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Displaying 100 of 197 results for "ESAM"
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  1. ESAM_RAT UniProt:Swiss-Prot

    ID: Q6AYD4

    Description: Endothelial cell-selective adhesion molecule Extracellular Helical Cytopla...

  2. Microarray analyses of ESAM positive cells in the CD34(+) CD38(-) fraction of collagenase-treated bones BioProject

    ID: PRJNA269303

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Microarray analyses of ESAM positive cells in the CD34(+) CD38(-) fraction of collagenase-treated bones OmicsDI

    ID: E-GEOD-63877

    Date Released: 01-02-2015

    Description: We previously identified endothelial cell-selective adhesion molecule (ESAM) as ...

  4. Microarray analyses of ESAM positive cells in the CD34(+) CD38(-) fraction of collagenase-treated bones ArrayExpress

    ID: E-GEOD-63877

    Description: We previously identified endothelial cell-selective adhesion molecule (ESAM) as ...

  5. Microarray analysis of WT ESAM+ and ESAM- cDC subsets BioProject

    ID: PRJNA195894

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Gene expression analysis of primitive erythroid progenitors from 5-FU-treated WT and ESAM-KO mice. BioProject

    ID: PRJNA297177

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Microarray analysis of WT ESAM+ and ESAM- cDC subsets ArrayExpress

    ID: E-GEOD-45679

    Description: echniques to deplete specific classical dendritic cell (cDC) subsets and analyze immunity to the A/E pathogen Citrobacter rodentium. We find that Zbtb46+ cDCs, and specifically Notch2-dependent intestinal CD11b+ cDCs, but not Batf3-dependent CD103+ cDCs, are required for IL-23 production and immunity against C. rodentium. Notch2 controls cDC differentiation at a terminal step mediated by lymphotoxin signaling. Importantly, these results provide the first demonstration of a non-redundant fun...

  8. ESAM_MOUSE UniProt:Swiss-Prot

    ID: Q925F2

    Description: Endothelial cell-selective adhesion molecule Extracellular Helical Cytopla...

  9. The affect of specific ablation of Runx3 from Esam splenic dendritic cells BioProject

    ID: PRJNA210762

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Transcription profiling of human ermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T241/VEGF-C/GFP metastatic fibrosarcoma reveals lymphatic endoth... ArrayExpress

    ID: E-GEOD-6255

    Description: paring the RNA profile of normal dermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T-241/VEGF-C metastatic fibrosarcoma. Our findings reveal significant changes in the expression of some 792 genes in tumour lymphatics (≥ 2 fold up/downregulation, p ≤ 0.05), involving particularly transcripts associated with junctional adhesion, immunomodulation, extracellular matrix and vessel growth/patterning, several of which we have confirmed by RT-PCR and/or immunohistochemistry. Interestingly, this altered phenotype could not be attributed sol...

  11. Transcription profiling of mouse CD31(+) cells isolated from embryonic stem cells ArrayExpress

    ID: E-TABM-1125

    Description: riment is the identification of genes involved in endothelial differentiation. This is of great interest for the understanding of the cellular and molecular mechanisms involved in the development of new blood vessels. Mouse embryonic stem (mES) cells serve as a potential source of endothelial cells for transcriptomic analysis. We isolated endothelial cells from 8-days old embryoid bodies by immuno-magnetic ...

  12. Microarray analysis of WT ESAM+ and ESAM- cDC subsets OmicsDI

    ID: E-GEOD-45679

    Date Released: 06-17-2013

    Description: echniques to deplete specific classical dendritic cell (cDC) subsets and analyze immunity to the A/E pathogen Citrobacter rodentium. We find that Zbtb46+ cDCs, and specifically Notch2-dependent intestinal CD11b+ cDCs, but not Batf3-dependent CD103+ cDCs, are required for IL-23 production and immunity against C. rodentium. Notch2 controls cDC differentiation at a terminal step mediated by lymphotoxin signaling. Importantly, these results provide the first demonstration of a non-redundant fun...

  13. PECA1_BOVIN UniProt:Swiss-Prot

    ID: P51866

    Description: Platelet endothelial cell adhesion molecule Extracellular Helical Cytoplasmic Ig-li...

  14. The affect of specific ablation of Runx3 from Esam splenic dendritic cells ArrayExpress

    ID: E-GEOD-48590

    Description: Esam/CD4+ dendritic cells are part of the innate immunity essential for priming and activating of CD4+ T cells To identify Runx3 re...

  15. ESAM_MACFA UniProt:Swiss-Prot

    ID: Q95KI3

    Description: Endothelial cell-selective adhesion molecule Extracellular Helical Cytopla...

  16. PECA1_PIG UniProt:Swiss-Prot

    ID: Q95242

    Description: Platelet endothelial cell adhesion molecule Extracellular Helical Cytoplasmic Ig-li...

  17. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine ArrayExpress

    ID: E-GEOD-31551

    Description: distinct population marked by high expression of adhesion molecule Esam. The Notch-dependent Esamhi DC subset also required lymphotoxin beta receptor signaling, proliferated in situ and facilitated efficient CD4+ T cell priming. The Notch-independent Esamlo DCs expressed monocyte-related genes and showed superior cytokine responses. In addition, Notch2 deletion led to the loss of CD11b+ CD103+ DCs in the intestinal lamina propria and to the corresponding decrease of IL-17-producing CD4+ T cells in the intestine. Thus,Notch2 is ...

  18. Lymphatic endothelium of metastatic tumours has a distinct transcription profile. BioProject

    ID: PRJNA99687

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: paring the RNA profile of normal dermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T-241/VEGF-C metastatic fibrosarcoma. Our findings reveal significant changes in the expression of some 792 genes in tumour lymphatics (≥ 2 fold up/downregulation, p ≤ 0.05), involving particularly transcripts associated with junctional adhesion, immunomodulation, extracellular matrix and vessel growth/patterning, several of which we have confirmed by RT-PCR and/or immunohistochemistry. Interestingly, this altered phenotype could not be attributed sol...
  19. The affect of specific ablation of Runx3 from Esam splenic dendritic cells OmicsDI

    ID: E-GEOD-48590

    Date Released: 06-28-2014

    Description: Esam/CD4+ dendritic cells are part of the innate immunity essential for priming and activating of CD4+ T cells To identify Runx3 re...

  20. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine OmicsDI

    ID: E-GEOD-31551

    Date Released: 12-05-2011

    Description: distinct population marked by high expression of adhesion molecule Esam. The Notch-dependent Esamhi DC subset also required lymphotoxin beta receptor signaling, proliferated in situ and facilitated efficient CD4+ T cell priming. The Notch-independent Esamlo DCs expressed monocyte-related genes and showed superior cytokine responses. In addition, Notch2 deletion led to the loss of CD11b+ CD103+ DCs in the intestinal lamina propria and to the corresponding decrease of IL-17-producing CD4+ T cells in the intestine. Thus,Notch2 is ...

  21. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine BioProject

    ID: PRJNA145485

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: distinct population marked by high expression of adhesion molecule Esam. The Notch-dependent Esamhi DC subset also required lymphotoxin beta receptor signaling, proliferated in situ and facilitated efficient CD4+ T cell priming. The Notch-independent Esamlo DCs expressed monocyte-related genes and showed superior cytokine responses. In addition, Notch2 deletion led to the loss of CD11b+ CD103+ DCs in the intestinal lamina propria and to the corresponding decrease of IL-17-producing CD4+ T cells in the intestine. Thus,Notch2 is ...
  22. Inflammatory signaling regulates fetal hematopoiesis BioProject

    ID: PRJNA239780

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Multiple signaling pathways contribute to blood cell formation in the fetus, but a role for innate immune/inflammatory signaling has not been described. Here we show that mouse fe...
  23. Transcription profiling of human ermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T241/VEGF-C/GFP metastatic fibrosarcoma reveals lymphatic endoth... OmicsDI

    ID: E-GEOD-6255

    Date Released: 03-27-2012

    Description: paring the RNA profile of normal dermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T-241/VEGF-C metastatic fibrosarcoma. Our findings reveal significant changes in the expression of some 792 genes in tumour lymphatics (≥ 2 fold up/downregulation, p ≤ 0.05), involving particularly transcripts associated with junctional adhesion, immunomodulation, extracellular matrix and vessel growth/patterning, several of which we have confirmed by RT-PCR and/or immunohistochemistry. Interestingly, this altered phenotype could not be attributed sol...

  24. Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood ArrayExpress

    ID: E-GEOD-50800

    Description: ment binding transcription factor 1 (SREBF1), and endothelial cell adhesion molecule (ESAM). There were 8 pathways identified that met the criteria for significance, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism. Participants that increased insulin sensitivity exhibited five times the number of significant genes altered compared to non-responders (1,144 vs. 230). These findings offer insight into the molecular mechanisms underlying health improvements among high-risk Latino youth. Lifestyle interventions may contribute to improved insulin sensitivity through pathways related to insulin signaling and immune response. Further, genetic factors may mediate response to lifestyle intervention. Fifteen (7M/8F) overweight/obese Latino Youth Whole blood RNA samples evaluated pre and post intervention....

  25. Transcription profiling of human blood outgrowth endothelial cells of 3 members of Kindred Vermont II - cell adhesion molecule ArrayExpress

    ID: E-GEOD-17078

    Description: microarray expression analysis of Blood Outgrowth Endothelial Cells of 3 members of Kindred Vermont II compared to a well established normal control group indicated that IgsF4 was decreased in patients versus controls. In addition, both statistical and pathway analysis results suggested that these genes are associated protein C. Further studies indicated that Cell Adhesion Molecule 1 (CADM1), a member of the IgsF4 superfamily, may be associated with VT. Experiment Overal...

  26. The crystal structure of PECAM-1 IgL1-2 trans-homophilic dimer PDB

    ID: PDB:5GNI

    Description: Platelet endothelial cell adhesion molecule

  27. Data from: Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors Dryad

    DateIssued: 07-18-2016

    Description: echanisms that govern their capture by the target cell. Next-generation pharmacokinetic (PK) models that systematically account for proteomic and mechanical factors can accelerate the design, validation and translation of targeted nanocarriers (NCs) in the clinic. Towards this objective, we have developed a computational m...

  28. Crystal structure of PECAM-1 D1D2 domain PDB

    ID: PDB:5C14

    Description: Platelet endothelial cell adhesion molecule

  29. Angiogenesis inhibitors ameliorates inflammatory infiltrate, fibrosis and portal pressure in cirrhotic rats BioProject

    ID: PRJNA98087

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nt of vascular density and expression of vascular endothelial growth factor-A (VEGF-A), angiopoietin-1, angiopoietin-2 and placental growth factor (PlGF) in cirrhotic livers. The newly formed hepatic vasculature expressed vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Interestingly, the expression of these adhesion molecules correlated well with local inflammatory infiltrate. Livers of cirrhotic rats treated with angiogenesis inhibitors presented a significant decrease in hepatic vascular density, inflammatory infiltrate, a-SMA abundance, collagen expression and portal pressure. Conclusion: Angiogenesis inhibitors may offer a potential novel therapy for cirrhosis due to its multiple mechanisms of action against angiogenesis, inflammation and fibrosis in cirrhotic livers. Keywords: angiogenesis, cirrhosis, liver, Affymetrix, fibrosis Overall design: RNA from liver of 4 non-treated cirrhotic rats or...
  30. Hydroxyurea stimulates production of pro-inflammatory cytokines in endothelial cells: Relevance to sickle cell disease. BioProject

    ID: PRJNA106597

    Keywords: Transcriptome or Gene expression

    Access Type: download

  31. Loss of Pim1 Imposes a Hyperadhesive Phenotype on Endothelial Cells BioProject

    ID: PRJNA147619

    Keywords: Transcriptome or Gene expression

    Access Type: download

  32. Transcription profiling of human blood outgrowth endothelial cells of 3 members of Kindred Vermont II - cell adhesion molecule OmicsDI

    ID: E-GEOD-17078

    Date Released: 06-10-2011

    Description: microarray expression analysis of Blood Outgrowth Endothelial Cells of 3 members of Kindred Vermont II compared to a well established normal control group indicated that IgsF4 was decreased in patients versus controls. In addition, both statistical and pathway analysis results suggested that these genes are associated protein C. Further studies indicated that Cell Adhesion Molecule 1 (CADM1), a member of the IgsF4 superfamily, may be associated with VT. Experiment Overal...

  33. Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood. BioProject

    ID: PRJNA219044

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ment binding transcription factor 1 (SREBF1), and endothelial cell adhesion molecule (ESAM). There were 8 pathways identified that met the criteria for significance, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism. Participants that increased insulin sensitivity exhibited five times the number of significant genes altered compared to non-responders (1,144 vs. 230). These findings offer insight into the molecular mechanisms underlying health improvements among high-risk Latino youth. Lifestyle interventions may contribute to improved insulin sensitivity through pathways related to insulin signaling and immune response. Further, genetic factors may mediate response to lifestyle intervention. Overall design: Fifteen (7M/8F) overweight/obese Latino Youth Whole blood RNA samples evaluated pre and post intervention....
  34. Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood. OmicsDI

    ID: E-GEOD-50800

    Date Released: 06-03-2014

    Description: ment binding transcription factor 1 (SREBF1), and endothelial cell adhesion molecule (ESAM). There were 8 pathways identified that met the criteria for significance, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism. Participants that increased insulin sensitivity exhibited five times the number of significant genes altered compared to non-responders (1,144 vs. 230). These findings offer insight into the molecular mechanisms underlying health improvements among high-risk Latino youth. Lifestyle interventions may contribute to improved insulin sensitivity through pathways related to insulin signaling and immune response. Further, genetic factors may mediate response to lifestyle intervention. Fifteen (7M/8F) overweight/obese Latino Youth Whole blood RNA samples evaluated pre and post intervention....

  35. Cell Adhesion Molecule 1 (CADM1): A Novel Risk Factor for Venous Thrombosis BioProject

    ID: PRJNA119805

    Keywords: Transcriptome or Gene expression

    Access Type: download

  36. MOESM2 of The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3616574_D6

    Release Date: 12-15-2016

    Description: ency inducing and non-inducing antigen presenting cell subpopulations using RNA-seq. Using the bioinformatics databases DAVID [80], GeneCards and GeneCodis, cell compartment gene function was determine of each gene. Genes expressed ...

  37. profiling by array of human HUVEC, HCAEC and MM6 cell lines for mechanistic investigation of the impact of cigarette smoke on adhesion between monocytes and ArrayExpress

    ID: E-MTAB-1173

    Description: The adhesion of monocytic cells to the “dysfunctional” endothelium constitutes a critical step in the initiation of atherosclerotic...

  38. Solution structure of the PECAM-1 cytoplasmic tail with DPC PDB

    ID: PDB:2KY5

    Description: Platelet endothelial cell adhesion molecule

  39. Global Expression Analysis of Vasculogenesis Induction by Zebrafish Ets1-Related Protein ArrayExpress

    ID: E-GEOD-12909

    Description: ion of Etsrp results in the expansion of vascular endothelial and myeloid lineages. To identify genes functioning downstream of Etsrp we performed microarray analysis of etsrp-overexpressing embryos. Etsrp RNA injected embryos and control uninjected embryos were frozen at the tailbud stage and analyzed for expression of more than 30,000 genes using Nimblegen expression arrays. Approximately 300 genes showed greater than two-fold induction in etsrp-overexpressing embryos. Scl, crl, egfl7, aqp8, fli1a, fli1b, lmo2, cdh5 were among the previously known hemangioblast or vasculature-specific genes which were strongly upregulated in Etsrp-overexpressing embryos. We i...

  40. Loss of Pim1 Imposes a Hyperadhesive Phenotype on Endothelial Cells ArrayExpress

    ID: E-GEOD-32059

    Description: utively active serine-threonine kinase regulating cell survival and proliferation. Increased PIM1 expression has been correlated with cancer metastasis by facilitating migration and anti-adhesion

  41. Endothelial Inflammatory Transcriptional Responses to an Altered Serum Exposome Following Inhalation of Diesel Emissions BioProject

    ID: PRJNA266611

    Keywords: Transcriptome or Gene expression

    Access Type: download

  42. Gene expression profiles of normal human mammary cell subpopulations FACS sorted based on expression of CD49f and EpCAM BioProject

    ID: PRJNA117321

    Keywords: Transcriptome or Gene expression

    Access Type: download

  43. Expression Data from Endothelial Cells as a Consequence of Ets2 Signaling in PyMT Tumor Associated Fibroblasts BioProject

    ID: PRJNA188714

    Keywords: Transcriptome or Gene expression

    Access Type: download

  44. IL-4 mediated gene expression profiles in vascular endothelial cells BioProject

    ID: PRJNA139837

    Keywords: Transcriptome or Gene expression

    Access Type: download

  45. Transcription profiling of human lymphatic endothelial cells, mouse dermal cells and human skin cells reveals an inflammation-induced mechanism for leukocyte transmigration o... ArrayExpress

    ID: E-GEOD-6257

    Description: cytokines trigger activation of dermal lymphatic endothelial cells (LEC) leading to expression of the key leukocyte adhesion receptors ICAM-1, VCAM-1 and E-selectin, as well as a discrete panel of chemokines and other potential regulators of leukocyte transmigration. Furthermore, we show that both ICAM-1 and VCAM-1 are induced in the dermal lymphatic vessels of mice exposed to skin contact hypersensitivity where they mediate lymph node trafficking of DC via afferent lymphat...

  46. PDGFRα+ cells in ESC cultures represent the in vitro equivalent of the pre-implantation primitive endoderm precursors BioProject

    ID: PRJNA275302

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ng between a PDGFRα+ (PrE-primed) and a Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1)-positive state (epiblast-primed). The two surface markers can be co-detected on a third subpopulation, e...
  47. Transcription profiling of rat cirrhotic liver treated with angiogenesis inhibitors ArrayExpress

    ID: E-GEOD-6929

    Description: nt of vascular density and expression of vascular endothelial growth factor-A (VEGF-A), angiopoietin-1, angiopoietin-2 and placental growth factor (PlGF) in cirrhotic livers. The newly formed hepatic vasculature expressed vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Interestingly, the expression of these adhesion molecules correlated well with local inflammatory infiltrate. Livers of cirrhotic rats treated with angiogenesis inhibitors presented a significant decrease in hepatic vascular density, inflammatory infiltrate, a-SMA abundance, collagen expression and portal pressure. Conclusion: Angiogenesis inhibitors may offer a potential novel therapy for cirrhosis due to its multiple mechanisms of action against angiogenesis, inflammation and fibrosis in cirrhotic livers. Experiment Overall Design: RNA from liver of 4 non-treated cirrhotic rats or 4 rats treated with angiogenesis inhibitors was hyb...

  48. IL-4 mediated gene expression profiles in vascular endothelial cells ArrayExpress

    ID: E-GEOD-28117

    Description: Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and infl...

  49. Carboplatin-treated human retinal endothelial cells BioProject

    ID: PRJNA156391

    Keywords: Transcriptome or Gene expression

    Access Type: download

  50. Melphalan-treated human retinal endothelial cells BioProject

    ID: PRJNA156393

    Keywords: Transcriptome or Gene expression

    Access Type: download

  51. An inflammation-induced mechanism for leukocyte transmigration of lymphatic vessel endothelium. BioProject

    ID: PRJNA100539

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cytokines trigger activation of dermal lymphatic endothelial cells (LEC) leading to expression of the key leukocyte adhesion receptors ICAM-1, VCAM-1 and E-selectin, as well as a discrete panel of chemokines and other potential regulators of leukocyte transmigration. Furthermore, we show that both ICAM-1 and VCAM-1 are induced in the dermal lymphatic vessels of mice exposed to skin contact hypersensitivity where they mediate lymph node trafficking of DC via afferent lymphat...
  52. rat including the novel junctional protein liver endothelial differentiation-associated protein-1... BioProject

    ID: PRJNA125481

    Keywords: Transcriptome or Gene expression

    Access Type: download

  53. Gene expression profiles of normal human mammary cell subpopulations FACS sorted based on expression of CD49f and EpCAM ArrayExpress

    ID: E-GEOD-16997

    Description: ations in human mammary tissue, hematopoietic and endothelial cells were depleted from freshly isolated cell suspensions derived from reduction mammoplasties by fluorescence-activated <

  54. Expression Data from Endothelial Cells as a Consequence of Ets2 Signaling in PyMT Tumor Associated Fibroblasts ArrayExpress

    ID: E-GEOD-44118

    Description: broblasts effected gene expression in surrounding endothelial cells in the MMTV-PyMT mammary tumor model. Inactivation of Ets2 specifically in fibroblasts using Fsp-cre significantly reduced tumor associated angiogenesis, and was indicated to effect ECM remodeling, cell adhesion and cell chemotaxis processes in neighboring endothelial cells. We have identified Ets2 in...

  55. The Impact of Security Overhead Traffic on Networks Resources Performance Figshare

    ID: doi:10.6084/M9.FIGSHARE.1335894

    Release Date: 07-31-2015

    Description:

    dataset.creators: Esam Suliman Mustafa Ahmed1, Dr.Amin Babiker A/Nabi Mustafa
  56. The Impact of Security Overhead Traffic on Network’s Resources Performance Figshare

    ID: doi:10.6084/M9.FIGSHARE.1335894.V1

    Release Date: 01-19-2016

    Description:

    dataset.creators: Esam Suliman Mustafa Ahmed1, Dr.Amin Babiker A/Nabi Mustafa
  57. The effect of Encryption algorithms Delay on TCP Traffic over data networks Figshare

    ID: doi:10.6084/M9.FIGSHARE.1335895

    Release Date: 07-31-2015

    Description:

    dataset.creators: Esam Suliman Mustafa Ahmed1, Dr.Amin Babiker A/Nabi Mustafa
  58. Global Expression Analysis of Vasculogenesis Induction by Zebrafish Ets1-Related Protein OmicsDI

    ID: E-GEOD-12909

    Date Released: 06-10-2011

    Description: ion of Etsrp results in the expansion of vascular endothelial and myeloid lineages. To identify genes functioning downstream of Etsrp we performed microarray analysis of etsrp-overexpressing embryos. Etsrp RNA injected embryos and control uninjected embryos were frozen at the tailbud stage and analyzed for expression of more than 30,000 genes using Nimblegen expression arrays. Approximately 300 genes showed greater than two-fold induction in etsrp-overexpressing embryos. Scl, crl, egfl7, aqp8, fli1a, fli1b, lmo2, cdh5 were among the previously known hemangioblast or vasculature-specific genes which were strongly upregulated in Etsrp-overexpressing embryos. We i...

  59. Transcriptional profiling of ex vivo isolated inflammed mouse lymphatic endothelial cells BioProject

    ID: PRJNA134995

    Keywords: Transcriptome or Gene expression

    Access Type: download

  60. LSEC: a microenvironment dependent differentiation program in rat including the novel junctional protein Leda-1 ArrayExpress

    ID: E-GEOD-20375

    Description: hly isolated ex vivo with both lung microvascular endothelial cells (LMEC) and with LSEC cultured for 42h. The LSEC signature consisted of 48 genes both down-regulated in LMEC and in LSEC upon culture (FC>7 in at least one comparison); qRT-PCR confirmation of these genes included numerous family members and signalling pathway-associated molecules. The LSEC differentiation program comprised distinct sets of growth (wnt2, Fzd4, 5, 9, wls, VEGFR1, 2, 3, Nrp2) and transcription factors (Gata4, Lmo3, Tcfec, Maf) as well as endocytosis-related (Stabilin-1/2, Lyve1 and Ehd3) and cytoskeleton-assoc...

  61. Transcriptional profiling of ex vivo isolated inflammed mouse lymphatic endothelial cells ArrayExpress

    ID: E-GEOD-26229

    Description: Chemokines and adhesion molecules upregulated in lymphatic endothelial cells (LECs) during tissue inflammation are believed to ...

  62. Transcriptome analysis of HUVEC BioProject

    ID: PRJEB14751

    Keywords: Other

    Access Type: download

    dataset.description: Human umbilical vein endothelial cells (HUVEC) were isolated from umbilical cords from four different donors, as previously described (Cooke et al., 199...
  63. Transcriptional profiling of immortalized LECs (imLECs) ArrayExpress

    ID: E-GEOD-28234

    Description: lood vessels into tissues, and the involvement of adhesion molecules and chemokines in this process, the migration of leukocytes from the tissue into lymphatic vessels is much less well understood. This can, in part be explained b...

  64. Endothelial Responses to Atheroprone Flow BioProject

    ID: PRJNA117357

    Keywords: Transcriptome or Gene expression

    Access Type: download

  65. Human thymic epithelial cell: untransfected control vs. scramble-siRNA transfected vs. CD49e-siRNA transfected BioProject

    ID: PRJNA119437

    Keywords: Transcriptome or Gene expression

    Access Type: download

  66. Transcriptional profiling of immortalized LECs (imLECs) BioProject

    ID: PRJNA139603

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lood vessels into tissues, and the involvement of adhesion molecules and chemokines in this process, the migration of leukocytes from the tissue into lymphatic vessels is much less well understood. This can, in part be explained b...
  67. Cell Adhesion Molecule 1 (CADM1): A Novel Risk Factor for Venous Thrombosis GEMMA

    ID: 1414

    Keywords: functional genomics

    Description: microarray expression analysis of Blood Outgrowth Endothelial Cells of 3 members of Kindred Vermont II compared to a well established normal control group indicated that IgsF4 was decreased in patients versus controls. In addition, both statistical and pathway analysis results suggested that these genes are associated protein C. Further studies indicated that Cell Adhesion Molecule 1 (CADM1), a member of the IgsF4 superfamily, may be associated with VT. Last Updated (by ...

  68. Transcription profiling of human HUVEC cells with internalised S. aureus ArrayExpress

    ID: E-MEXP-226

    Description: olated from patients with bloodstream infections. Endothelial cells (ECs) play an important role in host cell defence against bacteria, and recent reports have shown that infection of ECs with S. aureus induces a wide range o...

  69. Transcription profiling of mouse CD31(+) cells isolated from embryonic stem cells OmicsDI

    ID: E-TABM-1125

    Date Released: 05-02-2014

    Description: riment is the identification of genes involved in endothelial differentiation. This is of great interest for the understanding of the cellular and molecular mechanisms involved in the development of new blood vessels. Mouse embryonic stem (mES) cells serve as a potential source of endothelial cells for transcriptomic analysis. We isolated endothelial cells from 8-days old embryoid bodies by immuno-magnetic separation using platel...

  70. Global Expression Analysis of Vasculogenesis Induction by Zebrafish Ets1-Related Protein BioProject

    ID: PRJNA110817

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ion of Etsrp results in the expansion of vascular endothelial and myeloid lineages. To identify genes functioning downstream of Etsrp we performed microarray analysis of etsrp-overexpressing embryos. Etsrp RNA injected embryos and control uninjected embryos were frozen at the tailbud stage and analyzed for expression of more than 30,000 genes using Nimblegen expression arrays. Approximately 300 genes showed greater than two-fold induction in etsrp-overexpressing embryos. Scl, crl, egfl7, aqp8, fli1a, fli1b, lmo2, cdh5 were among the previously known hemangioblast or vasculature-specific genes which were strongly upregulated in Etsrp-overexpressing embryos. We i...
  71. Gene expression profiling reveals novel protective effects of Aminaphtone on ECV304 endothelial cells BioProject

    ID: PRJNA325507

    Keywords: Transcriptome or Gene expression

    Access Type: download

  72. Acute venous hypertension induces local release of inflammatory cytokines and endothelial activation in humans ArrayExpress

    ID: E-GEOD-38783

    Description: ions in homeostasis by promoting inflammation and endothelial cell (EC) activation. We used an experimental model of acute, local venous hypertension to study the changes in circulating inflammatory mediators and EC phenotype that occur in response to biomechanical stress. Methods and Results: Twenty-four healthy subjects (14 men, age 35±2 y...

  73. To identify specific glycosylated structures on brain endothelial cells that mediate rolling, adhesion, and diapedesis of leukocytes in the brain BioProject

    ID: PRJNA140877

    Keywords: Transcriptome or Gene expression

    Access Type: download

  74. Transcriptome analysis of HUVEC ArrayExpress

    ID: E-MTAB-4897

    Description: Human umbilical vein endothelial cells (HUVEC) were isolated from umbilical cords from four different donors, as previously described (Cooke et al., 199...

  75. IL-4 mediated gene expression profiles in vascular endothelial cells OmicsDI

    ID: E-GEOD-28117

    Date Released: 03-27-2012

    Description: Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and infl...

  76. Monocyte-Derived Dendritic Cells Differ in Cytoskeleton and Cell Adhesion-Related Expression Depending on VEGF Exposure BioProject

    ID: PRJNA115497

    Keywords: Transcriptome or Gene expression

    Access Type: download

  77. L1CAM overexpression in mouse lung endothelial cells (lECs) BioProject

    ID: PRJNA196510

    Keywords: Transcriptome or Gene expression

    Access Type: download

  78. Acute venous hypertension induces local release of inflammatory cytokines and endothelial activation in humans BioProject

    ID: PRJNA168633

    Keywords: Transcriptome or Gene expression

    Access Type: download

  79. Gene expression profile of colon endothelial cells in early GVHD with Microarray BioProject

    ID: PRJNA328083

    Keywords: Transcriptome or Gene expression

    Access Type: download

  80. e expression and function in acute versus chronic endothelial activation... ArrayExpress

    ID: E-GEOD-4518

    Description: ain insight into mechanisms of prolonged vascular endothelial activation we compared changes in gene expression induced by continuous activation in stable tmTNFalpha expressing cells with changes due to acute TNFalpha challenge in vitro. Affymetrix Genechip® analysis was performed on RNA from control, acute and continuous TNFalp...

  81. Gene expression profile of murine bone marrow endosteal populations (1) ArrayExpress

    ID: E-GEOD-17569

    Description: ions as a key component of the hematopoietic stem cell niche. But it is still unclear that the precise cellular and molecular contribution of endosteal cell populations on the HSC supportive ...

  82. Divergent and Convergent Effects on Gene Expression and Function in Acute versus Chronic Endothelial Activation BioProject

    ID: PRJNA94527

    Keywords: Transcriptome or Gene expression

    Access Type: download

  83. Gene expression profile of murine bone marrow endosteal populations (1) BioProject

    ID: PRJNA123353

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ions as a key component of the hematopoietic stem cell niche. But it is still unclear that the precise cellular and molecular contribution of endosteal cell populations on the HSC supportive ...
  84. To identify specific glycosylated structures on brain endothelial cells that mediate rolling, adhesion, and diapedesis of leukocytes in the brain ArrayExpress

    ID: E-GEOD-29932

    Description: functioning. It is made up of highly specialized endothelial cells (ECs) in the lining of the vascular wall. These ECs are surrounded by the basal lamina, astrocytic perivascular endfeet, pericytes, microglia and neuronal processes that have been shown to contribute to barrier function1. In essence, the brain ...

  85. Decorin and EphA2 mediate Carcinoembryonic Antigen Cell Adhesion Molecule 1-L inhibition of colorectal cancer metastasis BioProject

    ID: PRJNA296370

    Keywords: Transcriptome or Gene expression

    Access Type: download

  86. Effect of Notch1 pathway activation on high-grade glioma cells ArrayExpress

    ID: E-GEOD-44561

    Description: cer stem cells. These cells closely interact with endothelial cells in neurovascular niches. In this study we have uncovered a close link between the Notch1 pathway and the tumoral vascularization process of GBM stem cells. We observed that although the Notch1 receptor was activated, the typical target proteins (HES5, HEY1, HEY2) were not or barely expressed in two explored GBM stem cell cultures. Notch1 signalling activation by expression of the intracellular form (NICD) in these cells was found to redu...

  87. The expression of inflammatory genes in endothelial cells is inhibited by N-octanoyl dopamine via modulation of the NFkB pathway ArrayExpress

    ID: E-GEOD-34059

    Description: this was mediated. Methods: Human umbilical vein endothelial cells (HUVECs) were stimulated with TNF-α in the presence of various NOD concentrations. Affymetrix gene expression profiling (GEP), Western blotting, adhesion of peripheral blood mononuclear cells (PBMC) to endothelial cells and NFκB activation was studied. Compounds that were structurally related to NOD were used to address the molecular entities within NOD that were required for its anti-inflammatory properties. Results: GEP revealed that NOD down-regulates a...

  88. MEK5 is Activated by Shear Stress, Activates ERK5 And Induces KLF4 To Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells BioProject

    ID: PRJNA134487

    Keywords: Transcriptome or Gene expression

    Access Type: download

  89. Sod2 KO anemic mice ArrayExpress

    ID: E-GEOD-27053

    Description: function and stress response we find a number of cell surface molecules with significant differential expression. Thrombospondin is found at higher levels in SOD2-/- red cell membrane fractions. This is an extracellular matrix glycoprotein involved in cell adhesion and migration that interacts with glycosaminoglycans (especially the heparan sulfate proteoglycan perlecan) expressed at the endothelial cell surface (Feitsma J. Biol. Chem. 2000 275:9396, Vischer Eur. J. Cell. Biol. 1997 73:332, Sun J. Biol. Chem. 1989 15:2885). Thrombospondin is likely an acquired surface molecule on our red cells, which is of interest as this molecule has been found on the surface of sickle red cells and appears to mediate abnormal adhesion of red cells to vessel wall (Hillery Blood 1996 87:4879, Sugihara Blood 1992 15:2634). CD44 is also found at higher levels in SOD2-/- membrane fractions. CD44 is an adhesion receptor for the high molecular weight polysaccharide hyaluronic acid and has been shown recently to be involved in the trafficking of stem cells to the bone marrow (Avigdor Blood January 2004). Higher expression of these molecules on the surface of SOD2-/- red cells may affect t...

  90. Carboplatin-treated human retinal endothelial cells ArrayExpress

    ID: E-GEOD-34379

    Description: ave developed in vitro studies with human retinal endothelial cells to test the effects of the chemotherapeutics and a non-human primate model to monitor the SSIOAC treatment in real-time and post-treatment. Melphalan and carboplatin (another chemotherapeutic used to treat retinoblastoma via SSIOAC) triggered migration, proliferation, and apoptosis when used to treat human retinal endothelial cells. Melphalan was associated with increased adhesion of leukocytes to human retinal endothelial cells, and tended to increas...

  91. Melphalan-treated human retinal endothelial cells ArrayExpress

    ID: E-GEOD-34381

    Description: ave developed in vitro studies with human retinal endothelial cells to test the effects of the chemotherapeutics and a non-human primate model to monitor the SSIOAC treatment in real-time and post-treatment. Melphalan and carboplatin (another chemotherapeutic used to treat retinoblastoma via SSIOAC) triggered migration, proliferation, and apoptosis when used to treat human retinal endothelial cells. Melphalan was associated with increased adhesion of leukocytes to human retinal endothelial cells, and tended to increas...

  92. The effect of Encryption algorithms Delay on TCP Traffic over data networks Figshare

    ID: doi:10.6084/M9.FIGSHARE.1335895.V1

    Release Date: 01-19-2016

    Description:

    dataset.creators: Esam Suliman Mustafa Ahmed1, Dr.Amin Babiker A/Nabi Mustafa
  93. Increased CD226 Expression on CD8+ T cells in Patients with Systemic Sclerosis BioProject

    ID: PRJNA269377

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: xpression of genes related to immune response and cell adhesion, including CD226 (also known as DNAX accessory molecule-1, DNAM-1), was significantly altered. Moreover, detailed analysis of CD226 revealed that CD226highCD8+ T cells were increased in SSc patients (mean, 50.7%) compared with healthy controls (32.9%) and were appreciably associated with the severity of skin sclerosis and interstitial lung disease. Further, CD226highCD8+ T cells from SSc patients produced abundant IL-13 and were positively correlated with the cytotoxic capacity of CD8+ T cells against HUVECs. Finally, the neutralization of CD226 impaired IL-13 production and cytolysis against HUVECs. These findings indicate that upregulated CD226 expressio...
  94. Monocyte-Derived Dendritic Cells Differ in Cytoskeleton and Cell Adhesion-Related Expression Depending on VEGF Exposure ArrayExpress

    ID: E-GEOD-16072

    Description: eading to compromised anti-tumor immune response. Cell-to-cell interactions and cell migration are essential features of the immunological response in cancer. Vascular endothelial growth factor (VEGF) has been shown to affect DCs differentiation and ...

  95. The expression of inflammatory genes in endothelial cells is inhibited by N-octanoyl dopamine via modulation of the NFkB pathway BioProject

    ID: PRJNA150015

    Keywords: Transcriptome or Gene expression

    Access Type: download

  96. Effect of Notch1 pathway activation on high-grade glioma cells BioProject

    ID: PRJNA190058

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cer stem cells. These cells closely interact with endothelial cells in neurovascular niches. In this study we have uncovered a close link between the Notch1 pathway and the tumoral vascularization process of GBM stem cells. We observed that although the Notch1 receptor was activated, the typical target proteins (HES5, HEY1, HEY2) were not or barely expressed in two explored GBM stem cell cultures. Notch1 signalling activation by expression of the intracellular form (NICD) in these cells was found to red...
  97. Expression Data from Endothelial Cells as a Consequence of Ets2 Signaling in PyMT Tumor Associated Fibroblasts OmicsDI

    ID: E-GEOD-44118

    Date Released: 06-02-2014

    Description: broblasts effected gene expression in surrounding endothelial cells in the MMTV-PyMT mammary tumor model. Inactivation of Ets2 specifically in fibroblasts using Fsp-cre significantly reduced tumor associated angiogenesis, and was indicated to effect ECM remodeling, cell adhesion and cell chemotaxis processes in neighboring endothelial cells. We have identified Ets2 in...

  98. The Frequency Dependent Response of the Vascular Endothelium to Pulsatile Shear Stress BioProject

    ID: PRJNA94773

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: how in vivo arterial shear forces affect vascular endothelial gene expression. Complicated blood flow patterns at arterial branches create small regions that experience fluctuations in shear stress at frequencies higher than the heart rate. To...
  99. MEK5 is Activated by Shear Stress, Activates ERK5 And Induces KLF4 To Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells ArrayExpress

    ID: E-GEOD-25145

    Description: MEK5 is activated by shear stress in large vessel endothelial cells (ECs) and contributes to the suppression of pro-inflammatory changes in the arterial wall. We used microarray ana...

  100. Sod2 KO anemic mice BioProject

    ID: PRJNA137637

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: function and stress response we find a number of cell surface molecules with significant differential expression. Thrombospondin is found at higher levels in SOD2-/- red cell membrane fractions. This is an extracellular matrix glycoprotein involved in cell adhesion and migration that interacts with glycosaminoglycans (especially the heparan sulfate proteoglycan perlecan) expressed at the endothelial cell surface (Feitsma J. Biol. Chem. 2000 275:9396, Vischer Eur. J. Cell. Biol. 1997 73:332, Sun J. Biol. Chem. 1989 15:2885). Thrombospondin is likely an acquired surface molecule on our red cells, which is of interest as this molecule has been found on the surface of sickle red cells and appears to mediate abnormal adhesion of red cells to vessel wall (Hillery Blood 1996 87:4879, Sugihara Blood 1992 15:2634). CD44 is also found at higher levels in SOD2-/- membrane fractions. CD44 is an adhesion receptor for the high molecular weight polysaccharide hyaluronic acid and has been shown recently to be involved in the trafficking of stem cells to the bone marrow (Avigdor Blood January 2004). Higher expression of these molecules on the surface of SOD2-/- red cells may affect their adhesive in...

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