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Displaying 20 of 179 results for "AIG1"
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  1. Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-reductase Inhibition in Prostate Epithelial Cells BioProject

    ID: PRJNA320221

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ymptomatic benign prostatic hyperplasia (BPH), an androgen receptor (AR) driven, inflammatory disorder affecting elderly men, include 5α-reductase (5AR) inhibitors (i.e. dutasteride and finasteride) to block the...
  2. Transcription profiling of human primary hepatocytes after treatment with triazole ArrayExpress

    ID: E-GEOD-10410

    Description: d triadimefon (TDF) [Propiconazole CASNR 60207-90-1; Triadimefon CASNR 43121-43-3; Myclobutanil CASNR 88671-89-0] all disrupt steroid hormone homeostasis and cause varying degrees of hepatic toxicity. To identify biological pathways consistently ac...

  3. Convergence of oncogenic and hormone receptor pathways promotes pro-metastatic phenotypes ArrayExpress

    ID: E-GEOD-40794

    Description: c functions in human disease. While Cyclin D1b is induced during disease progression in many cancer types, the mechanisms underlying Cyclin D1b function remain poorly understood. Herein, models of human disease were utilized to resolve the downstream pathways requisite for the pro-tumorigenic functio...

  4. Small molecule-induced bioenergetic reprogramming directs prostate cancer inhibition via UPR signaling ArrayExpress

    ID: E-GEOD-48056

    Description: n in soft agar. However, the mechanism of SMIP004-induced cancer cell selective apoptosis remained unknown. We used profiling to unravel a SMIP004-induced pro-apoptotic pathway, which initiates with bioenergetic reprogramming at the level of mitochondria. SMIP004 causes downregulation of aerobic glycolysis, rapid upregulation of components of the mitochondrial electron transport chain, and oxidative stress. The latter, in turn, elicits cell cycle arrest by rapidly targeting cyclin D1 for proteasomal degradation, drives transcriptional ...

  5. Triazole Antifungal Toxicogenomics: human_primary_hepatocytes_CellzDirect GEMMA

    ID: 2131

    Keywords: functional genomics

    Description: d triadimefon (TDF) [Propiconazole CASNR 60207-90-1; Triadimefon CASNR 43121-43-3; Myclobutanil CASNR 88671-89-0] all disrupt steroid hormone homeostasis and cause varying degrees of hepatic toxicity. To identify biological pathways consistently ac...

  6. Transcription profiling of human primary hepatocytes after treatment with triazole OmicsDI

    ID: E-GEOD-10410

    Date Released: 10-12-2011

    Description: d triadimefon (TDF) [Propiconazole CASNR 60207-90-1; Triadimefon CASNR 43121-43-3; Myclobutanil CASNR 88671-89-0] all disrupt steroid hormone homeostasis and cause varying degrees of hepatic toxicity. To identify biological pathways consistently ac...

  7. Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-reductase Inhibition in Prostate Epithelial Cells OmicsDI

    ID: E-GEOD-80979

    Date Released: 05-23-2016

    Description: ymptomatic benign prostatic hyperplasia (BPH), an androgen receptor (AR) driven, inflammatory disorder affecting elderly men, include 5α-reductase (5AR) inhibitors (i.e. dutasteride and finasteride) to block the...

  8. CBS News/New York Times Monthly Poll #1, April 2009 Dataverse

    Description: This poll, fielded April 1-5, 2009, is a part of a continuing series of monthly surveys that solicit public opinion on the presidency and on a range of othe...

    Person: CBS News The New York Times

    Release Date: 04-08-2015

  9. Ligand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity ArrayExpress

    ID: E-GEOD-63202

    Description: m eRNA synthesis. Using dihydrotestosterone (DHT)-induced binding of androgen receptor (AR) to prostate cancer cell enhancers as a model, we show rapid recruitment, within minutes, of DNA topoisomerase I (TOP1) to a large cohort of AR-regulated enhancers. Furthermore, we show that the DNA nicking activity of TOP1 is a prerequisite for robust eRNA synthesis and enhancer activation and is kinetically accompanied by the recruitment of ATR and the MRN complex, fol...

  10. Unique signatures of estrogen independent growth of MCF-7 cells in low-estrogen versus complete estrogen depravation ArrayExpress

    ID: E-GEOD-33287

    Description: in culture has been successfully used to mimic AI-induced estrogen depletion to dissect mechanisms of AI resistance. However, we hypothesized that a subset of patients receiving AI therapy may maintain low circulating concentrations of estrogens that influence the development of endocrine resistance. We sought to expand established LTED models to account for these observations. MCF-7 cells were grown in medium with charcoal stripped serum suppl...

  11. Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-reductase Inhibition in Prostate Epithelial Cells ArrayExpress

    ID: E-GEOD-80979

    Description: ymptomatic benign prostatic hyperplasia (BPH), an androgen receptor (AR) driven, inflammatory disorder affecting elderly men, include 5α-reductase (5AR) inhibitors (i.e. dutasteride and finasteride) to block the...

  12. Pathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis ArrayExpress

    ID: E-GEOD-44311

    Description: n adrenal NCI-H295A cells, only six of which were induced more than 2-fold by treatment with 8-Br-cAMP. Key components of the ERK1/2 and MAPK/ERK kinase (MEK)1/2 pathways, which have been implicated in the insulin resistance of PCOS, were not found in NCI-H295A cells, implying that these pathways do not participate in P450c17 phosphorylation. Treatment with various kinase inhibitors that probe the protein kinase A/phosphatidylinositol 3-kinase/Akt pathway and the calcium/calmodulin/MAPK kinase pathway had no effect on the ratio of 17,20 lyase activity to 17alpha-hydroxylase activity, appearing to eliminate these pathways as candidates leading to the phosphorylation of P450c17. Two inhibitors that target the Rho-associated, coiled-coil containing protein kinase (ROCK)/Rho pathway suppressed 17,20 lyase activity and P450c17 phosphorylation, both in NCI-H295A cells and in COS-

  13. Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus. BioProject

    ID: PRJNA97607

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ed to play an important role in the regulation of androgen action in normal endometrium. Using microarray technology, a screening analysis of genes responding to DHT in the uterus of ovariectomized mice, has allowed us to highlight multiple genes of the ATM/Gadd45g pathway that are modulated following exposure to DHT. Two phases of regulation w...
  14. Transcription profiling of rat liver samples from animals treated with D3T (3H-1,2-dithiole-3-thione) and controls OmicsDI

    ID: E-GEOD-3173

    Date Released: 03-27-2012

    Description: 3H-1, 2-dithiole-3-thione (D3T), an inducer of antioxidant and phase 2 genes, is known to enhance the detoxification of environmental ...

  15. Pathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis OmicsDI

    ID: E-GEOD-44311

    Date Released: 06-02-2014

    Description: n adrenal NCI-H295A cells, only six of which were induced more than 2-fold by treatment with 8-Br-cAMP. Key components of the ERK1/2 and MAPK/ERK kinase (MEK)1/2 pathways, which have been implicated in the insulin resistance of PCOS, were not found in NCI-H295A cells, implying that these pathways do not participate in P450c17 phosphorylation. Treatment with various kinase inhibitors that probe the protein kinase A/phosphatidylinositol 3-kinase/Akt pathway and the calcium/calmodulin/MAPK kinase pathway had no effect on the ratio of 17,20 lyase activity to 17alpha-hydroxylase activity, appearing to eliminate these pathways as candidates leading to the phosphorylation of P450c17. Two inhibitors that target the Rho-associated, coiled-coil containing protein kinase (ROCK)/Rho pathway suppressed 17,20 lyase activity and P450c17 phosphorylation, both in NCI-H295A cells and in COS-

  16. Facilitates chromatin transcription complex is a marker and target of aggressive cancers with lower survival rates ArrayExpress

    ID: E-GEOD-45393

    Description: gene, but it increases the efficiency of oncogene-induced transformation. FACT expressing cancer cells cannot grow in the absence of FACT possibly due to the FACT involvement in selective chromatin remodeling of genes that stimulate proliferation, inhibit cell death and differentiation and that are induced in response to cell stress. We propose that FACT is a marker of an aggressive cancer phenotype and Patients with FACT-positive tumors are noted for an overall poorer survival rate. FACT expression in primary tumors may be used as a predictor of metastatic disease. FACT may also be used as a target of anti-cancer therapy because tumor cells expressing FACT are dependent on FACT function, while normal cells either do not express FACT or are not sensitive to FACT...

  17. Estrogen regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation ArrayExpress

    ID: E-GEOD-24672

    Description: global changes in testicular cell gene expression induced by the E2 treatment. By minimizing the changes in other hormones and also having concurrent data on the regulation of the genes by those hormones, we were able to dissect the effects of estrogen on gene expression, independent of gonadotropin or T changes. Expression of 20 genes, largely in somatic cells, was up- or down-regulated between 2- and 5-fold by E2. There were also early germ cell genes whose expression increased but this was a result of a small increase in spermatogonial numbers. The striking enrichment of transcripts not corresponding to known genes amo...

  18. CBS News Monthly Poll #2, March 2009 ICPSR

    ID: doi:10.3886/ICPSR26945.v1

    Description: financial institutions bailout, insurance company AIG bonuses, and foreign policy. Views were sought on the condition of the national economy, and the level of confidence in Secretary of the Treasury Tim Geithner's handling of the financial crisis. Respondents were also asked their views on companies receiving federal bailout money, whether they approved of the federal government providing money to banks and other financial institutions, whether the media, President Obama, and Congress was spendi...

    Creators: CBS News

  19. CBS News/New York Times Monthly Poll #1, April 2009 ICPSR

    ID: doi:10.3886/ICPSR26946.v1

    Description: This poll, fielded April 1-5, 2009, is a part of a continuing series of monthly surveys that solicit public opinion on the presidency and on a range of othe...

    Creators: CBS News The New York Times


Displaying 20 of 179 results for "AIG1"