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Displaying 20 of 692 results for "DNM2"
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  1. Microarrays analysis of anti-Enterovirus 71 activity of Heparin BioProject

    ID: PRJNA149797

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: y Hep include genes related to; (i) cell growth, (ii) DNA repair and replication, (iii) cytoplasmic microfilaments and related apoptosis, (iv) regulation of energy metabolism and mitochondrion-related apoptosis, (v) cytoplasmic viral transport, (vi) transmembrane proteins and the related signaling pathways, (vii) phosphoribosyltransferase, (viii) transcription factors, (ix) G protein-coupled receptors and G protein-coupled receptors-interacting proteins, (x) remodeling actin filament assembly, (xi) chemokin receptors, and (xii) immunosuppression. In addition, Hep sometimes appeared to be harmful for cells, like the case in that Hep likely suppresses regulation of Metallothionein 1E. Furthermore, it should not be ignored that the Hep-caused affects seen in this microarray analysis may partially be attributed to a significant inhibitory effect of Hep on EV71 entry into the cells. In conclusion, we propose that our microarray findings may suggest new directions for further studies on molecular targets of anti-EV71 activity of Hep. EV71 is a neurovirological virus that can cause s...
  2. Gene expression profile of human heart failure from different etiologies BioProject

    ID: PRJNA92123

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: we have identified down-regulation of LIM domain protein which may be an important pathway for the clinical progression of HF. We identified six genes, encoding LIM domain and Homer proteins, that are down-regulated in terminally failing hearts. The LIM and cysteine rich domain 1 (LMCD1) gene, in particular, was significantly down-regulated in all HF samples. This novel finding suggests that the LMCD 1 is a universal biomarker for end-stage HF. Other LIM domain genes were also down-regulated but only in non-familial dilated forms of cardiomyopathy. This is probably due to the fact that down-regulation of LIM protein expression may disrupt the cytoskeletal architecture, leading to dilated cardiomyopathy. In addition to identifying the LIM domain genes as possible regulatory genes involved in HF, we also demonstrated that the gene expression profile was able to classify multiple HF patients groups. This paper is the first to examine viral-induced cardiomyopathy, doxorubicin toxicity cardiomyopathy and perimartum cardiomyopathy and to perform the clustering analysis of those HF types providing new insights into human HF. Keywords: other...
  3. Mycoplasma pulmonis : Causes pneumonia-like disease in mice BioProject

    ID: PRJNA35097

    Access Type: download

    dataset.description: soft; cutis, skin). The cell membrane is rich in protein components (up to two thirds of the membrane mass) that to a great extent consists of highly structurally adaptive lipoproteins employed in invading the host immune system, attachment to the host cells, and pathogenic invasion. Motile mycoplasmas glide over the surface by an unknown mechanism that is suspected to employ actin-like cytoskeletal components as well as motility proteins unique for this microbial group. Cell division proceeds via normal binary fission or via elongation of a parental cell to form multinucleated filaments and the subsequent breakup to form coccoid bodies. Mycoplasmas carry the smallest genomes of self-replicating cells (less than 500 recognizable coding regions), which is one of the reasons they were among the first microorganisms selected for the genome-sequencing projects. The complete sequence of the genome of M. genitalium was the second to be reported following the report on the complete sequence of the Haemophilus influenzae genome. Examination of the mycoplasma genomic data indicates the biochemical pathways where gene reductions took place, and helps ...
  4. Mycoplasma crocodyli : Mycoplasma crocodyli overview BioProject

    ID: PRJNA36867

    Access Type: download

    dataset.description: soft; cutis, skin). The cell membrane is rich in protein components (up to two thirds of the membrane mass) that to a great extent consists of highly structurally adaptive lipoproteins employed in invading the host immune system, attachment to the host cells, and pathogenic invasion. Most mycoplasmas are non-motile, with the exception of a few flask-shaped human and animal pathogens (M. pneumoniae, M. genitalium, M. gallisepticum, M. pulmonis and M. mobile). Motile mycoplasmas glide over the surface by an unknown mechanism that is suspected to employ actin-like cytoskeletal components as well as motility proteins unique for this microbial group. Cell division proceeds via normal binary fission or via elongation of a parental cell to form multinucleated filaments and the subsequent breakup to form coccoid bodies. Mycoplasmas carry the smallest genomes of self-replicating cells (less than 500 recognizable coding regions), which is one of the reasons they were among the first microorganisms selected for the genome-sequencing projects. The complete sequence of the genome of M. genitalium was the second to be reported following the report on the c...
  5. Microarray Study Reveals Hormone-Modulated Gene Transcription During Human Podocyte Differentiation ArrayExpress

    ID: E-GEOD-39823

    Description: nal diseases characterized by severe proteinuria (protein in the urine) and hypoalbuminemia (low levels of blood albumin). Small lipopholic molecules such as steroids, fatty acids, prostaglandins and vitamin metabolites control many aspects of animal development, cell proliferation and differentiation, and homeostasis through binding to their intracellular receptors. Upon binding to their cognate ligands, these nuclear receptors (NRs) are capable of turning on or off of an array of gene networks. By doing so, they regulate a whole spectrum of cellular activities. The ability of small molecule hormones to regulate NR activity makes them excellent pharmaceu...

  6. Mycoplasma gallisepticum : Causes respiratory disease in birds BioProject

    ID: PRJNA35265

    Access Type: download

    dataset.description: soft; cutis, skin). The cell membrane is rich in protein components (up to two thirds of the membrane mass) that to a great extent consists of highly structurally adaptive lipoproteins employed in invading the host immune system, attachment to the host cells, and pathogenic invasion. Most mycoplasmas are non-motile, with the exception of a few flask-shaped human and animal pathogens (M. pneumoniae, M. genitalium, M. gallisepticum, M. pulmonis and M. mobile). Motile mycoplasmas glide over the surface by an unknown mechanism that is suspected to employ actin-like cytoskeletal components as well as motility proteins unique for this microbial group. Cell division proceeds via normal binary fission or via elongation of a parental cell to form multinucleated filaments and the subsequent breakup to form coccoid bodies. Mycoplasmas carry the smallest genomes of self-replicating cells (less than 500 recognizable coding regions), which is one of the reasons they were among the first microorganisms selected for the genome-sequencing projects. The complete sequence of the genome of M. genitalium was the second to be reported following the report on the c...
  7. Mycoplasma mycoides : Causative agent of contagious pleuropneumonia in livestock BioProject

    ID: PRJNA19247

    Access Type: download

    dataset.description: some species, through highly specialized surface protein appendages. In some cases, subsequent invasion of host cells results in a prolonged intracellular persistence that may cause lethality. The mycoplasmal cell membrane is rich in proteins that include extensive sets of prokaryotic lipoproteins, some of which contribute to surface diversity through mutation-prone contingency loci that mediate both phase-variable expression and structural variation. These adaptive strategies are involved in host cell attachment and invasion, as well as immune evasion. Most mycoplasmas are non-motile, with the exception of some flask-shaped human and animal pathogens (M. pneumoniae, M. genitalium, M. gallisepticum, M. pulmonis and M. mobile). Motile mycoplasmas glide on surfaces by mechanisms different from those of othe...
  8. Microarray Study Reveals Hormone-Modulated Gene Transcription During Human Podocyte Differentiation BioProject

    ID: PRJNA171922

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nal diseases characterized by severe proteinuria (protein in the urine) and hypoalbuminemia (low levels of blood albumin). Small lipopholic molecules such as steroids, fatty acids, prostaglandins and vitamin metabolites control many aspects of animal development, cell proliferation and differentiation, and homeostasis through binding to their intracellular receptors. Upon binding to their cognate ligands, these nuclear receptors (NRs) are capable of turning on or off of an array of gene networks. By doing so, they regulate a whole spectrum of cellular activities. The ability of small molecule hormones to regulate NR activity makes them excellent pharmaceu...
  9. EXPRESSION OF VAV1 IN GLIOBLASTOMA MULTIFORME ArrayExpress

    ID: E-GEOD-24072

    Description: c potential that is involved in the regulation of cytoskeletal dynamics and cell migration. Methodology/Principal Findings: VAV1 is overexpressed in 32 patients diagnosed with high-grade glioma. Such overexpression is linked to the parallel upregulation of a number of genes coding for proteins also involved in cell invasion- and migration-related processes. Unexpectedly, immunohistochemical experiments revealed that VAV1 is not expressed in glioma cells. Instead, VAV1 is found in non-tumoral astrocyte-like cells that are located either peritumoraly or perivascularly, suggesting that its expression is l...

  10. EXPRESSION OF VAV1 IN GLIOBLASTOMA MULTIFORME BioProject

    ID: PRJNA130241

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: c potential that is involved in the regulation of cytoskeletal dynamics and cell migration. Methodology/Principal Findings: VAV1 is overexpressed in 32 patients diagnosed with high-grade glioma. Such overexpression is linked to the parallel upregulation of a number of genes coding for proteins also involved in cell invasion- and migration-related processes. Unexpectedly, immunohistochemical experiments revealed that VAV1 is not expressed in glioma cells. Instead, VAV1 is found in non-tumoral astrocyte-like cells that are located either peritumoraly or perivascularly, suggesting that its expression is l...
  11. Influenza study YPED

    Description: ouped into several functional categories, such as cytoskeletal proteins, annexins, glycolytic enzymes, and tetraspanins. Interestingly, a significant number of these have also been reported to be present in virions of other virus families. Protease treatment of virions combined with immunoblot analysis was used to verify the presence of the cellular protein and also to determine whether it is located in the core of the influenza virus particle. Immunogold labeling confirmed the presence of membrane-bound host proteins on the influenza virus envelope. The identification of cellular constituents of influenza virions has important implications for understanding the interactions of influenza virus with its host and brings us a step closer to defining the cellular requirements for influenza virus replication. While not all of the host proteins are necessarily incorporated specifically, those that are a...

  12. Exploring the nicotinic Acetyalcholine Receptor-assopciated proteome with iTRAQ and Transgenic Mice YPED

    Description: ;42-nAChR, including proteins involved in cytoskeletal rearrangement and calcium signaling. These findings represent the first application of quantitative proteomics to produce a 2*-nAChR interactome and describe a novel technique used to discover potential targets for pharmacological manipulation of 42-nAChRs and their downstream signaling mechanisms....


Displaying 20 of 692 results for "DNM2"