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Displaying 20 of 607 results for "ATF1"
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  1. Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities BioProject

    ID: PRJNA265386

    Keywords: Other

    Access Type: download

    dataset.description: strategy to identify DNA recognition motifs for transcription factors that promote common or subset-specific binding of the macrophage lineage-determining factor PU.1. We find that distinct tissue environments drive divergent programs of gene expression by differentially activating a common enhancer repertoire and by inducing the expression of divergent secondary transcription factors that collaborate with PU.1 to establish tissue-specific enhancers. These findings provide insights into molecular mechanisms by which tissue environment influences macrophage phenotypes that are likely to be broadly applicable...
  2. Global transcriptional profiles of WT and HOIL-1L-/- BMDMs in response to LPS and TNFa BioProject

    ID: PRJNA245855

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: HOIL-1L has also been suggested to function as a transcription factor. Here we analyzed changes in the global transcriptional profiles of primary bone marrow derived macrophage (BMDMs) from WT and HOIL-1L-/- mice upon treatment with NF-kB activating simuli. Overall design: BMDMs were differentiated for 1 week and then treated with mock (unt...
  3. Gene expression of normal and ASCC1-mutant skin fibroblasts after serum starvation and serum challenge BioProject

    ID: PRJNA280514

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: estigate the genes that might be regulated by the activating signal cointegrator 1 (ASC-1) complex we performed an expression analysis using the GeneChip® Hu...
  4. RNA expression for dcr1D, rdp1D, ago1D and swi6D ArrayExpress

    ID: E-GEOD-36113

    Description: a role for nuclear pores and the stress response transcription factor Atf1 in coordinating the interplay between the RNAi machinery and the S. pombe genome and uncovers a novel mode of RNAi regulation in response to an environmental cue. Total RNA extracted from wild-type and mutant strains to compare global expression. At least 2 biological replicates for each sample were performed....

  5. Ath_Agilent_v2_Riechmann array expression profile AP1-GR ap1cal inflorescences - chx experiment BioProject

    ID: PRJNA125643

    Keywords: Variation

    Access Type: download

    dataset.description: GR ap1 cal line to induce a synchronized response activating the AP1-GR fusion protein in ap1 cal inflorescence-like meristems through dexamethasone or dexamethasone+cycloheximide treatment. Tissue samples were collected at 3hrs after the treatment. The expression profiles of the individual samples were then analyzed...
  6. The anti-inflammatory nature of HDL in macrophages is mediated by ATF3 BioProject

    ID: PRJNA188404

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: normocholesteremic conditions by suppressing the transcription of inflammatory cytokines in a manner independent of its ability to remove cellular cholesterol. We identify Activating Transcription Factor 3 (ATF3), a transcriptional repressor of the CREB family of basic leucine zipper transcription factors, as a HDL-inducible regulator of macrophage activation. HDL’s ability to down modulate TLR responses was severely compromised in ATF3-deficient cells demonstrating that ATF3 mediates HDL's anti-inflammatory effects and may explain the broad anti-inflammatory functions of HDL. Overall design: Bone marrow-derived macrophages (BMDMs) were obtained by culturing bone marrow cells from 6 to 8 week old wildtype C57BL/6 mice in DMEM supplemented with 10% FCS, 10 mg ml-1 Ciprobay-500 and 40 ng ml-1 M-CSF (R & D Systems). BMDMs of wt mice were pretreated for 6 h with HDL (2 mg ml-1 ) then stimulated with CpG (100 nM) for 4 h. Further wild type or Atf3-deficient BMDMs were pretreated with 2 mg ml-1 HDL for 6 h and subsequently stimulated with CpG (100 nM) or P3C (50 ng ml-1) for 4 h. For carotid artery injury appr...
  7. Mineralocorticoid receptor ligand-binding domain with compuond 2b PDB

    ID: PDB:3WFF

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR
  8. Differentially expressed genes between oncogene-introduced wild-type and Atf4-/- cells BioProject

    ID: PRJNA145731

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g cellular proliferation. Excessive expression of activating transcription factor 4 (ATF4) is often observed in mammalian malignant tumors. However, little is known about the role of ATF4 in the malignant transformation of normal cells. Here, we show th...
  9. Genome-wide DNase hypersensitive sites during osteoclastogenesis OmicsDI

    ID: E-GEOD-54139

    Date Released: 12-23-2014

    Description: uring early osteoclastogenesis and identify novel transcription factors involved in osteoclastogenesis, we investigated genome-wide analysis of open chromatin during receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis using DNase I hypersensitive sites sequencing (DNase-seq). DNase-seq was performed using the extracted nuclei obtained from RAW264 cells treated with or without RANKL for 24 hours, followed by several bioinformatic analyses. DNase I hypersensitive sites (DHSs) during RANKL-induced osteoclastogenesis were dynamically changed and accumulated in promoter regions, although the distrib...

  10. Mineralocorticoid receptor ligand-binding domain with compuond 2e PDB

    ID: PDB:3WFG

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR
  11. Erf chromatin binding-sites in E13.5 mouse embryo fibroblasts BioProject

    ID: PRJNA183890

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ed dosage of ERF, which encodes an inhibitory ETS transcription factor directly bound by ERK1/2 , causes complex craniosynostosis (premature fusion of the cranial sutures) in human...
  12. CBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression [ChIP-seq] BioProject

    ID: PRJNA182318

    Keywords: Epigenomics

    Access Type: download

    dataset.description: The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of...
  13. CBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression [gene expression] BioProject

    ID: PRJNA182317

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of...
  14. Transcription profiling by array of the RAMOS human cell line overexpressing Delta4-BAFF, a new alternative splice of B-Cell activating factor ArrayExpress

    ID: E-MEXP-3595

    Description: lated by a new alternative splice of BAFF (B-Cell Activating factor belonging to the TNF Family) that we called Delta4-BAFF (because it characterized by an alternative splice of exon 4). To do this we used human burkitt's lymphoma ...

  15. Expression data from human keratinocytes stimulated with streptococcal M1 protein BioProject

    ID: PRJNA262904

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 1 protein. Keratinocytes respond to M1 protein by activating pathways to induce the production of inflammatory signaltransducers, AP-1 and NFkB transcription factor subunits, together with inflammatory mediators such as IL-8, CCL20 and IL-
  16. Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420 PDB

    ID: PDB:2OAX

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION
  17. Erythroid differentiation: G1E model BioProject

    ID: PRJNA119293

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: addition activates an ectopically expressed Gata-1-estrogen receptor fusion protein, triggering synchronous differentiation. 30 hour time course corresponds roughly to late burst-forming unit-erythroid stage (t=0 hrs) through orthochromatic erythroblast stage (t=30 hrs). Ov...
  18. RNA-Seq experiment to identify genes regulated by ATF4 ArrayExpress

    ID: E-GEOD-69308

    Description: Activating Transcription Factor 4 (ATF4) is a transcription

  19. Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist PDB

    ID: PDB:3VHV

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR
  20. Mineralocorticoid receptor ligand-binding domain with spironolactone PDB

    ID: PDB:3VHU

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR

Displaying 20 of 607 results for "ATF1"