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Displaying 50 of 197 results for "ESAM"
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  1. ESAM_RAT UniProt:Swiss-Prot

    ID: Q6AYD4

    Description: Endothelial cell-selective adhesion molecule Extracellular Helical Cytopla...

  2. Microarray analyses of ESAM positive cells in the CD34(+) CD38(-) fraction of collagenase-treated bones BioProject

    ID: PRJNA269303

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Microarray analyses of ESAM positive cells in the CD34(+) CD38(-) fraction of collagenase-treated bones OmicsDI

    ID: E-GEOD-63877

    Date Released: 01-02-2015

    Description: We previously identified endothelial cell-selective adhesion molecule (ESAM) as ...

  4. Microarray analyses of ESAM positive cells in the CD34(+) CD38(-) fraction of collagenase-treated bones ArrayExpress

    ID: E-GEOD-63877

    Description: We previously identified endothelial cell-selective adhesion molecule (ESAM) as ...

  5. Microarray analysis of WT ESAM+ and ESAM- cDC subsets BioProject

    ID: PRJNA195894

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Gene expression analysis of primitive erythroid progenitors from 5-FU-treated WT and ESAM-KO mice. BioProject

    ID: PRJNA297177

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Microarray analysis of WT ESAM+ and ESAM- cDC subsets ArrayExpress

    ID: E-GEOD-45679

    Description: echniques to deplete specific classical dendritic cell (cDC) subsets and analyze immunity to the A/E pathogen Citrobacter rodentium. We find that Zbtb46+ cDCs, and specifically Notch2-dependent intestinal CD11b+ cDCs, but not Batf3-dependent CD103+ cDCs, are required for IL-23 production and immunity against C. rodentium. Notch2 controls cDC differentiation at a terminal step mediated by lymphotoxin signaling. Importantly, these results provide the first demonstration of a non-redundant fun...

  8. ESAM_MOUSE UniProt:Swiss-Prot

    ID: Q925F2

    Description: Endothelial cell-selective adhesion molecule Extracellular Helical Cytopla...

  9. The affect of specific ablation of Runx3 from Esam splenic dendritic cells BioProject

    ID: PRJNA210762

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Transcription profiling of human ermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T241/VEGF-C/GFP metastatic fibrosarcoma reveals lymphatic endoth... ArrayExpress

    ID: E-GEOD-6255

    Description: paring the RNA profile of normal dermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T-241/VEGF-C metastatic fibrosarcoma. Our findings reveal significant changes in the expression of some 792 genes in tumour lymphatics (≥ 2 fold up/downregulation, p ≤ 0.05), involving particularly transcripts associated with junctional adhesion, immunomodulation, extracellular matrix and vessel growth/patterning, several of which we have confirmed by RT-PCR and/or immunohistochemistry. Interestingly, this altered phenotype could not be attributed sol...

  11. Transcription profiling of mouse CD31(+) cells isolated from embryonic stem cells ArrayExpress

    ID: E-TABM-1125

    Description: riment is the identification of genes involved in endothelial differentiation. This is of great interest for the understanding of the cellular and molecular mechanisms involved in the development of new blood vessels. Mouse embryonic stem (mES) cells serve as a potential source of endothelial cells for transcriptomic analysis. We isolated endothelial cells from 8-days old embryoid bodies by immuno-magnetic ...

  12. Microarray analysis of WT ESAM+ and ESAM- cDC subsets OmicsDI

    ID: E-GEOD-45679

    Date Released: 06-17-2013

    Description: echniques to deplete specific classical dendritic cell (cDC) subsets and analyze immunity to the A/E pathogen Citrobacter rodentium. We find that Zbtb46+ cDCs, and specifically Notch2-dependent intestinal CD11b+ cDCs, but not Batf3-dependent CD103+ cDCs, are required for IL-23 production and immunity against C. rodentium. Notch2 controls cDC differentiation at a terminal step mediated by lymphotoxin signaling. Importantly, these results provide the first demonstration of a non-redundant fun...

  13. PECA1_BOVIN UniProt:Swiss-Prot

    ID: P51866

    Description: Platelet endothelial cell adhesion molecule Extracellular Helical Cytoplasmic Ig-li...

  14. The affect of specific ablation of Runx3 from Esam splenic dendritic cells ArrayExpress

    ID: E-GEOD-48590

    Description: Esam/CD4+ dendritic cells are part of the innate immunity essential for priming and activating of CD4+ T cells To identify Runx3 re...

  15. ESAM_MACFA UniProt:Swiss-Prot

    ID: Q95KI3

    Description: Endothelial cell-selective adhesion molecule Extracellular Helical Cytopla...

  16. PECA1_PIG UniProt:Swiss-Prot

    ID: Q95242

    Description: Platelet endothelial cell adhesion molecule Extracellular Helical Cytoplasmic Ig-li...

  17. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine ArrayExpress

    ID: E-GEOD-31551

    Description: distinct population marked by high expression of adhesion molecule Esam. The Notch-dependent Esamhi DC subset also required lymphotoxin beta receptor signaling, proliferated in situ and facilitated efficient CD4+ T cell priming. The Notch-independent Esamlo DCs expressed monocyte-related genes and showed superior cytokine responses. In addition, Notch2 deletion led to the loss of CD11b+ CD103+ DCs in the intestinal lamina propria and to the corresponding decrease of IL-17-producing CD4+ T cells in the intestine. Thus,Notch2 is ...

  18. Lymphatic endothelium of metastatic tumours has a distinct transcription profile. BioProject

    ID: PRJNA99687

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: paring the RNA profile of normal dermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T-241/VEGF-C metastatic fibrosarcoma. Our findings reveal significant changes in the expression of some 792 genes in tumour lymphatics (≥ 2 fold up/downregulation, p ≤ 0.05), involving particularly transcripts associated with junctional adhesion, immunomodulation, extracellular matrix and vessel growth/patterning, several of which we have confirmed by RT-PCR and/or immunohistochemistry. Interestingly, this altered phenotype could not be attributed sol...
  19. The affect of specific ablation of Runx3 from Esam splenic dendritic cells OmicsDI

    ID: E-GEOD-48590

    Date Released: 06-28-2014

    Description: Esam/CD4+ dendritic cells are part of the innate immunity essential for priming and activating of CD4+ T cells To identify Runx3 re...

  20. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine OmicsDI

    ID: E-GEOD-31551

    Date Released: 12-05-2011

    Description: distinct population marked by high expression of adhesion molecule Esam. The Notch-dependent Esamhi DC subset also required lymphotoxin beta receptor signaling, proliferated in situ and facilitated efficient CD4+ T cell priming. The Notch-independent Esamlo DCs expressed monocyte-related genes and showed superior cytokine responses. In addition, Notch2 deletion led to the loss of CD11b+ CD103+ DCs in the intestinal lamina propria and to the corresponding decrease of IL-17-producing CD4+ T cells in the intestine. Thus,Notch2 is ...

  21. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine BioProject

    ID: PRJNA145485

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: distinct population marked by high expression of adhesion molecule Esam. The Notch-dependent Esamhi DC subset also required lymphotoxin beta receptor signaling, proliferated in situ and facilitated efficient CD4+ T cell priming. The Notch-independent Esamlo DCs expressed monocyte-related genes and showed superior cytokine responses. In addition, Notch2 deletion led to the loss of CD11b+ CD103+ DCs in the intestinal lamina propria and to the corresponding decrease of IL-17-producing CD4+ T cells in the intestine. Thus,Notch2 is ...
  22. Inflammatory signaling regulates fetal hematopoiesis BioProject

    ID: PRJNA239780

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Multiple signaling pathways contribute to blood cell formation in the fetus, but a role for innate immune/inflammatory signaling has not been described. Here we show that mouse fe...
  23. Transcription profiling of human ermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T241/VEGF-C/GFP metastatic fibrosarcoma reveals lymphatic endoth... OmicsDI

    ID: E-GEOD-6255

    Date Released: 03-27-2012

    Description: paring the RNA profile of normal dermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T-241/VEGF-C metastatic fibrosarcoma. Our findings reveal significant changes in the expression of some 792 genes in tumour lymphatics (≥ 2 fold up/downregulation, p ≤ 0.05), involving particularly transcripts associated with junctional adhesion, immunomodulation, extracellular matrix and vessel growth/patterning, several of which we have confirmed by RT-PCR and/or immunohistochemistry. Interestingly, this altered phenotype could not be attributed sol...

  24. Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood ArrayExpress

    ID: E-GEOD-50800

    Description: ment binding transcription factor 1 (SREBF1), and endothelial cell adhesion molecule (ESAM). There were 8 pathways identified that met the criteria for significance, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism. Participants that increased insulin sensitivity exhibited five times the number of significant genes altered compared to non-responders (1,144 vs. 230). These findings offer insight into the molecular mechanisms underlying health improvements among high-risk Latino youth. Lifestyle interventions may contribute to improved insulin sensitivity through pathways related to insulin signaling and immune response. Further, genetic factors may mediate response to lifestyle intervention. Fifteen (7M/8F) overweight/obese Latino Youth Whole blood RNA samples evaluated pre and post intervention....

  25. Transcription profiling of human blood outgrowth endothelial cells of 3 members of Kindred Vermont II - cell adhesion molecule ArrayExpress

    ID: E-GEOD-17078

    Description: microarray expression analysis of Blood Outgrowth Endothelial Cells of 3 members of Kindred Vermont II compared to a well established normal control group indicated that IgsF4 was decreased in patients versus controls. In addition, both statistical and pathway analysis results suggested that these genes are associated protein C. Further studies indicated that Cell Adhesion Molecule 1 (CADM1), a member of the IgsF4 superfamily, may be associated with VT. Experiment Overal...

  26. The crystal structure of PECAM-1 IgL1-2 trans-homophilic dimer PDB

    ID: PDB:5GNI

    Description: Platelet endothelial cell adhesion molecule

  27. Data from: Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors Dryad

    DateIssued: 07-18-2016

    Description: echanisms that govern their capture by the target cell. Next-generation pharmacokinetic (PK) models that systematically account for proteomic and mechanical factors can accelerate the design, validation and translation of targeted nanocarriers (NCs) in the clinic. Towards this objective, we have developed a computational m...

  28. Crystal structure of PECAM-1 D1D2 domain PDB

    ID: PDB:5C14

    Description: Platelet endothelial cell adhesion molecule

  29. Angiogenesis inhibitors ameliorates inflammatory infiltrate, fibrosis and portal pressure in cirrhotic rats BioProject

    ID: PRJNA98087

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nt of vascular density and expression of vascular endothelial growth factor-A (VEGF-A), angiopoietin-1, angiopoietin-2 and placental growth factor (PlGF) in cirrhotic livers. The newly formed hepatic vasculature expressed vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Interestingly, the expression of these adhesion molecules correlated well with local inflammatory infiltrate. Livers of cirrhotic rats treated with angiogenesis inhibitors presented a significant decrease in hepatic vascular density, inflammatory infiltrate, a-SMA abundance, collagen expression and portal pressure. Conclusion: Angiogenesis inhibitors may offer a potential novel therapy for cirrhosis due to its multiple mechanisms of action against angiogenesis, inflammation and fibrosis in cirrhotic livers. Keywords: angiogenesis, cirrhosis, liver, Affymetrix, fibrosis Overall design: RNA from liver of 4 non-treated cirrhotic rats or...
  30. Hydroxyurea stimulates production of pro-inflammatory cytokines in endothelial cells: Relevance to sickle cell disease. BioProject

    ID: PRJNA106597

    Keywords: Transcriptome or Gene expression

    Access Type: download

  31. Loss of Pim1 Imposes a Hyperadhesive Phenotype on Endothelial Cells BioProject

    ID: PRJNA147619

    Keywords: Transcriptome or Gene expression

    Access Type: download

  32. Transcription profiling of human blood outgrowth endothelial cells of 3 members of Kindred Vermont II - cell adhesion molecule OmicsDI

    ID: E-GEOD-17078

    Date Released: 06-10-2011

    Description: microarray expression analysis of Blood Outgrowth Endothelial Cells of 3 members of Kindred Vermont II compared to a well established normal control group indicated that IgsF4 was decreased in patients versus controls. In addition, both statistical and pathway analysis results suggested that these genes are associated protein C. Further studies indicated that Cell Adhesion Molecule 1 (CADM1), a member of the IgsF4 superfamily, may be associated with VT. Experiment Overal...

  33. Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood. BioProject

    ID: PRJNA219044

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ment binding transcription factor 1 (SREBF1), and endothelial cell adhesion molecule (ESAM). There were 8 pathways identified that met the criteria for significance, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism. Participants that increased insulin sensitivity exhibited five times the number of significant genes altered compared to non-responders (1,144 vs. 230). These findings offer insight into the molecular mechanisms underlying health improvements among high-risk Latino youth. Lifestyle interventions may contribute to improved insulin sensitivity through pathways related to insulin signaling and immune response. Further, genetic factors may mediate response to lifestyle intervention. Overall design: Fifteen (7M/8F) overweight/obese Latino Youth Whole blood RNA samples evaluated pre and post intervention....
  34. Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood. OmicsDI

    ID: E-GEOD-50800

    Date Released: 06-03-2014

    Description: ment binding transcription factor 1 (SREBF1), and endothelial cell adhesion molecule (ESAM). There were 8 pathways identified that met the criteria for significance, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism. Participants that increased insulin sensitivity exhibited five times the number of significant genes altered compared to non-responders (1,144 vs. 230). These findings offer insight into the molecular mechanisms underlying health improvements among high-risk Latino youth. Lifestyle interventions may contribute to improved insulin sensitivity through pathways related to insulin signaling and immune response. Further, genetic factors may mediate response to lifestyle intervention. Fifteen (7M/8F) overweight/obese Latino Youth Whole blood RNA samples evaluated pre and post intervention....

  35. Cell Adhesion Molecule 1 (CADM1): A Novel Risk Factor for Venous Thrombosis BioProject

    ID: PRJNA119805

    Keywords: Transcriptome or Gene expression

    Access Type: download

  36. MOESM2 of The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3616574_D6

    Release Date: 12-15-2016

    Description: ency inducing and non-inducing antigen presenting cell subpopulations using RNA-seq. Using the bioinformatics databases DAVID [80], GeneCards and GeneCodis, cell compartment gene function was determine of each gene. Genes expressed ...

  37. profiling by array of human HUVEC, HCAEC and MM6 cell lines for mechanistic investigation of the impact of cigarette smoke on adhesion between monocytes and ArrayExpress

    ID: E-MTAB-1173

    Description: The adhesion of monocytic cells to the “dysfunctional” endothelium constitutes a critical step in the initiation of atherosclerotic...

  38. Solution structure of the PECAM-1 cytoplasmic tail with DPC PDB

    ID: PDB:2KY5

    Description: Platelet endothelial cell adhesion molecule

  39. Global Expression Analysis of Vasculogenesis Induction by Zebrafish Ets1-Related Protein ArrayExpress

    ID: E-GEOD-12909

    Description: ion of Etsrp results in the expansion of vascular endothelial and myeloid lineages. To identify genes functioning downstream of Etsrp we performed microarray analysis of etsrp-overexpressing embryos. Etsrp RNA injected embryos and control uninjected embryos were frozen at the tailbud stage and analyzed for expression of more than 30,000 genes using Nimblegen expression arrays. Approximately 300 genes showed greater than two-fold induction in etsrp-overexpressing embryos. Scl, crl, egfl7, aqp8, fli1a, fli1b, lmo2, cdh5 were among the previously known hemangioblast or vasculature-specific genes which were strongly upregulated in Etsrp-overexpressing embryos. We i...

  40. Loss of Pim1 Imposes a Hyperadhesive Phenotype on Endothelial Cells ArrayExpress

    ID: E-GEOD-32059

    Description: utively active serine-threonine kinase regulating cell survival and proliferation. Increased PIM1 expression has been correlated with cancer metastasis by facilitating migration and anti-adhesion

  41. Endothelial Inflammatory Transcriptional Responses to an Altered Serum Exposome Following Inhalation of Diesel Emissions BioProject

    ID: PRJNA266611

    Keywords: Transcriptome or Gene expression

    Access Type: download

  42. Gene expression profiles of normal human mammary cell subpopulations FACS sorted based on expression of CD49f and EpCAM BioProject

    ID: PRJNA117321

    Keywords: Transcriptome or Gene expression

    Access Type: download

  43. Expression Data from Endothelial Cells as a Consequence of Ets2 Signaling in PyMT Tumor Associated Fibroblasts BioProject

    ID: PRJNA188714

    Keywords: Transcriptome or Gene expression

    Access Type: download

  44. IL-4 mediated gene expression profiles in vascular endothelial cells BioProject

    ID: PRJNA139837

    Keywords: Transcriptome or Gene expression

    Access Type: download

  45. Transcription profiling of human lymphatic endothelial cells, mouse dermal cells and human skin cells reveals an inflammation-induced mechanism for leukocyte transmigration o... ArrayExpress

    ID: E-GEOD-6257

    Description: cytokines trigger activation of dermal lymphatic endothelial cells (LEC) leading to expression of the key leukocyte adhesion receptors ICAM-1, VCAM-1 and E-selectin, as well as a discrete panel of chemokines and other potential regulators of leukocyte transmigration. Furthermore, we show that both ICAM-1 and VCAM-1 are induced in the dermal lymphatic vessels of mice exposed to skin contact hypersensitivity where they mediate lymph node trafficking of DC via afferent lymphat...

  46. PDGFRα+ cells in ESC cultures represent the in vitro equivalent of the pre-implantation primitive endoderm precursors BioProject

    ID: PRJNA275302

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ng between a PDGFRα+ (PrE-primed) and a Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1)-positive state (epiblast-primed). The two surface markers can be co-detected on a third subpopulation, e...
  47. Transcription profiling of rat cirrhotic liver treated with angiogenesis inhibitors ArrayExpress

    ID: E-GEOD-6929

    Description: nt of vascular density and expression of vascular endothelial growth factor-A (VEGF-A), angiopoietin-1, angiopoietin-2 and placental growth factor (PlGF) in cirrhotic livers. The newly formed hepatic vasculature expressed vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Interestingly, the expression of these adhesion molecules correlated well with local inflammatory infiltrate. Livers of cirrhotic rats treated with angiogenesis inhibitors presented a significant decrease in hepatic vascular density, inflammatory infiltrate, a-SMA abundance, collagen expression and portal pressure. Conclusion: Angiogenesis inhibitors may offer a potential novel therapy for cirrhosis due to its multiple mechanisms of action against angiogenesis, inflammation and fibrosis in cirrhotic livers. Experiment Overall Design: RNA from liver of 4 non-treated cirrhotic rats or 4 rats treated with angiogenesis inhibitors was hyb...

  48. IL-4 mediated gene expression profiles in vascular endothelial cells ArrayExpress

    ID: E-GEOD-28117

    Description: Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and infl...

  49. Carboplatin-treated human retinal endothelial cells BioProject

    ID: PRJNA156391

    Keywords: Transcriptome or Gene expression

    Access Type: download

  50. Melphalan-treated human retinal endothelial cells BioProject

    ID: PRJNA156393

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 50 of 197 results for "ESAM"