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Displaying 20 of 262 results for "CFTR"
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  1. Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation adducted with the 1,2-epoxyhexane hydrolysis intermediate PDB

    ID: PDB:4DNO

    Description: Putative hydrolase

  2. CFTR map generated from 2D crystals grown using the epitaxial method. PDBe:EMDB

    Types: Image stored as Reals

    Person: Rosenberg MF, ORyan LP, Hughes G, Zhao Z, Aleksandrov LA, Riordan JR, Ford RC

    Release Date: 01-06-2012

  3. Influence of inflammation on the expression and activity of glycosyltransferases in human bronchial mucosa ArrayExpress

    ID: E-GEOD-27594

    Description: inflammation is common in patients suffering from Cystic Fibrosis (CF) and is commonly responsible for mortality from CF. It is known that this inflammation has an influenc...

  4. A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis BioProject

    ID: PRJNA197502

    Keywords: Epigenomics

    Access Type: download

    dataset.description: e, we found that simultaneous hypermethylation of CFTR and HTR1B is common in patients with high Gleason score and high ki-67 levels and might signal the population at higher risk of therapeutic failure. DNA hypermethylation profile was associated with cancer-specific mortality (log-rank, p=0.007) and biochemical recurrence-free survival (log-rank, p=0.0008). In conclusion, our data strongly indicate that epigenetic silencing of GSTM2 and PENK is a common event in prostate cancer that could be used as a molecular marker for prostate cancer diagnosis. In addition, simultaneous HTR1B and CFTR hypermethylation could help discriminate aggressive from indolent prostate tumors.A DNA hypermethylation profile associated with cancer-specific mortality and biochemical recurrence in patients receiving radical prostatectomy is presented. GST2 and PENK are new hipermethylated genes identified. Simultaneous hypermethylation of CFTR and HTR1B could help discriminate aggressive disease. Overall design: Total DNA isolated by standard procedures from prostate tumors and prostate cancer cell lines cultured under standard conditions...
  5. Gene expression in rectal epithelia of cystic fibrosis patients BioProject

    ID: PRJNA115739

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Cystic fibrosis transmembrane conductance regulator: So... PDB

    ID: PDB:1CKX

    Description: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (

  7. CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SO... PDB

    ID: PDB:1CKZ

    Description: CYSTIC FIBROSIS TRANSMEMBRANE CONDUNTANCE REGULATOR (CFTR

  8. Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1 PDB

    ID: PDB:4JL7

    Description: STRUCTURAL BASIS OF THE NHERF PDZ1-CFTR INTERACTION

  9. CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SO... PDB

    ID: PDB:1CKY

    Description: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (

  10. CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SO... PDB

    ID: PDB:1CKW

    Description: CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (

  11. Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP) PDB

    ID: PDB:3GD7

    Description: SGX CLONE 5832c684BSt1pi1

  12. Gene expression in rectal epithelia of cystic fibrosis patients ArrayExpress

    ID: E-GEOD-15568

    Description: es were recorded from rectal suction specimens of Cystic Fibrosis (CF) patients, carrying the CF-specific D508 mutated CFTR-allele. These profiles were compared wit...

  13. Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line GEMMA

    ID: 1698

    Keywords: functional genomics

    Description: Most individuals with cystic fibrosis (CF) carry one or two mutations that result in a maturation defect of the full-length <

  14. NHLBI GO-ESP: Family Studies (Atypical Cystic Fibrosis) dbGaP

    ID: phs000556.v1.p1

    Description: and 2 sequencing centers - BroadGO and SeattleGO. Cystic fibrosis (CF) patients without detectable disease-causing mutations in CFTR present a clinical phenotype very similar to, but possibly discrete from, classic CF. We hypothesize that the phenotype of these atypical CF patients is not due only to mutations in the carbonic anhydrase gene CA12 or in the genes encoding the epithelium sodium ion channel ENaC, but is due to mutations in novel genes that have yet to be associated with CF. The goal of this study is to determine the molecular etiology of this atypical CF....

  15. A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals novel candidate regulatory elements for male infertility [DNase-... ArrayExpress

    ID: E-GEOD-51002

    Description: n were seen in the androgen receptor gene and the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which has a critical role in regulating ion transport across the epididymis epithelium. In silico prediction of transcription factor binding sites that were over-represented in epididymis-selective DHS identified epithelial transcription factors including ELF5 and ELF3, the androgen receptor, Pax2 and Sox9, as components of epididymis transcriptional networks. Active genes, which are targets of each transcription factor, reveal important biological processes in the epididymis epithelium. To identify cis-regulatory elements for genes expressed in human epididymis epithelial cells we generated genome-wide maps of open chromatin by DNase-seq....

  16. c-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90 OmicsDI

    ID: PXD001737

    Date Released: 08-06-2015

    Description: The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hs...

  17. Influence of inflammation on the expression and activity of glycosyltransferases in human bronchial mucosa BioProject

    ID: PRJNA138363

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: inflammation is common in patients suffering from Cystic Fibrosis (CF) and is commonly responsible for mortality from CF. It is known that this inflammation has an influenc...
  18. Identification of a novel set of DNA methylation markers in bladder cancer using MBD-methylCap/seq and urine DNA screening in a Chinese population ArrayExpress

    ID: E-GEOD-33839

    Description: methylation targets (VAX1, KCNV1, TAL1, PPOX1 and CFTR) for BCa diagnosis with sensitivity and specificity of 86.32% and 87.13%, respectively. In addition, VAX1 and LMX1A methylation could predict the tumour recurrence. Conclusions: Tumor specific biomarkers of BCa could be established by first performing genome level methylation profiling with cell lines and then screening the potential targets in urine samples. The panel of methylated genes identified was promising for the early non-invasive detection and surveillance of BCa. MBD methylCap/seq was carried out to screen differentially methylated CpG islands using two BCa cell lines (5637 and T24), and two normal bladder tissue mix as control....

  19. A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals novel candidate regulatory elements for male infertility [Transc... ArrayExpress

    ID: E-GEOD-50605

    Description: n were seen in the androgen receptor gene and the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which has a critical role in regulating ion transport across the epididymis epithelium. In silico prediction of transcription factor binding sites that were over-represented in epididymis-selective DHS identified epithelial transcription factors including ELF5 and ELF3, the androgen receptor, Pax2 and Sox9, as components of epididymis transcriptional networks. Active genes, which are targets of each transcription factor, reveal important biological processes in the epididymis epithelium. HEE cells were cultured as described previously (Harris and Coleman 1989). RNA was isolated by Trizol extraction from three primary cultures of HEE cells. Total RNA was purified by Millipore Microcon YM-100 filter centrifugation and shipped to MoGene, MO, for gene expression analysis on Nimblegen 4 x 72K HG18 60mer arrays. This submission represents transcriptome component of study....

  20. MicroRNA profiling of cystic fibrosis intestinal disease in mice ArrayExpress

    ID: E-GEOD-19621

    Description: Cystic fibrosis (CF) intestinal disease is characterized by alterations in processes such as proliferation and a...


Displaying 20 of 262 results for "CFTR"