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  1. Analysis of 125DVD3- and 17β-estradiol (17βE2)-regulated transcriptomes in lymphoblastoid cells NURSA

    Keywords: lymphoid lineage B lymphocytes GM10855 cells

    Description: 125DVD3 (0.1 µM), 17βE2 (0.1 µM), a combination of both, or vehicle were adminstered to human lymphoblastoid cells (GM10855 or GM10861) for 36 h.

    ID: 10.1621/xY9TRZiL1u

  2. Mutational analysis of the estrogen receptor α (ERα/ESR1)-regulated transcriptome in MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF7 breast cancer cells were transfected with constructs expressing wild-type ERα/ESR1, a panel of ERα/ESR1 point mutants (S463P, Y537S, D538...

    ID: 10.1621/ETHEsG15w9

  3. Transcriptomic profiling of 17β-estradiol (17βE2)- and xenoestrogen-treated MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells were treated for 7 days with or without: (1) 10 nM 17βE2; (2) 500 µM methylparaben (MePara); or (3) 10 µM n-butyl-p...

    ID: 10.1621/9H4JneZBE5

  4. Time course transcriptomic analysis of dexamethasone (Dex)-treated mouse primary cortical astrocytes NURSA

    Keywords: cerebrum cerebral cortex astrocytes

    Description: Primary cortical astrocyte cultures were treated for a range of time periods between 15 min and 24 h with or without 100 nM Dex.

    ID: 10.1621/7en2mXGtwx

  5. Transcriptomic analysis of 17β-estradiol (17βE2)- and Fulvestrant (Fulv)-treated GH3 cells NURSA

    Keywords: pituitary GH3 cells

    Description: Rat pituitary GH3 cells were treated for 24 h with or without: (1) 1 nM 17βE2; (2) 100 nM Fulv; or (3) a combination of both.

    ID: 10.1621/CkOavd3L5q

  6. Time course transcriptomic analysis of adipogenic differentiation of human preadipocytes isolated from subcutaneous white adipose tissue (WAT) NURSA

    Keywords: WAT preadipocytes unspecified 1° cells

    Description: Commercially obtained human preadipocytes from normal female donors were induced to differentiate into adipocytes with an adipogenic coctail for 1 - 1...

    ID: 10.1621/bixFUjJNmc

  7. Analysis of the estrogen receptor-β (ESR1/ERβ)-regulated transcriptome in 17β-estradiol (17βE2)-treated and Fulvestrant (Fluv)-treated T47D cells NURSA

    Keywords: epithelium T47D cells

    Description: Human T47D breast cancer cells stably transfected with a tetracycline repressible ERβ/ESR2 were cultured: (1) in the presence of tetracycline for 12 ...

    ID: 10.1621/yAyJGMai3I

  8. Analysis of the estrogen receptor-α (ERα/ESR1)-regulated transcriptome in 17β-estradiol (17βE2)- and bisphenol A-treated MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells (C4-12 ERα-HA) stably overexpressing HA-tagged ERα/ESR1 were treated for 3 h with or without: (1) 1 µM BPA; or (2) ...

    ID: 10.1621/QW7wvDxDKb

  9. Analysis of the 17α-ethinylestradiol (17αEE2)- and raloxifene (Ral)-regulated transcriptomes in rat uterus NURSA

    Keywords: whole uterus

    Description: Uterine tissues were collected 24 h after the final dose from six month old ovariectomized Sprague Dawley rats treated for 35 days with or without ora...

    ID: 10.1621/rRFmLctKAu

  10. Analysis of the constitutively active peroxisome proliferator-activated receptor-γ (PPARγ/Pparg)-dependent transcriptome in MCF10A cells NURSA

    Keywords: epithelium NAFA cells

    Description: PPARγ/PPARG CA is a VP16-PPARγ/PPARG fusion that is constitutively active. Immortal MCF10A cells were transduced with expression vectors encoding ei...

    ID: 10.1621/yBPnd7v8hT

  11. Analysis of the miR-26a-regulated transcriptome in 17β-estradiol (17βE2)-treated MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells were treated with and without 10 nM 17βE2 for 48 h in the presence or absence of miR26-a or a control miRNA.

    ID: 10.1621/k8PfkZxKuy

  12. Analysis of the estrogen receptor-β (ERβ/ESR2)-regulated transcriptome in HEK293 cells NURSA

    Keywords: epithelium HEK293 cells

    Description: HEK293 cells lack functional endogenous estrogen receptors (ERs). HEK293 tet-on cells were transfected either with an empty vector or a vector express...

    ID: 10.1621/cinGeUpl3V

  13. Analysis of the pregnenolone carbonitrile (PCN)-regulated transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: Wild type male C57/Bl6 mice were treated with and without PCN (200 mg/kg) and livers removed after 12 h.

    ID: 10.1621/rVCNLZzcjj

  14. Transcriptomic profiling of all-trans retinoic acid (ATRA)- and 1,25-dihydroxyvitamin D3 (125DVD3)-treated HL-60 cells NURSA

    Keywords: myeloid lineage promyelocytes APL HL-60 cells

    Description: Human myeloid leukemia HL-60 cells were treated with and without 400 nM ATRA or 24 nM 125DVD3 for 3 days.

    ID: 10.1621/z9KJV3nwrx

  15. Analysis of the fenofibrate (Feno)-regulated transcriptome in female rat liver NURSA

    Keywords: whole liver

    Description: Samples of the left lateral lobe of the liver were collected from female rats treated with or without 30 mg/kg/d or 100 30 mg/kg/d Feno for 2 days.

    ID: 10.1621/KIuZCWY6l4

  16. Analysis of the 17β-estradiol (17βE2)-regulated transcriptome in diindolylmethane (Diindo)-treated MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells were treated for 16 h with or without: (1) 1 nM 17βE2; or (2) 1 nM 17βE2 + 25 µM Diindo.

    ID: 10.1621/1AD8vAf4sD

  17. Time course transcriptomic analysis of the 17α-ethinylestradiol (17αEE2)-regulated transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: C57BL/6 mice were treated with or without 100 µg/kg body weight 17αEE2 by oral gavage for a range of time periods up to 24 h

    ID: 10.1621/TF8VegSeaJ

  18. Analysis of the caveolin 1 (Cav1)-dependent mammary gland transcriptome in 17β-estradiol (17βE2)-treated mice NURSA

    Keywords: other whole mammary gland

    Description: Mammary glands were surgically removed from ovariectomized Cav-1(-/-) knockout and wild type female mice treated for 60 days with 125 µg/day 17βE2.

    ID: 10.1621/bYJR9zOxmV

  19. Analysis of the 17β-estradiol (17βE2)-regulated transcriptome in rat liver NURSA

    Keywords: whole liver

    Description: Adult female Sprague Dawley rats were exposed to 5 µg/kg body weight/day 17βE2 for 14 days prior to removal of livers.

    ID: 10.1621/h19uDj5YK3

  20. Analysis of the ciprofibrate (Ciprof)-treated transcriptome in rat liver NURSA

    Keywords: whole liver

    Description: Female Fisher rats were treated with or without 50 mg/kg body weight/day Ciprof by gastric intubation once daily for 60 days after which livers were r...

    ID: 10.1621/Emuixk6gFt

  21. Analysis of the R1881-regulated transcriptome in celastrol-treated LNCaP cells NURSA

    Keywords: epithelium LNCaP cells

    Description: Human LNCaP prostate cancer cells were treated for 24 h: (1) with or without 1 nM R1881; or (2) with 1 nM R1881 or a combination of 1 nM R1881 + 1.25 ...

    ID: 10.1621/aWNqvAebS2

  22. Analysis of the aldosterone (Aldo), corticosterone (Cortic) and cortivazol (Cortiv) dependent transcriptomes in rat cardiomyocytes NURSA

    Keywords: cardiac muscle cardiomyocytes 1° cells

    Description: Cardiomyocytes isolated from ventricles of neonatal Wistar rats were treated with Aldo, Cortic, or Cortiv.

    ID: 10.1621/eSwuCO5iv9

  23. Time course transcriptomic analysis of adipogenic differentiation of human white adipose tissue (WAT)-derived stromal cells NURSA

    Keywords: WAT preadipocytes unspecified 1° cells

    Description: Human stromal cells isolated from abdominal subcutaneous WAT from donors undergoing liposuction were induced to differentiate into adipocytes with an ...

    ID: 10.1621/D5ONGVElpz

  24. Analysis of the chronic human E74 like ETS transcription factor 5 (ELF5)-dependent transcriptome in the mouse mammary tumor virus-Polyoma Middle T (Py... NURSA

    Keywords: epithelium 1° cells

    Description: PyMT/ELF5 transgenic mice containing doxycycline-inducible human ELF5 were generated on a FVB/N background where ELF5 expression is characterized by E...

    ID: 10.1621/zNLnQwNkBg

  25. Comparative analysis of the isoform-dependence of the farnesoid X receptor α (Nr1h4/Fxr)-regulated murine hepatic transcriptome NURSA

    Keywords: whole liver

    Description: Liver was isolated from male Nr1h4 KO mice transduced with adenovirus expressing liver specific Nr1h4 isoforms Fxra2 or Fxra4. Transduced mice were fe...

    ID: 10.1621/83PDpeFqe0

  26. Analysis of the androgen receptor (AR/Ar)-dependent transcriptome in mouse skeletal muscle satellite cells NURSA

    Keywords: gastrocnemius whole

    Description: Gastrocnemius or levator ani skeletal muscle was isolated from male C57BL/6J satellite cell specific AR/Ar knockout and wild-type mice after orchidect...

    ID: 10.1621/hJW8yGEQmn

  27. Acute time course and dose-dependence analysis of the dexamethasone (Dex)-regulated transcriptome in rat liver NURSA

    Keywords: whole liver

    Description: Livers were isolated from rats treated for 3 - 24 h with or without 500 µg - 50 mg/kg bw/d Dex.

    ID: 10.1621/QbSpGciVT2

  28. Analysis of the perfluorononanoic acid (PFNA) and perfluorohexane sulfonate (PFHxS)-regulated peroxisome proliferator activated receptor α (Ppara)-de... NURSA

    Keywords: whole liver

    Description: Liver was isolated from Ppara KO and WT male mice 6-9 months of age treated for 7 d with 3-10 mg/kg bw/d PFHxS, 1-3 mg/kg bw/d PFNA, or vehicle in wat...

    ID: 10.1621/4ugp7Qi52n

  29. Time course analysis of the adipogenic transcriptome during adipocyte differentiation of mouse 3T3-L1 preadipocyte cells NURSA

    Keywords: WAT adipocytes 3T3-L1-derived

    Description: Confluent mouse 3T3-L1 preadipocyte cultures were induced to differentiate into adipocytes with an adipogenic cocktail for 2 - 7 d.

    ID: 10.1621/3ZRfyGzOFy

  30. Analysis of peroxisome proliferator activated receptor-α (PPARα/Ppara)-dependent, PPARα agonist-regulated transcriptomes in mouse liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from 2-6 month old male wild type 129S1/SvImJ or 129S4/SvJae PPARα/Ppara knockout mice, orally treated for 6 h with or without (1)...

    ID: 10.1621/NaZeSWN5o3

  31. Analysis of the testicular orphan receptor 4 (TR4/Nr2c2)-regulated transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from C57BL/6 TR4/Nr2c2 knockout and wild-type mice at one year of age.

    ID: 10.1621/jV6wKZptpU

  32. Time course analysis of 125DVD3-regulated transcriptomes in lymphoblastoid cells, fibroblasts and other cell types NURSA

    Keywords: lymphoid lineage B lymphocytes GM07019 cells

    Description: 0.1 µM 125DVD3 or vehicle were adminstered for 8 h or 36 h to human lymphoblastoid cells (GM07019, GM07348, GM10854 and GM12878), fibroblasts (Ag0930...

    ID: 10.1621/CwBu4UNKJK

  33. Analysis of the retinoic acid receptor-β (RARβ/Rarb)-regulated transcriptome in mouse mammary stroma NURSA

    Keywords: other stroma

    Description: Mammary stroma was isolated from 40 day old RARβ/Rarb knockout and wild-type mice.

    ID: 10.1621/VUYZK5mXsb

  34. Analysis of the peroxisome proliferator activated receptor- δ (PPARδ/Ppard)-regulated transcriptome in mouse pancreatic islets NURSA

    Keywords: islets whole

    Description: Pancreatic islets were isolated from two month old wild-type and pancreatic-specific PPARδ/Ppard knockout animals.

    ID: 10.1621/p6cdTUsRoE

  35. Analysis of the liver X receptor-α (LXRα/Nr1h3)-dependent, T1317-regulated transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from male C57B6 mice with liver-specific expression of GFP or LXRα/Nr1h3, treated with or without 5 mg/kg T1317, a synthetic LXRα...

    ID: 10.1621/DiALZkjgLj

  36. Analysis of the liver receptor homolog-1 (LRH1/Nr5a2)-regulated transcriptome in mouse embryonic fibroblasts NURSA

    Keywords: embryonic

    Description: Induced pluripotent stem cells (iPSCs), generated from mouse embryonic fibroblasts (MEFs) through the retroviral introduction of Lrh1, Sox2, Klf4, and...

    ID: 10.1621/YZGZLHAaNQ

  37. Analysis of the rosiglitazone (Rosi) dependent transcriptome in alternatively-activated human blood derived macrophages NURSA

    Keywords: myeloid lineage monocytes CD14+ blood

    Description: Human CD14 positive monocytes were purified from blood and cultured in-vitro. During culture macrophages were alternatively activated with 100 ng/ml I...

    ID: 10.1621/3btG3BUf5b

  38. Time course- and dose-dependent analysis of the rosiglitazone (Rosi)-dependent and peroxisome proliferator-activated receptor-γ (PPARγ/Pparg) DNA-bi... NURSA

    Keywords: dendritic cells unspecified

    Description: Normal human monocytes or human monocytes stably expressing the PPARγ/PPARG DNA binding domain mutants C114R or C131Y were differentiated into monocy...

    ID: 10.1621/p3ZSUojETc

  39. Analysis of the PHD finger protein 8 (PHF8)-dependent transcriptome in HeLa cervical cancer cells NURSA

    Keywords: epithelium endometrium cervical HeLa cells

    Description: Human HeLa cervical cancer cells were transfected with PHF8 siRNA or control siRNA.

    ID: 10.1621/tcKOfvv5Wo

  40. Analysis of the androgen receptor (AR/Ar)-regulated transcriptome in mouse Sertoli cells NURSA

    Keywords: other whole testis

    Description: Testes were removed from 10-day old Sertoli cell-selective AR knockout and wild-type mice.

    ID: 10.1621/7zfAKR1SVe

  41. Comparative analysis of the wild-type and CR7 mutant androgen receptor (AR)-regulated metabolomes in LNCaP cells NURSA

    Keywords: epithelium LNCaP cells

    Description: Human LNCaP prostate cancer cells containing a doxycycline-inducible constitutively-active form of AR (AR-V7) and parental human LNCaP prostate cancer...

    ID: 10.1621/F3qO0nGxC7

  42. Chronic time course and dose-dependence analysis of the clofibrate (Clofib)-regulated transcriptome in rat kidney NURSA

    Keywords: whole kidney

    Description: Kidneys were isolated from rats treated for 4 - 29 d with or without 30 - 300 mg/kg bw/d Clofib.

    ID: 10.1621/uH7DUbTZPc

  43. Time course transcriptomic analysis of rosiglitazone (Rosi)-treated 3T3-L1 adipocytes NURSA

    Keywords: WAT adipocytes 3T3-L1-derived

    Description: Fully differentiated 3T3-L1 adipocytes were cultured with 1 µM Rosi or vehicle for 1 h.

    ID: 10.1621/rP497GvEr2

  44. Acute and chronic time course analysis of the WY14643-regulated transcriptome in Female ovariectomized C57BL/6 mouse liver. NURSA

    Keywords: whole liver

    Description: Livers were isolated from mice treated for 2 - 24 h or 1 - 14 d with or without 300 mg/kg bw/d WY14643.

    ID: 10.1621/bhKR1Y5xgj

  45. Analysis of the glucocorticoid receptor (GR/Nr3c1)-dependent transcriptome during mouse embryonic lung development NURSA

    Keywords: whole lung

    Description: Lung tissue was isolated from mice with mesenchyme-specific GR/Nr3c1 knockout at E16.5 and E18.5.

    ID: 10.1621/IQw1iqh2i1

  46. Comparative analysis of estrogen receptor-α (ERα/ESR1) or ERβ/ESR2-dependent transcriptomes in 17β-estradiol (17βE2)- or 4HT- treated U2OS cells NURSA

    Keywords: osteoblasts U2OS cells

    Description: Human U2OS osteosarcoma cells stably transfected with tetracycline inducible ERα/ESR1, ERβ/ESR2, or both, were cultured with tetracycline for 24 h t...

    ID: 10.1621/4ZXZjH7niR

  47. Analysis of the 17β-estradiol (17βE2)-regulated, estrogen receptor-β (ERβ/ESR2)-dependent transcriptome in MCF-7 breast cancer cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells were transfected with an adenovirus expressing ERβ/ESR2 at a MOI of 50 for 48 h and then treated with 10 nM 17βE2 or...

    ID: 10.1621/fbqRi3ck3S

  48. Analysis of the Pgrmc2-dependent transcriptome during murine adipocyte differentiation NURSA

    Keywords: WAT adipocytes 3T3-L1-derived

    Description: Mouse 3T3-L1 preadipocytes stably expressing Pgrmc2 or GFP were induced to differentiate into adipocytes for 24 h.

    ID: 10.1621/Yi4vVHiTW2

  49. Analysis of the liver transcriptome in response to genotoxic carcinogens, nongenotoxic carcinogens, or non-hepatocarcinogens in male rats NURSA

    Keywords: whole liver

    Description: Male Wistar rats were treated by oral gavage with the eight nongenotoxic hepatocarcinogens phenobarbitol (Phenob, 80 mg/kg/d), piperonylbutoxide (1200...

    ID: 10.1621/tpWGcMRez6

  50. Acute time course and dose-dependence analysis of the 17α-ethinylestradiol (17αEE2)-regulated transcriptome in human primary hepatocytes NURSA

    Keywords: hepatocytes 1° cells

    Description: Primary human hepatocytes were treated for 8 - 24 h with or without 60 - 300 µM 17αEE2.

    ID: 10.1621/JYJxarikIb


Displaying 50 of 931 results for " "