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Displaying 20 of 233 results for "CXCR3"
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  1. Transcription profiling of human 3D cultured chrondrocytes treated with supernatant of synovial fibroblasts from an RA patients vs controls to investi... ArrayExpress

    ID: E-GEOD-10024

    Description: (TLR2), cytokines/chemokines and receptors (CXCL1-3, CCL20, CXCL8, CXCR4, IL-6, IL-1beta), matrix degradation (MMP-10, MMP-12) and suppressed matrix synthesis (COMP). Thus, transcriptome profiling of RASF and NDSF stimulated chondrocytes revealed a disturbed catabolic-anabolic homeostasis of chondrocyte function. This study provides a comprehensive insight into the molecular regulatory processes induced in human chondrocytes during RA-related cartilage destruction. Experiment Overall Design: To reveal the RA-related chondrocyte gene expression profile, genome-wide microarray analysis of RASF stimulated human chondrocytes compared to NDSF stimulation was performed. Unstimulated chondrocytes were analyzed for baseline gene expression. For microarray analysis of RASF and NDSF stimulated and unstimulated chondrocytes, respectively, two RNA pools were analyzed, each pool consisting of ...

  2. PI3 Kinase and FOXO1 activity differentially control B cells in the germinal center light and dark zone BioProject

    ID: PRJNA281616

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ferentiation. However, here FOXO1 is expressed in c-Myc+ cells destined for DZ reentry. Upon FOXO1 ablation by genetic means or induction of PI3K activity GCs become devoid of their DZ, due at least partly to the downregulation of the chemokine receptor CXCR4. While this is known to prevent proper cyclic selection of cells expressing high-affinity antibodies, the initiation of immunoglobulin switching is essentially dependent on FOXO1 activity. Overall design: All samples were obta...
  3. Tenascin-C Protects Cancer Stem-Like Cells from Immune Surveillance BioProject

    ID: PRJNA274232

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation ArrayExpress

    ID: E-GEOD-46533

    Description: nd leukotriene C4 were produced within minutes of C. albicans addition before cyclooxygenase 2 expression. The production of TNFa was lower in C. albicans-stimulated cPLA2a+/+ than cPLA2a-/- macrophages due to an autocrine effect of prostaglandins that increased cAMP to a greater extent in cPLA2a+/+ than cPLA2a-/- macrophages. For global insight, differential gene expression in C. albicans-stimulated cPLA2a+/+ and cPLA2a-/- macrophages (3

  5. Characterisation of Two New Th17-Subsets with Distinct Contribution to HIV-1 Persistence under Antiretroviral Therapy BioProject

    ID: PRJNA278524

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he existence of two new CCR6+CD161+ subsets, CCR4-CXCR3- (DN; double negative) and CCR4+CXCR3+ (DP; double positive), expressing typical Th17 transcripts (e.g., RORγt, RORα, PTPN13, ARNTL), C. albicans specificity, and exhibiting Th17-lineage commitment versus flexibility. Overall design: 4 cell populat...
  6. Expression data from human Th1 and Th1Th17 cells BioProject

    ID: PRJNA216967

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: from Th1Th17. Overall design: Primary human Th1 (CXCR3+CCR6- phenotype) and Th1Th17 (CXCR3+CCR6- phenotype) CD4+ T-cells were isolated by flow cytometry from HIV-uninfected, healthy donors. Cells were stimulated via CD3/CD28 for 3 days. The RNA was extracted and hybridized on the GeneChip® Human Genome U133 Plus 2.0 Array (Affymetrix)....
  7. Gene expression of Peg-interferon alfa-2b plus ribavirin in hepatitis C patients during the first 10 weeks of treatment BioProject

    ID: PRJNA106553

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Blood PD-1+ CXCR3- CXCR5+ CD4 T cells and active GC Tfh cells share a transcriptional profile signature OmicsDI

    ID: E-GEOD-50392

    Date Released: 06-03-2014

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  9. Expression profile of human ESC, ESC-drived definitive endoderm and endodermal progenitor cells ArrayExpress

    ID: E-GEOD-35461

    Description: ridized to Affimetrix microarrays. Each group had 3 biological replicates....

  10. Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation BioProject

    ID: PRJNA200793

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nd leukotriene C4 were produced within minutes of C. albicans addition before cyclooxygenase 2 expression. The production of TNFa was lower in C. albicans-stimulated cPLA2a+/+ than cPLA2a-/- macrophages due to an autocrine effect of prostaglandins that increased cAMP to a greater extent in cPLA2a+/+ than cPLA2a-/- macrophages. For global insight, differential gene expression in C. albicans-stimulated cPLA2a+/+ and cPLA2a-/- macrophages (3
  11. Transcription profiling of human hepatitis PBMC C patients treated with Peg-interferon alfa-2b plus ribavirin during the first 10 weeks of treatment ArrayExpress

    ID: E-GEOD-11342

    Description: HCV patients with the recently completed Virahep C study (9999) in which Peginterferon-alfa2a and ribavirin was administered. RNA was isolated from peripheral blood monocytes from twenty treatment-naïve patients just before treatment (day 0,) and at days 3, 6, 10, 13, 27, 42 and 70 days after treatment. Gene expression at each time was compared to that of day 0 using Affymetrix DNA-micro-arrays. Focusing upon genes that changed at least 1.5-fold and p<0.001, the numbers were high at day 3

  12. Transcription profiling of multiple mouse myeloma (MM) cells during intra-medullary progression in the 5T2MM mouse model ArrayExpress

    ID: E-MEXP-186

    Description: gated using the 5T2MM murine model. MM-cells from 3 subsequent disease stages, quiescent, intermediate and end stage were analyzed using microarrays containing 21,492 Unigene cDNA sequences. ~ 3000 calls of differentially expressed genes were obtained. Most of these genes were silenced during tumor progression. In the early stage the MM-cells had up-regulated genes involved in bone marrow (BM) homing (CCR2, CCR5), motility (tetraspanins, 67kD laminin receptor,...

  13. Synergism between curdlan and GM-CSF in mouse dendritic cells BioProject

    ID: PRJNA146443

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nct pathogens. For example, cross talk of TLR and c-type lectin signalling effectively shapes distinct gene expression patterns by integrating the signals at the level of NF-κB. Here, we extend this principle to a strong synergism between the Dectin-1 agonist, curdlan, and an inflammatory growth factor, GM-CSF. Both together ac...
  14. Key Regulatory Molecules of Cartilage Destruction in Rheumatoid Arthritis: An in vitro Study BioProject

    ID: PRJNA108161

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: (TLR2), cytokines/chemokines and receptors (CXCL1-3, CCL20, CXCL8, CXCR4, IL-6, IL-1beta), matrix degradation (MMP-10, MMP-12) and suppressed matrix synthesis (COMP). Thus, transcriptome profiling of RASF and NDSF stimulated chondrocytes revealed a disturbed catabolic-anabolic homeostasis of chondrocyte function. This study provides a comprehensive insight into the molecular regulatory processes induced in human chondrocytes during RA-related cartilage destruction. Keywords: dose response Overall design: To reveal the RA-related chondrocyte gene expression profile, genome-wide microarray analysis of RASF stimulated human chondrocytes compared to NDSF stimulation was performed. Unstimulated chondrocytes were analyzed for baseline gene expression. For microarray analysis of RASF and NDSF stimulated and unstimulated chondrocytes, respectively, two RNA pools were analyzed, each pool c...
  15. Expression profile of human ESC, ESC-drived definitive endoderm and endodermal progenitor cells BioProject

    ID: PRJNA152335

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ridized to Affimetrix microarrays. Each group had 3 biological replicates....
  16. Human osteosarcoma cells respond to sorafenib chemotherapy by downregulation of the tumor progression factors S100A4, CXCR4 and the oncogene FOS ArrayExpress

    ID: E-GEOD-53155

    Description: g DNA microarray-based gene expression profiling. 3 untreated replicates of human osteosarcoma cells (ATCC CRL-1543™), 3 replicates of human osteosarcoma cells (ATCC CRL-1543™) treated with 4 µM Sorafenib...

  17. Transcription profiling of mouse Splenic CD4+CXCR5+ T (TFH) cells OmicsDI

    ID: E-GEOD-11924

    Date Released: 06-10-2011

    Description: entiate; into distinct effector subsets. Although chemokine; (C-X-C motif) receptor 5-expressing T follicular; helper (Tfh) cells are i...

  18. Expression data from human Th1 and Th1Th17 cells OmicsDI

    ID: E-GEOD-50175

    Date Released: 06-03-2014

    Description: rizing Th1 cells from Th1Th17. Primary human Th1 (CXCR3+CCR6- phenotype) and Th1Th17 (CXCR3+CCR6- phenotype) CD4+ T-cells were isolated by flow cytometry from HIV-uninfected, healthy donors. Cells were stimulated via CD3/CD28 for 3 days. The RNA was extracted and hybridized on the GeneChip® Human Genome U133 Plus 2.0 Array (Affymetrix)....

  19. Gene expression changes in 786-O cells in response to 5DC treatment. OmicsDI

    ID: E-GEOD-32298

    Date Released: 01-11-2013

    Description: 27 trimethylation (H3K27me3) activates HIF-driven chemokine (C-X-C motif) receptor 4 (CXCR4) expression in support of chemotactic cell invasion, whereas loss of DNA methylation enables HIF-driven cytohesin 1 interacting protein (CYTIP) expression to protect cancer cells from death cytokine signals. Thus, metastasis in ccRCC is based on an epigenetically expanded output of the tumor-initiating pathway. Gene expression data from 786-O cells after 3-day treatment with 100uM 5’-aza-deoxycytidine (5DC) or vehicle (DMSO)....

  20. Characterisation of Two New Th17-Subsets with Distinct Contribution to HIV-1 Persistence under Antiretroviral Therapy ArrayExpress

    ID: E-GEOD-66972

    Description: he existence of two new CCR6+CD161+ subsets, CCR4-CXCR3- (DN; double negative) and CCR4+CXCR3+ (DP; double positive), expressing typical Th17 transcripts (e.g., RORγt, RORα, PTPN13, ARNTL), C. albicans specificity, and exhibiting Th17-lineage commitment versus flexibility. 4 cell populations from up to ...


Displaying 20 of 233 results for "CXCR3"