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Displaying 20 of 607 results for "ATF1"
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  1. Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock BioProject

    ID: PRJNA263810

    Keywords: Epigenomics

    Access Type: download

    dataset.description: y regulate RNA synthesis. Unlike the ubiquitously activating effect of histone K acetylation, the effects of histone K methylation vary with the number of methyl groups added and with the position of these groups in the histone tails. Histone K demethylases (KDMs) countera...
  2. In vitro response of fibroblasts isolated from patients with immunodeficiencies GEMMA

    ID: 1571

    Keywords: functional genomics

    Description: ed distinct patterns or responsiveness to stimuli activating the Toll-like/IL1 Receptor pathway in either an MYD88-dependent (IL1B) or independent (poly(I:C)) fashion, or activating the TNF pathway. The prototypic signatures in cell lines derived from patients were as follows: NEMO-deficient cells were unresponsive to all three stimuli, UNC-93B-deficient cells did not respond to poly(I:C), and STAT1-deficient cells responded only weakly to poly(I:C) after eight hours (not shown). MyD88- and IRAK-4-defi...

  3. Transcription profiling of human peripheral blood mononuclear cells WITH a germline NRAS mutation vs controls reveals NRAScauses ... ArrayExpress

    ID: E-GEOD-7345

    Description: ling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leading to Noonan, cardio-facial-cutaneous and Costello syndrome, but activating germline mutations of NRAS have no...

  4. uanine Nucleotide Exchange Factors (GEFs), GTPase-activating proteins (GAPs), and Rho Guanine nucleotide disassociation inhibitors (GDI)... BioProject

    ID: PRJNA243869

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Hepatic gene expression in C56BL/6J mice fed a quercetin diet for 20 weeks OmicsDI

    ID: E-GEOD-62805

    Date Released: 08-19-2015

    Description: Both the 0.05% and 1% querceitn diets did not significantly affect the body weight, fat accumulation, and blood components. However, 0.05% quercetin s...

  6. Upstream Anti-sense Promoters Act as Local Enhancers of Mammalian Protein-coding Genes BioProject

    ID: PRJNA263290

    Keywords: Other

    Access Type: download

    dataset.description: Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is know...
  7. Leukotriene D4 induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. BioProject

    ID: PRJNA100025

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: leukotriene type I receptor (CysLTR1) transcript 1 is predominantly expressed in human monocytes and cysLTs signal through CysLTR1 in these cells. Several immediate-early genes, including early growth response (Egr) -2, 3, FosB, activating transcription factor 3 and nuclear receptor subfamily 4 were significantly induced by LTD4. This effect was mediated by CysLTR1 coupled to Gαi/o, activation of phospholipase C, and inositol-1,4,5-triphosphate (IP3) and store operated calcium channels. LTD4 induced p38 MAP kinase phosphorylation, a pathway also involved in the regulation of immediate-early genes expression in monocytes. LTD4 stimulated monocyte chemotactic activity that was fully blocked by a selective CysLTR1 inhibitor MK571 and pertussis toxin, suggesting that CysLTR1 c...
  8. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [ChIP-seq] ArrayExpress

    ID: E-GEOD-62499

    Description: g with mutations in NF1. NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives cancer by activating Ras4. We show that SUZ12 loss potentiates the effects of NF1 mutations by amplifying Ras-driven transcription through effects on chromatin. Importantly, however, SUZ12 inactivation also triggers an epigenetic switch that sensitizes these cancers to bromodomain inhib- itors. Collectively, these studies not only reveal an unexpected con- nection between the PRC2 complex, NF1 and Ras, but also identify a promising epigenetic-based therapeutic strategy that may be exploited for a variety of cancers. 2x3 samples (...

  9. Platelet Activating Factor Receptor and Innate Immunity OmicsDI

    ID: E-GEOD-5545

    Date Released: 05-03-2014

    Description: that causes >100,000 deaths each year in the US (1). In the case of Gram positive infection, a key bacterial element recognized by the innate immune system is the cell wall, a complex network of peptidoglycan covalently linked to teichoic acids, proteins and lipoproteins. The current model of innate immune recognition of Gram positive bacteria suggests bacterial cell wall interacts with host recognition proteins, such as toll-like receptors (TLR) and Nod proteins. We describe an additional recognition system media...

  10. Influence of alkyl-phospholipids on the gene expression profile of immortalized keratinocytes HaCaT ArrayExpress

    ID: E-GEOD-20722

    Description: ) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere ...

  11. Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance. BioProject

    ID: PRJNA257642

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e balance and signals the progression to diabetes 1. Glucagon like Peptide 1 (GLP1) agonists improve glucose tolerance in insulin resistance, although some individuals are unresponsive to treatment. Here we show that increases in GLP1 during feeding promote beta cell function in part through the PKA-mediated activation of CREB and its coactivator CRTC2 2. Mice with a knockout of C...
  12. Activating transcription factor 3 regulates immune and metabolic homeostasis ArrayExpress

    ID: E-GEOD-36377

    Description: phila basic region-leucine zipper (bZIP) protein, Activating transcription factor 3 (Atf3), safeguards a balance of metabolic and immune system responses during fly development. Loss of Atf3 function results in lethality during late-larval and pupal stages. Atf3-deficient larvae exhibit phenotypes resembling the metabolic syndrome in mammals. Excessive accumulation of lipids in the larval fat body and gut is accompanied by altered expression of genes involved in lipid metabolism. Moreover, the fat body of atf3 mutants becomes infiltrated by hemocytes. The maj...

  13. Pdx-1 activates islet α- and β-cell proliferation via a TRPC3/6- and ERK 1/2-regulated mechanism OmicsDI

    ID: E-GEOD-49786

    Date Released: 06-03-2014

    Description: The homeodomain transcription factor, Pdx-1, has important roles in pancreatic development and β-cell functi...

  14. HIRA, a Conserved Histone Chaperone, Plays an Essential Role in Low-dose Stress Response via Transcriptional Stimulation in Fission Yeast OmicsDI

    ID: E-GEOD-35281

    Date Released: 08-06-2012

    Description: -responsive gene loci upon stress treatment in an Atf1-dependent manner. The expression of stress-responsive genes under stress conditions was compromised in HIRA disruptants. Consistent with this, Pol II recruitment and nucleosome eviction at these gene loci were impaired in slm9D cells. Furthermore, we found that the priming stress enhanced the expression of stress-responsive genes in wild-type cells that were exposed to the severe stress. These observations suggest that HIRA functions in stress response through transcriptional regulation. To determine whether fission yeast HIRA specifically regulates stress-responsive genes under stress condition, we performed genome-wide analysis by using Affymetrix GeneChip oligonucleotide microarrays. Fission yeast cells (WT, slm9D, hip1D) were grown in quadruplicate at 32°C to the logarithmic phase and an aliquot was collected as the unstressed control. The other three aliquots were exposed to 40°C for 1 h, 2...

  15. Transcription profiling of fetal lung from wild type and CREB knock-out mice OmicsDI

    ID: E-MEXP-1295

    Date Released: 05-02-2014

    Description: ng protein (Creb) is a member of a leucine zipper transcription factor family that regulates gene expression primarily in response to the intracellular cAMP signalling pathway. Previous studies...

  16. A mesodermal factor, T (Brachyury), specifies mouse germ cell fate by directly activating germline determinants ArrayExpress

    ID: E-GEOD-50394

    Description: cification system, we show that WNT3 induces many transcription factors associated with mesoderm in epiblast-like cells (EpiLCs) through b-CATENIN. Among these, T (BRACHYURY), a classical and conserved mesodermal factor, was essential for robust activation of Blimp1 and Prdm14, two of the germline determinants. T, but not SMAD1 or b-CATENIN/TCF1, binds distinct regulatory elements of ...

  17. Integrated analyses of genome-wide DNA occupancy and expression profiling identify key genes and pathways involved in cellular transformation by Marek... BioProject

    ID: PRJNA210197

    Keywords: Epigenomics

    Access Type: download

    dataset.description: anism of MDV-induced tumor formation. Meq, a bZIP transcription factor discovered in the 1990s, is critically involved in viral oncogenicity but only a few of its host target genes have been described impeding our understanding of MDV-induced tumorigenesis. Using ChIP-seq and microarray analysis, a high confidence list of Meq-binding s...
  18. Transcription profiling by array of human malignant peripheral nerve sheath tumour (MPNST) cell line 90-8TL with re-expressed SUZ12... ArrayExpress

    ID: E-GEOD-62500

    Description: g with mutations in NF1. NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives cancer by activating Ras4. We show that SUZ12 loss potentiates the effects of NF1 mutations by amplifying Ras-driven transcription through effects on chromatin. Importantly, however, SUZ12 inactivation also triggers an epigenetic switch that sensitizes these cancers to bromodomain inhib- itors. Collectively, these studies not only reveal an unexpected con- nection between the PRC2 complex, NF1 and Ras, but also identify a promising epigenetic-based therapeutic strategy that may be exploited for a variety of cancers. 9 samples in tr...

  19. Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells BioProject

    ID: PRJNA122515

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: togen, Sonic Hedgehog, activates a Gli1-dependent transcription program that drives proliferation of granule neuron progenitors (GNPs) within the external germinal layer of the postnatally developing c...
  20. Over-expression of MBF1c enhances stress tolerance BioProject

    ID: PRJNA96027

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Multiprotein bridging factor 1c MBF1c (At3g24500) is a stress-response transcription co-activator. To test the function of MBF1c, we o...

Displaying 20 of 607 results for "ATF1"