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Displaying 10 of 14 results for "ADAM28"
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  1. Additional file 3: Table S2. of ADAM23 is a common risk gene for canine idiopathic epilepsy Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3678799_D2

    Release Date: 02-01-2017

    Description: Allelic association results of the ADAM23 variants. (XLSX 16 kb)

  2. Additional file 1: Table S1. of ADAM23 is a common risk gene for canine idiopathic epilepsy Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3678799_D3

    Release Date: 02-01-2017

    Description: Summary of the epilepsy questionnaires. (XLSX 13 kb)

  3. Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis are Highly Related Diseases that Appear t... ArrayExpress

    ID: E-GEOD-80047

    Description: cal entities. Increased expression of GPRIN1, and ADAM23 in keratinocytes suggests that these proteins could be new therapeutic targets for PPP/PPPP. Skin biopsies from subjects with PPP (3), PPPP (6), psoriasis vulgaris (10) and acral skin from normal subjects (7) were analyzed using gene expression microarray. Principal component analysis showed that PPP and PPPP were different from psoriasis vulgaris and normal acral skin. However gene expression of PPP and PPPP clustered together and could not be used to differentiate PPP from PPPP. Gene-wise comparison between PPP ...

  4. Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis are Highly Related Diseases that Appear t... BioProject

    ID: PRJNA317683

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cal entities. Increased expression of GPRIN1, and ADAM23 in keratinocytes suggests that these proteins could be new therapeutic targets for PPP/PPPP. Overall design: Skin biopsies from subjects with PPP (3), PPPP (6), psoriasis vulgaris (10) and acral skin from normal subjects (7) were analyzed using gene expression microarray. Principal component analysis showed that PPP and PPPP were different from psoriasis vulgaris and normal acral skin. However gene expression of PPP and PPPP clustered together and could not be used to differentiate PPP from PPPP. Gene-wise compari...

  5. Gene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours ArrayExpress

    ID: E-GEOD-72536

    Description: ancers and included CD200, STAG3, GGA2, SPIB and ADAM28. Differential expression of these genes was confirmed by real-time quantitative PCR and immunohistochemistry. Conclusion: In our dataset, the difference associated with T-cells between patients with HPV(+) and (-) HNSCC was predominantly numerical. However, when TIL numbers are corrected, a distinct differential B-cell signature was revealed. mRNA profiles of 10 HPV driven (HPV+) and 13 HPV independant (HPV-) head and neck squamous cell carcinoma (HNSCC) tumours were generated by RNA-Seq, using Illumina HiSeq 2000....

  6. ADA28_MACFA UniProt:Swiss-Prot

    ID: Q9XSL6

    Description: Disintegrin and metalloproteinase domain-containing protein 28 Extracellular Helical Cytoplasmic Peptidase M12B Disintegrin EGF-like Cysteine swit...

  7. Gene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours. BioProject

    ID: PRJNA294293

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ancers and included CD200, STAG3, GGA2, SPIB and ADAM28. Differential expression of these genes was confirmed by real-time quantitative PCR and immunohistochemistry. Conclusion: In our dataset, the difference associated with T-cells between patients with HPV(+) and (-) HNSCC was predominantly numerical. However, when TIL numbers are corrected, a distinct differential B-cell signature was revealed. Overall design: mRNA profiles of 10 HPV driven (HPV+) and 13 HPV independant (HPV-) head and neck squamous cell carcinoma (HNSCC) tumours were generated by RNA-Seq, using Illumina HiSeq 2000....

  8. Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming ArrayExpress

    ID: E-GEOD-47629

    Description: t an EBNA 3-only intergenic enhancer site between ADAM28 and ADAMDEC1 EBNA 3C was also able to independently direct epigenetic repression of both genes through enhancer-promoter looping. Significantly, studying shared or unique EBNA 3 binding sites at WEE1, CTBP2, ITGAL (LFA-1 alpha chain), BCL2L11 (Bim) and the ADAMs, we also discovered that different sets of EBNA 3 proteins bind regulatory elements in a gene and cell-type specific manner. Binding profiles correlated with the effects of individual EBNA 3 proteins on the expression of these genes, providing a molecular mechanism for the targeting of different sets of cellular genes by the EBNA 3s. Our results therefore highlight the influence of the genomic and cellular context in determining the specificity of gene deregulation by EBV and provide a paradigm for host-cell reprogramming through modulation of enhancer-promoter interactions by viral transcription factors. Examination of EBNA 3 protein binding (EBNA 3A, 3B and 3C) using a pan-specific antibody and EBNA 2 binding in single ChIP-seq experiments carried out in the Mutu III Burkitt's lymphoma cell-line....

  9. IMPACT OF MALE FERTILITY STATUS ON THE TRANSCRIPTOME OF THE BOVINE EPIDIDYMIS BioProject

    ID: PRJNA379141

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: AKAP4, SMCP, SPATA3, TCP11, ODF1, CTCFL, SPATA18, ADAM28, SORD and FAM161A) were found to exert functions related to reproductive systems and 5 genes (including DEAD, CYST11, DEFB119, DEFB124 and MX1) were found to be associated with the defence response. Limitations, reasons for caution: Further work is required to correlate these modulations of epididymal functions with sperm fertilizing ability in order to understand the aetiology of certain cases of idiopathic infertility in livestock and men. Wider implications of the findings: As fertility can be quantified in bulls used for artificial insemination, this species is a unique model to aid in the understanding of male fertility/subfertility in man.Our data provide a molecular characterization that will facilitate advances in understanding the involvement of epididymalphysiology in sub/infertility aetiology. Overall design: Epididymides from 6 Holstein bulls with documented fertility were used. These bulls were divided into 2 groups: high fertility (HF) (n = 3), and medium–low fertility (n = 3) and their epididymal transcriptomic profiles were analyzed. Bovine cDNA microarray probing and bioinformatic tools were used to identify differentially expressed genes between caput, corpus and cauda epididymidal tissues of bulls with documented fertility index....

  10. Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming BioProject

    ID: PRJNA206727

    Keywords: Epigenomics

    Access Type: download

    dataset.description: t an EBNA 3-only intergenic enhancer site between ADAM28 and ADAMDEC1 EBNA 3C was also able to independently direct epigenetic repression of both genes through enhancer-promoter looping. Significantly, studying shared or unique EBNA 3 binding sites at WEE1, CTBP2, ITGAL (LFA-1 alpha chain), BCL2L11 (Bim) and the ADAMs, we also discovered that different sets of EBNA 3 proteins bind regulatory elements in a gene and cell-type specific manner. Binding profiles correlated with the effects of individual EBNA 3 proteins on the expression of these genes, providing a molecular mechanism for the targeting of different sets of cellular genes by the EBNA 3s. Our results therefore highlight the influence of the genomic and cellular context in determining the specificity of gene deregulation by EBV and provide a paradigm for host-cell reprogramming through modulation of enhancer-promoter interactions by viral transcription factors. Overall design: Examination of EBNA 3 protein binding (EBNA 3A, 3B and 3C) using a pan-specific antibody and EBNA 2 binding in single ChIP-seq experiments carried out in the Mutu III Burkitt's lymphoma cell-line....
Displaying 10 of 14 results for "ADAM28"

bioCADDIE is supported by the National Institutes of Health through the Big Data to Knowledge, Grant 1U24AI117966-01. NIH | UCSD | DBMI

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