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Displaying 20 of 179 results for "AIG1"
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  1. Pathways leading to phosphorylation of p450c17 and to the post-translational regulation of androgen biosynthesis BioProject

    ID: PRJNA189440

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. MCF-7 and ZR-75-1 cell lines hypoxia OmicsDI

    ID: E-GEOD-33438

    Date Released: 05-03-2014

    Description: N-myc downstream-regulated gene 1 (*NDRG1*) is induced by cellular stress such as hypoxia and DNA damage, and in humans, germ line mutations cau...

  3. Systems biology of tributyltin-induced pathogenesis in thicklip grey mullets (Chelon labrosus) ArrayExpress

    ID: E-GEOD-36811

    Description: studying the molecular mechanisms that elicit TBT-induced pathogenesis in fish, thicklip grey mullets Chelon labrosus were exposed to low (10 ng/L) and high (500 ng/L) TBT concentrations for 1, 7 and 21 days, and gene transcription and metabolome profiles were studied. With this purpose, the multitissue transcriptome of mullet was sequenced by 454 pyrosequencing obtaining 126 Mb of sequence information. Assembly and annotation allowed spotting 8330 gene signatures on an oli...

  4. Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome. BioProject

    ID: PRJNA101573

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lterations in mRNA levels of genes similar to the AIG1 plant antibacterial proteins. Decreases in oxygen detoxification pathways were observed as expected in the anaerobic colonic lumen. Of the known virulence factors the most remarkable changes were a 20-35-fold increase in a cysteine proteinase four-like gene, and a 2-3-fold decrease in two members of the Gal/GalNAc lectin light subunit family. Control of the observed changes in mRNA abundance in the intestine might potentially rest with four related proteins with DNA binding domains that were down-regulated 6-16-fold in the intestinal environment. In conclusion, the first genome-wide analysis of the transcriptome of E. histolytica demonstrated that the vast majority of genes are transcribed in trophozoites, and that in the host intestine trophozoi...
  5. TMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progressio... OmicsDI

    ID: E-GEOD-28950

    Date Released: 06-26-2012

    Description: Deregulation of the Androgen Receptor (AR) transcriptional network is a common hallmark in prostate cancers. To achieve its precise transcriptional rol...

  6. Transcription profiling by array of induced pluripotent cell clones expressing either wild-type or mutated CDKL5 gene to study the gene's role in transcriptional regul... ArrayExpress

    ID: E-MTAB-2223

    Description: ono-allelic expression of CDKL5 were confirmed by androgen receptor assay and direct sequencing of CDKL5 mRNA. The clone derived from the male patient (CDKL5 mutation p.Thr288Ile) was compared to a clone derived from a normal newborn male. For each mutant/control pair four technical replicates were performed for a total of eight chip hybridizations....

  7. Systems biology of tributyltin-induced pathogenesis in thicklip grey mullets (Chelon labrosus) OmicsDI

    ID: E-GEOD-36811

    Date Released: 08-07-2016

    Description: studying the molecular mechanisms that elicit TBT-induced pathogenesis in fish, thicklip grey mullets Chelon labrosus were exposed to low (10 ng/L) and high (500 ng/L) TBT concentrations for 1, 7 and 21 days, and gene transcription and metabolome profiles were studied. With this purpose, the multitissue transcriptome of mullet was sequenced by 454 pyrosequencing obtaining 126 Mb of sequence information. Assembly and annotation allowed spotting 8330 gene signatures on an oli...

  8. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq II] OmicsDI

    ID: E-GEOD-47806

    Date Released: 09-05-2013

    Description: ncer, PRNCR1 and PCGEM1, bind successively to the androgen receptor (AR) and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the C-terminally acetylated AR on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM, to the N-terminally methylated AR. Unexpectedly, recognition of the H3K4me3 pro...

  9. Triazole Antifungal Toxicogenomics: human_primary_hepatocytes_CellzDirect BioProject

    ID: PRJNA108051

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d triadimefon (TDF) [Propiconazole CASNR 60207-90-1; Triadimefon CASNR 43121-43-3; Myclobutanil CASNR 88671-89-0] all disrupt steroid hormone homeostasis and cause varying degrees of hepatic toxicity. To identify biological pathways consistently ac...
  10. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [ChIRP-seq] OmicsDI

    ID: E-GEOD-47804

    Date Released: 09-05-2013

    Description: ncer, PRNCR1 and PCGEM1, bind successively to the androgen receptor (AR) and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the C-terminally acetylated AR on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM, to the N-terminally methylated AR. Unexpectedly, recognition of the H3K4me3 pro...

  11. NDRG1 siRNA and overexpression in breast cell lines OmicsDI

    ID: E-GEOD-33437

    Date Released: 05-03-2014

    Description: N-myc downstream-regulated gene 1 (*NDRG1*) is induced by cellular stress such as hypoxia and DNA damage, and in humans, germ line mutations cau...

  12. Transcription profiling of human LNCaP cell lines transfected with AIbZIP ArrayExpress

    ID: E-GEOD-7223

    Description: Androgen-induced bZIP (AIbZIP) is a basic leucine zipper (bZIP); transcription factor that is encoded by the CRE...

  13. A molecular and phenotypic integrative approach to identify a no effect dose level for anti-androgen induced testicular toxicity OmicsDI

    ID: E-GEOD-28202

    Date Released: 06-02-2014

    Description: served differential gene expression starting from 1 mg/kg/day and a deregulation of more than 1500 genes at 30 mg/kg/day. Dose-related changes were identified for the major pathways associated with the testicular lesion (eg fatty acid metabolism), that were confirmed by qPCR. These data, along with standard measurements supported the no effect dose of 0.2 mg/kg/day. Flutamide was administered in suspension to rats (7 weeks old at start of treatment, 10 per group) by oral gavage at a daily dose of 0 (control), 0.2, 1, 6 and 30 mg/kg body weight, for 28 consecutive days. Dose-related changes in gene expression were determined in the testes using whole genome oligonu...

  14. A molecular and phenotypic integrative approach to identify a no effect dose level for anti-androgen induced testicular toxicity ArrayExpress

    ID: E-GEOD-28202

    Description: served differential gene expression starting from 1 mg/kg/day and a deregulation of more than 1500 genes at 30 mg/kg/day. Dose-related changes were identified for the major pathways associated with the testicular lesion (eg fatty acid metabolism), that were confirmed by qPCR. These data, along with standard measurements supported the no effect dose of 0.2 mg/kg/day. Flutamide was administered in suspension to rats (7 weeks old at start of treatment, 10 per group) by oral gavage at a daily dose of 0 (control), 0.2, 1, 6 and 30 mg/kg body weight, for 28 consecutive days. Dose-related changes in gene expression were determined in the testes using whole genome oligonu...

  15. Genome-wide expression profiling of SGTA knockdown in C4-2B prostate cancer cells ArrayExpress

    ID: E-GEOD-43521

    Description: ing the effect of the co-chaperone SGTA on global androgen receptor transcriptional activity in C4-2B prostate cancer cells with view to further elucidating the broader biological role of S...

  16. Transcription profiling of rat primary hepatocyte cells after triazole antifungal toxicogenomics ArrayExpress

    ID: E-GEOD-9387

    Description: en rodents and humans. Pathways affected included androgen and estrogen metabolism, xenobiotic metabolism signaling through CAR and PXR, and CYP mediated metabolism. Many of the differentially expressed genes are regulated by the nuclear receptors CAR, PPAR alpha and PXR, including ABC transporter genes (Abcb1 and MDR1), genes significant to xenobiotic, fatty acid, sterol and steroid metabolism (Cyp2b2 and CYP2B6; Cyp3a1 and CYP3A4; Cyp4a22 and CYP4A11) and xxx (Ugt1a1 and UGT1A1). Modulation of hepatic sterol and steroid metabolism is a plausible mechanism for triazole induced increases in serum testosterone. The gene expression changes caused by all three triazoles appear to focus on pathways regulating lipid and testosterone homeostasis, identifying potential common mechanisms of triazole hepatotoxicity that are conserved between rodents and humans. Experiment Overall Design: A total of 35 samples were ...

  17. Menthol effect on gene expression profile in malignant prostate cancer cell lines, PC-3 ArrayExpress

    ID: E-GEOD-28241

    Description: nt oil, induces an anti-proliferative activity in androgen-independent prostate cancer (AIPC). Previously, we found that menthol affects PC-3 cells viability through activating JNK but the mechanism is not fully clear. We thus studied that ...

  18. Integrative genomic, transcriptomic and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer ArrayExpress

    ID: E-GEOD-28403

    Description: ro, and this effect was substantially enhanced in androgen deficient conditions. Ectopic FAM110B expression in non-cancerous epithelial prostate cells induced aneuploidy and impaired antigen presentation. Conclusions: The DNA / RNA gene outlier detection combined with siRNA cell proliferation assay identified FAM110B as a potential growth promoting key gene for CRPC. FAM110B appears to have a key role in the androgen signaling and progression of CRPC impacting multiple cancer hallmarks and therefore highlighting a potential therapeutic target. [1] Gene expression levels from 13 samples were measured using Affymetrix GeneChip Human Genome U133 plus 2.0 arrays. Sample processing and labeling were done according to the protocol provided by Affymetrix. Three micrograms of total RNA from each sample was used for the initial one-cycle cDNA synthesis. Arrays were scanned immediately after staining using a GeneChip scanner (Affymetrix). [2] aCGH was performed from 18 prostate cancer samples using 44K arrays by Agilent Technologies. Male genomic DNA (catalog number G1471, Promega, Madison, WI) was used as reference in all hybridizations. [3] Gene expression changes following FAM110B silencing in LNCaP prostate cancer cells (48 h: pooled FAM110B siRNA vs. Scrambled siRN...

  19. Transcription profiling of rat liver samples from animals treated with D3T (3H-1,2-dithiole-3-thione) and controls ArrayExpress

    ID: E-GEOD-3173

    Description: 3H-1, 2-dithiole-3-thione (D3T), an inducer of antioxidant and phase 2 genes, is known to enhance the detoxification of environmental ...

  20. Integrative genomic, transcriptomic and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer. OmicsDI

    ID: E-GEOD-28403

    Date Released: 05-03-2014

    Description: ro, and this effect was substantially enhanced in androgen deficient conditions. Ectopic FAM110B expression in non-cancerous epithelial prostate cells induced aneuploidy and impaired antigen presentation. Conclusions: The DNA / RNA gene outlier detection combined with siRNA cell proliferation assay identified FAM110B as a potential growth promoting key gene for CRPC. FAM110B appears to have a key role in the androgen signaling and progression of CRPC impacting multiple cancer hallmarks and therefore highlighting a potential therapeutic target. [1] Gene expression levels from 13 samples were measured using Affymetrix GeneChip Human Genome U133 plus 2.0 arrays. Sample processing and labeling were done according to the protocol provided by Affymetrix. Three micrograms of total RNA from each sample was used for the initial one-cycle cDNA synthesis. Arrays were scanned immediately after staining using a GeneChip scanner (Affymetrix). [2] aCGH was performed from 18 prostate cancer samples using 44K arrays by Agilent Technologies. Male genomic DNA (catalog number G1471, Promega, Madison, WI) was used as reference in all hybridizations. [3] Gene expression changes following FAM110B silencing in LNCaP prostate cancer cells (48 h: pooled FAM110B siRNA vs. Scrambled siRN...


Displaying 20 of 179 results for "AIG1"