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Displaying 20 of 262 results for "CFTR"
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  1. Molecular mechanisms of cigarette smoke-induced lung emphysema ArrayExpress

    ID: E-MTAB-2756

    Description: ncreased transcriptional activity of PU.1, STAT1, C/EBP, FOXM1, YY1 and N-cor, and increased IL-17 cytokine expression, and reduced protein expression of ITGB6 and CFTR. We also corroborated, by using targeted proteomic approaches, several predictions such as reduced expression of ITGB6 and increased expression of BRCA1, C/EBPs, PU.1, TNF-a, IL-1b or CSF2. We believe this study will provide more insights into better understanding of CS-induced molecular processes underlying emphysema development in mice that may eventually be relevant in humans....

  2. Role of microRNAs on the pattern of gene expression in the different segments of human epididymis ArrayExpress

    ID: E-GEOD-35522

    Description: n10 mRNA (r= -0,92, P<0.001) and with miR-145 and Cftr mRNA (r= -0,69, P<0.05). We confirmed that miR-145 and miR-892b inhibit the expression of the luciferase reporter via Cldn10 and Esrrg 3’ UTRs respectively, whereas miR-145 does not affect the expression of luciferase after its co-transfection with the plasmid containing the Cftr 3’UTR. CONCLUSION: Overall, our study shows that the expression of miRNAs is segmented along the different regions of the human epididymal duct and correlates with the pattern of target gene expression in these regions. Therefore, epididymal miRNAs may be in charge of the maintenance of gene expression profile in the epididymis that dictate segment-specific secretion of proteins and establish physiological compartments that directly or indirectly affect sperm maturation and fertility. Normal human epididymides from three donors of 26–50 years of age, were collected and dissected into 3 anatomical regions (caput, corpus and cauda).A cross-comparison between the miRNA signature found in different segments was performed using GeneChip miRNA Array 1.0 (Affimetrix, Santa Clara, CA)....

  3. Identification of a novel set of DNA methylation markers in bladder cancer using MBD-methylCap/seq and urine DNA screening in a Chinese population BioProject

    ID: PRJNA148095

    Keywords: Epigenomics

    Access Type: download

    dataset.description: methylation targets (VAX1, KCNV1, TAL1, PPOX1 and CFTR) for BCa diagnosis with sensitivity and specificity of 86.32% and 87.13%, respectively. In addition, VAX1 and LMX1A methylation could predict the tumour recurrence. Conclusions: Tumor specific biomarkers of BCa could be established by first performing genome level methylation profiling with cell lines and then screening the potential targets in urine samples. The panel of methylated genes identified was promising for the early non-invasive detection and surveillance of BCa. Overall design: MBD methylCap/seq was carried out to screen differentially methylated CpG islands using two BCa cell lines (5637 and T24), and two normal bladder tissue mix as control....
  4. Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to F-iCAL36 (ANSRFPTSII) peptide PDB

    ID: PDB:4NNL

    Description: Tax1-binding protein 3, TIP-1 PDZ domain

  5. Solution structures of the PDZ domain of mus musculus PDZ domain-containing protein 1 PDB

    ID: PDB:2EDZ

    Description: PDZ domain-containing protein 1

  6. Structural Basis for Adenylate Kinase Activity in ABC ATPases PDB

    ID: PDB:3KTA

    Description: Chromosome segregation protein smc

  7. A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals novel candidate regulatory elements for male infertility [Transc... BioProject

    ID: PRJNA218065

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n were seen in the androgen receptor gene and the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which has a critical role in regulating ion transport across the epididymis epithelium. In silico prediction of transcription factor binding sites that were over-represented in epididymis-selective DHS identified epithelial transcription factors including ELF5 and ELF3, the androgen receptor, Pax2 and Sox9, as components of epididymis transcriptional networks. Active genes, which are targets of each transcription factor, reveal important biological processes in the epididymis epithelium. Overall design: HEE cells were cultured as described previously (Harris and Coleman 1989). RNA was isolated by Trizol extraction from three primary cultures of HEE cells. Total RNA was purified by Millipore Microcon YM-100 filter centrifugation and shipped to MoGene, MO, for gene expression analysis on Nimblegen 4 x 72K HG18 60mer arrays. This submission represents transcriptome component of study....
  8. A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals novel candidate regulatory elements for male infertility [DNase-... BioProject

    ID: PRJNA219502

    Keywords: Epigenomics

    Access Type: download

    dataset.description: n were seen in the androgen receptor gene and the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which has a critical role in regulating ion transport across the epididymis epithelium. In silico prediction of transcription factor binding sites that were over-represented in epididymis-selective DHS identified epithelial transcription factors including ELF5 and ELF3, the androgen receptor, Pax2 and Sox9, as components of epididymis transcriptional networks. Active genes, which are targets of each transcription factor, reveal important biological processes in the epididymis epithelium. Overall design: To identify cis-regulatory elements for genes expressed in human epididymis epithelial cells we generated genome-wide maps of open chromatin by DNase-seq....
  9. MicroRNA profiling of cystic fibrosis intestinal disease in mice BioProject

    ID: PRJNA122575

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to Y-iCAL36 (YPTSII) peptide PDB

    ID: PDB:4NNM

    Description: Tax1-binding protein 3, TIP-1 PDZ domain

  11. PDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand) PDB

    ID: PDB:2LOB

    Description: i-associated PDZ and coiled-coil motif-containing protein, Cystic fibrosis transmembrane conductance

  12. Crystal Structure of Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to iCAL36 inhibitor peptide PDB

    ID: PDB:3SFJ

    Description: Tax1-binding protein 3, decameric peptide, iCAL36

  13. Transcription profiling of human cystic fibrosis (CF) IB3-1 bronchial epithelial cells treated with 4-phenylbutyrate for 12 or 24 hours to study ... OmicsDI

    ID: E-GEOD-620

    Date Released: 04-30-2015

    Description: Most individuals with cystic fibrosis (CF) carry one or two mutations that result in a maturation defect of the full-length <

  14. Consanguinity and Rare Mutations Outside of MCCC Genes Underlie Non-Specific Phenotypes of MCC Deficiency dbGaP

    ID: phs000776.v1.p1

    Description: 3-Methylcrotonyl-CoA Carboxylase Deficiency (MCCD) is an autosomal recessive disorder of leucine catabolism, which has a highly variable clinical phen...

    Study Types: Case-Control

    disease.name: IGHMBP2 protein, human
  15. ARRA - NHLBI Lung Cohorts Sequencing Project dbGaP

    ID: phs000254.v2.p1

    Description: lection of two longitudinal population cohorts of cystic fibrosis patients that have been well characterized for a comprehensive set of clinical traits. In Phase I, exome sequencing was performed on 43 cystic fibrosis patients with early Pa infection and 48 cystic

  16. Crystal Structure of NHERF2 PDZ1 Domain in Complex with LPA2 PDB

    ID: PDB:4P0C

    Description: Na(+)/H(+) exchange regulatory cofactor NHE-RF2,Lysophosphatidic acid receptor 2

    dataset.creators: Li, C.
  17. Role of microRNAs on the pattern of gene expression in the different segments of human epididymis. BioProject

    ID: PRJNA152243

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n10 mRNA (r= -0,92, P<0.001) and with miR-145 and Cftr mRNA (r= -0,69, P<0.05). We confirmed that miR-145 and miR-892b inhibit the expression of the luciferase reporter via Cldn10 and Esrrg 3’ UTRs respectively, whereas miR-145 does not affect the expression of luciferase after its co-transfection with the plasmid containing the Cftr 3’UTR. CONCLUSION: Overall, our study shows that the expression of miRNAs is segmented along the different regions of the human epididymal duct and correlates with the pattern of target gene expression in these regions. Therefore, epididymal miRNAs may be in charge of the maintenance of gene expression profile in the epididymis that dictate segment-specific secretion of proteins and establish physiological compartments that directly or indirectly affect sperm maturation and fertility. Overall design: Normal human epididymides from three donors of 26–50 years of age, were collected and dissected into 3 anatomical regions (caput, corpus and cauda).A cross-comparison between the miRNA signature found in different segments was performed using GeneChip miRNA Array 1.0 (Affimetrix, Santa Clara, CA)....
  18. Molecular mechanisms of cigarette smoke-induced lung emphysema OmicsDI

    ID: E-MTAB-2756

    Date Released: 07-16-2014

    Description: ncreased transcriptional activity of PU.1, STAT1, C/EBP, FOXM1, YY1 and N-cor, and increased IL-17 cytokine expression, and reduced protein expression of ITGB6 and CFTR. We also corroborated, by using targeted proteomic approaches, several predictions such as reduced expression of ITGB6 and increased expression of BRCA1, C/EBPs, PU.1, TNF-a, IL-1b or CSF2. We believe this study will provide more insights into better understanding of CS-induced molecular processes underlying emphysema development in mice that may eventually be relevant in humans....

  19. MicroRNA profiling of cystic fibrosis intestinal disease in mice OmicsDI

    ID: E-GEOD-19621

    Date Released: 05-01-2014

    Description: Cystic fibrosis (CF) intestinal disease is characterized by alterations in processes such as proliferation and a...

  20. normal human CFTR overexpression in mouse lung BioProject

    ID: PRJNA94515

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 262 results for "CFTR"