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  1. CHD5, A Brain-Specific Chromatin Remodeling Enzyme, Regulates Expression Of Neuronal Genes. OmicsDI

    ID: E-GEOD-27620

    Date Released: 10-12-2011

    Description: CHD5 is frequently deleted in neuroblastoma, and appears to be a tumor suppressor gene; however, little is known about the role of ...

  2. CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and Polycomb gene repression OmicsDI

    ID: E-GEOD-48314

    Date Released: 09-19-2013

    Description: The chromatin remodeler CHD5 is expressed in neural tissue and is frequently deleted in aggressive neuroblastoma. Very little is known about the function o...

  3. Transient expression of CHD5 in KELLY cells OmicsDI

    ID: E-GEOD-59899

    Date Released: 09-27-2014

    Description: Loss of the tumor suppressor CHD5 frequently occurs during neuroblastoma progression. We used microarray analyses to identify genes that change expression follo...

  4. Genomes of Relapsing Neuroblastoma OmicsDI

    ID: EGAS00001001387

    Date Released:

    Description: -exome sequencing, mRNA expression, array CGH and DNA methylation analysis to holistically characterize 16 paired samples from neuroblastoma patients at diagnosis and relapse. The mutational burden significantly increased in relapsing tumors accompanied by altered mutational signatures and reduced subclonal heterogeneity. Global allele frequencies at relapse indicated clonal mutatio...

  5. The NuRD chromatin remodelling complex regulates brain cortical development OmicsDI

    ID: E-GEOD-70298

    Date Released: 08-20-2015

    Description: he ATPase subunits of NuRD complex CHD3, CHD4 and CHD5 undergo a functional switch, thereby regulating distinct aspects of neuronal differentiation and migration in a sequential and mostly non-overlapping manner. We conclude that the recruitment of NuRD complexes containing specific CHDs to gene promoters and enhancers plays an instructive role in brain development. Gene expression analysis was performed in the mouse embryonic cortex at three developmental stages: E12.5, E15.5 and E18.5 using total RNA obtained from four embryos for each time point....

Displaying 5 of 5 results for "CHD5"