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Displaying 20 of 179 results for "AIG1"
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  1. NDRG1 siRNA and overexpression in breast cell lines BioProject

    ID: PRJNA154295

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: N-myc downstream-regulated gene 1 (*NDRG1*) is induced by cellular stress such as hypoxia and DNA damage, and in humans, germ line mutations cau...
  2. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq II] BioProject

    ID: PRJNA207828

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Transcription profiling of mouse 15P-1 Sertoli cell clones stably transfected with mouse Rhox5-expression vector reveals androgen-Induced OmicsDI

    ID: E-GEOD-18785

    Date Released: 05-02-2014

    Description: identify Rhox5-regulated genes, we generated 15P-1 Sertoli cell clones expressing physiological levels of Rhox5 from a stably transfected expression vector. Microarray analysis identified many genes altered in expression in response to Rhox5, including those encoding proteins controlling cell cycle regulation, apoptosis, metabolism, and cell-cell interactions. Fifteen of these Rhox5-regulated genes were chosen for further analy...

  4. Transcription profiling of mouse 15P-1 Sertoli cell clones stably transfected with mouse Rhox5-expression vector reveals androgen-Induced ArrayExpress

    ID: E-GEOD-18785

    Description: identify Rhox5-regulated genes, we generated 15P-1 Sertoli cell clones expressing physiological levels of Rhox5 from a stably transfected expression vector. Microarray analysis identified many genes altered in expression in response to Rhox5, including those encoding proteins controlling cell cycle regulation, apoptosis, metabolism, and cell-cell interactions. Fifteen of these Rhox5-regulated genes were chosen for further analy...

  5. An Integrated Network of Androgen Receptor and TMPRSS2-ERG Gene Fusion in Prostate Cancer Progression (II) ArrayExpress

    ID: E-GEOD-14092

    Description: Androgen receptor (AR) is a transcription factor that plays a central role in the growth and development of the normal prostate and...

  6. Induced Pluripotency of Human Prostatic Epithelial Cells ArrayExpress

    ID: E-GEOD-45469

    Description: Induced pluripotent stem (iPS) cells are a valuable resource for discovery of epigenetic changes critical to cell type-specific dif...

  7. Dryad Dryad

    DateIssued: 01-25-2017

    Description: eus, of the western Mediterranean: Aigues-Mortes (AIG), southern France (N 43° 33’, E 4° 11’); Fuente de Piedra (FDP), southern Spain (37° 06’N, 04° 45’W) and the heavily polluted Odiel marshes (ODI), southern Spain (37º 17′ N, 06º 55′ W)....

  8. Transcription profiling of human LNCaP prostate cancer cells to investigate the effect of HDAC inhibitors on expression of androgen induced genes ArrayExpress

    ID: E-GEOD-9000

    Description: Elevated levels of androgen receptor (AR) in prostate cancer confer resistance to current antiandrogens and play a causal role in disease progression ...

  9. Transcription profiling of human prostate cancer cell line PC3 cells (low in PURa expression) stably over-expressing PUR reveals aPUR alpha protein in... ArrayExpress

    ID: E-GEOD-14464

    Description: Following androgen ablation treatment for advanced prostate cancer, almost all men relapse after a period of initial response to therapy, whi...

  10. Identification of EP4 as a Potential Target for the Treatment of Castration-Resistant Prostate Cancer Using a Novel Xenograft Model BioProject

    ID: PRJNA126897

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: te cancer, KUCaP-2, which expresses the wild-type androgen receptor (AR) and which produces the prostate-specific antigen (PSA). In this model, tumors regress soon after castration, but then reproducibly restore their ability to proliferate after 1 to 2 months without AR mutation, mimicking the clinical behavior of CRPC. In the present study, we used this model to identify novel therapeutic targets for CRPC. Evaluating ...
  11. "Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [GRO-seq] ArrayExpress

    ID: E-GEOD-55903

    Description: ing for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatized form of SD70 that permits its application for a ChIP-seq-like approach, referred to as Drug-seq, we were next able to efficiently map the genome-wide binding locations of this small molecule, revealing that it larg...

  12. Transcription profiling by array of human prostate cancer xenograft tissue at different stages of growth OmicsDI

    ID: E-GEOD-21887

    Date Released: 05-02-2014

    Description: te cancer, KUCaP-2, which expresses the wild-type androgen receptor (AR) and which produces the prostate-specific antigen (PSA). In this model, tumors regress soon after castration, but then reproducibly restore their ability to proliferate after 1 to 2 months without AR mutation, mimicking the clinical behavior of CRPC. In the present study, we used this model to identify novel therapeutic targets for CRPC. Evaluating ...

  13. "Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [Drug-seq] ArrayExpress

    ID: E-GEOD-55901

    Description: ing for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Based on synthesis of a derivatized form of SD70 that permits its application for a ChIP-seq-like approach, referred to as Drug-seq, we were next able to efficiently map the genome-wide binding locations of this small molecule, revealing that it larg...

  14. Gene Expression in Castration-Resistant C4-2 Cells after AR Knockdown ArrayExpress

    ID: E-GEOD-13332

    Description: e most common, lethal malignancy in men. Although androgen withdrawal therapies are used to treat advanced disease, progression to a castration-resistant, end-stage is the usual outcome. In this study, ...

  15. CBS News/New York Times Poll: Recession/Economy Dataverse

    Description: issues and topics: Barack Obama job performance (1); direction of country (1); Barack Obama handling issues (4); Congress job performance (1); economic conditions (3); most i...

    Person: CBS News and The New York Times

    Release Date: 12-21-2010

  16. Testosterone-induced persistent dysregulations and transdifferentiation to exocrine pancreas in the female liver BioProject

    ID: PRJNA109813

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. mRNA profiling by androgen-induced tumor suppressor U19/EAF2 in the mouse prostate U19/EAF2 knockout ArrayExpress

    ID: E-GEOD-34511

    Description: To elucidate potential mechanisms of U19/EAF2 action, we performed cDNA microarray analysis and identified 202 mRNA transcripts regulated by U19/EAF2 ...

  18. Selenomethionine induced transcriptional programs in human prostate cancer cells ArrayExpress

    ID: E-GEOD-8769

    Description: w cytometry analysis showed that selenomethionine induced G2/M arrest in LNCaP at low concentrations. Selenomethionine also affected expression levels of 35 known androgen responsive genes and 18 of these transcripts showed changes that were the inverse of those seen after androgen stimulation. At high concentrations selenomethionine decreased prostate specific antigen promoter driven luciferase expression. CONCLUSIONS: Selenomethionine modulates transcript levels of genes involved in a number of biological processes, including cell cycle/apoptosis androgen signaling, signal transduction and transcriptional regulation. Although the pathways affected paralleled in many ways those that are modulated by methylselenic acid, distinct differences in transcript patterns and effects on cell cycle regulation suggest that different selenium compounds could exert unique effects in prostate cells. Groups of assays that are related as part of a time series. Computed...

  19. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq I] ArrayExpress

    ID: E-GEOD-47805

    Description: ncer, PRNCR1 and PCGEM1, bind successively to the androgen receptor (AR) and strongly enhance both ligand-dependent and ligand-independent AR-mediated gene activation programs and proliferation in prostate cancer cells. Binding of PRNCR1 to the C-terminally acetylated AR on enhancers and its association with DOT1L appear to be required for recruitment of the second lncRNA, PCGEM, to the N-terminally methylated AR. Unexpectedly, recognition of the H3K4me3 pro...

  20. Genome-wide expression profiling of Hic-5 and TGFB in WPMY fibroblasts ArrayExpress

    ID: E-GEOD-47354

    Description: urs in PShTert-AR cells significantly altered the androgen regulation of approximately 1347 genes. The effect of Hic-5 knockdown was to suppress androgen regulation of approximately 85% of those transcripts, by either reducing androgen mediated repression or activition of gene expression. Isogenic WPMY-1 fibroblasts stably transfected with short-hairpin RNA against Hic-5 or transfe...


Displaying 20 of 179 results for "AIG1"