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  1. Transcriptomic profiling of LGD1069-treated anaplastic thyroid carcinoma DRO cells NURSA

    Keywords: DRO cells

    Description: Anaplastic thyroid carcinoma DRO cells were treated with and without 1 µM LGD1069 for 24 h

    ID: 10.1621/IJ7xKFI4Hx

  2. Age dependence analysis of the R5020-regulated transcriptome in mouse mammary gland NURSA

    Keywords: epithelium organoid cultures

    Description: The PR/PGR A isoform (PR-A) is highly expressed in mouse pubertal mammary glands while PR-B is detectable only during pregnancy. Mammary organoid cult...

    ID: 10.1621/T2pyrsMPAB

  3. Analysis of the testosterone (Test)-, Flutamide (Flut)- and diethylhexylphthalate (DEHP)-regulated transcriptomes in rat testis NURSA

    Keywords: other whole testis

    Description: Testes were removed from immature male Sprague Dawley rats treated via oral gavage for 14 days with or without 1 mg/kg body weight/day Test propionate...

    ID: 10.1621/HupEFZzekz

  4. Analysis of the estrogen receptor-α (ERα/Esr1)-regulated transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: Livers were removed from three month old ERα/Esr1 null mutant and wild-type female C57BL/6J mice.

    ID: 10.1621/xyZZLDZJDZ

  5. Dose dependence analysis of the thyroid hormone (T3)-regulated transcriptome in rat striatum NURSA

    Keywords: striatum whole

    Description: Thyroidectomized adult male Wistar rats were given (i) a single dose of 250 µg/kg body weight T3 24 h prior to sacrifice and removal of striatum; or ...

    ID: 10.1621/fV2RSXFvcL

  6. Analysis of the 17β-estradiol (17βE2)- and diarylpropionitrile (DPN)-regulated transcriptomes in U2OS cells stably expressing estrogen receptor-α (... NURSA

    Keywords: osteoblasts U2OS cells

    Description: U2OS cells overexpressing ERα/ESR1 or ERβ/ESR2 were treated for 6 h with and without 10 nM 17βE2 or 1 µM DPN.

    ID: 10.1621/rGRCXFd8iw

  7. Analysis of the estrogen receptor-α (ERα/ESR1) and ERβ/ESR2-regulated transcriptomes in 17β-estradiol (17βE2)-treated HUVS-112D cells NURSA

    Keywords: smooth muscle HUVSMCs HUVS-112D cells

    Description: (1) ERα/ESR1+ & ERβ/ESR2- or (2) ERβ/ESR2+ & ERα/ESR1- umbilical cord-derived human HUVS-112D vascular smooth muscle cells were treated wi...

    ID: 10.1621/jW7QC7JeJL

  8. Analysis of the AKT-regulated transcriptome in 17β-estradiol (17βE2)-treated MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Parental human MCF-7 breast cancer cells or MCF-7 cells overexpressing the serine/threonine kinase AKT were treated with and without 10 nM 17βE2 for ...

    ID: 10.1621/GjIgi8XmOk

  9. Analysis of the Rev-Erbα/Nr1d1 dependent transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from Rev-Erbα/Nr1d1 knockout and wild-type mice at Zeitgeber time 12.

    ID: 10.1621/jNzqntK6gJ

  10. Comparative analysis of the Per2-dependent transcriptome in white (WAT) and brown (BAT) adipose tissue NURSA

    Keywords: WAT unspecified

    Description: WAT and BAT was isolated from Per2 KO and WT male mice 20 weeks of age.

    ID: 10.1621/ezy0k4MTGY

  11. Time course analysis of adipocyte differentiation in human SGBS preadipocyte cells NURSA

    Keywords: WAT adipocytes SGBS cells

    Description: Human SGBS preadipocyte cells were cultured for 4 h - 12 d with adipocyte differentiation cocktail containing human transferrin, T3, cortisol, insulin...

    ID: 10.1621/VaqwZrrodW

  12. Analysis of the cell death inducing DFFA like effector c (Cidec) and leptin (Lep)-dependent transcriptome in mouse white adipose tissue (WAT) NURSA

    Keywords: WAT unspecified

    Description: Gonadal WAT was removed from 4 month old male Cidec/Lep double knockout and Lep knockout mice.

    ID: 10.1621/L0honIuQ7x

  13. Analysis of the mutant picornavirus RNA-dependent RNA polymerase with disrupted primary and secondary RNA structure (RdRPΔrna)-dependent transcriptom... NURSA

    Keywords: myeloid lineage myeloblasts AML THP-1 cells

    Description: Human THP-1 monocytic leukemia cells were transduced with a lentiviral vector containing a mutant picornavirus RNA-dependent RNA polymerase with disru...

    ID: 10.1621/gTqItVnDEP

  14. Time course analyses of the 17β-estradiol (17βE2)-regulated transcriptome in Hepa-1c17 cells NURSA

    Keywords: epithelium Hepa-1c1c7 cells

    Description: Mouse Hepa-1c17 hepatoma cells were treated with or without 10 nM 17βE2 for a range of time periods up to 24 h.

    ID: 10.1621/lEnP5n4dC8

  15. Proteomic analysis of nuclear receptor coregulator complexes NURSA

    Keywords: HeLa

    Description: This dataset shows interacting proteins for nuclear receptor coregulators determined by affinity purification and mass spectroscopy. 15 mg total prote...

    ID: 10.1621/datasets.04005

  16. Analysis of the E6-associated protein (E6AP/Ube3a)-regulated transcriptome in female mouse cerebellum NURSA

    Keywords: cerebellum whole

    Description: Cerebellum total RNA was extracted from 6 week-old female wild-type and E6-AP knockout (Ube3a m-/p+) mice.

    ID: 10.1621/pJXmmJiy45

  17. Analysis of free fatty acid receptor 4 (Ffar4)-dependent metabolic tissue transcriptomes in a mouse model of diet-induced obesity NURSA

    Keywords: WAT epididymal

    Description: Epididymal white adipose tissue and liver were isolated from Ffar4 KO and WT male 5 week old mice fed a high fat diet (HFD; 60% fat) or a normal diet ...

    ID: 10.1621/bl5w1Ir7eN

  18. Comparative analysis of the white adipose tissue (WAT)-deposit specific transcriptomes in mice NURSA

    Keywords: WAT unspecified

    Description: WAT was isolated from two subcutaneous deposits (inguinal and axillary) and two visceral deposits (epididymal and mesenteric) from 8-10 week old male ...

    ID: 10.1621/ysuFOXIUaK

  19. Analysis of the mutant picornavirus RNA-dependent RNA polymerase lacking catalytic activity (RdRPΔcat)-dependent transcriptome in human THP-1 monocyt... NURSA

    Keywords: myeloid lineage myeloblasts AML THP-1 cells

    Description: Human THP-1 monocytic leukemia cells were transduced with a lentiviral vector containing a mutant picornavirus RNA-dependent RNA polymerase lacking ca...

    ID: 10.1621/ZjtRLPbE0k

  20. Analysis of the acute E74 like ETS transcription factor 5 (ELF5)-dependent transcriptome in the mouse mammary tumor virus-Polyoma Middle T (PyMT/ELF5)... NURSA

    Keywords: epithelium 1° cells

    Description: PyMT/ELF5 transgenic mice containing doxycycline-inducible human ELF5 were generated on a FVB/N background where ELF5 expression is characterized by E...

    ID: 10.1621/axENpMb8qe

  21. Analysis of the peroxisome proliferator activated receptor-α (PPARα/Ppara)-regulated transcriptome in mouse skeletal muscle NURSA

    Keywords: gastrocnemius whole

    Description: Gastrocnemius muscle was isolated from 6 week old hybrid B6/CBA transgenic mice overexpressing PPARα/Ppara in skeletal muscle or from hybrid B6/CBA n...

    ID: 10.1621/4rQYtJ4ZdB

  22. Time course transcriptomic profiling of all-trans retinoic acid (ATRA)-treated HL-60 cells NURSA

    Keywords: myeloid lineage promyelocytes APL HL-60 cells

    Description: Human myeloid leukemia HL-60 cells were treated with and without 1 µM ATRA for 4 days or 6 days.

    ID: 10.1621/PZwk7Lwtd2

  23. Analysis of the Flutamide (Flut)-regulated transcriptomes in male and female fetal mouse lung NURSA

    Keywords: whole lung

    Description: Fetal lung tissue was isolated from fetuses harvested from pregnant BALB/c mice treated with 1 mg/d Flut from gestational day 10 to gestational day 17...

    ID: 10.1621/MCbKlwnbdC

  24. Analysis of the Fulvestrant (Fulv)-regulated transcriptome in EGF-treated MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells were pre-treated with (1) vehicle or (2) 100 nM Fulv for 3 h, and then treated with or without 100 µg/ml EGF for 3 h ...

    ID: 10.1621/x6n3bdzH7q

  25. Analysis of the peroxisome proliferator activated receptor-α (PPARα/Pppara)-dependent, Wy 14,643-regulated transcriptomes in mouse liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from 3-5 month old wild type or PPARα/Ppara knockout male 129S4/SvJae mice treated with or without 0.1% w/w WY14643 for 5 days.

    ID: 10.1621/ZLIzlILSol

  26. Analysis of the mediator complex subunit 1 (Med1)-dependent transcriptome in mouse embryonic fibroblasts NURSA

    Keywords: embryonic

    Description: Mouse embryonic fibroblasts (MEFs) were isolated from mediator complex subunit 1 (Med1) knockout and wild-type E10 embryos.

    ID: 10.1621/wsSonXUBcr

  27. Analysis of the dihydrotestosterone (DHT)-regulated FOXA1-dependent transcriptome in LNCaP prostate cancer cells NURSA

    Keywords: epithelium LNCaP cells

    Description: Human LNCaP prostate cancer cells were transfected with non-specific siRNA or FOXA1 siRNA and treated with 100 nM DHT or vehicle for 20h.

    ID: 10.1621/t588AUh5jf

  28. Analysis of the retinoid orphan receptor-α (RORα/Rora)- RORγ/Rorg- or RORα/RORγ-dependent transcriptomes in mouse liver NURSA

    Keywords: whole liver

    Description: Livers were isolated from 8-12 week old RORα null, RORγ null, RORα/RORγ double null, or wild-type mice at circadian time 19.

    ID: 10.1621/7fcCpytc5p

  29. Analysis of the Rac1-dependent transcriptome in mouse primary endothelial cells NURSA

    Keywords: endothelium 1° cells

    Description: Mouse heart primary endothelial cells were isolated from endothelial cell-specific Rac1 HET and WT mice.

    ID: 10.1621/urNFoseorg

  30. Analysis of the peroxisome proliferator activated receptor-δ (PPARδ/Ppard)-regulated transcriptome in mouse skeletal muscle NURSA

    Keywords: gastrocnemius whole

    Description: Gastrocnemius muscle was isolated from 6 week old hybrid B6/CBA transgenic mice overexpressing PPARδ/Ppard in skeletal muscle or from hybrid B6/CBA n...

    ID: 10.1621/qVT5ZB9JYH

  31. Analysis of the retinoid orphan receptor-α (RORα/Rora)-regulated transcriptome in mouse liver and white adipose tissue NURSA

    Keywords: whole liver

    Description: Liver or white adipose tissue were isolated from RORα/Rora-deficient staggerer (sg/sg) and wild-type mice fed a high fat diet (35% fat) for 6 weeks.

    ID: 10.1621/b2n1yyAn8P

  32. Comparative transcriptomic analysis of white, brown and beige fat cell lines NURSA

    Keywords: other adipocytes immortalized

    Description: Immortalized clonal fat cell lines were derived from primary inguinal (beige and white) or interscapular (brown) stromal-vascular cells. Derived subcl...

    ID: 10.1621/Hn4dqri4Pd

  33. Comparative transcriptomic analysis of spleen- and thymus-derived adult and perinate mouse regulatory T cells (Tregs) NURSA

    Keywords: lymphoid lineage T lymphocytes regulatory spleen

    Description: Transcriptomes were compared between the following populations of Tregs (i) perinate and adult spleen-derived; (ii) perinate and adult thymus-derived...

    ID: 10.1621/tFD8zoxH65

  34. Time course analysis of the 17β-estradiol (17βE2) and insulin-like growth factor-1 (IGF1)-regulated transcrptomes in human MCF-7 breast cancer cells NURSA

    Keywords: epithelium MCF-7 BUS cells

    Description: Human MCF-7 breast cancer cells were treated for 3 h or 24 h with or without 10 nM 17βE2 or 100 ng/ml IGF1.

    ID: 10.1621/HmGe8Loijj

  35. Analysis of the mineralocorticoid receptor (MR/Nr3c2)-dependent transcriptome in mouse peritoneal macrophages treated with corticosterone (Cortic) NURSA

    Keywords: myeloid lineage macrophages peritoneal cavity-derived

    Description: Peritoneal macrophages were isolated from MR/Nr3c2 knockout and wild-type animals treated with and without 1 µM Cortic for 24 h.

    ID: 10.1621/LOO5hhCEtn

  36. Analysis of the peroxisome proliferator-activated receptor-γ (PPARγ/Pparg)-regulated transcriptome in colitic mouse colon NURSA

    Keywords: other mucosa whole mucosa

    Description: Colonic tissue was isolated from wild-type and macrophage-specific PPARγ/Pparg knockout animals treated with 2.5% dextran sodium sulfate (S) in the d...

    ID: 10.1621/9vNOcUCexJ

  37. Analysis of the dexamethasone (Dex)-regulated transcriptome in lipopolysaccharide (LPS)-activated inflammatory mouse macrophages NURSA

    Keywords: myeloid lineage macrophages bone marrow-derived

    Description: Primary bone marrow derived-macrophages from male 10 week old mice were treated overnight with 1 µM Dex, 100 ng/ml LPS or both.

    ID: 10.1621/NjyEDq96T7

  38. Analysis of the all-trans retinoic acid (ATRA)-regulated transcriptome in murine E14Tg2A embryonic stem cells NURSA

    Keywords: pluripotent ESCs E14Tg2A cells

    Description: Mouse E14Tg2A embryonic stem cells were treated for 2 d with or without 1 µM ATRA to induce neuronal differentiation.

    ID: 10.1621/pZbsyIDmOw

  39. Analysis of glucocorticoid receptor (GR/NR3C1) isoform-regulated transcriptomes in dexamethasone (Dex)-treated U2OS cells NURSA

    Keywords: osteoblasts U2OS cells

    Description: Human U2OS osteosarcoma cells stably expressing human GR/NR3C1 isoforms under the Tet-off system were cultured in the absence of tetracycline prior to...

    ID: 10.1621/bCuUTHXkhy

  40. Comparative analysis of the dexamethasone (Dex)-regulated transcriptomes in male and female rat hepatocytes NURSA

    Keywords: hepatocytes 1° cells

    Description: Hepatocytes from livers of adult female and female, adrenalectomized or non-adrenalectomized Sprague-Dawley rats were treated with or without 100 nM D...

    ID: 10.1621/IMD4wj7kJP

  41. Analysis of the chicken ovalbumin upstream promoter factor II (COUPTFII/NR2F2)-regulated transcriptome in PC3 cells NURSA

    Keywords: epithelium PC3 cells

    Description: Human PC3 prostatic carcinoma cells were transfected with control or COUPTFII/NR2F2 siRNA duplexes for 48 h.

    ID: 10.1621/8yQpjWrlDh

  42. Transcriptomic analysis of 17β-estradiol (17βE2)-treated human umbilical vein endothelial cells NURSA

    Keywords: endothelium HUVECs 1° cells

    Description: Primary human umbilical vein endothelial cells were treated with or without 1 nM 17βE2 for 24 h.

    ID: 10.1621/xeipTwH7A8

  43. Analysis of the ELK and R1881-dependent transcriptomes in LNCaP prostate cancer cells NURSA

    Keywords: epithelium LNCaP cells

    Description: Human LNCaP prostate cancer cells were infected with ELK1 shRNA or control shRNA for 96 h. Cells were treated with 1 nM R1881 or vehicle for 48 h.

    ID: 10.1621/xZngfuhLwA

  44. Transcriptomic analysis of hydrocortisone (Hydcrt)-treated mouse fibroblasts from keloids or normal scars NURSA

    Keywords: fibroblasts keloid

    Description: Low-passage fibroblasts from keloids or normal scars were treated with or without 1.5 µM Hydcrt for 10 d.

    ID: 10.1621/MIgSfljDs3

  45. Analysis of the estrogen receptor-related receptor-γ (ERRγ/Esrrg)-regulated transcriptome in mouse heart ventricle NURSA

    Keywords: ventricle whole

    Description: Heart ventricles were removed from wild type and E18.5 ERRγ/Esrrg heterozygte or null mutants.

    ID: 10.1621/datasets.04007

  46. Time course analysis of the dexamethasone (Dex) and leukemia inhibitory factor (Lif)-regulated transcriptomes in mouse AtT-20 pituitary corticotrope t... NURSA

    Keywords: pituitary corticotrophs AtT-20 cells

    Description: Mouse AtT-20 pituitary corticotrope tumor cells were treated for 3 h or 18 h with or without 100 nM Dex or 10 ng/ml Lif.

    ID: 10.1621/U2mYyLhddH

  47. Analysis of the docosahexaneoic acid (Docos)-regulated HUVEC transcriptome in a model of IL-1β-induced inflammation NURSA

    Keywords: endothelium HUVECs 1° cells

    Description: Human umbilical cord epithelial cells were treated for 48 h with or without 25 µM Docos followed by treatment for 3 h with 5 ng/ml IL-1β to induce a...

    ID: 10.1621/HDZ35Ll8IU

  48. Analysis of the childhood obese transcriptomic signature in omental adipose tissue NURSA

    Keywords: WAT omental

    Description: Omental adipose tissue was obtained from prepubertal obese and normal weight children.

    ID: 10.1621/C3ldwlGLkd

  49. Time course analysis of the all-trans retinoic acid (ATRA)-regulated transcriptome in rat testis NURSA

    Keywords: other whole testis

    Description: Testies were isolated from male Sprague-Dawley rats fed a vitamin-A deficient diet for 9 weeks (control) and subsequently injected with 7.5 mg ATRA fo...

    ID: 10.1621/pj7lKPryAA

  50. Analysis of the adrenergic β3 receptor agonist CL316243-regulated transcriptome in the stromal vascular fraction of murine white adipose tissue (WAT) NURSA

    Keywords: WAT unspecified

    Description: The stromal vascular fraction from gonadonal WAT was isolated from female C57Bl/6 mice 8 weeks of age treated for 3 d with 1 mg/kg bw/d CL316243 or ve...

    ID: 10.1621/U35Nkcxdo1


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