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Displaying 20 of 46 results for "COTL1"
  1. Serum-Mediated Responses in Normal and Transformed Oral Keratinocyte Lines ArrayExpress

    ID: E-GEOD-39376

    Description: luding in the Human Gene Expression Map and Human Protein Atlas databases, confirmed novel association to HNSCC for genes COTL1 and INSIG1 and novel poor outcome prediction for the genes CUL4B and PDGFRL. The definition of normal and aberrant serum responses in keratinocyte models therefore coupled new genes to HNSCC including with relevance to prognosis. Analysis of gene expression changes in serum-exposed normal and transformed cells relative the respective un-exposed states. Significantly differentially expressed genes were next assessed by bioinformatics processing using Gene Ontology categories and network analyses. Findings were also validated relative independent HNSCC data sets as well as transcriptomics and proteomics databases....

  2. The Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy ArrayExpress

    ID: E-GEOD-64065

    Description: b:ΔRv2745c. Induction of clgR in Mtb did lead to Clp protease induction, indicating that clgR plays a role in differntially activating downstream genes in a condition dependent manner. Disruption of genes involved in the dosR regulon, the Enduring Hypoxia Response, lipid synthesis, and mycolic acid synthesis also occurred in the knock out, implicating clgR as a possible regulator of downstream signaling cascades that facilitate Mtb survival. There was also a differnetial response of ge...

  3. Genes affected by SFRP5 overexpression in LSK cells and CLP ArrayExpress

    ID: E-GEOD-55646

    Description: microarrays were conducted with Lin- c-kitHi Sca-1+ cells and Lin- c-kitLo Sca-1Lo IL7Rα+ CLP-enriched cells derived from adult bone marrow of SFRP5-transgenic mice or their WT littermates....

  4. IL7R: WT vs mutant in vitro and in vivo ArrayExpress

    ID: E-GEOD-51211

    Description: ndidate genes downstream of IL7R-INS in vitro KSL/CLP and in vivo (depicted as B-neoplasm, Notch-T-ALL, or myeloid disorder) in comparison to WT. Five-condition experiment: WT-KSL vs. INS-KSL cells; WT-

  5. Genes affected by Satb1 deficiency in HSC, LMPP and CLP ArrayExpress

    ID: E-GEOD-45299

    Description: microarrays were conducted with Lin- c-kitHi Sca-1+ Flt3- HSC-enriched cells, Lin- c-kitHi Sca-1+ Flt3+LMPP-enriched cells, and Lin- c-kitLo Sca-1Lo IL7Rα+ CLP-enriched cells derived from E18.5 FL of Satb1-null mice or their WT littermates....

  6. Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis ArrayExpress

    ID: E-GEOD-24357

    Description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were c...

  7. Expression profiling of early lymphoid progenitors deficient for Ebf1 and Foxo1 ArrayExpress

    ID: E-GEOD-41931

    Description: t at the level of the common lymphoid progenitor (CLP). Both mouse strains display the existance of LY6D+ CLPs but a marked/complete lack of proB cells. To investigate similarities of the developmental defects observed we generated gene expression profiles from bo...

  8. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis ArrayExpress

    ID: E-GEOD-40180

    Description: in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were collected for analyses. Total RNA ...

  9. Transcription profiling by array of Mycobacterium tuberculosis clp gene regulator (ClgR) mutants ArrayExpress

    ID: E-BUGS-96

    Description: omics and targeted mutagenesis to reveal that the clp gene regulator (ClgR) of Mycobacterium tuberculosis activates the transcription of at least ten genes, including four that encode protease systems (ClpP1/C, ClpP2/C, PtrB and HtrA-like protease Rv1043c) and three that encode chaperones (Acr2, ClpB and the chaperonin Rv3269). Thus, M. tuberculosis ClgR controls a larger network of protein homeostatic and regulatory systems than ClgR in any other bacterium studied to date. We demonstrate that ClgR-regulated transcriptional activation of these systems is essential for M. tuberculo...

  10. Expression data from WT, HEB-KO and E2A-KO LY6D- CLP cells ArrayExpress

    ID: E-GEOD-27402

    Description: The E-protein transcription factors E2A and HEB play important roles at several stages of hematopoiesis. However, the exact mechanism for...

  11. etic stem cells (HSC) early B lineage stages(MLP, CLP, Fr.A, Fr.B) to identify coordinately regulated gene as cells progress down the B cell development pathway... ArrayExpress

    ID: E-MEXP-559

    Description: re prepared from four early B lineage stages(MLP, CLP, Fr.A, Fr.B) from mouse bone marrow, and microarrays were done to identify sets of genes that were coordinately regulated as cells progressed down the B cell development pathway....

  12. The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor ArrayExpress

    ID: E-GEOD-62337

    Description: 3 was required in the common lymphoid progenitor (CLP), and was essential for the differentiation of CLP, a bone marrow cell population that gives rise to all known ILC lineages. Clonal differentiation studies revealed that CXCR6+ cells within the CLP population differentiate into all ILC lineages but not T- and B-cells. We further show that NFIL3 governs ILC development by directly regulating expression of the transcription factor TOX. These findings establish that NFIL3 directs the differentiation...

  13. Streptococcus mutans UA159 vs. clp mutant strains ArrayExpress

    ID: E-GEOD-29871

    Description: Transcriptional profiling to investigate the roles of ClpP and ClpX of S. mutans RNA was extracted from four replicate samples of each strain of inter...

  14. Host Responses to Sepsis Vary in Different Low-Lethality Murine Models ArrayExpress

    ID: E-GEOD-55238

    Description: The CS and CLP murine models of intra-abdominal sepsis have unique transcriptomic respones 2 hrs, 1 and 3 days after sepsis...

  15. Reaeration timecourse from a defined hypoxia model ArrayExpress

    ID: E-GEOD-21590

    Description: s, as well as the transcription factor Rv2745c, a Clp protease gene regulator (ClgR) orthologue. During reaeration, genes repressed during hypoxia are also upregulated in a wave of transcription that includes genes crucial to transcription, translation and oxidative phosphorylation. Each reaerating culture compared at multiple timepoints to a sample from the same culture at seven days of hypoxia. Three or more replicates at each timepoint....

  16. Transcription profiling of mouse models of sepsis cecal ligation and puncture and tracheal instillation of P. aeruginosa reveals bcl-2 overexpression ... ArrayExpress

    ID: E-GEOD-5811

    Description: ding bcl2L11 (bim), bcl-2L2 (bcl-w), bmf, and mcl-1. Sepsis in bcl-2 transgenic animals resulted in alteration of RNA abundance for only a single gene, ceacam1. Conclusion: These findings are consistent with sepsis-induced alterations in the balance of pro- and anti-apoptotic transcriptional networks. In addition, our data suggest that the ability of bcl-2 overexpression to improve survival in sepsis in this model is related in part to prevention of sepsis-induced alterations in spleen transcriptional responses. Experiment Overall Design: To determine the splenic response in these lethal models of CLP and Pseudomonas pneumonia, microarray analysis was performed on each spleen harvested from wild-type animals 6 hours after CLP or tracheal instillation of bacteria. The responses of the CLP or Pseudomonas spleens were compared concurrently to those of the wild-type controls, sham laparotomy and tracheal instillation of saline, respectively. This study was repeated in animals overexpressing bcl-2. Thus, the splenocyte effect of sepsis secondary to CLP (n=6) or Pseudomonas pneumonia (n=5) could be determined compared to their controls (n=6 and 5, respectively), and the effect of bcl-2 overexpression in turn also could be determined in both CLP (n=5) and pneumonia models (n=5) compared to controls (n=5 and...

  17. Transcription profiling of rat liver samples from individuals subjected to burn injury or cecal ligation and puncture ArrayExpress

    ID: E-GEOD-1781

    Description: for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study...

  18. Profiling circulating microRNA expression in experimental sepsis by cecal ligation and puncture ArrayExpress

    ID: E-GEOD-47094

    Description: perimental sepsis by cecal ligation and puncture (CLP), the whole blood samples were obtained from C57BL/6 mice at 4, 8, and 24 h following CLP for miRNA expression analysis using a miRNA array (The Mouse & Rat miRNA OneArray® v3). Br...

  19. Transcription profiling of mouse hematopoietic cells (GMP, CMP, CLP and HSC), FACS sorted from wild type and Mll-AF9 knock-ins ArrayExpress

    ID: E-GEOD-10627

    Description: mong four types of hematopoietic cells (GMP, CMP, CLP and HSC), FACS sorted from wild type and Mll-AF9 knock-in mice. The goal was to identify genes differentially expressed in each Mll-AF9 cell type compared to the corresponding wild type cells....

  20. Single cell analysis of the Common Lymphoid Progenitor compartment reveals functional and molecular heterogeneity ArrayExpress

    ID: E-GEOD-19142

    Description: ells also expressed a higher level of the surface protein LY6D providing an additional tool for the analysis of early lymphoid development. These data suggest that the classical CLP compartment composes a mixture of cells with more or less restricted lineage potentials opening new possibilities to investigate early hematopoiesis. Two newly identified subpopulations of common lymphoid progenitors (CLP), hereafter called CLP_RAGhigh and CLP_RAGlow, have been sorted in 2 replicates. RNA was extracted from 2,000 purified adult BM cells using the RNAeasy microkit. RNA was labeled and amplified by dual amplification and hybridized to Affymetrix microarray MOE430_2, according to AffymetrixTM GeneChip Expression Analysis Technical Manual. Probe level expression values were calculated using the RMA algorithm....

Displaying 20 of 46 results for "COTL1"