DNM2 | bioCADDIE Data Discovery Index
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Displaying 20 of 692 results for "DNM2"
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  1. SYP1_SCHPO UniProt:Swiss-Prot

    ID: O43059

    Description: Cytoskeletal protein syp1 F-BAR MHD Phosphothreonine

  2. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing OmicsDI

    ID: E-GEOD-28703

    Date Released: 06-26-2012

    Description: also identified new targets of mutation including DNM2, ECT2L and RELN. Ten of 12 ETP ALL cases harboured chromosomal rearrangements, several of which complex and resulted in the expression of novel chimeric in-frame fusion genes disrupting haemopoietic regulators. Thus, similar to myeloid malignancies, mutations that drive proliferation, impair differentiation and disrupt histone modification are hallmarks of ETP ALL. Moreover, the global transcriptional profile of ETP ALL was similar to that of normal and myeloid leukaemia haemopoietic stem cells. These findings suggest that addition of myeloid-directed therapies might improve the poor outcome of ETP ALL. Gene expression profiling was performed on 52 single diagnosis tumor samples. No control or reference samples were included....

  3. Nucleotide-free Dynamin 1-like protein (DNM1L, DRP1, DLP1) PDB

    ID: PDB:4BEJ

    Description: DYNAMIN 1-LIKE PROTEIN (E.C.3.6.5.5)

  4. Crystal structure of human Dlp1 in complex with GMP-PN.Pi PDB

    ID: PDB:3W6N

    Description: Dynamin-1-like protein (E.C.3.6.5.5)

  5. K2C1B_MOUSE UniProt:Swiss-Prot

    ID: Q6IFZ6

    Description: Keratin, type II cytoskeletal 1b Head Rod Coil 1A Linker 1 Coil 1B Linker 12 Coil 2 Tail Stutter...

  6. K1C15_RAT UniProt:Swiss-Prot

    ID: Q6IFV3

    Description: Keratin, type I cytoskeletal 15 Head Rod Coil 1A Linker 1 Coil 1B Linker 12 Coil 2 Tail Gly-rich Phosphoserine Phosphoserine Pho...

  7. Crystal structure of nucleotide-free human dynamin1 PDB

    ID: PDB:3SNH

    Description: Dynamin-1 (E.C.3.6.5.5)

  8. DYNAMIN 1 GTPASE DIMER, SHORT AXIS FORM PDB

    ID: PDB:2X2F

    Description: DYNAMIN-1 (E.C.3.6.5.5)

  9. K2C6A_RAT UniProt:Swiss-Prot

    ID: Q4FZU2

    Description: Keratin, type II cytoskeletal 6A Head Rod Coil 1A Linker 1 Coil 1B Linker 12 Coil 2 Tail Stutter...

  10. K2C73_MOUSE UniProt:Swiss-Prot

    ID: Q6NXH9

    Description: Keratin, type II cytoskeletal 73 Head Rod Coil 1A Linker 1 Coil 1B Linker 12 Coil 2 Tail Gly-rich Stutter...

  11. Profiling of microRNA expression in lung cancer cells with up-regulation of Zeb1 OmicsDI

    ID: E-GEOD-38386

    Date Released: 08-20-2012

    Description: e microRNAs (miRs). Zeb1 stimulated pro-migratory cytoskeletal processes by down-regulating miR-34a and activated Rho GTPases through Arhgap1, a Cdc42 GTPase activating protein and novel miR-34a target gene. Poor-prognosis human lung adenocarcinomas were highly enriched in a cytoskeletal gene signature activated by miR-34a down-regulation. These findings suggest that Zeb1 regulates a miR network and drives pro-migrato...

  12. Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics OmicsDI

    ID: PXD003239

    Date Released: 11-27-2015

    Description: Protein degradation provides an important regulatory mechanism used to control cell cycle progression and many other cellular pathw...

  13. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukaemia by whole genome sequencing OmicsDI

    ID: E-GEOD-33315

    Date Released: 01-16-2012

    Description: ets of mutation in including GATA3, EP300, RUNX1, DNM2, ECT2L, HNRNPA1 and HNRNPR, as well as genes known to be mutated in T-ALL, including NOTCH1, PHF6, and WT1.. Five of 12 ETP ALL cases harboured novel chromosomal translocations, several of which accompanied complex multichromosomal rearrangements and resulted in the expression of chimeric in-frame fusion genes disrupting hematopoietic regulators, including ETV6-INO80D, NAP1L1-MLLT10 and RUNX1-EVX1. These results indicate that although ETP ALL is genetically heterogeneous, activation of Ras and cytokine receptor signalling distinguishes this disease from non-ETP ALL. These findings suggest that targeting this pathway may improve the currently dismal outcome of this disease. Gene expression profiling of an extended panel of childhood B-lineage and T-lineage acute lymphoblastic le...

  14. Discovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukaemia by whole genome sequencing OmicsDI

    ID: E-GEOD-28497

    Date Released: 05-20-2011

    Description: ets of mutation in including GATA3, EP300, RUNX1, DNM2, ECT2L, HNRNPA1 and HNRNPR, as well as genes known to be mutated in T-ALL, including NOTCH1, PHF6, and WT1.. Five of 12 ETP ALL cases harboured novel chromosomal translocations, several of which accompanied complex multichromosomal rearrangements and resulted in the expression of chimeric in-frame fusion genes disrupting hematopoietic regulators, including ETV6-INO80D, NAP1L1-MLLT10 and RUNX1-EVX1. These results indicate that although ETP ALL is genetically heterogeneous, activation of Ras and cytokine receptor signalling distinguishes this disease from non-ETP ALL. These findings suggest that targeting this pathway may improve the currently dismal outcome of this disease. Gene expression profiling of an extended panel of childhood B-lineage and T-lineage acute lymphoblastic le...

  15. Crystal structure of human Dlp1 in complex with GDP.AlF4 PDB

    ID: PDB:3W6P

    Description: Dynamin-1-like protein (E.C.3.6.5.5)

  16. structures of the NO factor SlmA bound to DNA and the cytoskeletal cell division protein FtsZ PDB

    ID: PDB:5HAW

    Description: Nucleoid occlusion factor SlmA, FtsZ CTT/DNA Complex

  17. The Trichomonas PACK proteome OmicsDI

    ID: PXD003212

    Date Released: 01-01-1000

    Description: e intermediate filament (IF) family. Canonical IF protein families appear restricted to Metazoa, although protists are well known for an extensive number of filamentous structures that neither involve actin nor tubulin, yet support the complex cell architecture. Trichomonadida are an evolutionary...

  18. Transcriptional profiling of lung cancer cells over-expression miR-34a. BioProject

    ID: PRJNA167686

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e microRNAs (miRs). Zeb1 stimulated pro-migratory cytoskeletal processes by down-regulating miR-34a and activated Rho GTPases through Arhgap1, a Cdc42 GTPase activating protein and novel miR-34a target gene. Poor-prognosis human lung adenocarcinomas were highly enriched in a cytoskeletal gene signature activated by miR-34a down-regulation. These findings suggest that Zeb1 regulates a miR network and drives pro-migrato...
  19. Data from: The core planar cell polarity gene, Vangl2, directs adult corneal epithelial cell alignment and migration Dryad

    DateIssued: 11-01-2016

    Description: ted activator of morphogenesis and Rho-associated protein kinase directs the alignment of HCE cells by affecting cytoskeletal reorganization. Cells in which VANGL2 was disrupted tended to misalign on grooved surfaces and migrate across, rather than parallel to the grooves. Adult corneal epithelial cells in which Vangl2 had been conditionally deleted showed a reduced rate of wound-healing migration. Conditional deletion of Vangl2 in the mouse corneal epithelium ablated the normal highly stereotyped patterns of centripetal cell migration in vivo from the periphery (limbus) to the centre of the cornea. Corneal opacity owing to chronic wounding is a major cause of degenerative blindness across the world, and this study shows that Vangl2 activity is required for directional corneal epithelial migrati...

  20. Structure of the K. pneumonia SlmA protein bound to the C-terminal tail of the cytoskeletal cell division protein FtsZ PDB

    ID: PDB:5HSZ

    Description: Nucleoid occlusion factor SlmA, C-terminal Tail of FtsZ


Displaying 20 of 692 results for "DNM2"