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  1. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells [Agilent]. BioProject

    ID: PRJNA176041

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells [Agilent]. OmicsDI

    ID: E-GEOD-41122

    Date Released: 05-13-2014

    Description: tion, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated EWS/

  3. Atf1-mediated active gene response to H2O2 challenge. BioProject

    ID: PRJNA109969

    Keywords: Other

    Access Type: download

  4. EWS/ATF1 activates Fos and induces soft tissue sarcomas [Affymetrix]. BioProject

    ID: PRJNA176040

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Atf1 overexpression gene expression changesS. pombe OmicsDI

    ID: E-GEOD-71820

    Date Released: 09-06-2015

    Description: Atf1 was overexpressed in wt S. pombe cells for 24 hours and gene expression changes were analysed all samples were processed in du...

  6. Atf1-mediated active gene response to H2O2 challenge ArrayExpress

    ID: E-GEOD-13053

    Description: ip mapping of the genomic binding sites for Sty1, Atf1, and the Atf1's binding partner Pcr1; the genome-wide transcriptional profiling of the atf1 and pcr1 strains in response to ...

  7. EWS/ATF1 activates Fos and induces soft tissue sarcomas [Affymetrix] ArrayExpress

    ID: E-GEOD-41121

    Description: tion, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated EWS/

  8. Atf1-mediated active gene response to H2O2 challenge. OmicsDI

    ID: E-GEOD-13053

    Date Released: 05-04-2014

    Description: ip mapping of the genomic binding sites for Sty1, Atf1, and the Atf1's binding partner Pcr1; the genome-wide transcriptional profiling of the atf1 and pcr1 strains in response to ...

  9. EWS/ATF1 activates Fos and induces soft tissue sarcomas [Affymetrix]. OmicsDI

    ID: E-GEOD-41121

    Date Released: 04-22-2013

    Description: tion, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated EWS/

  10. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells [Agilent] ArrayExpress

    ID: E-GEOD-41122

    Description: tion, leading to the expression of a chimeric EWS/ATF1 fusion gene. However, little is known about the mechanisms underlying how EWS/ATF1 is involved in the development of CCSs. In addition, the cells of origin for CCSs remain to be determined. We generated EWS/

  11. The bZIP transcription factor Atf1 governs the oxidative stress response and sexual differentiation of... ArrayExpress

    ID: E-GEOD-64871

    Description: K module, have been elucidated but its downstream transcription factors remain unclear. Here we demonstrated that Atf1 with a basic leucine zipper domain is the transcription factor downstream of Hog1 in C. neoformans. We found that ATF1 expression was differentially regulated by oxidative damaging agents, mainly in a Hog1-dependent, but Mpk1-independent, manner. Interestingly, Atf1 not only promoted oxidative stress response a...

  12. Atf1 overexpression gene expression changesS. pombe BioProject

    ID: PRJNA292131

    Keywords: Transcriptome or Gene expression

    Access Type: download

  13. The bZIP transcription factor Atf1 governs the oxidative stress response and sexual differentiation of... OmicsDI

    ID: E-GEOD-64871

    Date Released: 01-17-2015

    Description: K module, have been elucidated but its downstream transcription factors remain unclear. Here we demonstrated that Atf1 with a basic leucine zipper domain is the transcription factor downstream of Hog1 in C. neoformans. We found that ATF1 expression was differentially regulated by oxidative damaging agents, mainly in a Hog1-dependent, but Mpk1-independent, manner. Interestingly, Atf1 not only promoted oxidative stress response a...

  14. Atf1 overexpression gene expression changesS. pombe ArrayExpress

    ID: E-GEOD-71820

    Description: Atf1 was overexpressed in wt S. pombe cells for 24 hours and gene expression changes were analysed all samples were processed in du...

  15. Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase BioProject

    ID: PRJNA267234

    Keywords: Other

    Access Type: download

    dataset.description: profiling of S. pombe set1/COMPASS/H3K4 mutants, atf1 and set1 atf1 deletion mutants, set1 clr3 deletion mutants; ChIP-chip tiling microarray profiling of S. pombe Set1,
  16. The bZIP transcription factor Atf1 governs the oxidative stress response and sexual differentiation of... BioProject

    ID: PRJNA272403

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells ArrayExpress

    ID: E-GEOD-41123

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  18. The transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation OmicsDI

    ID: E-TABM-447

    Date Released: 05-02-2014

    Description: e expression was monitored in the knockout of two transcription factors, Pcr1 and Atf1, in the presence and absence of oxidative stress induced by KCl....

  19. Mus musculus strain:ICR : Nakai_MEF BioProject

    ID: PRJNA237998

    Keywords: genome sequencing

    Access Type: download

    dataset.description: ATF1/CREB members modulate proteostasis capacity by regulating the stress-inducible HSF1-transcription complex
  20. Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase ArrayExpress

    ID: E-GEOD-63301

    Description: profiling of S. pombe set1/COMPASS/H3K4 mutants, atf1 and set1 atf1 deletion mutants, set1 clr3 deletion mutants; ChIP-chip tiling microarray profiling of S. pombe Set1,

  21. Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase OmicsDI

    ID: E-GEOD-63301

    Date Released: 01-02-2015

    Description: profiling of S. pombe set1/COMPASS/H3K4 mutants, atf1 and set1 atf1 deletion mutants, set1 clr3 deletion mutants; ChIP-chip tiling microarray profiling of S. pombe Set1,

  22. Mus musculus : Nakai_ChIP-seq BioProject

    ID: PRJNA238001

    Keywords: genome sequencing

    Access Type: download

    dataset.description: ATF1/CREB members modulate proteostasis capacity by regulating the stress-inducible HSF1-transcription complex
  23. The transcription factors Pcr1 and Atf1 have distinct roles in stress- and Sty1-dependent gene regulation ArrayExpress

    ID: E-TABM-447

    Description: e expression was monitored in the knockout of two transcription factors, Pcr1 and Atf1, in the presence and absence of oxidative stress induced by KCl....

  24. 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) increase CREB1 binding to the C/EBP half-site GCAA BioProject

    ID: PRJNA349036

    Keywords: Other

    Access Type: download

    dataset.description: he double-stranded DNA binding of the mouse B-ZIP transcription factors (TFs) CREB1, ATF1, and JUND. 5mC inhibited CREB1 binding to the canonical CRE half-site |GTCA, but increased binding to the C/EBP half-site |GCAA. 5hmC inhibited CREB1 binding to all 8-mers except TGAT|GCAA, where binding is enhanced. We observed similar DNA binding patterns with the closely related TF: ATF1. In contrast, both 5mC and 5h...
  25. Mouse Model of Clear Cell Sarcoma ArrayExpress

    ID: E-GEOD-41293

    Description: lop in mice bearing conditional activation of EWS-ATF1, compared to control mouse tissues from the chest wall as well as tumor samples from mouse models of synovial sarcoma and osteosarcoma achieved by conditional disruption o...

  26. EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells. OmicsDI

    ID: E-GEOD-41123

    Date Released: 04-22-2013

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  27. Transcription profiling of stress treated fission yeast (stressors: compound: heavy metal, oxidation, alkylation and osmosis ArrayExpress

    ID: E-MEXP-29

    Description: employed on wild type and mutant cells (sty1 and atf1 knock-out cells). The 5 stresses were heat, and four types of compound: heavy metal, oxidation, alkylation and osmosis....

  28. ATF1_MOUSE UniProt:Swiss-Prot

    ID: P81269

    Description: Cyclic AMP-dependent transcription factor ATF-1 KID bZIP Basic motif Leucine-zipper Phosphoserine; by CaMK1, CDK3,...

  29. ATF1_BOVIN UniProt:Swiss-Prot

    ID: Q08DA8

    Description: Cyclic AMP-dependent transcription factor ATF-1 KID bZIP Basic motif Leucine-zipper Phosphoserine; by CaMK1, CDK3,...

  30. Mouse Model of Clear Cell Sarcoma BioProject

    ID: PRJNA176464

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lop in mice bearing conditional activation of EWS-ATF1, compared to control mouse tissues from the chest wall as well as tumor samples from mouse models of synovial sarcoma and osteosarcoma achieved by conditional disruption o...
  31. ATFC_BOMMO UniProt:Swiss-Prot

    ID: Q9GPH3

    Description: Activating transcription factor of chaperone bZIP Basic motif Leucine-zipper

  32. Clear cell sarcoma human HEEBO microarray data ArrayExpress

    ID: E-GEOD-43045

    Description: lanoma, with a predilection for young adults. EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12, is considered the definitional feature of the tumor. Conditional expression of the EWS-ATF1 human cDNA in the mouse ...

  33. Clear cell sarcoma human HEEBO microarray data BioProject

    ID: PRJNA184178

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lanoma, with a predilection for young adults. EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12, is considered the definitional feature of the tumor. Conditional expression of the EWS-ATF1 human cDNA in the mouse ...
  34. RNA-Seq experiment to identify genes regulated by ATF4 BioProject

    ID: PRJNA285117

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Activating Transcription Factor 4 (ATF4) is a transcription
  35. Schizosaccharomyces pombe : ChIP-seq analysis of glucose starvation response in S. pombe BioProject

    ID: PRJDB4338

    Keywords: Genome sequencing

    Access Type: download

    dataset.description: Genomic distribution of Atf1, histone H3 and H3K9ac was analyzed by ChIP sequencing. 101 bp single end on illumina GAIIx.
  36. Comparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans OmicsDI

    ID: E-GEOD-21192

    Date Released: 05-02-2014

    Description: d genes, including an oxidative stress-responsive Atf1 transcription factor, although a majority of them do not have any orthologs in other fungi. The present study revealed other roles of Atf1 in capsule and melanin production and diverse stress responses, including thermotolerance and antifungal drug resistance, of C. neoformans. This study provides further insights into the signaling network of CA/CO2-sensing pathway in pathogenic fungi. 17 slides are used in this analysis, 3 or 2 biological replicate experiments are performed, total RNAs are extracted from 2 strains (H99 Wild type strain, CTR4::CAN2) at 2 time points (0hr time, 12hr time) in 2 conditions (BCS, CuSO4). We use the mixed all of total RNAs from this experiment as a control RNA. We use Cy5 as Sample dye and Cy3 as a control dye. Several experiment samples are dye swaped....

  37. Transcription profiling of stress treated fission yeast (stressors: compound: heavy metal, oxidation, alkylation and osmosis OmicsDI

    ID: E-MEXP-29

    Date Released: 06-03-2014

    Description: employed on wild type and mutant cells (sty1 and atf1 knock-out cells). The 5 stresses were heat, and four types of compound: heavy metal, oxidation, alkylation and osmosis....

  38. Comparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans ArrayExpress

    ID: E-GEOD-21192

    Description: d genes, including an oxidative stress-responsive Atf1 transcription factor, although a majority of them do not have any orthologs in other fungi. The present study revealed other roles of Atf1 in capsule and melanin production and diverse stress responses, including thermotolerance and antifungal drug resistance, of C. neoformans. This study provides further insights into the signaling network of CA/CO2-sensing pathway in pathogenic fungi. 17 slides are used in this analysis, 3 or 2 biological replicate experiments are performed, total RNAs are extracted from 2 strains (H99 Wild type strain, CTR4::CAN2) at 2 time points (0hr time, 12hr time) in 2 conditions (BCS, CuSO4). We use the mixed all of total RNAs from this experiment as a control RNA. We use Cy5 as Sample dye and Cy3 as a control dye. Several experiment samples are dye swaped....

  39. MCAF1_CHICK UniProt:Swiss-Prot

    ID: Q5ZIE8

    Description: Activating transcription factor 7-interacting protein 1 Fibronectin type-I...

  40. Clear cell sarcoma human HEEBO microarray data OmicsDI

    ID: E-GEOD-43045

    Date Released: 06-02-2014

    Description: lanoma, with a predilection for young adults. EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12, is considered the definitional feature of the tumor. Conditional expression of the EWS-ATF1 human cDNA in the mouse ...

  41. TRANSCRIPTION FACTOR ATF4-C/EBP BETA BZIP HETERODIMER PDB

    ID: PDB:1CI6

    Description: TRANSCRIPTION FACTOR ATF-4, TRANSCRIPTION FACTOR C/EBP BETA COMPLEX

  42. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish BioProject

    ID: PRJNA243510

    Keywords: Transcriptome or Gene expression

    Access Type: download

  43. Solution Structure of a SUMO-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3 PDB

    ID: PDB:2RPQ

    Description: Small ubiquitin-related modifier 2, Activating transcription factor 7-interacting protein 1...

  44. Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1 PDB

    ID: PDB:3FK2

    Description: Glucocorticoid receptor DNA-binding factor 1

  45. Multifunctional role of the transcription factor Blimp1 in coordinating plasma cell differentiation BioProject

    ID: PRJNA291849

    Keywords: Other

    Access Type: download

  46. Disruption of Drp1 in the liver protects mice against diet-induced obesity through induction of fibroblast growth factor 21 BioProject

    ID: PRJNA270467

    Keywords: Transcriptome or Gene expression

    Access Type: download

  47. Pdx-1 activates islet α- and β-cell proliferation via a TRPC3/6- and ERK 1/2-regulated mechanism BioProject

    ID: PRJNA214905

    Keywords: Transcriptome or Gene expression

    Access Type: download

  48. NMR structure of Guanylyl Cyclase Activator Protein 1 (GCAP1) mutant V77E in a Ca2+-free/Mg2+-bound Activator State PDB

    ID: PDB:2NA0

    Description: Guanylyl cyclase-activating protein 1

  49. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [ChIP-seq] BioProject

    ID: PRJNA264623

    Keywords: Epigenomics

    Access Type: download

  50. Downstream targets of ID1 transcription factor in Non-Small Cell Lung Carcinoma (NSCLC) BioProject

    ID: PRJNA169351

    Keywords: Transcriptome or Gene expression

    Access Type: download

  51. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies [expression array] BioProject

    ID: PRJNA264622

    Keywords: Transcriptome or Gene expression

    Access Type: download

  52. Mouse Model of Clear Cell Sarcoma OmicsDI

    ID: E-GEOD-41293

    Date Released: 05-12-2016

    Description: lop in mice bearing conditional activation of EWS-ATF1, compared to control mouse tissues from the chest wall as well as tumor samples from mouse models of synovial sarcoma and osteosarcoma achieved by conditional disruption o...

  53. Comparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans BioProject

    ID: PRJNA126545

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d genes, including an oxidative stress-responsive Atf1 transcription factor, although a majority of them do not have any orthologs in other fungi. The present study revealed other roles of Atf1 in capsule and melanin production and diverse stress responses, including thermotolerance and antifungal drug resistance, of C. neoformans. This study provides further insights into the signaling network of CA/CO2-sensing pathway in pathogenic fungi. Overall design: 17 slides are used in this analysis, 3 or 2 biological replicate experiments are performed, total RNAs are extracted from 2 strains (H99 Wild type strain, CTR4::CAN2) at 2 time points (0hr time, 12hr time) in 2 conditions (BCS, CuSO4). We use the mixed all of total RNAs from this experiment as a control RNA. We use Cy5 as Sample dye and Cy3 as a control dye. Several experiment samples are dye swaped....
  54. Transcription profiling of human keratinocytes treated with arachidonic acid and platelet activiating factor 16 ArrayExpress

    ID: E-TABM-472

    Description: Functional role of platelet-activating factor (PAF) induced arachidonic acid release

  55. Mus musculus : Synovial and Clear Cell Sarcoma Mouse Models BioProject

    ID: PRJNA247995

    Keywords: exome

    Access Type: download

    dataset.description: models after the expression of SS18-SSX2 and EWS-ATF1 fusion genes, respectively. A very rapid onset of visible tumors in the mouse CCS model relative to synovial sarcoma suggest that fewer additional hits may be required to foster progression of the tumor in CCS model. This may represent a fundamental difference between...
  56. RNAseq data from in vitro-stimulated (6 hours) murine nfkb2fl/flCD19-Cre and CD19-Cre splenic B cells purified by magnetic cell separation (BAFF) BioProject

    ID: PRJNA305289

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: splenic B cells identifies genes regulated by the transcription factor NF-kB2 in BAFF-stimulated B cells. Overall design: Splenic B cells from 12-week old relfl/flCD19-Cre and CD19-Cre littermate mice were isolated by magnetic cell separation from splenic mononuclear cells and stimulated in vitro for 6 hours with...
  57. GC-rich Sequence Elements Recruit Polycomb Repressive Complex 2 (PRC2) in ES cells BioProject

    ID: PRJNA134307

    Keywords: Epigenomics

    Access Type: download

    dataset.description: othesized that large GC-rich elements depleted of activating transcription factor motifs mediate PRC2 recruitment in mammals. We validated this model in two ways. First, we showed that a constitutively active CpG island is able to recruit PRC2 after excision of a cluster of activating motifs. Second, we showed that two 1 kb sequence intervals from the E. coli genome with GC-contents comparable to a mammalian CpG island are both capable of recruiting PRC2 when integrated into the ES cell genome. Our findings demonstrate a causal role for GC-rich sequences in PRC2 recruitment and implicate a specific subset of CpG islands depleted of activating motifs as instrumental for the initial localization of this key regulator in mammalian genomes. Overall design: Analysis of YY1 binding in two cell types...
  58. Hepatic gene expression in C56BL/6J mice fed a quercetin diet for 20 weeks BioProject

    ID: PRJNA265188

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Both the 0.05% and 1% querceitn diets did not significantly affect the body weight, fat accumulation, and blood components. However, 0.05% quercetin s...
  59. IRE1 and XBP-1 effects on the Drosophila unfolded protein response BioProject

    ID: PRJNA95757

    Keywords: Transcriptome or Gene expression

    Access Type: download

  60. Gene expression analysis to identify Klf2 target genes in B-cell progenitors [Klf2_KO] BioProject

    ID: PRJNA297343

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ure B-cell. Here, we show that activation of Mef2 transcription factors by preBCR is necessary for initiating the subsequent genetic network. We demonstrate that B-cell development is blocked at the preB-cell stage in mice deficient for Mef2c and Mef2d transcription factors and that preBCR signaling enhances the transcriptional activity of Mef2c/d through phosphorylation by the ERK5 mitogen activating kinase. This activation is instrumental in inducing Krüppel-like
  61. Genome-wide mapping of Mef2c-bound sites in early B-cell progenitors BioProject

    ID: PRJNA297044

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ure B-cell. Here, we show that activation of Mef2 transcription factors by preBCR is necessary for initiating the subsequent genetic network. We demonstrate that B-cell development is blocked at the preB-cell stage in mice deficient for Mef2c and Mef2d transcription factors and that preBCR signaling enhances the transcriptional activity of Mef2c/d through phosphorylation by the ERK5 mitogen activating kinase. This activation is instrumental in inducing Krüppel-like
  62. RNA expression for dcr1D, rdp1D, ago1D and swi6D OmicsDI

    ID: E-GEOD-36113

    Date Released: 07-24-2012

    Description: a role for nuclear pores and the stress response transcription factor Atf1 in coordinating the interplay between the RNAi machinery and the S. pombe genome and uncovers a novel mode of RNAi regulation in response to an environmental cue. Total RNA extracted from wild-type and mutant strains to compare global expression. At least 2 biological replicates for each sample were performed....

  63. A global non-coding RNA system modulates fission yeast protein levels in response to stress OmicsDI

    ID: PXD000894

    Date Released: 05-19-2014

    Description: tresses, to a variety of downstream effectors and transcription factors. The fission yeast stress activated MAP kinase (SAPK) pathway is conserved with the p38 and JNK pathways in humans, and comprises the MAPKKKs Win1, Wis4, the MAPKK Wis1, and the MAPK, Sty1. Sty1 and its main downstream effector Atf1 reg...

  64. Gene expression analysis to identify Mef2c/d target genes in B-cell progenitors BioProject

    ID: PRJNA297342

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ure B-cell. Here, we show that activation of Mef2 transcription factors by preBCR is necessary for initiating the subsequent genetic network. We demonstrate that B-cell development is blocked at the preB-cell stage in mice deficient for Mef2c and Mef2d transcription factors and that preBCR signaling enhances the transcriptional activity of Mef2c/d through phosphorylation by the ERK5 mitogen activating kinase. This activation is instrumental in inducing Krüppel-like
  65. Gene expression analysis to identify Klf2 target genes in B-cell progenitors [+Klf2] BioProject

    ID: PRJNA297344

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ure B-cell. Here, we show that activation of Mef2 transcription factors by preBCR is necessary for initiating the subsequent genetic network. We demonstrate that B-cell development is blocked at the preB-cell stage in mice deficient for Mef2c and Mef2d transcription factors and that preBCR signaling enhances the transcriptional activity of Mef2c/d through phosphorylation by the ERK5 mitogen activating kinase. This activation is instrumental in inducing Krüppel-like
  66. Gene expression analysis to identify target genes activated after preBCR signaling BioProject

    ID: PRJNA297341

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ure B-cell. Here, we show that activation of Mef2 transcription factors by preBCR is necessary for initiating the subsequent genetic network. We demonstrate that B-cell development is blocked at the preB-cell stage in mice deficient for Mef2c and Mef2d transcription factors and that preBCR signaling enhances the transcriptional activity of Mef2c/d through phosphorylation by the ERK5 mitogen activating kinase. This activation is instrumental in inducing Krüppel-like
  67. Time-course gene expression profiles of gefitinib-sensitive or -resistant lung adenocarcinoma cells stimulated with EGF, in the presence or absence of... BioProject

    ID: PRJNA149785

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), induces substantial clinical responses for non-small cell lung cancer (NSCL...
  68. Vitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells BioProject

    ID: PRJNA257489

    Keywords: Transcriptome or Gene expression

    Access Type: download

  69. Profiling of H3K9me3 levels predicts Transcription Factor Activity and Survival in Acute Myeloid Leukemia BioProject

    ID: PRJNA125111

    Keywords: Epigenomics

    Access Type: download

  70. Influence of alkyl-phospholipids on the gene expression profile of immortalized keratinocytes HaCaT BioProject

    ID: PRJNA125067

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere ...
  71. Gene expression profiles of HMEC-1 after exposure to the chemotherapeutic drugs bleomycin and cisplatin with untreated samples as control BioProject

    ID: PRJNA264363

    Keywords: Transcriptome or Gene expression

    Access Type: download

  72. Expression Profiling of Spalax ehrenbergi: bioprospecting for hypoxia tolerance BioProject

    ID: PRJNA93939

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: riking, cardiac ankyrin repeat protein (Carp) and activating transcription factor 3 (Atf3), LIM and cysteine-rich domains 1 (Lmcd1) and syndecan 2 (Sdc2). These results support the hypothesis that Spalax is variably adapted to fluctuating oxygen tension. Differences may involve very specific metabolic pathways and functional adaptations at the structural and molecular levels. Elucidation of the natural variation and evolutionary changes under hypoxia within this superspecies may have biomedical applications in ischemic syndromes and cancer. Keywords: hypoxia, Spalax, cDNA microarray Overall design: 12 animalsin total, 2 species (s52;S. galili, s60; S. judaei), 2 conditions (normoxia, hypoxia), 3 biological replicates. Loop design with dye swap....
  73. p190-A RhoGAP FF1 domain PDB

    ID: PDB:2K85

    Description: Glucocorticoid receptor DNA-binding factor 1

  74. Suppression of Lung Adenocarcinoma Progression by Nkx2-1 BioProject

    ID: PRJNA136113

    Keywords: Transcriptome or Gene expression

    Access Type: download

  75. mTORC1 balances cellular amino acid supply with demand for protein synthesis through post-transcriptional control of ATF4 BioProject

    ID: PRJNA381596

    Keywords: Other

    Access Type: download

    dataset.description: The mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that is commonly deregulated in human diseases. Here we find that mTORC1 controls a...
  76. Analysis of BAFF-mediated gene expression in primary CLL cells BioProject

    ID: PRJNA352159

    Keywords: Transcriptome or Gene expression

    Access Type: download

  77. Essential role of the transcription factor Bhlhe41 in regulating the self-renewal and BCR repertoire of B-1a cells BioProject

    ID: PRJNA362312

    Keywords: Other

    Access Type: download

  78. IGH analysis in pro-B cells with H3K4me3, H3K4me2 and H3K9ac BioProject

    ID: PRJNA117955

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ught to control B-lymphopoiesis by regulating key transcription factor genes and activating VH gene segments at the Igh locus. Using conditional mutagenesis, we demonstrate th...
  79. Mus musculus : Mus musculus FLI1 BioProject

    ID: PRJNA327789

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: Transcription factors are key proteins for normal development. Their aberrant expression is often observed during cancer. This stud...
  80. Mus musculus : ChIP-seq in MEL cells BioProject

    ID: PRJNA300837

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: Transcription factors (TFs) act as complexes with other co-factors to tune gene expression. Here a comprehensive analysis of the ge...
  81. Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities BioProject

    ID: PRJNA265386

    Keywords: Other

    Access Type: download

    dataset.description: strategy to identify DNA recognition motifs for transcription factors that promote common or subset-specific binding of the macrophage lineage-determining factor PU.1. We find that distinct tissue environments drive divergent programs of gene expression by differentially activating a common enhancer repertoire and by inducing the expression of divergent secondary transcription factors that collaborate with PU.1 to establish tissue-specific enhancers. These findings provide insights into molecular mechanisms by which tissue environment influences macrophage phenotypes that are likely to be broadly applicable...
  82. Global transcriptional profiles of WT and HOIL-1L-/- BMDMs in response to LPS and TNFa BioProject

    ID: PRJNA245855

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: HOIL-1L has also been suggested to function as a transcription factor. Here we analyzed changes in the global transcriptional profiles of primary bone marrow derived macrophage (BMDMs) from WT and HOIL-1L-/- mice upon treatment with NF-kB activating simuli. Overall design: BMDMs were differentiated for 1 week and then treated with mock (unt...
  83. Gene expression of normal and ASCC1-mutant skin fibroblasts after serum starvation and serum challenge BioProject

    ID: PRJNA280514

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: estigate the genes that might be regulated by the activating signal cointegrator 1 (ASC-1) complex we performed an expression analysis using the GeneChip® Hu...
  84. RNA expression for dcr1D, rdp1D, ago1D and swi6D ArrayExpress

    ID: E-GEOD-36113

    Description: a role for nuclear pores and the stress response transcription factor Atf1 in coordinating the interplay between the RNAi machinery and the S. pombe genome and uncovers a novel mode of RNAi regulation in response to an environmental cue. Total RNA extracted from wild-type and mutant strains to compare global expression. At least 2 biological replicates for each sample were performed....

  85. Ath_Agilent_v2_Riechmann array expression profile AP1-GR ap1cal inflorescences - chx experiment BioProject

    ID: PRJNA125643

    Keywords: Variation

    Access Type: download

    dataset.description: GR ap1 cal line to induce a synchronized response activating the AP1-GR fusion protein in ap1 cal inflorescence-like meristems through dexamethasone or dexamethasone+cycloheximide treatment. Tissue samples were collected at 3hrs after the treatment. The expression profiles of the individual samples were then analyzed...
  86. The anti-inflammatory nature of HDL in macrophages is mediated by ATF3 BioProject

    ID: PRJNA188404

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: normocholesteremic conditions by suppressing the transcription of inflammatory cytokines in a manner independent of its ability to remove cellular cholesterol. We identify Activating Transcription Factor 3 (ATF3), a transcriptional repressor of the CREB family of basic leucine zipper transcription factors, as a HDL-inducible regulator of macrophage activation. HDL’s ability to down modulate TLR responses was severely compromised in ATF3-deficient cells demonstrating that ATF3 mediates HDL's anti-inflammatory effects and may explain the broad anti-inflammatory functions of HDL. Overall design: Bone marrow-derived macrophages (BMDMs) were obtained by culturing bone marrow cells from 6 to 8 week old wildtype C57BL/6 mice in DMEM supplemented with 10% FCS, 10 mg ml-1 Ciprobay-500 and 40 ng ml-1 M-CSF (R & D Systems). BMDMs of wt mice were pretreated for 6 h with HDL (2 mg ml-1 ) then stimulated with CpG (100 nM) for 4 h. Further wild type or Atf3-deficient BMDMs were pretreated with 2 mg ml-1 HDL for 6 h and subsequently stimulated with CpG (100 nM) or P3C (50 ng ml-1) for 4 h. For carotid artery injury appr...
  87. Mineralocorticoid receptor ligand-binding domain with compuond 2b PDB

    ID: PDB:3WFF

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR
  88. Differentially expressed genes between oncogene-introduced wild-type and Atf4-/- cells BioProject

    ID: PRJNA145731

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: g cellular proliferation. Excessive expression of activating transcription factor 4 (ATF4) is often observed in mammalian malignant tumors. However, little is known about the role of ATF4 in the malignant transformation of normal cells. Here, we show th...
  89. Genome-wide DNase hypersensitive sites during osteoclastogenesis OmicsDI

    ID: E-GEOD-54139

    Date Released: 12-23-2014

    Description: uring early osteoclastogenesis and identify novel transcription factors involved in osteoclastogenesis, we investigated genome-wide analysis of open chromatin during receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis using DNase I hypersensitive sites sequencing (DNase-seq). DNase-seq was performed using the extracted nuclei obtained from RAW264 cells treated with or without RANKL for 24 hours, followed by several bioinformatic analyses. DNase I hypersensitive sites (DHSs) during RANKL-induced osteoclastogenesis were dynamically changed and accumulated in promoter regions, although the distrib...

  90. Mineralocorticoid receptor ligand-binding domain with compuond 2e PDB

    ID: PDB:3WFG

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR
  91. Erf chromatin binding-sites in E13.5 mouse embryo fibroblasts BioProject

    ID: PRJNA183890

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ed dosage of ERF, which encodes an inhibitory ETS transcription factor directly bound by ERK1/2 , causes complex craniosynostosis (premature fusion of the cranial sutures) in human...
  92. CBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression [ChIP-seq] BioProject

    ID: PRJNA182318

    Keywords: Epigenomics

    Access Type: download

    dataset.description: The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of...
  93. CBFb Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression [gene expression] BioProject

    ID: PRJNA182317

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The HIV-1 accessory protein Vif hijacks a cellular Cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 (A3) family of...
  94. Transcription profiling by array of the RAMOS human cell line overexpressing Delta4-BAFF, a new alternative splice of B-Cell activating factor ArrayExpress

    ID: E-MEXP-3595

    Description: lated by a new alternative splice of BAFF (B-Cell Activating factor belonging to the TNF Family) that we called Delta4-BAFF (because it characterized by an alternative splice of exon 4). To do this we used human burkitt's lymphoma ...

  95. Expression data from human keratinocytes stimulated with streptococcal M1 protein BioProject

    ID: PRJNA262904

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 1 protein. Keratinocytes respond to M1 protein by activating pathways to induce the production of inflammatory signaltransducers, AP-1 and NFkB transcription factor subunits, together with inflammatory mediators such as IL-8, CCL20 and IL-
  96. Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420 PDB

    ID: PDB:2OAX

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION
  97. Erythroid differentiation: G1E model BioProject

    ID: PRJNA119293

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: addition activates an ectopically expressed Gata-1-estrogen receptor fusion protein, triggering synchronous differentiation. 30 hour time course corresponds roughly to late burst-forming unit-erythroid stage (t=0 hrs) through orthochromatic erythroblast stage (t=30 hrs). Ov...
  98. RNA-Seq experiment to identify genes regulated by ATF4 ArrayExpress

    ID: E-GEOD-69308

    Description: Activating Transcription Factor 4 (ATF4) is a transcription

  99. Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist PDB

    ID: PDB:3VHV

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR
  100. Mineralocorticoid receptor ligand-binding domain with spironolactone PDB

    ID: PDB:3VHU

    Description: Mineralocorticoid receptor

    dataset.keywords: TRANSCRIPTION/INHIBITOR

Displaying 100 of 607 results for "ATF1"