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Displaying 20 of 179 results for "AIG1"
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  1. DNA methylation variations are required for reversible EMT induced by cancer-associated fibroblasts in PCa cells ArrayExpress

    ID: E-MTAB-4752

    Description: DNA methylation and transcriptional variations in androgen independent PC3, but not in androgen dependent LN-CaP cells. Focal CpG islands hyper-methylation associated to transcriptional repression of epithelial markers occurs together with widespread hypo-methylation, including promoters of EMT and stemness regulating genes resulting in their transcriptional activation. Remarkably, DNA methylation and transcription patte...

  2. DNA methylation variations are required for reversible EMT induced by cancer-associated fibroblasts in PCa cells ArrayExpress

    ID: E-MTAB-4753

    Description: DNA methylation and transcriptional variations in androgen independent PC3, but not in androgen dependent LN-CaP cells. Focal CpG islands hyper-methylation associated to transcriptional repression of epithelial markers occurs together with widespread hypo-methylation, including promoters of EMT and stemness regulating genes resulting in their transcriptional activation. Remarkably, DNA methylation and transcription patterns are entirely r...

  3. Transcription profiling by array of human prostate cancer xenograft tissue at different stages of growth ArrayExpress

    ID: E-GEOD-21887

    Description: te cancer, KUCaP-2, which expresses the wild-type androgen receptor (AR) and which produces the prostate-specific antigen (PSA). In this model, tumors regress soon after castration, but then reproducibly restore their ability to proliferate after 1 to 2 months without AR mutation, mimicking the clinical behavior of CRPC. In the present study, we used this model to identify novel therapeutic targets for CRPC. Evaluating ...

  4. ect of individual HDAC knockdown on expression of androgen induced genes... ArrayExpress

    ID: E-GEOD-12438

    Description: Elevated levels of androgen receptor (AR) in prostate cancer confer resistance to current antiandrogens and play a causal role in disease progression ...

  5. Flutamide treated rat hepatocytes in microfluidic biochips ArrayExpress

    ID: E-GEOD-44317

    Description: investigated the effects of the flutamide (FLU) -induced liver injury in primary rat hepatocytes using our liver microfluidic biochips. Flutamide is used a non-steroidal anti-androge...

  6. Induced Pluripotency of Human Prostatic Epithelial Cells OmicsDI

    ID: E-GEOD-45469

    Date Released: 01-25-2016

    Description: Induced pluripotent stem (iPS) cells are a valuable resource for discovery of epigenetic changes critical to cell type-specific dif...

  7. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq II] ArrayExpress

    ID: E-GEOD-47806

    Description: ncer, PRNCR1 and PCGEM1, bind successively to the androgen receptor (AR) and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the C-terminally acetylated AR on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM, to the N-terminally methylated AR. Unexpectedly, recognition of the H3K4me3 pro...

  8. tion 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth... BioProject

    ID: PRJNA239365

    Keywords: Variation

    Access Type: download

  9. Systems biology of tributyltin-induced pathogenesis in thicklip grey mullets (Chelon labrosus) BioProject

    ID: PRJNA156837

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Integrative genomic, transcriptomic and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer. BioProject

    ID: PRJNA139179

    Keywords: Other

    Access Type: download

    dataset.description: ro, and this effect was substantially enhanced in androgen deficient conditions. Ectopic FAM110B expression in non-cancerous epithelial prostate cells induced aneuploidy and impaired antigen presentation. Conclusions: The DNA / RNA gene outlier detection combined with siRNA cell proliferation assay identified FAM110B as a potential growth promoting key gene for CRPC. FAM110B appears to have a key role in the androgen signaling and progression of CRPC impacting multiple cancer hallmarks and therefore highlighting a potential therapeutic target. Overall design: [1] Gene expression levels from 13 samples were measured using Affymetrix GeneChip Human Genome U133 plus 2.0 arrays. Sample processing and labeling were done according to the protocol provided by Affymetrix. Three micrograms of total RNA from each sample was used for the initial one-cycle cDNA synthesis. Arrays were scanned immediately after staining using a GeneChip scanner (Affymetrix). [2] aCGH was performed from 18 prostate cancer samples using 44K arrays by Agilent Technologies. Male genomic DNA (catalog number G1471, Promega, Madison, WI) was used as reference in all hybridizations. [3] Gene expression changes following FAM110B silencing in LNCaP prostate cancer cells (48 h: pooled FAM110B siRNA vs. S...
  11. Dihydrotestosterone induced changes in gene expression in immortalized human conjunctival epithelial cells ArrayExpress

    ID: E-GEOD-18094

    Description: Genome-wide analysis of dihydrotestosterone (DHT) induced changes in gene expression in immortalized human conjunctival epithelial cells. Analysis of regulation of immortalized hum...

  12. Dihydrotestosterone induced changes in gene expression in primary and immortalized human corneal epithelial cells ArrayExpress

    ID: E-GEOD-18093

    Description: Genome-wide analysis of dihydrotestosterone (DHT) induced changes in gene expression in primary and immortalized human corneal epithelial cells. Analysis of regulation of primary a...

  13. Abiraterone acetate and di-n-butyl phthalate (DBP) response in a human fetal testis xenograft bioassay ArrayExpress

    ID: E-GEOD-49244

    Description: etermine the effects of a well-characterized anti-androgen, abiraterone acetate, and a suspected human anti-androgen, di-n-butyl phthalate (DBP) on the androgenic function of human fetal testis...

  14. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [ChIRP-seq] ArrayExpress

    ID: E-GEOD-47804

    Description: ncer, PRNCR1 and PCGEM1, bind successively to the androgen receptor (AR) and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the C-terminally acetylated AR on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM, to the N-terminally methylated AR. Unexpectedly, recognition of the H3K4me3 pro...

  15. TMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progressio... ArrayExpress

    ID: E-GEOD-28950

    Description: Deregulation of the Androgen Receptor (AR) transcriptional network is a common hallmark in prostate cancers. To achieve its precise transcriptional rol...

  16. Genome-wide transcriptome analysis of the dietary chemopreventive phytochemical sulforaphane on normal and prostate cancer cells. OmicsDI

    ID: E-GEOD-48812

    Date Released: 12-18-2015

    Description: rogression. Normal prostate epithelial cells, and androgen-dependent and androgen-independent prostate cancer cells were treated with 15 µM SFN and the transcriptome was determined at 6 and 24 hour time points. SFN altered the expression of ~3,000 genes in each cell line and the response was highly dynamic over time. SFN influenced the expression of genes in functional groups and pathways that are critical in cancer including cell cycle, apoptosis and angiogenesis, but the specific effects of SFN differed depending on the state of cancer progression. Network analysis suggested that a transcription factor that is overexpressed in many cancers, Specificity protein 1 (Sp1), is a major mediator of SFN-

  17. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq I] OmicsDI

    ID: E-GEOD-47805

    Date Released: 09-05-2013

    Description: ncer, PRNCR1 and PCGEM1, bind successively to the androgen receptor (AR) and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the C-terminally acetylated AR on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM, to the N-terminally methylated AR. Unexpectedly, recognition of the H3K4me3 pro...

  18. Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules PDB

    ID: PDB:1XJB

    Description: Aldo-keto reductase family 1 member C2 (E.C.1.1.1.213)

  19. Effects of Disperse Yellow 7 in Silurana tropicalis Gene Network Analysis ArrayExpress

    ID: E-GEOD-40149

    Description: stage 12 to 46. Data suggest that the azo dye DY7 induced cellular stress and interfered with androgen biosynthesis in early tadpole development. At exposure completion, RNA was isolated from whole larvae and quality was ascertained using bioanalyzer analysis. A custom Agilent 4 X 44 K microarray for S. tropicalis was used to characterize gene regulatory networks underlying toxicity. This study presents the transcriptional regulatory pathways affected by DY7 in S. tropicalis early development. Embryos were exposed to the DY7 dye during development. There were 4 control groups exposed and 4 treatment groups exposed....

  20. Transcription profiling by array of mouse liver from mice treated with testosterone ArrayExpress

    ID: E-GEOD-13388

    Description: der to understand more about short- and long-term androgen effects on a molecular level, we have analyzed hepatic gene expression in female C57BL/6 mice immediately after subcutaneous treatment with testosterone for 3 weeks and after 12 weeks hormone withdrawal using Affymetrix array technology and quantitative real-time RT-PCR. Among about 14,000 genes examined, 48 were up- and 65 genes were downreg...


Displaying 20 of 179 results for "AIG1"