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Displaying 50 of 260 results for "ERBB3"
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  1. Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP PDB

    ID: PDB:3LMG

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  2. Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation PDB

    ID: PDB:4RIY

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Epidermal growth factor receptor (E.C.2.7.10.1)

  3. Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3) PDB

    ID: PDB:4LEO

    Description: RG7116 Fab heavy chain, RG7116 Fab light chain, Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  4. Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation PDB

    ID: PDB:4RIX

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Epidermal growth factor receptor (E.C.2.7.10.1)

  5. Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3) PDB

    ID: PDB:3KEX

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  6. Crystal structure of an EGFR/HER3 kinase domain heterodimer PDB

    ID: PDB:4RIW

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Epidermal growth factor receptor (E.C.2.7.10.1)

  7. anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region PDB

    ID: PDB:3P11

    Description: Fab DL11 heavy chain, Fab DL11 light chain, Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  8. HER3 extracellular domain in complex with Fab fragment of MOR09825 PDB

    ID: PDB:4P59

    Description: HER3 ectodomain, MOR09825 Fab fragment heavy chain, MOR09825 Fab fragment light chain

  9. Targeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment BioProject

    ID: PRJNA147437

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Spatial structure of dimeric ErbB3 transmembrane domain PDB

    ID: PDB:2L9U

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  11. MCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures BioProject

    ID: PRJNA157529

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Structure of the HER3 (ERBB3) Extracellular Domain PDB

    ID: PDB:1M6B

    Description: Receptor protein-tyrosine kinase erbB-3 (E.C.2.7.10.1)

  13. MCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures ArrayExpress

    ID: E-GEOD-37009

    Description: The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated ...

  14. NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells BioProject

    ID: PRJNA125813

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Down-regulation of ERBB3 by shRNA in the T47D cell line BioProject

    ID: PRJNA121989

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells OmicsDI

    ID: E-GEOD-21463

    Date Released: 03-27-2012

    Description: ) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/

  17. Quantitative phosphoproteomics analysis of ERBB3/ERBB4 signaling OmicsDI

    ID: PXD002665

    Date Released: 01-15-2016

    Description: the molecular level, signal transduction through ERBB3/ERBB4 heterodimers is less well understood. Here, we generated isogenic mouse Ba/F3 cells that express full-length and functional membrane-integrated ERBB3 and ERBB4 or ERBB4 alone, to serve as a defined cellular model for biological and phosphoproteomics analysis of ERBB3/ERBB4 signaling. ERBB3 co-expression significantly enhanced Ba/F...

  18. Crystal Structure of sErbB3-Fab3379 Complex PDB

    ID: PDB:5CUS

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Fab HC region of KTN3379, Fab LC region of KTN3379

  19. HER3 pseudokinase domain bound to bosutinib PDB

    ID: PDB:4OTW

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  20. NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells ArrayExpress

    ID: E-GEOD-21463

    Description: ) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/

  21. Transcription profiling by array of mouse mammary epithelial organoids after doxycyline-induced repression of ErbB3 expression ArrayExpress

    ID: E-GEOD-32129

    Description: Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3

  22. Transcription profiling by array of mouse mammary epithelial organoids after doxycyline-induced repression of ErbB3 expression OmicsDI

    ID: E-GEOD-32129

    Date Released: 04-30-2015

    Description: Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3

  23. Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or sign... BioProject

    ID: PRJNA184147

    Keywords: Transcriptome or Gene expression

    Access Type: download

  24. Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or sign... ArrayExpress

    ID: E-GEOD-43037

    Description: es or adaptors. We examined in transgenic mice if ErbB3, a powerful activator of PI3K, is required for mutant PIK3CA-mediated MEC transformation. ErbB3 loss delayed PIK3CAH1047R-dependent mammary gland hyperplasia, but tumor latency, gene expression and markers of PI3K signaling were unaffected. In ErbB3-deficient tumors, mutant PI3K remained associated with other tyrosine p...

  25. Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or sign... OmicsDI

    ID: E-GEOD-43037

    Date Released: 05-04-2014

    Description: es or adaptors. We examined in transgenic mice if ErbB3, a powerful activator of PI3K, is required for mutant PIK3CA-mediated MEC transformation. ErbB3 loss delayed PIK3CAH1047R-dependent mammary gland hyperplasia, but tumor latency, gene expression and markers of PI3K signaling were unaffected. In ErbB3-deficient tumors, mutant PI3K remained associated with other tyrosine p...

  26. Upregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors BioProject

    ID: PRJNA188229

    Keywords: Transcriptome or Gene expression

    Access Type: download

  27. A secreted isoform of ErbB3 promotes osteomectin expression in bone BioProject

    ID: PRJNA100789

    Keywords: Transcriptome or Gene expression

    Access Type: download

  28. Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas ArrayExpress

    ID: E-GEOD-37441

    Description: Analysis of transcriptome kinetics of SW1736 thyroid cancer cell line vs SK-MEL-28 melanoma cell line at various times after addition of 2 µM vemuraf...

  29. Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. BioProject

    ID: PRJNA159927

    Keywords: Transcriptome or Gene expression

    Access Type: download

  30. CD74-NRG1 fusions in lung adenocarcinoma OmicsDI

    ID: EGAS00001000653

    Date Released:

    Description: III-beta3, thereby providing the ligand for ERBB2-ERBB3 receptor complexes. Accordingly, ERBB2 and ERBB3 expression was high in the index case and expression of phospho-ERBB3 was specifically found in tumors bearing the fusion (p<0.0001). Ectopic expression of CD74-NRG1 in lung cancer cell lines expressing ERBB2 and ERBB3 activated ERBB3 and the PI3K-AKT pathway, and led to increased colony formation in soft agar. Thus, CD74-NRG1 gene fusions are activating genomic alterations in invasive mucinous a...

  31. ERBB3 and NGFR mark distinct skeletal muscle progenitor cells in human development enabling enrichment and maturation of hPSC muscle BioProject

    ID: PRJNA344494

    Keywords: Transcriptome or Gene expression

    Access Type: download

  32. Upregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors ArrayExpress

    ID: E-GEOD-43962

    Description: served. Comparison of gene signatures between the 3 cell lines produced approximately 2,600 common genes differentially regulated by FOXD3-expressing cells compared to the LacZ controls. Three unrelated mutant B-RAF melanoma cell lines (WM115, WM793, and A375) were induced to express FOXD3 and compared against the same cell lines expressing the control gene, β-galactosidase (LacZ)....

  33. CRYSTAL STRUCTURE OF ERBB3 BINDING PROTEIN 1 (EBP1) PDB

    ID: PDB:2V6C

    Description: PROLIFERATION-ASSOCIATED PROTEIN 2G4

  34. A secreted isoform of ErbB3 promotes osteomectin expression in bone ArrayExpress

    ID: E-GEOD-8001

    Description: ne. We previous identified a secreted isoform of ErbB3 (p45-sErbB3) from the bone marrow supernatants of patients with prostate cancer and bone metastasis. Immunohistochemical analysis of p45-sErbB3 expression in human specimens showed that p45-sErbB3 was highly expressed in metastatic prostate cancer cells in bone. Here we show that p45-sErbB3 stimulates calvarial bone to secrete factors th...

  35. Hematogenous metastasis of ovarian cancer: Re-thinking mode of spread BioProject

    ID: PRJNA230644

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cer to the omentum. Our studies revealed that the ErbB3-neuregulin1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer substantially impaired omental metastasis. Our results highlight hematogenous met...
  36. Alterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice BioProject

    ID: PRJNA110395

    Keywords: Transcriptome or Gene expression

    Access Type: download

  37. Alterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice ArrayExpress

    ID: E-GEOD-13718

    Description: Background: The ErbB3 binding protein-1 (Ebp1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, apoptosis and differentia...

  38. Transcription profiling of zebrafish mutants affected in neural crest development ArrayExpress

    ID: E-TABM-748

    Description: ected in neural crest development (cls/sox10, hps/erbb3, low/tfap2a, nac/mitfa, pfe/csfr1, shd/ltk, spa/kit tdo/trpm7) were compared to their wild type siblings or to wild type controls during development ...

  39. Quantitative phosphoproteomics analysis of ERBB3/ERBB4 signaling ProteomeXchange

    ID: PXD002665

    Instrument: LTQ Orbitrap Velos

    Date Released: 01-15-2016

  40. Transcription profiling of mouse Tie2-Cre transgene endothelial cells with inactivated Gata4 reveals development of heart valves requires Gata4 expres... ArrayExpress

    ID: E-GEOD-5298

    Description: cushions. Mutant cushions had decreased levels of Erbb3, an EGF-family receptor essential for EMT in the atrioventricular cushions. In Gata4 mutant embryos, Erbb3 downregulation was associated with impaired activation of Erk, which is also required for EMT. Expression of a Gata4 mutant protein defective in interaction with Friend of Gata (FOG) cofactors rescued the EMT defect, but resulted in decreased proliferation of mesenchyme and hypoplastic cushions that failed to septate the ventricular inlet. We demonstrate two novel functions of Gata4 in development of the AV valves. First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling. Experiment Overall Design: To further investigate the role of Gata4 in EC development, we specifically inactivated Gata4 in endothelium and endothelium-derived cushion mesenchyme. All mice were maintain...

  41. A secreted isoform of ErbB3 promotes osteomectin expression in bone OmicsDI

    ID: E-GEOD-8001

    Date Released: 10-18-2011

    Description: ne. We previous identified a secreted isoform of ErbB3 (p45-sErbB3) from the bone marrow supernatants of patients with prostate cancer and bone metastasis. Immunohistochemical analysis of p45-sErbB3 expression in human specimens showed that p45-sErbB3 was highly expressed in metastatic prostate cancer cells in bone. Here we show that p45-sErbB3 stimulates calvarial bone to secrete factors th...

  42. Transcription profiling of mouse Tie2-Cre transgene endothelial cells with inactivated Gata4 reveals development of heart valves requires Gata4 expres... OmicsDI

    ID: E-GEOD-5298

    Date Released: 03-27-2012

    Description: cushions. Mutant cushions had decreased levels of Erbb3, an EGF-family receptor essential for EMT in the atrioventricular cushions. In Gata4 mutant embryos, Erbb3 downregulation was associated with impaired activation of Erk, which is also required for EMT. Expression of a Gata4 mutant protein defective in interaction with Friend of Gata (FOG) cofactors rescued the EMT defect, but resulted in decreased proliferation of mesenchyme and hypoplastic cushions that failed to septate the ventricular inlet. We demonstrate two novel functions of Gata4 in development of the AV valves. First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling. Experiment Overall Design: To further investigate the role of Gata4 in EC development, we specifically inactivated Gata4 in endothelium and endothelium-derived cushion mesenchyme. All mice were maintain...

  43. Alterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice OmicsDI

    ID: E-GEOD-13718

    Date Released: 03-27-2012

    Description: Background: The ErbB3 binding protein-1 (Ebp1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, apoptosis and differentia...

  44. Whole exome sequencing for gallbladder cancer in Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine OmicsDI

    ID: EGAS00001000853

    Date Released:

    Description: mutations include TP53 (47.1%), KRAS (7.8%), and ERBB3 (11.8%). Moreover, ErbB signaling (including EGFR, ERBB2, ERBB3, ERBB4 and their downstream genes) is the most extensively mutated pathway, affecting 36.8% (21 of 57) of the GBC samples. Multivariate analyses further reveal that patients with ErbB pathway mutations have a worse outcome (P = 0.001). These findings provide insight into the somatic mutational landscape in GBC and highlight the key role of the ErbB signaling pathway in the pathogenesis of GBCs....

  45. XinHua Hospital Gallbladder cancer sequencing project : 32 pairs of gallbladder cancer tissues and matched normal tissues were sequenced by whole exom... BioProject

    ID: PRJEB6460

    Keywords: Other

    Access Type: download

    dataset.description: mutations include TP53 (47.1%), KRAS (7.8%), and ERBB3 (11.8%). Moreover, ErbB signaling (including EGFR, ERBB2, ERBB3, ERBB4 and their downstream genes) is the most extensively mutated pathway, affecting 36.8% (21 of 57) of the GBC samples. Multivariate analyses further reveal that patients with ErbB pathway mutations have a worse outcome (P = 0.001). These findings provide insight into the somatic mutational landscape in GBC and highlight the key role of the ErbB signaling pathway in the pathogenesis of GBCs....
  46. Gene expression signatures for lumber 5 dorsal horn of spinal cord in spinal nerve ligation (SNL) mice with WTD intervention BioProject

    ID: PRJNA380631

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: on of 12 genes (Crk1, Fgf13, Fgfr1, Crk1, Adrbk1, Erbb3, Gnas, Vegfa, Crk1, Erbb3, Drd2, Gnas) were identified as the efficacy of differentially expressed genes. Overall design: Gene expression in lumber 5 dorsal horn of spinal cord of ICR mice was measured 21 days after chronic administration of vehicle (saline, 10 ml/kg, p.o.), vehicle (saline, 10 ml/kg, p.o.) and WTD (12.60 g/kg, p.o.) in sham group, SNL group and WTD group, respectively....
  47. MCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures OmicsDI

    ID: E-GEOD-37009

    Date Released: 09-26-2012

    Description: The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated ...

  48. Upregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors OmicsDI

    ID: E-GEOD-43962

    Date Released: 06-02-2014

    Description: served. Comparison of gene signatures between the 3 cell lines produced approximately 2,600 common genes differentially regulated by FOXD3-expressing cells compared to the LacZ controls. Three unrelated mutant B-RAF melanoma cell lines (WM115, WM793, and A375) were induced to express FOXD3 and compared against the same cell lines expressing the control gene, β-galactosidase (LacZ)....

  49. Dual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer ArrayExpress

    ID: E-GEOD-43610

    Description: he epidermal growth factor receptor family member Erbb3 as a novel GRHL2 target gene. In breast cancer cell lines, shRNA-mediated knockdown of GRHL2 expression or functional inactivation of GRHL2 using dominant-negative GRHL2 proteins induce downregulation of ERBB3 gene expression, a striking reduction in cell proliferation and morphological and phenotypical alterations characteristic of an epithelial-to-mesenchymal transition (EMT), thus implying dual roles of GRHL2 in breast carcinogenesis. Interestingly, we could further demonstrate that expression of GRHL2 is directly suppressed by the transcrip...

  50. Ebp1's effect in prostate cancer BioProject

    ID: PRJNA113425

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t Ebp1, a protein isolated by its ability to bind ErbB3, is a downstream effector of heregulin activated pathways and an AR corepressor. As Ebp1 is decreased in preclinical models of hormone refractory prostate cancer, we studied the ability of Ebp1 to mitigate the hormone refractory phenotype. As we previously found that ...

Displaying 50 of 260 results for "ERBB3"