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  1. Increased DNA Methylation of Dnmt3b-Targets Impairs Leukemogenesis (expression) ArrayExpress

    ID: E-GEOD-71040

    Description: Here, we analyzed global gene expression changes that were associated with over expression of Dnmt3b in MLL-AF9 induced leukemias using the Affymetrix...

  2. Alternative cleavage and polyadenylation in spermatogenesis coordinates chromatin regulation and post-transcriptional control ArrayExpress

    ID: E-GEOD-73973

    Description: Most mammalian genes display alternative cleavage and polyadenylation (APA). Previous studies have indicated preferential expression of APA isoforms w...

  3. Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphoma ArrayExpress

    ID: E-GEOD-63265

    Description: Aggressive double and triple hit (DH/TH) DLBCL feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls post-transcriptional ...

  4. The Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML [Mouse Dot1l ko RNA-seq] ArrayExpress

    ID: E-GEOD-76748

    Description: Purpose: To characterize transcriptional changes associated with homozygous inactivation of Dot1l or Mll1 in MN1 driven AML Methods: We sequenced mRNA...

  5. MDM33 overexpression suppressor screen ArrayExpress

    ID: E-GEOD-49580

    Description: We performed a genome-wide screen for genetic MDM33 interaction partners. Using the opposite approach of the well known synthetic dosage lethality (sc...

  6. microRNA expression in hematopoietic-associated populations differentiated from induced pluripotent stem cells ArrayExpress

    ID: E-GEOD-69503

    Description: In vitro generation of mature neutrophils from human induced pluripotent stem cells (iPSCs) requires hematopoietic progenitor development followed by ...

  7. The Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML ArrayExpress

    ID: E-GEOD-76750

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  8. Transcription profiling of human umbilical vein endothelial cells overexpressing constitutively active FOXO1 to identify FOXO1 target genes ArrayExpress

    ID: E-MTAB-4023

    Description: Adenoviral expression of a constitutive active FOXO1 vs. control GFP in human umbilical vein endothelial cells (HUVEC). Expression analysis 16 h after...

  9. Role of ST2 expession in regulatory Tcells on muscle regneration ArrayExpress

    ID: E-GEOD-76697

    Description: We describe the effects of Treg ST2 expression on muscle regeneration. We compare regneration from cryo-injured tibialis anterior muscle from Foxp3-C...

  10. Beta-catenin stabilization of skin fibroblasts causes fibrotic lesions by preventing adipocyte differentiation of the reticular dermis ArrayExpress

    ID: E-GEOD-76751

    Description: The Wnt/alpha-catenin pathway plays a central role in epidermal homeostasis and regeneration but how it affects fibroblast fate decisions is unknown. ...

  11. Transcriptome analysis upon SIN3 or dKDM5/LID knockdown or both under normal and paraquat induced stress conditions in Drosophila S2 cultured cells ArrayExpress

    ID: E-GEOD-68775

    Description: SIN3 the scaffold protein of a histone deacetylase complex interacts with a histone demethylase KDM5 (little imaginal discs - LID) in Drosophila. Redu...

  12. Gene expression analysis of untreated and NT-shRNA transduced kidney proximal tubular epithelial cells (PTECs) at day 6 and day 16 after transduction,... ArrayExpress

    ID: E-GEOD-72792

    Description: Primary kidney PTECs gradually became senescesince day 16, but SETD2 depletion prevented PTECs from senescence and maintained their proliferation beyo...

  13. Analysis of the role of Micu1 in maintaining functional homeostasis in mouse liver ArrayExpress

    ID: E-GEOD-69801

    Description: In this study, we analyzed global liver gene expression in MICU1 knock-down (KD) mice. To generate liver-specific MICU1 KD mice, MICU1loxp/loxp male m...

  14. The human cellular nucleic acid binding protien binds G-rich elements close to translation initiation sires and promotes translation. [RNA-Seq] ArrayExpress

    ID: E-GEOD-76627

    Description: CNBP is a eukaryote-conserved nucleic-acid binding protein required in mammals for embryonic development. It contains seven CCHC-type zinc-finger doma...

  15. Downstream genes regulated by TSHZ2 in MCF-7 cells ArrayExpress

    ID: E-GEOD-64351

    Description: To clarify downstream genes regulated by TSHZ2, MCF-7 cells were lentivirally transduced by TSHZ2 and its control LacZ and served their RNA samples fo...

  16. Expression data from rat orthotopic bladder cancer ArrayExpress

    ID: E-GEOD-76702

    Description: In the development and progression of bladder cancer, there are many genetic changes. We established a SD rat orthotopic bladder cancer model through ...

  17. Transcriptional reprogramming and resistance to colonic mucosal injury in PARP1-deficient mice ArrayExpress

    ID: E-GEOD-76658

    Description: Poly(ADP-ribose) polymerases (PARPs) synthesize and bind branched polymers of ADP-ribose to acceptor proteins using NAD as a substrate, ...

  18. Gene expression data from lung of mice infected with H5N1 or H1N1 virus ArrayExpress

    ID: E-GEOD-76719

    Description: To find the different host response during H5N1 and H1N1 infection, we have employed whole genome microarray expression profiling as a discovery platf...

  19. Identification of differentially expressed microRNAs between the fenpropathrin resistant and susceptible strains in Tetranychus cinnabarinus ArrayExpress

    ID: E-GEOD-76584

    Description: Purpose: The present study provides the firstly large-scale characterization of miRNAs in Tetranychus cinnabarinus and the comparison between fenpropa...

  20. Cell wall-deficient Mycoplasma hominis represses biofilm formation of uropathogenic Escherichia coli ArrayExpress

    ID: E-GEOD-43376

    Description: The features of Mycoplasma in human organ such lung and urinary tract are enigmatic. Here, the role of M. hominis in regard to biofilm formation of u...

  21. C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection ArrayExpress

    ID: E-GEOD-72503

    Description: Whole-genome data was developed from influenza virus infected A549 cells to better characterize the effect of C646 on influenza virus infection A549 c...

  22. Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus ArrayExpress

    ID: E-GEOD-74709

    Description: Higher order chromatin structure establishes domains that organize the genome and coordinate gene expression. However, the molecular mechanisms contr...

  23. Transcriptional profiling of endobronchial ultrasound guided lymph node samples to aid diagnosis of mediastinal lymphadenopathy ArrayExpress

    ID: E-MTAB-2547

    Description: Endobronchial ultrasound (EBUS) guided biopsy is becoming the mainstay for investigation of mediastinal lymphadenopathy to aid laboratory diagnosis of...

  24. Invariant TAD boundaries constrain cell type-specific looping interactions between promoters and distal elements around the CFTR locus ArrayExpress

    ID: E-GEOD-75634

    Description: Three-dimensional genome structure plays an important role in gene regulation. Globally chromosomes are organized into active and inactive compartmen...

  25. The cytokine DIEDEL and a viral homologue suppress deleterious IMD-dependent gene expression in drosophila ArrayExpress

    ID: E-GEOD-68174

    Description: Viral infection in Drosophila triggers inducible gene expression, but the function of many of these genes and the biological significance of their ind...

  26. Neuronal and glial Gene expression from control and healthy patient iPSC-derived forebrain neurons (A) ArrayExpress

    ID: E-GEOD-76545

    Description: Neuronal or glial cell fates related gene expression from single cells with variety of sAPPa or total Aβ secretion profiles were presented here. Sing...

  27. Orbital Cavernous Hemangioma Tissues: Control vs. Benign Lymphoepithelial Lesions of the Lacrimal Gland tissues ArrayExpress

    ID: E-GEOD-76497

    Description: Aim to investigate the pathogenesis of BLEL of the lacrimal gland, which is a kind of IgG4 related disease. A prospective study. Orbital Cavernous Hem...

  28. Transcriptome analysis of Pseudomonas aeruginosa PAO1 Response to L-Glutamate or D-Arginine ArrayExpress

    ID: E-GEOD-76493

    Description: Arginine utilization in Pseudomonas aeruginosa with multiple catabolic pathways represents one of the best examples of metabolic versatility of this o...

  29. Arabidopsis thaliana Growth is Negatively Regulated by the Class III Peroxidase AtPrx71 during Development and in Response to Cell Wall Damage ArrayExpress

    ID: E-GEOD-66980

    Description: The cell wall is a crucial structure in plant cells, and modifications in its composition often have a major impact on growth and development. However...

  30. Suppression of Transcriptional Drift Extends C. elegans Lifespan by Postponing the Onset of Mortality ArrayExpress

    ID: E-GEOD-63528

    Description: Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging co...

  31. Genome-wide peripheral blood transcriptome analysis of Arab female Lupus and Lupus nephritis ArrayExpress

    ID: E-GEOD-62764

    Description: Genome-wide alternative splice analysis of RNA from lupus and its severe form lupus nephritis We aimed to explore the genome-wide peripheral blood tra...

  32. A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells ArrayExpress

    ID: E-GEOD-76502

    Description: There is little insight into or agreement about the signals that control differentiation of memory B cells (MBC) and long-lived plasma cells (LLPC). B...

  33. A conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing ArrayExpress

    ID: E-GEOD-74741

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  34. Expression profile of Pseudomonas aeruginosa ΔgcsR PAO1 using RNA-Seq ArrayExpress

    ID: E-GEOD-76522

    Description: The TyrR-like enhancer-binding protein GcsR (or PA2449) was shown to regulate the expression of genes required for glycine metabolism. In order to def...

  35. Transcriptome and/or marker frequency analysis of S. pneumoniae (control vs. HPUra/Kanamycin/Ciprofloxacin/Hydroxyurea/Rifampicin) ArrayExpress

    ID: E-GEOD-69729

    Description: Pneumococcal bacteriocins (pneumocins) are antibacterial toxins that mediate intra- and interspecies competition within the human host. What triggers ...

  36. Cancer stem cell features shift during skin squamous cell carcinoma progression ArrayExpress

    ID: E-GEOD-59439

    Description: Cancer stem cells (CSCs) play a key role in tumour growth and metastasis. Although an expansion of CSC population was previously described in advanced...

  37. Transcriptome Sequencing (RNAseq) enables utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Explorati... ArrayExpress

    ID: E-GEOD-76207

    Description: Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq...

  38. Transcriptome profile of liver at different physiological stages in laying hens ArrayExpress

    ID: E-GEOD-70010

    Description: In this study, RNA-Seq technology was adopted to investigate the differences in expression profiles of the hepatic lipid metabolism-related genes and ...

  39. Tumor suppressor role of Ezh2 in an NRASQ61K driven model of Early T-cell Precursor Acute Lymphoblastic Leukemia (RNA-Seq) ArrayExpress

    ID: E-GEOD-76602

    Description: Purpose: To characterize transcriptional changes associated with homozygous inactivation the Polycomb Repressive Complex 2 (PRC2) lysine methyltransfe...

  40. Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine ArrayExpress

    ID: E-GEOD-36563

    Description: BACKGROUND: Therapy resistance remains one of the major challenges to improve the prognosis of patients with pancreatic cancer. Chemoresistant cells, ...

  41. Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma ArrayExpress

    ID: E-GEOD-71911

    Description: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

  42. Insights into responses of human astrocytes to H5N1 infection by transcriptional analysis ArrayExpress

    ID: E-GEOD-66597

    Description: Increasing evidence demonstrates influenza virus can not only affect the respiratory system, but also infect CNS and lead to CNS disorder and encephal...

  43. caArray_EXP-578: Gene Expression Profiles of Pediatric B-Precursor High-Risk Acute Lymphoblastic Leukemia (COG Study AALL0232 - Cohort 1) ArrayExpress

    ID: E-GEOD-68790

    Description: This experiment comprises 283 CEL files generated on the Affymetrix U133 Plus 2.0 gene expression microarray platform, using patient peripheral blood ...

  44. Exon array profiles of primary human Ewing sarcoma tumors ArrayExpress

    ID: E-GEOD-68776

    Description: Affymetrix exon array data were generated from total RNA that was isolated from localized Ewing sarcoma biopsy specimens. Expression of transcript sum...

  45. FACT and Spt6 Prevent Cryptic Transcription by Impeding H2A.Z Loading in Gene Bodies ArrayExpress

    ID: E-GEOD-62880

    Description: H2A.Z is a highly conserved histone variant involved in several key nuclear processes. It is incorporated into promoters by SWR-C-related chromatin re...

  46. Transcriptome profiling of Bmi1 silenced-K562 CML cell line ArrayExpress

    ID: E-GEOD-54262

    Description: The Bmi1 Polycomb protein is involved in the epigenetic repressive control of self renewal and survival of cancer initiating cells. In Chronic Myeloid...

  47. 3' RNA-seq of fly expressing cabut RNAi after exposure to different levels of sucrose ArrayExpress

    ID: E-GEOD-58854

    Description: Control (+/cbtE1-UAS-cbt RNAi) or cabut RNAi flies (Tim-gal4, UAS-cbt RNAi) were starved for 16 hours and then exposed to food containing different co...

  48. Early depletion of primordial germ cells in zebrafish promotes testis formation ArrayExpress

    ID: E-GEOD-57046

    Description: The requirement for primordial germ cells (PGCs) during sexual differentiation is variable among vertebrates. It has been shown that in zebrafish comp...

  49. The expression profiles of extracellular matrix-related genes in the presence or absence of EBI3 in the PCR array ArrayExpress

    ID: E-GEOD-68649

    Description: We performed a PCR array of 84 ECM-related genes using RNA obtained from dermal fibroblasts stimulated with or without EBI3. 18 of the 84 genes were u...

  50. YBX1 small-RNA HITS-CLIP ArrayExpress

    ID: E-GEOD-63597

    Description: In order to identify YBX1 binding sites on tRNA fragments, we performed small-RNA HITS-CLIP on endogenous YBX1 We used a previously published method t...

Displaying 50 of 2,122,300 results for " "