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Displaying 20 of 607 results for "ATF1"
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  1. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA ArrayExpress

    ID: E-GEOD-63794

    Description: uencing of wild-type or Interferon Alpha receptor 1 Knockout MEF cells treated with DMSO or the Broad-spectrum Caspase Inhibitor Q-VD-OPh The mechanism by which cells undergo death determi...

  2. The DNA methylation signature of human TCRαβ+CD4-CD8- double negative T cells reveals CG demethylation and a unique epigenetic architecture permissi... ArrayExpress

    ID: E-GEOD-61195

    Description: lthy women (age range 25-60) (Supplementary Table 1) by Ficoll-gradient centrifugation (GE Healthcare Bio-Sciences AB, Uppsala, Sweden). Subsequently, T cells were negatively-selected using the Human Pan T Cell Isolation II kit (Miltenyi Biotec, Cambridge, MA). T cells were then analyzed and sorted into TCRαβ+ CD4+ T cells, TCRαβ+ CD8+ T cells, and TCRαβ+ DN T cell subsets by flow cytometry. DNA was isolated from CD4+, CD8+, and DN T cell subsets using the DNeasy Blood and Tissue Kit (Qiagen, Valencia, CA), then bisulfite-converted using the EZ DNA Methylation kit (Zymo Research, Irvine, CA) for DNA methylation studies....

  3. BET Bromodomain Protein BRD4 Regulates MEK Inhibitor-induced Kinome Reprogramming in Triple Negative Breast Cancer BioProject

    ID: PRJNA218091

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: selection of mutations in the targeted kinase7,8, activating mutations or amplification of RAS or downstream kinases9,10 or kinome reprogramming, a process in which there are system-wide changes in kinase networks11-13. Each of these resistance mechanisms allows the cancer cell to circumvent the targeted inhibition of specific kinases14. We previously developed chemical, proteomic methods that assay the activation state of protein kinases en masse15,16. Our methods utilize ¬Multiplexed Inhibitor Beads (MIBs), mixtures of covalently immobilized, linker adapted, kinase inhibitors. The immobilized inhibitors are primarily type I kinase inhibitors that preferentially bind activated (versus inactive) kinase17. Kinase capture is highly reproducible and is a function of kinase affinity for different immobilized inhibitors as well as the kinase activation state. Activated kinases preferentially bind, inactive kinases do not. By coupling MIB capture with mass spectrometry (MIB/MS), the technique allows quantitative interrogation of hundreds of kinases in a single mass spectrometry run. This also interrogates kinases known by sequence but which have been understudied due to lack of reagents such as specific phospho-antibodies. We report here both in preclinical models and patients that BL and CL TNBC have different baseline kinome activation states and both respond differently to MEKi with subtype-specific tyrosine kinase reprogramming. To avoid treatment strategy that uses multiple kinase inhibitors in individual patients, we discovered a novel pharmacologic strategy to block the initial reprogramming response to MEKi involving inhibition of epigenetic processes. Overall design: reference x sample...
  4. Homo sapiens : VACCINATION STATUS AGAINST HEPATITIS B AMONG DOCTORS OF AYUB TEACHING HOSPITAL, ABBOTTABAD BioProject

    ID: PRJNA377938

    Keywords: other

    Access Type: download

    dataset.description: BLESTable 01: Genderwise distribution of ageTable 1:Ward wise distibution of Doctors 9Table 2: Duration of medical practice of doctors in ATH 10Table 3: Designation of doctors 11Table 4: Vaccination status in male and female doctors 12Table 5: Vaccination status in the different categories of doctors 13Table 6: Vaccination status with regard to risk of HBV infection to doctors 14Table 7: Vaccination status in doctors having needle stick or cutting injury 14Table 8: Vaccination status in doctors coming in contact with hepatitis B positive patients…………………..Table 9: Reason for vaccination…………………………………………………………………………………………………………..Table 10: Reason for non-vaccination………………………………………………………………………………Table 11: Opinion of doctors regarding HBV vaccination whether it should be made mandatory for doctors or not……………………………………………………………………………………………………………………………………LIST OF FIGUREFigure 1 Age wise distribution of doctors 9Figure 2: Gender of doctors 10Figure 3: Marital status 11Figure 4: Area of residence 12Figure 5:Percentage of doctors showing risk of HBV infection 13Figure 6: Percentage of doctors showing whether they have inflicted needle stick injury or not 14Figure 7: Percentage of doctors showing contact with HBV positive patients………………………………………Figure 8: Vaccination against HBV…………………………………………………………………………………………………….Figure 9: Frequency of HBV vaccine doses received by doctors……………………………………….............Figure 10: Frequency of doctors regarding screening for HBV infection…………………………………………Figure 11: Percentage of doctors showing their intention to HBV vaccination………………………………Abstract:Background:Hepatitis B is a major health problem for doctors all over the world, which is preventable by vaccination against HBV infection. Our study was conducted to assess the vaccination status of doctors working at Ayub Teaching Hospital and the possible reasons of vaccination and non vaccination.Methods:It was a cross sectional study conducted in different wards at Ayub Te...
  5. Gene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus OmicsDI

    ID: E-GEOD-36284

    Date Released: 07-17-2012

    Description: and these Th cells also infiltrate vital organs (1-9). Macrophages (e.g. tingible body MΦ), and DCs are normally tolerant to apoptotic cell antigens (10), but they are activated to present such autoantigens after binding to IgG immune complexes (IC) containing apoptotic cell derived DNA/RNA, which then dually stimulate their TLR and FcGammaR (11-16). Hence, to generate the activating IC...

  6. Transcription factor c-JUN knockout effect on B lymphoid cells GEO

    ID: geo.datasets:GDS4205

    Description: Analysis of B lymphoid cells depleted of activating protein 1 (AP-1) transcription factor c-JUN....

    Types: Expression profiling by array

    Instrument: GPL6246

  7. Mitochondrial stress effect on ATFS-1 mutants GEO

    ID: geo.datasets:GDS4570

    Description: Analysis of atfs-1 mutants raised on spg-7(RNAi) which induces mitochondrial stress (MS). ATFS-1 (activating <...

    Types: Expression profiling by array

    Instrument: GPL200


Displaying 20 of 607 results for "ATF1"