types. Our data show that the three populations of neutrophils are significantly different in their mRNA profiles with NN and G-MDSC being more closely related to each other than to TAN. Structural genes and genes related to cell-cytotoxicity (i.e. respiratory burst) were significantly down-regulated in TAN. In contrast, many immune-related genes and pathways, including genes related to the antigen presenting complex (e.g. all six MHC-II complex genes), and cytokines (e.g. TNF-a, IL-1-a/b), were up-regulated in G-MDSC, and further up-regulated in TAN. Thirteen of t...
  15. ER alpha rapid signaling is required for estrogen induced proliferation and migration of vascular endothelial cells OmicsDI

    ID: E-GEOD-72180

    Date Released: 03-26-2016

    Description: diated by interaction between ERa and the adaptor molecule striatin. Here we identify a triple point mutation (AA 231,233 & 234 KRR->AAA) of full length ERa that blocks its association with striatin and eliminates its ability to perform rapid signaling (without affecting its ability to perform genomic signaling). We have created stably-transfected human vascular endothelial cell lines expressing either WT ERa (WT ECs) or KRR mutant ERa (KRR ECs), and use these cells to show that rapid signaling through ERa is required for the proper regulation of most E2-regulated genes (the data presented in this record), and...

  16. Positive and Negative Spatial Gradients of High Wall Shear Stress Have Different Effects on Endothelial Gene Expression ArrayExpress

    ID: E-GEOD-37127

    Description: tive WSSG. Little is known about the responses of endothelial cells (ECs) to either positive or negative WSSG under high WSS conditions. We used cDNA microarrays to profile EC gene expression exposed to positive WSSG vs. negative WSSG for 24 hours in a flow chamber with converging and diverging channels, respectively. WSS varied between 3.5 and 28.4 Pa in each gradient channel. GO and biological pathway analysis indicated that positive WSSG favored proliferation, apoptosis, and extracellular matrix pr...

  17. Synthetic mRNA switches for detection and purification of cardiomyocytes and endothelial cells derived from human pluripotent stem cells [mRNA] ArrayExpress

    ID: E-GEOD-60632

    Description: tumor. Simultaneous purification of two different cell types, cardiomyocytes and endothelial cells, was also performed by transfecting the mRNA responding to the both miR-208 and miR-126, into heterogeneous cell population derived from hPSCs. In addition, selective induction of apoptosis in noncardiomyocytes triggered by miR-1/208-Bim switch enriched cardiomyocytes without cell sorting. The mRNA switch could purify desired cell types and control cell death pathways by monitoring the miRNA expression dynami...

  18. Positive and Negative Spatial Gradients of High Wall Shear Stress Have Different Effects on Endothelial Gene Expression BioProject

    ID: PRJNA158301

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils ArrayExpress

    ID: E-GEOD-43254

    Description: tomics approach was used in mice to compare these cell types. Our data show that the three populations of neutrophils are significantly different in their mRNA profiles with NN and G-MDSC being more closely related to each other than to TAN. Structural genes and genes related to cell-cytotoxicity (i.e. respiratory burst) were significantly down-regulated in TAN. In contrast, many immune-related genes and pathways, including genes related to the antigen presenting complex (e.g. all six MHC-II complex genes), and cytokines (e.g. TNF-a, IL-1-a/b), were up-regulated in G-MDSC, and further up-regulated in TAN. Thirteen of t...

  20. The Drosophila surface glia transcriptome: insights into conserved blood-brain barrier physiologies BioProject

    ID: PRJNA193507

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: scriptome contains many ABC and SLC transporters, cell adhesion molecules, xenobiotic metabolism pathways, metabolic enzymes, and signaling molecules. Using gene set enrichment analyses and sequence-based comparisons, we compare the Drosophila surface glia to the vertebrate vascular endothelial BBB. Overall design: Each replicate for the microarray analysis represented sorted cells originating from different growth bottles and processed on different days. Five total replicates were run for each of the following genotypes: wildtype whole brain, and sorted GFP positive cells from Repo, Elav, and 9-137....

Displaying 20 of 197 results for "ESAM"