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Displaying 20 of 50 results for "CLEC7A"
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  1. Transcription profiling of mouse MyD88-deficient bone marrow-derived macrophages treated with Zymosan ArrayExpress

    ID: E-GEOD-6376

    Description: trated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, and have elucidated some of the mechanisms by which Dectin-1 signals to coordinate the antifungal response. While Dectin-1

  2. Expression data from pDC infected with Aspergillus fumigatus BioProject

    ID: PRJNA239693

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ition and downstream events in pDCs stimulated by A. fumigatus hyphae. Our data show that Dectin-2 but not Dectin-1 participates in hyphal recognition by pDCs and that Dectin-2 acts in cooperation with the FcRγ chain to trigger signaling responses. In addition, using confocal and electron microscopy we demonstrated that the interaction between pDCs and A. fumigatus induced the formation of pDC extracellular traps (pETs) containing DNA and citrulli...
  3. Microarray analysis of CurDC versus BMDC BioProject

    ID: PRJNA320544

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: We found that dendritic cells (DCs) activated by dectin-1 agonists Curdlan potently promoted naïve CD4+ T cells to differentiate into Th9 cells. To clarify the ...
  4. Dectin-1/Syk pathway activates autophagy-dependent unconventional protein secretion from human macrophages ProteomeXchange

    ID: PXD000574

    Instrument: QSTAR

    Date Released: 05-12-2014

  5. Data from: Impaired T Cell Responsiveness to Interleukin-6 in Hematological Patients with Invasive Aspergillosis Dryad

    DateIssued: 04-16-2015

    Description: of the pattern recognition receptors pentraxin 3, dectin-1, and Toll-like receptors (TLR) 2 and 4 in peripheral blood of chemotherapy and HSCT recipients with IMI. Compared to hematological controls, individuals with IA and mucormycosis had defective expression of dectin-1; in addition, patients with mucormycosis had decreased TLR2 and increased TLR4 expression. Since fungal recognition via dectin-1 favors T helper 17 responses and the latter are highly dependent on activation of the signal transducer and activator of transcription (STAT) 3, we next used phospho-flow cytometry to measure the phosphorylation of the transcription factors STAT1 and STAT3 in response to interferon-gamma (IFN-γ)...

  6. Synergism between curdlan and GM-CSF in mouse dendritic cells ArrayExpress

    ID: E-GEOD-32986

    Description: A simultaneous engagement of different pathogen recognition receptors provides a tailor made adaptive immunity f...

  7. Dectin-1-mediated signaling leads to characteristic gene expressions in rat mast cells OmicsDI

    ID: E-GEOD-56246

    Date Released: 04-11-2014

    Description: nalyzed to investigate the molecular mechanism of Dectin-1-mediated activation and responses of mast cells. Dectin-1-mediated signaling stimulated character...

  8. Synergism between curdlan and GM-CSF in mouse dendritic cells BioProject

    ID: PRJNA146443

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: A simultaneous engagement of different pathogen recognition receptors provides a tailor made adaptive immunity f...
  9. Vav proteins are key regulators of Card9 signaling for innate antifungal immunity BioProject

    ID: PRJNA326900

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ate immune system senses fungal pathogens through a family of Syk-coupled C-type lectin receptors (CLRs), which signal through the conserved immune adapter Card9. Although Card9 complexes are essential for antifungal def...
  10. Genome wide mapping of NFAT1 binding sites in dendritic cells and of chromatin state in steady and dectin-1 activated dendritic cell line D1 OmicsDI

    ID: E-GEOD-59998

    Date Released: 04-03-2015

    Description: state maps of mouse dendritic cells in steady and dectin-1 activated with or without NFAT inhibitor FK506. We found the differential H3K4me3 signatures in these cells. This study provides the epige...

  11. Gene expression profiling of dectin-1 and NFAT responsive genes in dendritic cells OmicsDI

    ID: E-GEOD-59896

    Date Released: 02-06-2015

    Description: This study provides the dectin-1 and NFAT responsive genes for 2h and 4h of curdlan treatment. Affymetrix Mouse Gene 1.0ST Arrays were u...

  12. Expression data from tail skin in young (5 months) and old (30 months) CB6F1 mice ArrayExpress

    ID: E-GEOD-35322

    Description: tive capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood and conservation of these mechanisms between humans and mice is uncertain. Results: We used genome-wide expression profiling to investigate the aging skin transcriptome. In humans, age-related shifts in gene...

  13. Transcription profiling of mouse MyD88-deficient bone marrow-derived macrophages treated with Zymosan OmicsDI

    ID: E-GEOD-6376

    Date Released: 03-27-2012

    Description: trated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, and have elucidated some of the mechanisms by which Dectin-1 signals to coordinate the antifungal response. While Dectin-1

  14. Immunoregulatory function of placental dendritic cells: tolerance against intracellular bacteria BioProject

    ID: PRJNA230354

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s), and several DCs markers such as DC-SIGN, BDCA-1, ASGPR and Dectin-1. They also express HLA-G and ILT4 two molecules involved in tolerance maintain during pregnancy. At the transcriptomic level, plaDCs showed reduced expression of class II MHC and costimulatory moecules genes, while that of Toll like receptors and MHC class I we...
  15. Expression data from tail skin in young (5 months) and old (30 months) CB6F1 mice BioProject

    ID: PRJNA151549

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: tive capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood and conservation of these mechanisms between humans and mice is uncertain. Results: We used genome-wide expression profiling to investigate the aging skin transcriptome. In humans, age-related shifts in gene...
  16. CANCOLOLORETA : The Role of Candida in the Lower Respiratory Tract of Intubated and Mechanically Ventilated ICU Patients BioProject

    ID: PRJEB7613

    Keywords: Other

    Access Type: download

    dataset.description: osed projects intends to test the hypothesis that 1.) invasive Candida strains from the lower respiratory tract differ from colonizing Candida strains with regard to production and expression of putative virulence factors and/or that 2.) patients suffering from pulmonary invasive candidiasis differ from patients colonized by Candida spp. with regard to inflammatory markers, other serum markers (fungal antigen) and composition of indigenous pulmonary bacterial flora. For this purpose, pathogen related factors such as Candida prevalence, Candida quantity, phospholipases, secreted aspartyl proteinases, chromosome length polymorphism, transcriptional profiles, DFG16, SAP1-3, and SAP5 mRNA as well as human cellular and serum markers such as Dectin-1, TLR-2, TLR-4, TNF-α, IL-2, IL-10, IL-12, procalcitonin and (1→3) ß-D-Glucan, the indigenous pulmonary bacterial flora and underlying risk factors will be investigated in 6 different patient groups in this project. The results of this study should contribute to a better understanding of Candida colonization and Candida infections in the lower respiratory tract in critically ill patients. This should prospectively lead to a more targeted antifungal therapy and to a better outcome as well as to a reduction of unnecessary antifungal treatments and to a red...
  17. Phenotypical and functional characterization of human skin dermal dendritic cells and Langerhans cells. BioProject

    ID: PRJNA292927

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: two separated locations. While CD1ahigh LCs form a dense network in the epidermis, the CD14+ and CD1a+ APCs reside in the dermal compartment. A better understanding of the biology of human skin APC subsets is necessary for the improvement of vaccine strategies that use the skin as administration route. In particular, progress in the characterization of uptake and activat...
  18. Impaired calcineurin signaling in dendritic cells and macrophages increases susceptibility to aspergillosis through pentraxin-3 downregulation BioProject

    ID: PRJNA292504

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he calcineurin-NFAT pathway, such as Cyclosporine A or Tacrolimus, are commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe life-threating conditions. A
  19. Candida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway OmicsDI

    ID: E-GEOD-34260

    Date Released: 05-04-2014

    Description: mphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induced functional programming of monocytes, leading to enhanced cytokine production in vivo and in vitro. The training required the beta glucan receptor dectin 1

  20. Synergism between curdlan and GM-CSF in mouse dendritic cells OmicsDI

    ID: E-GEOD-32986

    Date Released: 11-14-2011

    Description: A simultaneous engagement of different pathogen recognition receptors provides a tailor made adaptive immunity f...


Displaying 20 of 50 results for "CLEC7A"