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  1. Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP PDB

    ID: PDB:3LMG

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  2. Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation PDB

    ID: PDB:4RIY

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Epidermal growth factor receptor (E.C.2.7.10.1)

  3. Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3) PDB

    ID: PDB:4LEO

    Description: RG7116 Fab heavy chain, RG7116 Fab light chain, Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  4. Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation PDB

    ID: PDB:4RIX

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Epidermal growth factor receptor (E.C.2.7.10.1)

  5. Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3) PDB

    ID: PDB:3KEX

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  6. Crystal structure of an EGFR/HER3 kinase domain heterodimer PDB

    ID: PDB:4RIW

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Epidermal growth factor receptor (E.C.2.7.10.1)

  7. anti-EGFR/HER3 Fab DL11 in complex with domains I-III of the HER3 extracellular region PDB

    ID: PDB:3P11

    Description: Fab DL11 heavy chain, Fab DL11 light chain, Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  8. HER3 extracellular domain in complex with Fab fragment of MOR09825 PDB

    ID: PDB:4P59

    Description: HER3 ectodomain, MOR09825 Fab fragment heavy chain, MOR09825 Fab fragment light chain

  9. Targeted ErbB3 loss in mammary organoids harvested from ErbB3 DOX-KO mice +/- DOX treatment BioProject

    ID: PRJNA147437

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Spatial structure of dimeric ErbB3 transmembrane domain PDB

    ID: PDB:2L9U

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  11. MCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures BioProject

    ID: PRJNA157529

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Structure of the HER3 (ERBB3) Extracellular Domain PDB

    ID: PDB:1M6B

    Description: Receptor protein-tyrosine kinase erbB-3 (E.C.2.7.10.1)

  13. MCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures ArrayExpress

    ID: E-GEOD-37009

    Description: The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated ...

  14. NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells BioProject

    ID: PRJNA125813

    Keywords: Transcriptome or Gene expression

    Access Type: download

  15. Down-regulation of ERBB3 by shRNA in the T47D cell line BioProject

    ID: PRJNA121989

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells OmicsDI

    ID: E-GEOD-21463

    Date Released: 03-27-2012

    Description: ) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/

  17. Quantitative phosphoproteomics analysis of ERBB3/ERBB4 signaling OmicsDI

    ID: PXD002665

    Date Released: 01-15-2016

    Description: the molecular level, signal transduction through ERBB3/ERBB4 heterodimers is less well understood. Here, we generated isogenic mouse Ba/F3 cells that express full-length and functional membrane-integrated ERBB3 and ERBB4 or ERBB4 alone, to serve as a defined cellular model for biological and phosphoproteomics analysis of ERBB3/ERBB4 signaling. ERBB3 co-expression significantly enhanced Ba/F...

  18. Crystal Structure of sErbB3-Fab3379 Complex PDB

    ID: PDB:5CUS

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1), Fab HC region of KTN3379, Fab LC region of KTN3379

  19. HER3 pseudokinase domain bound to bosutinib PDB

    ID: PDB:4OTW

    Description: Receptor tyrosine-protein kinase erbB-3 (E.C.2.7.10.1)

  20. NRG1/ERBB3 signaling in melanocyte Melan-Ink4a cells ArrayExpress

    ID: E-GEOD-21463

    Description: ) signaling through the receptor tyrosine kinase, ERBB3, is required for embryonic development, and dysregulated signaling has been associated with cancer progression. Here, we show that NRG1/

  21. Transcription profiling by array of mouse mammary epithelial organoids after doxycyline-induced repression of ErbB3 expression ArrayExpress

    ID: E-GEOD-32129

    Description: Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3

  22. Transcription profiling by array of mouse mammary epithelial organoids after doxycyline-induced repression of ErbB3 expression OmicsDI

    ID: E-GEOD-32129

    Date Released: 04-30-2015

    Description: Mammary organoids harvested from ErbB3 DOX-KO mice, which utilize MMTV-Cre transgene expression in the LE to cause genomic recombination at floxed ErbB3

  23. Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or sign... BioProject

    ID: PRJNA184147

    Keywords: Transcriptome or Gene expression

    Access Type: download

  24. Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or sign... ArrayExpress

    ID: E-GEOD-43037

    Description: es or adaptors. We examined in transgenic mice if ErbB3, a powerful activator of PI3K, is required for mutant PIK3CA-mediated MEC transformation. ErbB3 loss delayed PIK3CAH1047R-dependent mammary gland hyperplasia, but tumor latency, gene expression and markers of PI3K signaling were unaffected. In ErbB3-deficient tumors, mutant PI3K remained associated with other tyrosine p...

  25. Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or sign... OmicsDI

    ID: E-GEOD-43037

    Date Released: 05-04-2014

    Description: es or adaptors. We examined in transgenic mice if ErbB3, a powerful activator of PI3K, is required for mutant PIK3CA-mediated MEC transformation. ErbB3 loss delayed PIK3CAH1047R-dependent mammary gland hyperplasia, but tumor latency, gene expression and markers of PI3K signaling were unaffected. In ErbB3-deficient tumors, mutant PI3K remained associated with other tyrosine p...

  26. Upregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors BioProject

    ID: PRJNA188229

    Keywords: Transcriptome or Gene expression

    Access Type: download

  27. A secreted isoform of ErbB3 promotes osteomectin expression in bone BioProject

    ID: PRJNA100789

    Keywords: Transcriptome or Gene expression

    Access Type: download

  28. Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas ArrayExpress

    ID: E-GEOD-37441

    Description: Analysis of transcriptome kinetics of SW1736 thyroid cancer cell line vs SK-MEL-28 melanoma cell line at various times after addition of 2 µM vemuraf...

  29. Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. BioProject

    ID: PRJNA159927

    Keywords: Transcriptome or Gene expression

    Access Type: download

  30. CD74-NRG1 fusions in lung adenocarcinoma OmicsDI

    ID: EGAS00001000653

    Date Released:

    Description: III-beta3, thereby providing the ligand for ERBB2-ERBB3 receptor complexes. Accordingly, ERBB2 and ERBB3 expression was high in the index case and expression of phospho-ERBB3 was specifically found in tumors bearing the fusion (p<0.0001). Ectopic expression of CD74-NRG1 in lung cancer cell lines expressing ERBB2 and ERBB3 activated ERBB3 and the PI3K-AKT pathway, and led to increased colony formation in soft agar. Thus, CD74-NRG1 gene fusions are activating genomic alterations in invasive mucinous a...

  31. ERBB3 and NGFR mark distinct skeletal muscle progenitor cells in human development enabling enrichment and maturation of hPSC muscle BioProject

    ID: PRJNA344494

    Keywords: Transcriptome or Gene expression

    Access Type: download

  32. Upregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors ArrayExpress

    ID: E-GEOD-43962

    Description: served. Comparison of gene signatures between the 3 cell lines produced approximately 2,600 common genes differentially regulated by FOXD3-expressing cells compared to the LacZ controls. Three unrelated mutant B-RAF melanoma cell lines (WM115, WM793, and A375) were induced to express FOXD3 and compared against the same cell lines expressing the control gene, β-galactosidase (LacZ)....

  33. CRYSTAL STRUCTURE OF ERBB3 BINDING PROTEIN 1 (EBP1) PDB

    ID: PDB:2V6C

    Description: PROLIFERATION-ASSOCIATED PROTEIN 2G4

  34. A secreted isoform of ErbB3 promotes osteomectin expression in bone ArrayExpress

    ID: E-GEOD-8001

    Description: ne. We previous identified a secreted isoform of ErbB3 (p45-sErbB3) from the bone marrow supernatants of patients with prostate cancer and bone metastasis. Immunohistochemical analysis of p45-sErbB3 expression in human specimens showed that p45-sErbB3 was highly expressed in metastatic prostate cancer cells in bone. Here we show that p45-sErbB3 stimulates calvarial bone to secrete factors th...

  35. Hematogenous metastasis of ovarian cancer: Re-thinking mode of spread BioProject

    ID: PRJNA230644

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cer to the omentum. Our studies revealed that the ErbB3-neuregulin1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer substantially impaired omental metastasis. Our results highlight hematogenous met...
  36. Alterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice BioProject

    ID: PRJNA110395

    Keywords: Transcriptome or Gene expression

    Access Type: download

  37. Alterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice ArrayExpress

    ID: E-GEOD-13718

    Description: Background: The ErbB3 binding protein-1 (Ebp1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, apoptosis and differentia...

  38. Transcription profiling of zebrafish mutants affected in neural crest development ArrayExpress

    ID: E-TABM-748

    Description: ected in neural crest development (cls/sox10, hps/erbb3, low/tfap2a, nac/mitfa, pfe/csfr1, shd/ltk, spa/kit tdo/trpm7) were compared to their wild type siblings or to wild type controls during development ...

  39. Quantitative phosphoproteomics analysis of ERBB3/ERBB4 signaling ProteomeXchange

    ID: PXD002665

    Instrument: LTQ Orbitrap Velos

    Date Released: 01-15-2016

  40. Transcription profiling of mouse Tie2-Cre transgene endothelial cells with inactivated Gata4 reveals development of heart valves requires Gata4 expres... ArrayExpress

    ID: E-GEOD-5298

    Description: cushions. Mutant cushions had decreased levels of Erbb3, an EGF-family receptor essential for EMT in the atrioventricular cushions. In Gata4 mutant embryos, Erbb3 downregulation was associated with impaired activation of Erk, which is also required for EMT. Expression of a Gata4 mutant protein defective in interaction with Friend of Gata (FOG) cofactors rescued the EMT defect, but resulted in decreased proliferation of mesenchyme and hypoplastic cushions that failed to septate the ventricular inlet. We demonstrate two novel functions of Gata4 in development of the AV valves. First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling. Experiment Overall Design: To further investigate the role of Gata4 in EC development, we specifically inactivated Gata4 in endothelium and endothelium-derived cushion mesenchyme. All mice were maintain...

  41. A secreted isoform of ErbB3 promotes osteomectin expression in bone OmicsDI

    ID: E-GEOD-8001

    Date Released: 10-18-2011

    Description: ne. We previous identified a secreted isoform of ErbB3 (p45-sErbB3) from the bone marrow supernatants of patients with prostate cancer and bone metastasis. Immunohistochemical analysis of p45-sErbB3 expression in human specimens showed that p45-sErbB3 was highly expressed in metastatic prostate cancer cells in bone. Here we show that p45-sErbB3 stimulates calvarial bone to secrete factors th...

  42. Transcription profiling of mouse Tie2-Cre transgene endothelial cells with inactivated Gata4 reveals development of heart valves requires Gata4 expres... OmicsDI

    ID: E-GEOD-5298

    Date Released: 03-27-2012

    Description: cushions. Mutant cushions had decreased levels of Erbb3, an EGF-family receptor essential for EMT in the atrioventricular cushions. In Gata4 mutant embryos, Erbb3 downregulation was associated with impaired activation of Erk, which is also required for EMT. Expression of a Gata4 mutant protein defective in interaction with Friend of Gata (FOG) cofactors rescued the EMT defect, but resulted in decreased proliferation of mesenchyme and hypoplastic cushions that failed to septate the ventricular inlet. We demonstrate two novel functions of Gata4 in development of the AV valves. First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling. Experiment Overall Design: To further investigate the role of Gata4 in EC development, we specifically inactivated Gata4 in endothelium and endothelium-derived cushion mesenchyme. All mice were maintain...

  43. Alterations in Cell Growth and Signaling in ErbB3 Binding Protein -1 (Ebp1) Deficient Mice OmicsDI

    ID: E-GEOD-13718

    Date Released: 03-27-2012

    Description: Background: The ErbB3 binding protein-1 (Ebp1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, apoptosis and differentia...

  44. Whole exome sequencing for gallbladder cancer in Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine OmicsDI

    ID: EGAS00001000853

    Date Released:

    Description: mutations include TP53 (47.1%), KRAS (7.8%), and ERBB3 (11.8%). Moreover, ErbB signaling (including EGFR, ERBB2, ERBB3, ERBB4 and their downstream genes) is the most extensively mutated pathway, affecting 36.8% (21 of 57) of the GBC samples. Multivariate analyses further reveal that patients with ErbB pathway mutations have a worse outcome (P = 0.001). These findings provide insight into the somatic mutational landscape in GBC and highlight the key role of the ErbB signaling pathway in the pathogenesis of GBCs....

  45. XinHua Hospital Gallbladder cancer sequencing project : 32 pairs of gallbladder cancer tissues and matched normal tissues were sequenced by whole exom... BioProject

    ID: PRJEB6460

    Keywords: Other

    Access Type: download

    dataset.description: mutations include TP53 (47.1%), KRAS (7.8%), and ERBB3 (11.8%). Moreover, ErbB signaling (including EGFR, ERBB2, ERBB3, ERBB4 and their downstream genes) is the most extensively mutated pathway, affecting 36.8% (21 of 57) of the GBC samples. Multivariate analyses further reveal that patients with ErbB pathway mutations have a worse outcome (P = 0.001). These findings provide insight into the somatic mutational landscape in GBC and highlight the key role of the ErbB signaling pathway in the pathogenesis of GBCs....
  46. Gene expression signatures for lumber 5 dorsal horn of spinal cord in spinal nerve ligation (SNL) mice with WTD intervention BioProject

    ID: PRJNA380631

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: on of 12 genes (Crk1, Fgf13, Fgfr1, Crk1, Adrbk1, Erbb3, Gnas, Vegfa, Crk1, Erbb3, Drd2, Gnas) were identified as the efficacy of differentially expressed genes. Overall design: Gene expression in lumber 5 dorsal horn of spinal cord of ICR mice was measured 21 days after chronic administration of vehicle (saline, 10 ml/kg, p.o.), vehicle (saline, 10 ml/kg, p.o.) and WTD (12.60 g/kg, p.o.) in sham group, SNL group and WTD group, respectively....
  47. MCF10A cells expressing HER2 and HER3 and grown in three-dimensional cultures OmicsDI

    ID: E-GEOD-37009

    Date Released: 09-26-2012

    Description: The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated ...

  48. Upregulation of ERBB3 by FOXD3, an adaptive response to RAF and MEK inhibitors OmicsDI

    ID: E-GEOD-43962

    Date Released: 06-02-2014

    Description: served. Comparison of gene signatures between the 3 cell lines produced approximately 2,600 common genes differentially regulated by FOXD3-expressing cells compared to the LacZ controls. Three unrelated mutant B-RAF melanoma cell lines (WM115, WM793, and A375) were induced to express FOXD3 and compared against the same cell lines expressing the control gene, β-galactosidase (LacZ)....

  49. Dual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer ArrayExpress

    ID: E-GEOD-43610

    Description: he epidermal growth factor receptor family member Erbb3 as a novel GRHL2 target gene. In breast cancer cell lines, shRNA-mediated knockdown of GRHL2 expression or functional inactivation of GRHL2 using dominant-negative GRHL2 proteins induce downregulation of ERBB3 gene expression, a striking reduction in cell proliferation and morphological and phenotypical alterations characteristic of an epithelial-to-mesenchymal transition (EMT), thus implying dual roles of GRHL2 in breast carcinogenesis. Interestingly, we could further demonstrate that expression of GRHL2 is directly suppressed by the transcrip...

  50. Ebp1's effect in prostate cancer BioProject

    ID: PRJNA113425

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t Ebp1, a protein isolated by its ability to bind ErbB3, is a downstream effector of heregulin activated pathways and an AR corepressor. As Ebp1 is decreased in preclinical models of hormone refractory prostate cancer, we studied the ability of Ebp1 to mitigate the hormone refractory phenotype. As we previously found that ...
  51. Development of heart valves requires Gata4 expression in endothelial-derived cells BioProject

    ID: PRJNA95397

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cushions. Mutant cushions had decreased levels of Erbb3, an EGF-family receptor essential for EMT in the atrioventricular cushions. In Gata4 mutant embryos, Erbb3 downregulation was associated with impaired activation of Erk, which is also required for EMT. Expression of a Gata4 mutant protein defective in interaction with Friend of Gata (FOG) cofactors rescued the EMT defect, but resulted in decreased proliferation of mesenchyme and hypoplastic cushions that failed to septate the ventricular inlet. We demonstrate two novel functions of Gata4 in development of the AV valves. First, Gata4 functions as an upstream regulator of an Erbb3-Erk pathway necessary for EMT, and second, Gata4 acts to promote cushion mesenchyme growth and remodeling. Keywords: genetic modification Overall design: To further investigate the role of Gata4 in EC development, we specifically inactivated Gata4 in endothelium and endothelium-derived cushion mesenchyme. Al...
  52. Expression data from MAP3K11/GDF15 axis is a critical driver of cancer cachexia ArrayExpress

    ID: E-GEOD-68162

    Description: or growth when expression of an inducible driving oncogene is turned off. In this case, we tested the ability of MAP3K7/TAK1 or MAP3K11/MLK3 to form tumors in vivo in a genetically engineered model originally driven by a doxycycline-inducible HER2(V659E) oncogene. In this system, the expression and activity of HER2 was suppressed by doxycycline withdrawal and followed by the introduction of one of 13 genes (ErbB3, FAK1,...

  53. Expression data from MAP3K11/GDF15 axis is a critical driver of cancer cachexia BioProject

    ID: PRJNA281929

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: or growth when expression of an inducible driving oncogene is turned off. In this case, we tested the ability of MAP3K7/TAK1 or MAP3K11/MLK3 to form tumors in vivo in a genetically engineered model originally driven by a doxycycline-inducible HER2(V659E) oncogene. In this system, the expression and activity of HER2 was suppressed by doxycycline withdrawal and followed by the introduction of one of 13 genes (ErbB3, FAK1, FGFR2aIIIb, FGF...
  54. Transcription profiling of human prostate cancer cell line to determine Ebp1 effect in prostate cancer ArrayExpress

    ID: E-GEOD-12200

    Description: t Ebp1, a protein isolated by its ability to bind ErbB3, is a downstream effector of heregulin activated pathways and an AR corepressor. As Ebp1 is decreased in preclinical models of hormone refractory prostate cancer, we studied the ability of Ebp1 to mitigate the hormone refractory phenotype. As we previously found that ...

  55. ERBB3_PONAB UniProt:Swiss-Prot

    ID: Q5RB22

    Description: Receptor tyrosine-protein kinase erbB-3 Extracellular Helical Cytoplasmic Protein kinase ATP ATP ATP Proton acceptor ATP Phosphoserine Phosphoserine N-linked (GlcNAc...)...

  56. Transcription profiling of zebrafish mutants affected in neural crest development OmicsDI

    ID: E-TABM-748

    Date Released: 05-02-2014

    Description: ected in neural crest development (cls/sox10, hps/erbb3, low/tfap2a, nac/mitfa, pfe/csfr1, shd/ltk, spa/kit tdo/trpm7) were compared to their wild type siblings or to wild type controls during development ...

  57. Elucidating the gene expression profiles of human mammary subpopulations ArrayExpress

    ID: E-GEOD-35399

    Description: notype, but is characterised by low expression of ERBB3 and low proliferative potential. Parent-progeny relationship experiments demonstrated that all luminal progenitor populations in both species are highly plastic and, at low frequencies, can generate progeny representing all mammary cell types. Gene expression profiling demonstrates that the ER- luminal progenitors in the mouse and the undifferentiated ALDH+ luminal progenitors in the human have gene signatures that resemble those obtained from basal-like breast tumours. Overall, our work reveals a more defined mammary cell hierarchy, which may in turn provide greater insight into the aetiology of breast cancer. Normal human breast tissues from reduction mammoplasties were dissociated into single cells and the epithelial cell populations were flow sorted. Total RNA was extracted for each group in 11 independent patient samples....

  58. Metastatic breast cancer to the brain: set 1 ArrayExpress

    ID: E-GEOD-14682

    Description: ype. Metastatic cells to the brain over-expressed HER3 compared to primaries and showed evidence of higher activation of the MAPK pathways. Inhibition using anti-neuregulin antibody, Herceptin and Lapatinib reduced tumour growth in vitro and in vivo. Conclusions: The data demonstrate activation of neuregulin-HER3 pathway in brain metastases from breast cancer and suggest that even in absence of HER2 amplification (as with triple negative and basal cancers), anti-epidermal growth factor receptor family inhibitors may have a role in treating these patients An initial set of 29 matched pairs of primary breast cancer and their brain metastases and 22 unmatched brain metastases of from breast cancer was were available as for...

  59. Metastatic breast cancer to the brain: set 2 ArrayExpress

    ID: E-GEOD-14683

    Description: ype. Metastatic cells to the brain over-expressed HER3 compared to primaries and showed evidence of higher activation of the MAPK pathways. Inhibition using anti-neuregulin antibody, Herceptin and Lapatinib reduced tumour growth in vitro and in vivo. Conclusions: The data demonstrate activation of neuregulin-HER3 pathway in brain metastases from breast cancer and suggest that even in absence of HER2 amplification (as with triple negative and basal cancers), anti-epidermal growth factor receptor family inhibitors may have a role in treating these patients. An initial set of 29 matched pairs of primary breast cancer and their brain metastases and 22 unmatched brain metastases of from breast cancer was were available as fo...

  60. anti-EGFR/HER3 Fab DL11 alone PDB

    ID: PDB:3P0V

    Description: Fab DL11 light chain, Fab DL11 heavy chain

  61. Dual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer OmicsDI

    ID: E-GEOD-43610

    Date Released: 06-02-2014

    Description: he epidermal growth factor receptor family member Erbb3 as a novel GRHL2 target gene. In breast cancer cell lines, shRNA-mediated knockdown of GRHL2 expression or functional inactivation of GRHL2 using dominant-negative GRHL2 proteins induce downregulation of ERBB3 gene expression, a striking reduction in cell proliferation and morphological and phenotypical alterations characteristic of an epithelial-to-mesenchymal transition (EMT), thus implying dual roles of GRHL2 in breast carcinogenesis. Interestingly, we could further demonstrate that expression of GRHL2 is directly suppressed by the transcrip...

  62. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex ArrayExpress

    ID: E-GEOD-11546

    Description: nd DARPP-32 was shown to increase with age. NRG1, ERBB3, and NGFR show expression changes during the years of greatest risk for the development of schizophrenia. Expression of FEZ1, GAD1, and RGS4 showed especially high correlation with one another, in addition to the strongest mean levels of absolute correlation with all other genes studied here. Keywords: postmortem human brain collection Supplementary files: Gene expression measures in Matrix1379Normalized.txt include all data from the 1379 probes on the arrays, and are NOT adjusted for PMI, brain pH, and RIN, and are NOT averaged over multiple probes within genes. Raw data are located in Raw_1241842_gene_probe_profile.txt. We have used custom DNA microarrays to investigate gene expression in the normal human brain. Expression was measured in Brodmann's area 10 (BA10) in the prefrontal cortex of 72 postmortem brain samples spanning half a century of human aging (18-67 years), each without history of neuropsychiatric illness, neurological disease, or drug abuse....

  63. Comparison of gene expression in human embyronic stem cells grown in MEF-CM or defined media conditions BioProject

    ID: PRJNA98823

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s well as EGFR family members including ERBB2 and ERBB3 led to the design of a simple defined media which supported robust long-term growth of multiple hESC lines and allowed massive expansion of undifferentiated cells. Illumina bead arrays were used to demonstrate the maintenance of gene expression profiles characteristic of pluripotent cells in cultures grown in CM or defined media. Keywords: Comparison of cells in different culture conditions Overall design: Human embyronic stem cells...
  64. Activation of different signaling pathways in the regulation of biological properties of human pancreatic cancer cells by the mucin MUC4 and the oncog... ArrayExpress

    ID: E-GEOD-31322

    Description: xpression, G1 cell cycle arrest and altered ErbB2/ErbB3 expression. Their migration properties were reduced whereas invasive properties were increased. Importantly, inhibition of ErbB2 and MUC4 expression did not impair the same signalling pathways (inhibition of MUC4 expression affected the JNK pathway whereas that of ErbB2 altered the MAPK pathway). Finally, ErbB2-KD and MUC4-KD cells showed impaired tumour growth in vivo. This indicates that ErbB2 and MUC4, that physically interact, activate different intracellular signalling pathways to regulate biological properties of pancreatic cancer cells. Altogether, these data bring new information regarding molecular mechanisms under the control of both MUC4 and ErbB2 that will have to be taken into account for developing efficient targeting of both proteins in order to slow down/stop pancreatic tumourigenesis. profiling of pancreatic cells depleted for ErbB2 and MUC4...

  65. MicroRNA expression analysis of tumor tropic mesenchymal stem cells ArrayExpress

    ID: E-GEOD-35901

    Description: -CM contains higher amounts of IGFBP2, TRAIL, and ErbB3. Gene expression profiling suggests that despite the distinct differences, both migratory subset of B-ASCs towards MDA-CM and MCF-CM display perturbed expression of genes like KISS1, TNSF1, IL18 and MMP2, which could be associated with a defensive role of B-ASCs. In addition, the BC microenvironment alters microRNA (miRNA) expressions in B-ASCs. in this study the migratory cells were evaluated for miRNA expression versus non-migratory counterparts. as controls unexposed parental cell lines (2) were used on the same hybridization chip in which one labeled Hy3 and other labeled Hy5. The ratio of the control parental cells was used as base nanalysis of miRNA expression in MSCs. we also include another control in this study, the migratory subpopulations of MSCs which display migratory potentials against protein gradient (M5) were analyzed for miRNA expression versus non-migratory counterparts (NM-5). using this control facilitate identification of those miRNA responsive to tumor CM. the data analysis confirm that altered gene and miRNA profiles resulted from exposure of MCF-CM and MDA-CM on B-ASCs are similar to those observed in B-ASCs isolated from breast adipose tissue of...

  66. Dual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer BioProject

    ID: PRJNA186816

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he epidermal growth factor receptor family member Erbb3 as a novel GRHL2 target gene. In breast cancer cell lines, shRNA-mediated knockdown of GRHL2 expression or functional inactivation of GRHL2 using dominant-negative GRHL2 proteins induce downregulation of ERBB3 gene expression, a striking reduction in cell proliferation and morphological and phenotypical alterations characteristic of an epithelial-to-mesenchymal transition (EMT), thus implying dual roles of GRHL2 in breast carcinogenesis. Interestingly, we could further demonstrate that expression of GRHL2 is directly suppressed by the transcrip...
  67. 6KR-EGFR expressing MCF7 following EGF or HRG stimulation BioProject

    ID: PRJNA246684

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: EGF and HRG, growth factor ligands for EGFR and ErbB3/4 receptor, induce transient and sustained ERK activity associated with cellular proliferation and differentiation of MCF-7 c...
  68. Characterization of a P-REX1 gene signature in breast cancer cells ArrayExpress

    ID: E-GEOD-77974

    Description: ion of P-Rex1 and Rac1 in breast cancer cells via ErbB3, leading to a motile response. Since there is limited information about P-Rex1 downstream effectors, we carried out a microarray analysis to identify genes regulated by P-Rex1 in the context of HRG stimulation. In T-47D breast cancer cells, HRG treatment caused major changes in gene expression, including genes associated with motility, adhesion, invasiveness and metastasis. Silencing P-Rex1 expression from T-47D cells using RNAi altered the induction and repression of a subset...

  69. Transient activation of the WNT pathway after disruption/remodeling of colorectal cancer cell clusters promotes a malignant phenotype BioProject

    ID: PRJNA305551

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: gnosis of the colorectal cancer patients. WNT and HER3 signaling was increased in the reformed spheroids, and suppression of these signaling pathways attenuated the increases in growth and stemness after disruption. Thus, disorganized architecture in patient tumors might reflect the processes of disruption and subsequent remodeling and represent a cause rather than simply a consequence of malignancy progression. Overall design: Gene expression in cancer tissue-originated spheroids (CTOSs) was measured at pre, 6 hr, 24 hr, and 4 days after mechanical disruption. One experiment was performed at each time point....
  70. Solution structure and dynamics of the EGF/TGF-alpha chimera T1E PDB

    ID: PDB:1P9J

    Description: chimera of Epidermal growth factor(EGF) and Transforming growth factor alpha (TGF-alpha)

    dataset.keywords: ErbB3
  71. Expression data from MAP3K11/GDF15 axis is a critical driver of cancer cachexia OmicsDI

    ID: E-GEOD-68162

    Date Released: 04-27-2015

    Description: or growth when expression of an inducible driving oncogene is turned off. In this case, we tested the ability of MAP3K7/TAK1 or MAP3K11/MLK3 to form tumors in vivo in a genetically engineered model originally driven by a doxycycline-inducible HER2(V659E) oncogene. In this system, the expression and activity of HER2 was suppressed by doxycycline withdrawal and followed by the introduction of one of 13 genes (ErbB3, FAK1,...

  72. AKT antagonist AZD5363 influences estrogen receptor function in endocrine resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo ArrayExpress

    ID: E-GEOD-69893

    Description: Phosphoinositide-3-kinase/protein-kinaseB/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling plays an important role in breast cancer (BC). It...

  73. Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. BioProject

    ID: PRJNA270059

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: IGF2) is a key target of NF-κB activated by HER2/HER3 signaling to form tumor spheres in breast cancer cells. The IGF2 receptor, IGF1 R, was expressed at high levels in CSC-enriched populations in primary breast cancer cells. Moreover, IGF2-PI3K (IGF2-phosphatidyl inositol 3 kinase) signaling induced expression of a stemness transcription factor, inhibitor of DNA-...
  74. Crystal structure of the C-terminal domain of mouse Nrdp1 PDB

    ID: PDB:2OGB

    Description: RING finger protein 41

    primaryPublication.title: the binding site for the receptor tyrosine kinase ErbB3....
  75. Transient activation of the WNT pathway after disruption/remodeling of colorectal cancer cell clusters promotes a malignant phenotype ArrayExpress

    ID: E-GEOD-75867

    Description: gnosis of the colorectal cancer patients. WNT and HER3 signaling was increased in the reformed spheroids, and suppression of these signaling pathways attenuated the increases in growth and stemness after disruption. Thus, disorganized architecture in patient tumors might reflect the processes of disruption and subsequent remodeling and represent a cause rather than simply a consequence of malignancy progression. Gene expression in cancer tissue-originated spheroids (CTOSs) was measured at pre, 6 hr, 24 hr, and 4 days after mechanical disruption. One experiment was performed at each time point....

  76. Transcription profiling of human prostate cancer cell line to determine Ebp1 effect in prostate cancer OmicsDI

    ID: E-GEOD-12200

    Date Released: 05-03-2014

    Description: t Ebp1, a protein isolated by its ability to bind ErbB3, is a downstream effector of heregulin activated pathways and an AR corepressor. As Ebp1 is decreased in preclinical models of hormone refractory prostate cancer, we studied the ability of Ebp1 to mitigate the hormone refractory phenotype. As we previously found that ...

  77. Genentech Colon Cancer Screen OmicsDI

    ID: EGAS00001000288

    Date Released:

    Description: and TET3 and receptor tyrosine kinases including ERBB3. Our analysis for significantly mutated cancer genes identified 23 candidates, including the cell cycle checkpoint kinase ATM. Copy-number and RNA-seq data analysis identified amplifications and corresponding overexpression of IGF2 in a subset of colon tumours. Furthermore, using RNA-seq data we identified multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours. The RSPO fusions were mutually exclusive with APC mutations, indicating that they probably have a role in the activation of Wnt signalling and tu...

  78. The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem-cell-niche function ArrayExpress

    ID: E-GEOD-61695

    Description: on of these cells to the bone marrow requires the ErbB3 receptor. The neonatal Nestin-GFP+ PDGFR- Cell population also contains Schwann-cell precursors, But does not comprise mature Schwann cells. Thus, In the developing bone marrow HSC-niche-forming MSCs share a common origin with sympathetic peripheral neurons and glial cells, And ontogenically distinct MSCs have non-overlapping functions in endochondrogenesis and HSC niche formation. Total RNA was isolated from small numbers of FACS sorted stromal cells, obtained from neonatal Nes-Gfp bone marrow preparations (2 biological replicates). Each independent set of samples was obtained from pooled skeletal elements (long bones and sterna) form multiple littermates....

  79. Metastatic breast cancer to the brain: set 1 BioProject

    ID: PRJNA114425

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ype. Metastatic cells to the brain over-expressed HER3 compared to primaries and showed evidence of higher activation of the MAPK pathways. Inhibition using anti-neuregulin antibody, Herceptin and Lapatinib reduced tumour growth in vitro and in vivo. Conclusions: The data demonstrate activation of neuregulin-HER3 pathway in brain metastases from breast cancer and suggest that even in absence of HER2 amplification (as with triple negative and basal cancers), anti-epidermal growth factor receptor family inhibitors may have a role in treating these patients Overall design: An initial set of 29 matched pairs of primary breast cancer and their brain metastases and 22 unmatched brain metastases of from breast cancer was were a...
  80. anti-EGFR/HER3 Fab DL11 in complex with domain III of EGFR extracellular region PDB

    ID: PDB:3P0Y

    Description: Epidermal growth factor receptor(E.C.2.7.10.1), Fab DL11 heavy chain, Fab DL11 light chain

  81. The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem-cell-niche function OmicsDI

    ID: E-GEOD-61695

    Date Released: 10-19-2014

    Description: on of these cells to the bone marrow requires the ErbB3 receptor. The neonatal Nestin-GFP+ PDGFR- Cell population also contains Schwann-cell precursors, But does not comprise mature Schwann cells. Thus, In the developing bone marrow HSC-niche-forming MSCs share a common origin with sympathetic peripheral neurons and glial cells, And ontogenically distinct MSCs have non-overlapping functions in endochondrogenesis and HSC niche formation. Total RNA was isolated from small numbers of FACS sorted stromal cells, obtained from neonatal Nes-Gfp bone marrow preparations (2 biological replicates). Each independent set of samples was obtained from pooled skeletal elements (long bones and sterna) form multiple littermates....

  82. Inhibition of protein–protein interaction of HER2–EGFR and HER2–HER3 by a rationally designed peptidomimetic Figshare

    ID: doi:10.6084/M9.FIGSHARE.825604.V1

    Release Date: 03-10-2016

    Description:

  83. Metastatic breast cancer to the brain: set 2 BioProject

    ID: PRJNA114409

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ype. Metastatic cells to the brain over-expressed HER3 compared to primaries and showed evidence of higher activation of the MAPK pathways. Inhibition using anti-neuregulin antibody, Herceptin and Lapatinib reduced tumour growth in vitro and in vivo. Conclusions: The data demonstrate activation of neuregulin-HER3 pathway in brain metastases from breast cancer and suggest that even in absence of HER2 amplification (as with triple negative and basal cancers), anti-epidermal growth factor receptor family inhibitors may have a role in treating these patients. Overall design: An initial set of 29 matched pairs of primary breast cancer and their brain metastases and 22 unmatched brain metastases of from breast cancer was were ...
  84. Inhibition of protein–protein interaction of HER2–EGFR and HER2–HER3 by a rationally designed peptidomimetic Figshare

    ID: doi:10.6084/M9.FIGSHARE.825604

    Release Date: 03-10-2016

    Description:

  85. Elucidating the gene expression profiles of human mammary subpopulations BioProject

    ID: PRJNA152785

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: notype, but is characterised by low expression of ERBB3 and low proliferative potential. Parent-progeny relationship experiments demonstrated that all luminal progenitor populations in both species are highly plastic and, at low frequencies, can generate progeny representing all mammary cell types. Gene expression profiling demonstrates that the ER- luminal progenitors in the mouse and the undifferentiated ALDH+ luminal progenitors in the human have gene signatures that resemble those obtained from basal-like breast tumours. Overall, our work reveals a more defined mammary cell hierarchy, which may in turn provide greater insight into the aetiology of breast cancer. Overall design: Normal human breast tissues from reduction mammoplasties were dissociated into single cells and the epithelial cell populations were flow sorted. Total RNA was extracted for each group in 11 independent patient samples....
  86. Activation of different signaling pathways in the regulation of biological properties of human pancreatic cancer cells by the mucin MUC4 and the oncog... BioProject

    ID: PRJNA146097

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: xpression, G1 cell cycle arrest and altered ErbB2/ErbB3 expression. Their migration properties were reduced whereas invasive properties were increased. Importantly, inhibition of ErbB2 and MUC4 expression did not impair the same signalling pathways (inhibition of MUC4 expression affected the JNK pathway whereas that of ErbB2 altered the MAPK pathway). Finally, ErbB2-KD and MUC4-KD cells showed impaired tumour growth in vivo. This indicates that ErbB2 and MUC4, that physically interact, activate different intracellular signalling pathways to regulate biological properties of pancreatic cancer cells. Altogether, these data bring new information regarding molecular mechanisms under the control of both MUC4 and ErbB2 that will have to be taken into account for developing efficient targeting of both proteins in order to slow down/stop pancreatic tumourigenesis. Overall design: profiling of pancreatic cells depleted for ErbB2 and MUC4...
  87. Additional file 1: Table S1. of Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3637346_D1

    Release Date: 12-15-2016

    Description: or the validation screens of ELF3, GNAS, KLF5 and ERBB3. Table S5. Mean mutation rates. Table S6. Somatic mutations identified in the validation cohort. (XLSX 208 kb)...

  88. MicroRNA expression analysis of tumor tropic mesenchymal stem cells BioProject

    ID: PRJNA151999

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -CM contains higher amounts of IGFBP2, TRAIL, and ErbB3. Gene expression profiling suggests that despite the distinct differences, both migratory subset of B-ASCs towards MDA-CM and MCF-CM display perturbed expression of genes like KISS1, TNSF1, IL18 and MMP2, which could be associated with a defensive role of B-ASCs. In addition, the BC microenvironment alters microRNA (miRNA) expressions in B-ASCs. in this study the migratory cells were evaluated for miRNA expression versus non-migratory counterparts. as controls unexposed parental cell lines (2) were used on the same hybridization chip in which one labeled Hy3 and other labeled Hy5. The ratio of the control parental cells was used as base nanalysis of miRNA expression in MSCs. we also include another control in this study, the migratory subpopulations of MSCs which display migratory potentials against protein gradient (M5) were analyzed for miRNA expression versus non-migratory counterparts (NM-5). using this control facilitate identification of those miRNA responsive to tumor CM. the data analysis confirm that altered gene and miRNA profiles resulted from exposure of MCF-CM and MDA-CM on B-ASCs are similar to those observed in B-ASCs isolated from breast adipose tissue of...
  89. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex BioProject

    ID: PRJNA106271

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nd DARPP-32 was shown to increase with age. NRG1, ERBB3, and NGFR show expression changes during the years of greatest risk for the development of schizophrenia. Expression of FEZ1, GAD1, and RGS4 showed especially high correlation with one another, in addition to the strongest mean levels of absolute correlation with all other genes studied here. Keywords: postmortem human brain collection Supplementary files: Gene expression measures in Matrix1379Normalized.txt include all data from the 1379 probes on the arrays, and are NOT adjusted for PMI, brain pH, and RIN, and are NOT averaged over multiple probes within genes. Raw data are located in Raw_1241842_gene_probe_profile.txt. Overall design: We have used custom DNA microarrays to investigate gene expression in the normal human brain. Expression was measured in Brodmann's area 10 (BA10) in the prefrontal cortex of 72 postmortem brain samples spanning half a century of human aging (18-67 years), each without history of neuropsychiatric illness, neurological disease, or drug abuse....
  90. The Epidermal Growth Factor Receptor Critically Regulates Endometrial Function during Early Pregnancy BioProject

    ID: PRJNA377897

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: during early pregnancy. While ablation of Her2 or Erbb3 led to only a modest reduction in litter size, mice lacking Egfr expression are severely subfertile. Pregnancy demise occurred shortly after blastocyst implantation due to defects in decidualization including decreased proliferation, cell survival, differentiation and target gene expression. To place Egfr in a genetic regulatory hierarchy, transcriptome analyses was used to compare the gene signatures from mice with conditional ablation of Egfr, wingless-related MMTV integration site 4 (Wnt4) or boneless morphogenic protein 2 (Bmp2); revealing that not only are Bmp2 and Wnt4 key downstream effectors of Egfr, but they also regulate distinct physiological functions. In ...
  91. Characterization of a P-REX1 gene signature in breast cancer cells BioProject

    ID: PRJNA312230

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ion of P-Rex1 and Rac1 in breast cancer cells via ErbB3, leading to a motile response. Since there is limited information about P-Rex1 downstream effectors, we carried out a microarray analysis to identify genes regulated by P-Rex1 in the context of HRG stimulation. In T-47D breast cancer cells, HRG treatment caused major changes in gene expression, including genes associated with motility, adhesion, invasiveness and metastasis. Silencing P-Rex1 expression from T-47D cells using RNAi altered the induction and repression of a subset...
  92. AKT antagonist AZD5363 influences estrogen receptor function in endocrine resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo BioProject

    ID: PRJNA287034

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Phosphoinositide-3-kinase/protein-kinaseB/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling plays an important role in breast cancer (BC). It...
  93. The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer OmicsDI

    ID: E-GEOD-40949

    Date Released: 05-03-2014

    Description: -1 gene, an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes Chromatin was extracted from hyperglycemic (HyG) and euglycemic (Control) cancer cells; FAIRE DNA and input DNA from each sample were used to generate libraries for single end sequencing on the the SOLiD 4 HQ system...

  94. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex GEMMA

    ID: 1623

    Keywords: functional genomics

    Description: nd DARPP-32 was shown to increase with age. NRG1, ERBB3, and NGFR show expression changes during the years of greatest risk for the development of schizophrenia. Expression of FEZ1, GAD1, and RGS4 showed especially high correlation with one another, in addition to the strongest mean levels of absolute correlation with all other genes studied here. Supplementary files: Gene expression measures in Matrix1379Normalized.txt include all data from the 1379 probes on the arrays, and are NOT adjusted for PMI, brain pH, and RIN, and are NOT averaged over multiple probes within genes. Raw data are located in Raw_1241842_gene_probe_profile.txt. Last Updated (by provider): May 23 2008 Contributers: Carlo Colantuoni Johanna Creswell Joel E Kleinman Thomas M Hyde Andrew Joseph Amy Deep-Soboslay Barbara K Lipska Shruti Mitkus Elizabeth Johnson Mary M Herman Claudia Aguirre Daniel R Weinberger Leah Sartorius...

  95. The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer ArrayExpress

    ID: E-GEOD-40949

    Description: -1 gene, an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes Chromatin was extracted from hyperglycemic (HyG) and euglycemic (Control) cancer cells; FAIRE DNA and input DNA from each sample were used to generate libraries for single end sequencing on the the SOLiD 4 HQ system...

  96. Elucidating the gene expression profiles of human mammary subpopulations OmicsDI

    ID: E-GEOD-35399

    Date Released: 10-22-2012

    Description: notype, but is characterised by low expression of ERBB3 and low proliferative potential. Parent-progeny relationship experiments demonstrated that all luminal progenitor populations in both species are highly plastic and, at low frequencies, can generate progeny representing all mammary cell types. Gene expression profiling demonstrates that the ER- luminal progenitors in the mouse and the undifferentiated ALDH+ luminal progenitors in the human have gene signatures that resemble those obtained from basal-like breast tumours. Overall, our work reveals a more defined mammary cell hierarchy, which may in turn provide greater insight into the aetiology of breast cancer. Normal human breast tissues from reduction mammoplasties were dissociated into single cells and the epithelial cell populations were flow sorted. Total RNA was extracted for each group in 11 independent patient samples....

  97. Metastatic breast cancer to the brain: set 1 OmicsDI

    ID: E-GEOD-14682

    Date Released: 06-10-2011

    Description: ype. Metastatic cells to the brain over-expressed HER3 compared to primaries and showed evidence of higher activation of the MAPK pathways. Inhibition using anti-neuregulin antibody, Herceptin and Lapatinib reduced tumour growth in vitro and in vivo. Conclusions: The data demonstrate activation of neuregulin-HER3 pathway in brain metastases from breast cancer and suggest that even in absence of HER2 amplification (as with triple negative and basal cancers), anti-epidermal growth factor receptor family inhibitors may have a role in treating these patients An initial set of 29 matched pairs of primary breast cancer and their brain metastases and 22 unmatched brain metastases of from breast cancer was were available as for...

  98. AKT antagonist AZD5363 influences estrogen receptor function in endocrine resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo OmicsDI

    ID: E-GEOD-69893

    Date Released: 08-20-2015

    Description: Phosphoinositide-3-kinase/protein-kinaseB/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling plays an important role in breast cancer (BC). It...

  99. Whole-exome Sequencing Combined with Functional Genomics Reveals Novel Candidate Driver Cancer Genes in Endometrial Cancer OmicsDI

    ID: EGAS00001000318

    Date Released:

    Description: 8, IGFBP3, AKTIP, PHKA2, TRPS1 and WNT11) and two oncogene candidates (ERBB3 and RPS6KC1). The results in the “sensor” cell line were recapitulated by siRNA-mediated knockdown in endometrial cancer cell lines. Focusing on ARID1A, we integrated mutation profiles with functional proteomics in 222 endometrial cancer samples, demonstrating that ARID1A mutations frequently co-occur with mutations in the phosphatidylinositol 3-kinase (PI3K) pathway and are associated with PI3K pathway activation. siRNA knockdown in endometrial cancer cell lines increased AKT phosphorylation supporting ARID1A as a novel regulator of PI3K pathway activity. Our study presents the first unbiased view of somatic coding mutations in endometrial cancer and provides functional evidence for diverse driver genes and mutations in this disease....

  100. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex OmicsDI

    ID: E-GEOD-11546

    Date Released: 03-27-2012

    Description: nd DARPP-32 was shown to increase with age. NRG1, ERBB3, and NGFR show expression changes during the years of greatest risk for the development of schizophrenia. Expression of FEZ1, GAD1, and RGS4 showed especially high correlation with one another, in addition to the strongest mean levels of absolute correlation with all other genes studied here. Keywords: postmortem human brain collection Supplementary files: Gene expression measures in Matrix1379Normalized.txt include all data from the 1379 probes on the arrays, and are NOT adjusted for PMI, brain pH, and RIN, and are NOT averaged over multiple probes within genes. Raw data are located in Raw_1241842_gene_probe_profile.txt. We have used custom DNA microarrays to investigate gene expression in the normal human brain. Expression was measured in Brodmann's area 10 (BA10) in the prefrontal cortex of 72 postmortem brain samples spanning half a century of human aging (18-67 years), each without history of neuropsychiatric illness, neurological disease, or drug abuse....


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