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Displaying 100 of 1,893 results for "COTL1"
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  1. COTL1_RAT UniProt:Swiss-Prot

    ID: B0BNA5

    Description: Removed Coactosin-like protein ADF-H Flexible and important for F-actin

  2. Solution structure of Human Coactosin Like Protein D123N PDB

    ID: PDB:1TMW

    Description: Coactosin-like protein

  3. Burn-CLP BioProject

    ID: PRJNA90575

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. COTL1_BOVIN UniProt:Swiss-Prot

    ID: Q2HJ57

    Description: Removed Coactosin-like protein ADF-H Flexible and important for F-actin

  5. Expression data from bone marrow CLP and B-cell progenitor subfractions. BioProject

    ID: PRJNA106999

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Serum-Mediated Responses in Normal and Transformed Oral Keratinocyte Lines ArrayExpress

    ID: E-GEOD-39376

    Description: luding in the Human Gene Expression Map and Human Protein Atlas databases, confirmed novel association to HNSCC for genes COTL1 and INSIG1 and novel poor outcome prediction for the genes CUL4B and PDGFRL. The definition of normal and aberrant serum responses in keratinocyte models therefore coupled new genes to HNSCC including with relevance to prognosis. Analysis of gene expression changes in serum-exposed normal and transformed cells relative the respective un-exposed states. Significantly differentially expressed genes were next assessed by bioinformatics processing using Gene Ontology categories and network analyses. Findings were also validated relative independent HNSCC data sets as well as transcriptomics and proteomics databases....

  7. LOX5_MESAU UniProt:Swiss-Prot

    ID: P51399

    Description: hidonate 5-lipoxygenase PLAT Lipoxygenase Calcium 1; via carbonyl oxygen; structural Calcium 2; via carbonyl oxygen; structural Calcium 2; structural Calcium 2; structural Calcium 2; vi...

  8. LOX5_RAT UniProt:Swiss-Prot

    ID: P12527

    Description: hidonate 5-lipoxygenase PLAT Lipoxygenase Calcium 1; via carbonyl oxygen; structural Calcium 2; via carbonyl oxygen; structural Calcium 2; structural Calcium 2; structural Calcium 2; vi...

  9. Genes affected by Satb1 deficiency in HSC, LMPP and CLP BioProject

    ID: PRJNA193433

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Genes affected by SFRP5 overexpression in LSK cells and CLP BioProject

    ID: PRJNA240285

    Keywords: Transcriptome or Gene expression

    Access Type: download

  11. The Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy BioProject

    ID: PRJNA270020

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. ATP-dependent Clp protease ATP-binding subunit clpA/ATP-dependent Clp protease adaptor protein clpS PDB

    ID: PDB:1R6O

    Description: ATP-dependent Clp protease ATP-binding subunit clpA/ATP-dependent Clp protease adaptor protein

  13. Streptococcus mutans UA159 vs. clp mutant strains BioProject

    ID: PRJNA140985

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. The Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy ArrayExpress

    ID: E-GEOD-64065

    Description: b:ΔRv2745c. Induction of clgR in Mtb did lead to Clp protease induction, indicating that clgR plays a role in differntially activating downstream genes in a condition dependent manner. Disruption of genes involved in the dosR regulon, the Enduring Hypoxia Response, lipid synthesis, and mycolic acid synthesis also occurred in the knock out, implicating clgR as a possible regulator of downstream signaling cascades that facilitate Mtb survival. There was also a differnetial response of ge...

  15. Crystal Structure of the ATP-dependent Clp Protease ClpC from Clostridium difficile PDB

    ID: PDB:3FES

    Description: ATP-dependent Clp endopeptidase

  16. The Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy OmicsDI

    ID: E-GEOD-64065

    Date Released: 01-02-2015

    Description: b:ΔRv2745c. Induction of clgR in Mtb did lead to Clp protease induction, indicating that clgR plays a role in differntially activating downstream genes in a condition dependent manner. Disruption of genes involved in the dosR regulon, the Enduring Hypoxia Response, lipid synthesis, and mycolic acid synthesis also occurred in the knock out, implicating clgR as a possible regulator of downstream signaling cascades that facilitate Mtb survival. There was also a differnetial response of ge...

  17. Genes affected by SFRP5 overexpression in LSK cells and CLP OmicsDI

    ID: E-GEOD-55646

    Date Released: 06-03-2014

    Description: microarrays were conducted with Lin- c-kitHi Sca-1+ cells and Lin- c-kitLo Sca-1Lo IL7Rα+ CLP-enriched cells derived from adult bone marrow of SFRP5-transgenic mice or their WT littermates....

  18. CRYSTAL STRUCTURE OF THE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 (CLPP1) FROM MYCOBACTERIUM TUBERCULOSIS PDB

    ID: PDB:2CE3

    Description: ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 (E.C.3.4.21.92)

  19. CRYSTAL STRUCTURE OF THE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 (CLPP1) FROM MYCOBACTERIUM TUBERCULOSIS PDB

    ID: PDB:2CBY

    Description: ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 (E.C.3.4.21.92)

  20. Structure of the ClpP subunit of the ATP-dependent Clp Protease from Coxiella burnetii PDB

    ID: PDB:3Q7H

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  21. Crystal Structure of ATP-dependent Clp protease subunit P from Francisella tularensis PDB

    ID: PDB:3P2L

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  22. Expression data from WT, HEB-KO and E2A-KO LY6D- CLP cells BioProject

    ID: PRJNA137263

    Keywords: Transcriptome or Gene expression

    Access Type: download

  23. Genes affected by SFRP5 overexpression in LSK cells and CLP ArrayExpress

    ID: E-GEOD-55646

    Description: microarrays were conducted with Lin- c-kitHi Sca-1+ cells and Lin- c-kitLo Sca-1Lo IL7Rα+ CLP-enriched cells derived from adult bone marrow of SFRP5-transgenic mice or their WT littermates....

  24. Serum-Mediated Responses in Normal and Transformed Oral Keratinocyte Lines BioProject

    ID: PRJNA170821

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: luding in the Human Gene Expression Map and Human Protein Atlas databases, confirmed novel association to HNSCC for genes COTL1 and INSIG1 and novel poor outcome prediction for the genes CUL4B and PDGFRL. The definition of normal and aberrant serum responses in keratinocyte models therefore coupled new genes to HNSCC including with relevance to prognosis. Overall design: Analysis of gene expression changes in serum-exposed normal and transformed cells relative the respective un-exposed states. Significantly differentially expressed genes were next assessed by bioinformatics processing using Gene Ontology categories and network analyses. Findings were also validated relative independent HNSCC data sets as well as transcriptomics and proteomics databases....
  25. IL7R: WT vs mutant in vitro and in vivo ArrayExpress

    ID: E-GEOD-51211

    Description: ndidate genes downstream of IL7R-INS in vitro KSL/CLP and in vivo (depicted as B-neoplasm, Notch-T-ALL, or myeloid disorder) in comparison to WT. Five-condition experiment: WT-KSL vs. INS-KSL cells; WT-

  26. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. OmicsDI

    ID: E-GEOD-40180

    Date Released: 06-02-2014

    Description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were collected for analyses. Total RNA ...

  27. Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis OmicsDI

    ID: E-GEOD-24357

    Date Released: 06-26-2012

    Description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were c...

  28. Genes affected by Satb1 deficiency in HSC, LMPP and CLP ArrayExpress

    ID: E-GEOD-45299

    Description: microarrays were conducted with Lin- c-kitHi Sca-1+ Flt3- HSC-enriched cells, Lin- c-kitHi Sca-1+ Flt3+LMPP-enriched cells, and Lin- c-kitLo Sca-1Lo IL7Rα+ CLP-enriched cells derived from E18.5 FL of Satb1-null mice or their WT littermates....

  29. THE 3.0 A RESOLUTION STRUCTURE OF CASEINOLYTIC CLP PROTEASE 1 FROM MYCOBACTERIUM TUBERCULOSIS PDB

    ID: PDB:2C8T

    Description: ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 (E.C.3.4.21.92)

  30. Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1 PDB

    ID: PDB:2PKT

    Description: PDZ and LIM domain protein 1

  31. Crystal Structure of Stabilin-1 Interacting Chitinase-Like Protein, SI-CLP PDB

    ID: PDB:3BXW

    Description: Chitinase domain-containing protein 1

  32. IL7R: WT vs mutant in vitro and in vivo. OmicsDI

    ID: E-GEOD-51211

    Date Released: 06-03-2014

    Description: ndidate genes downstream of IL7R-INS in vitro KSL/CLP and in vivo (depicted as B-neoplasm, Notch-T-ALL, or myeloid disorder) in comparison to WT. Five-condition experiment: WT-KSL vs. INS-KSL cells; WT-

  33. Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis ArrayExpress

    ID: E-GEOD-24357

    Description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were c...

  34. The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris PDB

    ID: PDB:3IWZ

    Description: Catabolite activation-like protein

  35. IL7R: WT vs mutant in vitro and in vivo. BioProject

    ID: PRJNA221627

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ndidate genes downstream of IL7R-INS in vitro KSL/CLP and in vivo (depicted as B-neoplasm, Notch-T-ALL, or myeloid disorder) in comparison to WT. Overall design: Five-condition experiment: WT-KSL vs. INS-KSL c...
  36. Expression profiling of early lymphoid progenitors deficient for Ebf1 and Foxo1 ArrayExpress

    ID: E-GEOD-41931

    Description: t at the level of the common lymphoid progenitor (CLP). Both mouse strains display the existance of LY6D+ CLPs but a marked/complete lack of proB cells. To investigate similarities of the developmental defects observed we generated gene expression profiles from bo...

  37. Genes affected by Satb1 deficiency in HSC, LMPP and CLP OmicsDI

    ID: E-GEOD-45299

    Date Released: 06-02-2014

    Description: microarrays were conducted with Lin- c-kitHi Sca-1+ Flt3- HSC-enriched cells, Lin- c-kitHi Sca-1+ Flt3+LMPP-enriched cells, and Lin- c-kitLo Sca-1Lo IL7Rα+ CLP-enriched cells derived from E18.5 FL of Satb1-null mice or their WT littermates....

  38. Serum-Mediated Responses in Normal and Transformed Oral Keratinocyte Lines OmicsDI

    ID: E-GEOD-39376

    Date Released: 06-02-2014

    Description: luding in the Human Gene Expression Map and Human Protein Atlas databases, confirmed novel association to HNSCC for genes COTL1 and INSIG1 and novel poor outcome prediction for the genes CUL4B and PDGFRL. The definition of normal and aberrant serum responses in keratinocyte models therefore coupled new genes to HNSCC including with relevance to prognosis. Analysis of gene expression changes in serum-exposed normal and transformed cells relative the respective un-exposed states. Significantly differentially expressed genes were next assessed by bioinformatics processing using Gene Ontology categories and network analyses. Findings were also validated relative independent HNSCC data sets as well as transcriptomics and proteomics databases....

  39. Crystal structure of ClpP in tetradecameric form from Staphylococcus aureus PDB

    ID: PDB:3STA

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  40. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis ArrayExpress

    ID: E-GEOD-40180

    Description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were collected for analyses. Total RNA ...

  41. Expression data from WT, HEB-KO and E2A-KO LY6D- CLP cells OmicsDI

    ID: E-GEOD-27402

    Date Released: 12-06-2011

    Description: The E-protein transcription factors E2A and HEB play important roles at several stages of hematopoiesis. However, the exact mechanism for...

  42. Transcription profiling by array of Mycobacterium tuberculosis clp gene regulator (ClgR) mutants ArrayExpress

    ID: E-BUGS-96

    Description: omics and targeted mutagenesis to reveal that the clp gene regulator (ClgR) of Mycobacterium tuberculosis activates the transcription of at least ten genes, including four that encode protease systems (ClpP1/C, ClpP2/C, PtrB and HtrA-like protease Rv1043c) and three that encode chaperones (Acr2, ClpB and the chaperonin Rv3269). Thus, M. tuberculosis ClgR controls a larger network of protein homeostatic and regulatory systems than ClgR in any other bacterium studied to date. We demonstrate that ClgR-regulated transcriptional activation of these systems is essential for M. tuberculo...

  43. Transcription profiling of rat liver samples from individuals subjected to burn injury or cecal ligation and puncture OmicsDI

    ID: E-GEOD-1781

    Date Released: 03-27-2012

    Description: for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study...

  44. Crystal structure of the ClpP protease catalytic domain from Plasmodium falciparum PDB

    ID: PDB:2F6I

    Description: ATP-dependent CLP protease, putative (E.C.3.4.21.92)

  45. CRYSTAL STRUCTURE ANALYSIS OF ClpSN HETERODIMER TETRAGONAL FORM PDB

    ID: PDB:1MBV

    Description: ATP-Dependent clp Protease ATP-Binding Subunit clp A/Protein yljA

  46. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. BioProject

    ID: PRJNA173022

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were collected for analyses. Total RNA ...
  47. Expression data from WT, HEB-KO and E2A-KO LY6D- CLP cells ArrayExpress

    ID: E-GEOD-27402

    Description: The E-protein transcription factors E2A and HEB play important roles at several stages of hematopoiesis. However, the exact mechanism for...

  48. etic stem cells (HSC) early B lineage stages(MLP, CLP, Fr.A, Fr.B) to identify coordinately regulated gene as cells progress down the B cell development pathway... ArrayExpress

    ID: E-MEXP-559

    Description: re prepared from four early B lineage stages(MLP, CLP, Fr.A, Fr.B) from mouse bone marrow, and microarrays were done to identify sets of genes that were coordinately regulated as cells progressed down the B cell development pathway....

  49. CRYSTAL STRUCTURE ANALYSIS OF ClpSN WITH TRANSITION METAL ION BOUND PDB

    ID: PDB:1MBX

    Description: ATP-Dependent clp Protease ATP-Binding Subunit clp A/Protein yljA

  50. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor ArrayExpress

    ID: E-GEOD-62337

    Description: 3 was required in the common lymphoid progenitor (CLP), and was essential for the differentiation of CLP, a bone marrow cell population that gives rise to all known ILC lineages. Clonal differentiation studies revealed that CXCR6+ cells within the CLP population differentiate into all ILC lineages but not T- and B-cells. We further show that NFIL3 governs ILC development by directly regulating expression of the transcription factor TOX. These findings establish that NFIL3 directs the differentiation...

  51. Crystal structure of the mutant of ClpP E137A from Staphylococcus aureus PDB

    ID: PDB:4EMP

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  52. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor OmicsDI

    ID: E-GEOD-62337

    Date Released: 10-20-2014

    Description: 3 was required in the common lymphoid progenitor (CLP), and was essential for the differentiation of CLP, a bone marrow cell population that gives rise to all known ILC lineages. Clonal differentiation studies revealed that CXCR6+ cells within the CLP population differentiate into all ILC lineages but not T- and B-cells. We further show that NFIL3 governs ILC development by directly regulating expression of the transcription factor TOX. These findings establish that NFIL3 directs the differentiation...

  53. Crystal Structure of the clp gene regulator ClgR from Corynebacterium glutamicum PDB

    ID: PDB:3F51

    Description: clp gene regulator (ClgR)

  54. Streptococcus mutans UA159 vs. clp mutant strains ArrayExpress

    ID: E-GEOD-29871

    Description: Transcriptional profiling to investigate the roles of ClpP and ClpX of S. mutans RNA was extracted from four replicate samples of each strain of inter...

  55. Expression profiling of early lymphoid progenitors deficient for Ebf1 and Foxo1 OmicsDI

    ID: E-GEOD-41931

    Date Released: 11-09-2012

    Description: t at the level of the common lymphoid progenitor (CLP). Both mouse strains display the existance of LY6D+ CLPs but a marked/complete lack of proB cells. To investigate similarities of the developmental defects observed we generated gene expression profiles from bo...

  56. Arabidopsis thaliana comparative leaf proteomics of Clp protease mutant OmicsDI

    ID: PRD000393

    Date Released: 04-24-2013

    Description: Arabidopsis total leaf proteomics p3mutant biol replicate1 SDS-PAGE Band10, in-gel trypsin digestion LTQ Orbitrap

  57. Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis BioProject

    ID: PRJNA132813

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were c...
  58. Transcription profiling by array of Mycobacterium tuberculosis clp gene regulator (ClgR) mutants OmicsDI

    ID: E-BUGS-96

    Date Released: 05-01-2014

    Description: omics and targeted mutagenesis to reveal that the clp gene regulator (ClgR) of Mycobacterium tuberculosis activates the transcription of at least ten genes, including four that encode protease systems (ClpP1/C, ClpP2/C, PtrB and HtrA-like protease Rv1043c) and three that encode chaperones (Acr2, ClpB and the chaperonin Rv3269). Thus, M. tuberculosis ClgR controls a larger network of protein homeostatic and regulatory systems than ClgR in any other bacterium studied to date. We demonstrate that ClgR-regulated transcriptional activation of these systems is essential for M. tuberculo...

  59. Host Responses to Sepsis Vary in Different Low-Lethality Murine Models ArrayExpress

    ID: E-GEOD-55238

    Description: The CS and CLP murine models of intra-abdominal sepsis have unique transcriptomic respones 2 hrs, 1 and 3 days after sepsis...

  60. Expression data from early B cell progenitors including CLP,ProB and PreB of Pax5 knockout and wild type C57Bl6 mice BioProject

    ID: PRJNA171116

    Keywords: Transcriptome or Gene expression

    Access Type: download

  61. Profiling circulating microRNA expression in experimental sepsis by cecal ligation and puncture BioProject

    ID: PRJNA203549

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: perimental sepsis by cecal ligation and puncture (CLP), the whole blood samples were obtained from C57BL/6 mice at 4, 8, and 24 h following CLP for miRNA expression analysis using a miRNA array (The Mouse & Rat miRNA OneArray® v3). Br...
  62. Streptococcus mutans UA159 vs. clp mutant strains OmicsDI

    ID: E-GEOD-29871

    Date Released: 05-02-2014

    Description: Transcriptional profiling to investigate the roles of ClpP and ClpX of S. mutans RNA was extracted from four replicate samples of each strain of inter...

  63. ClpP2 from Listeria monocytogenes PDB

    ID: PDB:4JCT

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  64. Crystal structure of the clp gene regulator ClgR from C. glutamicum PDB

    ID: PDB:3F52

    Description: clp gene regulator (ClgR)

  65. Host Responses to Sepsis Vary in Different Low-Lethality Murine Models BioProject

    ID: PRJNA238983

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The CS and CLP murine models of intra-abdominal sepsis have unique transcriptomic respones 2 hrs, 1 and 3 days after sepsis...
  66. Reaeration timecourse from a defined hypoxia model ArrayExpress

    ID: E-GEOD-21590

    Description: s, as well as the transcription factor Rv2745c, a Clp protease gene regulator (ClgR) orthologue. During reaeration, genes repressed during hypoxia are also upregulated in a wave of transcription that includes genes crucial to transcription, translation and oxidative phosphorylation. Each reaerating culture compared at multiple timepoints to a sample from the same culture at seven days of hypoxia. Three or more replicates at each timepoint....

  67. Transcription profiling of mouse models of sepsis cecal ligation and puncture and tracheal instillation of P. aeruginosa reveals bcl-2 overexpression ... ArrayExpress

    ID: E-GEOD-5811

    Description: ding bcl2L11 (bim), bcl-2L2 (bcl-w), bmf, and mcl-1. Sepsis in bcl-2 transgenic animals resulted in alteration of RNA abundance for only a single gene, ceacam1. Conclusion: These findings are consistent with sepsis-induced alterations in the balance of pro- and anti-apoptotic transcriptional networks. In addition, our data suggest that the ability of bcl-2 overexpression to improve survival in sepsis in this model is related in part to prevention of sepsis-induced alterations in spleen transcriptional responses. Experiment Overall Design: To determine the splenic response in these lethal models of CLP and Pseudomonas pneumonia, microarray analysis was performed on each spleen harvested from wild-type animals 6 hours after CLP or tracheal instillation of bacteria. The responses of the CLP or Pseudomonas spleens were compared concurrently to those of the wild-type controls, sham laparotomy and tracheal instillation of saline, respectively. This study was repeated in animals overexpressing bcl-2. Thus, the splenocyte effect of sepsis secondary to CLP (n=6) or Pseudomonas pneumonia (n=5) could be determined compared to their controls (n=6 and 5, respectively), and the effect of bcl-2 overexpression in turn also could be determined in both CLP (n=5) and pneumonia models (n=5) compared to controls (n=5 and...

  68. Langfuzz Zenodo

    ID: doi:10.5281/ZENODO.268519

    Release Date: 02-03-2017

    Description: uzzing: sto (the stochastic grammar approach) and clp (our CLP-based approach). The comparison is a bit misleading because CLP can implement stochastic grammars; in fact, all of the approaches are implemented in SWI...

  69. The structure of a V6A variant of ClpP. PDB

    ID: PDB:1YG8

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  70. Crystal structure of Staphylococcus aureus ClpP in compact conformation PDB

    ID: PDB:4EMM

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  71. Crystal structure of the active form of the proteolytic complex clpP1 and clpP2 PDB

    ID: PDB:5DZK

    Description: ATP-dependent Clp protease proteolytic subunit 2 (E.C.3.4.21.92), BEZ-LEU-LEU, ATP-dependent Clp protease proteolytic subunit ...

  72. Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP PDB

    ID: PDB:1TG6

    Description: Putative ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  73. etic stem cells (HSC) early B lineage stages(MLP, CLP, Fr.A, Fr.B) to identify coordinately regulated gene as cells progress down the B cell development pathway... OmicsDI

    ID: E-MEXP-559

    Date Released: 06-03-2014

    Description: re prepared from four early B lineage stages(MLP, CLP, Fr.A, Fr.B) from mouse bone marrow, and microarrays were done to identify sets of genes that were coordinately regulated as cells progressed down the B cell development pathway....

  74. Crystal structure of ClpP in heptameric form from Staphylococcus aureus PDB

    ID: PDB:3ST9

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  75. Crystal Structure Analysis of ClpSN heterodimer PDB

    ID: PDB:1MBU

    Description: ATP-Dependent clp Protease ATP-Binding Subunit clp A/Protein yljA

  76. ClpP PDB

    ID: PDB:1YG6

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  77. Profiling circulating microRNA expression in experimental sepsis by cecal ligation and puncture OmicsDI

    ID: E-GEOD-47094

    Date Released: 05-25-2015

    Description: perimental sepsis by cecal ligation and puncture (CLP), the whole blood samples were obtained from C57BL/6 mice at 4, 8, and 24 h following CLP for miRNA expression analysis using a miRNA array (The Mouse & Rat miRNA OneArray® v3). Br...

  78. ClpP1 N165D mutant from Listeria monocytogenes PDB

    ID: PDB:4JCR

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  79. Structure of ClpP from Escherichia coli in complex with ADEP1 PDB

    ID: PDB:3MT6

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  80. Staphylococcus aureus ClpP mutant - Y63A PDB

    ID: PDB:5C90

    Description: ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92)

  81. Crystal Structure of M. tuberculosis ClpP1P2 bound to ADEP and agonist PDB

    ID: PDB:4U0G

    Description: ATP-dependent Clp protease proteolytic subunit 2 (E.C.3.4.21.92), ATP-dependent Clp protease proteolytic subunit 1

  82. ClpNS with fragments PDB

    ID: PDB:1R6Q

    Description: ATP-dependent Clp protease ATP-binding subunit clpA, ATP-dependent Clp protease adaptor protein

  83. Transcription profiling of rat liver samples from individuals subjected to burn injury or cecal ligation and puncture ArrayExpress

    ID: E-GEOD-1781

    Description: for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study...

  84. crystal structure of the active form of the proteolytic complex clpP1 and clpP2 PDB

    ID: PDB:5E0S

    Description: ATP-dependent Clp protease proteolytic subunit 2 (E.C.3.4.21.92), ATP-dependent Clp protease proteolytic subunit 1

  85. Differential Expression of microRNAs following activated protein C treatment in a rat model of septic shock OmicsDI

    ID: E-GEOD-34790

    Date Released: 01-02-2015

    Description: on and end organ failure, events modulated by the Protein C pathway. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene transcription yet their role in sepsis remains poorly defined. We hypothesized that aPC selectively alters the expression of specific miR...

  86. Expression profiling of early lymphoid progenitors deficient for Ebf1 and Foxo1 BioProject

    ID: PRJNA178539

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t at the level of the common lymphoid progenitor (CLP). Both mouse strains display the existance of LY6D+ CLPs but a marked/complete lack of proB cells. To investigate similarities of the developmental defects observed we generated gene expression profiles from bo...
  87. Profiling circulating microRNA expression in experimental sepsis by cecal ligation and puncture ArrayExpress

    ID: E-GEOD-47094

    Description: perimental sepsis by cecal ligation and puncture (CLP), the whole blood samples were obtained from C57BL/6 mice at 4, 8, and 24 h following CLP for miRNA expression analysis using a miRNA array (The Mouse & Rat miRNA OneArray® v3). Br...

  88. Transcription profiling of mouse hematopoietic cells (GMP, CMP, CLP and HSC), FACS sorted from wild type and Mll-AF9 knock-ins OmicsDI

    ID: E-GEOD-10627

    Date Released: 06-10-2011

    Description: mong four types of hematopoietic cells (GMP, CMP, CLP and HSC), FACS sorted from wild type and Mll-AF9 knock-in mice. The goal was to identify genes differentially expressed in each Mll-AF9 cell type compared to the corresponding wild type cells....

  89. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor BioProject

    ID: PRJNA263871

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 3 was required in the common lymphoid progenitor (CLP), and was essential for the differentiation of CLP, a bone marrow cell population that gives rise to all known ILC lineages. Clonal differentiation studies revealed that CXCR6+ cells within the CLP population differentiate into all ILC lineages but not T- and B-cells. We further show that NFIL3 governs ILC development by directly regulating expression of the transcription factor TOX. These findings establish that NFIL3 directs the differentiation...
  90. Transcription profiling of mouse models of sepsis cecal ligation and puncture and tracheal instillation of P. aeruginosa reveals bcl-2 overexpression ... OmicsDI

    ID: E-GEOD-5811

    Date Released: 03-27-2012

    Description: ding bcl2L11 (bim), bcl-2L2 (bcl-w), bmf, and mcl-1. Sepsis in bcl-2 transgenic animals resulted in alteration of RNA abundance for only a single gene, ceacam1. Conclusion: These findings are consistent with sepsis-induced alterations in the balance of pro- and anti-apoptotic transcriptional networks. In addition, our data suggest that the ability of bcl-2 overexpression to improve survival in sepsis in this model is related in part to prevention of sepsis-induced alterations in spleen transcriptional responses. Experiment Overall Design: To determine the splenic response in these lethal models of CLP and Pseudomonas pneumonia, microarray analysis was performed on each spleen harvested from wild-type animals 6 hours after CLP or tracheal instillation of bacteria. The responses of the CLP or Pseudomonas spleens were compared concurrently to those of the wild-type controls, sham laparotomy and tracheal instillation of saline, respectively. This study was repeated in animals overexpressing bcl-2. Thus, the splenocyte effect of sepsis secondary to CLP (n=6) or Pseudomonas pneumonia (n=5) could be determined compared to their controls (n=6 and 5, respectively), and the effect of bcl-2 overexpression in turn also could be determined in both CLP (n=5) and pneumonia models (n=5) compared to controls (n=5 and...

  91. Transcription profiling of mouse hematopoietic cells (GMP, CMP, CLP and HSC), FACS sorted from wild type and Mll-AF9 knock-ins ArrayExpress

    ID: E-GEOD-10627

    Description: mong four types of hematopoietic cells (GMP, CMP, CLP and HSC), FACS sorted from wild type and Mll-AF9 knock-in mice. The goal was to identify genes differentially expressed in each Mll-AF9 cell type compared to the corresponding wild type cells....

  92. The 8q24 cleft lip susceptibility locus is a remote Myc enhancer required for normal face morphology OmicsDI

    ID: E-GEOD-52974

    Date Released: 05-30-2014

    Description: eased risk of non-syndromic cleft lip and palate (CLP) in humans, but the genes and pathways involved in this genetic susceptibility have remained elusive. With a large series of rearrangements engineered over the syntenic mouse region, we showed th...

  93. ILC progenitor CEL-seq BioProject

    ID: PRJNA305531

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: uding NK cells, and the CD25- ILC2-restricted Sca-1+ CILP. We mapped the transcriptional changes that occur in ILC progenitor commitment identifying new regulatory factors and provide a map for early ILC differentiation. Finally, we mapped the subsequent transc...
  94. CD34+DNAMbrightCXCR4+ CLP mobilized in chronic inflammation BioProject

    ID: PRJNA285952

    Keywords: Transcriptome or Gene expression

    Access Type: download

  95. Comprensión lectora y rendimiento académico en estudiantes del primer grado de secundaria de la isntitución educativa "Emma Dettman" - Callao Zenodo

    ID: doi:10.5281/ZENODO.20832

    Release Date: 07-20-2015

    Description: riables: Sexo, Edad, Grado, Sección, Rendimiento CLP, Total CLP, Comprensión lectora, Rendimiento académico, y 124 casos....

  96. Differential protein expression by Porphyromonas gingivalis in response to secreted epithelial cell components BioProject

    ID: PRJNA93359

    Keywords: Other

    Access Type: download

  97. The Mycobacterium tuberculosis Rv2745c Plays an Important Role in Responding to Redox Stress BioProject

    ID: PRJNA242600

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The Rv2745c (clgR) gene encodes a Clp protease gene regulator that is induced in response to a variety of stress conditions and potentially plays a role in Mtb patho...
  98. Single cell analysis of the Common Lymphoid Progenitor compartment reveals functional and molecular heterogeneity ArrayExpress

    ID: E-GEOD-19142

    Description: ells also expressed a higher level of the surface protein LY6D providing an additional tool for the analysis of early lymphoid development. These data suggest that the classical CLP compartment composes a mixture of cells with more or less restricted lineage potentials opening new possibilities to investigate early hematopoiesis. Two newly identified subpopulations of common lymphoid progenitors (CLP), hereafter called CLP_RAGhigh and CLP_RAGlow, have been sorted in 2 replicates. RNA was extracted from 2,000 purified adult BM cells using the RNAeasy microkit. RNA was labeled and amplified by dual amplification and hybridized to Affymetrix microarray MOE430_2, according to AffymetrixTM GeneChip Expression Analysis Technical Manual. Probe level expression values were calculated using the RMA algorithm....

  99. Surviving Sepsis: bcl-2 Overexpression Modulates Splenocyte Transcriptional Responses in vivo BioProject

    ID: PRJNA97191

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ding bcl2L11 (bim), bcl-2L2 (bcl-w), bmf, and mcl-1. Sepsis in bcl-2 transgenic animals resulted in alteration of RNA abundance for only a single gene, ceacam1. Conclusion: These findings are consistent with sepsis-induced alterations in the balance of pro- and anti-apoptotic transcriptional networks. In addition, our data suggest that the ability of bcl-2 overexpression to improve survival in sepsis in this model is related in part to prevention of sepsis-induced alterations in spleen transcriptional responses. Keywords: Sepsis, bcl-2, wildtype, spleen, RNA expression, microarray Overall design: To determine the splenic response in these lethal models of CLP and Pseudomonas pneumonia, microarray analysis was performed on each spleen harvested from wild-type animals 6 hours after CLP or tracheal instillation of bacteria. The responses of the CLP or Pseudomonas spleens were compared concurrently to those of the wild-type controls, sham laparotomy and tracheal instillation of saline, respectively. This study was repeated in animals overexpressing bcl-2. Thus, the splenocyte effect of sepsis secondary to CLP (n=6) or Pseudomonas pneumonia (n=5) could be determined compared to their controls (n=6 and 5, respectively), and the effect of bcl-2 overexpression in turn also could be determined in both CLP (n=...
  100. Host Responses to Sepsis Vary in Different Low-Lethality Murine Models OmicsDI

    ID: E-GEOD-55238

    Date Released: 06-03-2014

    Description: The CS and CLP murine models of intra-abdominal sepsis have unique transcriptomic respones 2 hrs, 1 and 3 days after sepsis...


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